Lbp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lbp
Entrez Gene ID	16803
Full Name	lipopolysaccharide binding protein
Synonyms	Bpifd2,Ly88
General protein information	Preferred Names lipopolysaccharide binding protein Names lipopolysaccharide-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H1\|2 78.72 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008489.2	NP_032515.2	lipopolysaccharide-binding protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	LBP	NP_004130.2
Bos taurus (cattle)	LBP	NP_001033763.1
Mus musculus (house mouse)	Lbp	NP_032515.2
	LBP	XP_001094451.1
Rattus norvegicus (Norway rat)	Lbp	NP_058904.2
Canis lupus familiaris (dog)	LBP	XP_542993.3

Gene Ontology
Bibliography

Related articles in PubMed

Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice.
Jin CJ, Engstler AJ, Ziegenhardt D, Bischoff SC, Trautwein C, Bergheim I
Journal of gastroenterology and hepatology32(3)708-715(2017 Mar)

Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans.
Gavald?-Navarro A, Moreno-Navarrete JM, Quesada-L?pez T, Cair? M, Giralt M, Fern?ndez-Real JM, Villarroya F
Diabetologia59(10)2208-18(2016 Oct)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, Towne JE
Immunity43(4)739-50(2015 Oct)

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.
Summa KC, Jiang P, Fitzpatrick K, Voigt RM, Bowers SJ, Forsyth CB, Vitaterna MH, Keshavarzian A, Turek FW
Alcoholism, clinical and experimental research39(10)1917-29(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LBP is a critical factor in the development of non-alcoholic fatty liver disease.
Title: Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice.

LBP is a proinflammatory soluble adipokine that acts as a brake for adipogenesis, strengthening the negative effects of palmitate and LPS on adipocyte differentiation.
Title: Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.

The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
Title: The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.

Differential expression of LBP and TGFB1, along with other genes, in different mesenchymal stromal cells preparations, produces the variable responses to external stimuli.
Title: Divergent levels of LBP and TGF?1 in murine MSCs lead to heterogenic response to TLR and proinflammatory cytokine activation.

findings describe a novel role for LBP in normal hippocampal development and raise the possibility that some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP during a critical period of neurodevelopment.
Title: Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.

The following Lbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20673	NM_008489.2 Latest version!	Mus musculus lipopolysaccharide binding protein (Lbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lbp ( NM_008489.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032515.2 Mus musculus lipopolysaccharide binding protein (Lbp), mRNA.

Price & Availability↑

CloneID	OMu20673
Clone ID Related Accession (Same CDS sequence)	NM_008489.2
Accession Version	NM_008489.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	lipopolysaccharide-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK143562.1, AA207419.1, BQ176753.1, AL663063.14 and AI643881.1. On Sep 1, 2006 this sequence version replaced NM_008489.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X99347.1, BC004795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCTG GGACTGGACC TCTGCTCTCT ACATTGCTGG GGCTGCTGTT CCTGTCCATA 
CAGGGAACTG GCGGTGTCAA CCCCGGTGTG GTGGCCAGGA TCACCGACAA GGGCCTGGCC 
TACGCGGCCA AGGAGGGGCT GGTGGCTCTG CAGAGAGAGC TGTACAAGAT CACACTACCG 
GACTTCAGCG GGGACTTCAA GATCAAGGCC GTGGGTCGTG GGCAGTACGA GTTTCATAGC 
CTGGAGATTC AGAACTGTGA GCTGCGTGGC TCCTCTCTGA AGCTGCTCCC AGGCCAGGGC 
CTGAGTCTCG CCATCTCTGA CTCTTCCATC GGTGTCCGAG GCAAATGGAA GGTGCGCAAA 
TCCTTCCTGA AACTTCATGG CTCCTTTGAC CTGGATGTCA AAGGTGTCAC CATTTCAGTG 
GACCTCCTCC TGGGCATGGA TCCCTCAGGG CGGCCCACAG TCTCTGCCTC TGGGTGCAGC 
AGCCGCATTT GTGATTTGGA TGTGCACATA TCAGGAAATG TGGGGTGGCT GCTGAATCTC 
TTCCACAACC AGATCGAGTC GAAGCTCCAG AAAGTACTGG AGAATAAGGT TTGTGAGATG 
ATCCAGAAGT CTGTGACCTC TGACCTGCAG CCTTATCTCC AGACTCTGCC AGTCACAGCA 
GAGATCGACA ATGTCCTGGG CATTGACTAC AGTTTGGTGG CGGCTCCCCA AGCGAAGGCC 
CAGGTGCTGG ATGTCATGTT TAAGGGTGAA ATTTTTAATC GGAATCACCG CTCTCCAGTT 
GCTACCCCCA CTCCGACCAT GAGCCTACCT GAGGACAGTA AGCAAATGGT CTACTTTGCC 
ATCTCAGATT ATGCCTTCAA CATAGCCAGC CGGGTTTATC ACCAGGCTGG GTACCTGAAT 
TTTTCCATCA CAGATGACAT GTTACCACAT GACTCCGGCA TCCGGTTGAA CACCAAGGCC 
TTCCGTCCCT TCACTCCCCA GATATACAAA AAGTATCCCG ACATGAAATT GGAGCTCCTT 
GGAACAGTGG TCTCTGCCCC GATTCTGAAT GTCAGTCCTG GGAATCTGTC CTTGGCCCCA 
CAGATGGAGA TCGAAGGCTT TGTGATCCTG CCCACCTCCG CCCGGGAACC TGTCTTCCGG 
CTTGGCGTGG TCACTAATGT ATTTGCCTCA TTAACTTTCA ACAACAGCAA GGTTACCGGG 
ATGCTGCATC CAGACAAGGC ACAAGTGAGA CTGATCGAAT CCAAAGTCGG CATGTTCAAT 
GTGAACCTGT TCCAGGCATT CCTTAACTAC TACCTTCTCA ACAGCCTCTA CCCTGATGTC 
AATGCTGAGC TGGCCCAGGG CTTCCCCCTC CCTCTGCCAA GGCATATTCA GCTCCACGAC 
CTCGACTTCC AGATCCGCAA GGACTTCTTA TACTTGGGTG CCAATGTCCA GTATATGAGA 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032515.2
CDS	178..1623
Translation	MKAGTGPLLSTLLGLLFLSIQGTGGVNPGVVARITDKGLAYAAKEGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELRGSSLKLLPGQGLSLAISDSSIGVRGKWKVRKSFLKLHGSFDLDVKGVTISVDLLLGMDPSGRPTVSASGCSSRICDLDVHISGNVGWLLNLFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLQTLPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRSPVATPTPTMSLPEDSKQMVYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLNTKAFRPFTPQIYKKYPDMKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAREPVFRLGVVTNVFASLTFNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNAELAQGFPLPLPRHIQLHDLDFQIRKDFLYLGANVQYMRV

Target ORF information:

RefSeq Version	NM_008489.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lipopolysaccharide binding protein (Lbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008489.2

ORF Insert Sequence:

ATGAAGGCTG GGACTGGACC TCTGCTCTCT ACATTGCTGG GGCTGCTGTT CCTGTCCATA 
CAGGGAACTG GCGGTGTCAA CCCCGGTGTG GTGGCCAGGA TCACCGACAA GGGCCTGGCC 
TACGCGGCCA AGGAGGGGCT GGTGGCTCTG CAGAGAGAGC TGTACAAGAT CACACTACCG 
GACTTCAGCG GGGACTTCAA GATCAAGGCC GTGGGTCGTG GGCAGTACGA GTTTCATAGC 
CTGGAGATTC AGAACTGTGA GCTGCGTGGC TCCTCTCTGA AGCTGCTCCC AGGCCAGGGC 
CTGAGTCTCG CCATCTCTGA CTCTTCCATC GGTGTCCGAG GCAAATGGAA GGTGCGCAAA 
TCCTTCCTGA AACTTCATGG CTCCTTTGAC CTGGATGTCA AAGGTGTCAC CATTTCAGTG 
GACCTCCTCC TGGGCATGGA TCCCTCAGGG CGGCCCACAG TCTCTGCCTC TGGGTGCAGC 
AGCCGCATTT GTGATTTGGA TGTGCACATA TCAGGAAATG TGGGGTGGCT GCTGAATCTC 
TTCCACAACC AGATCGAGTC GAAGCTCCAG AAAGTACTGG AGAATAAGGT TTGTGAGATG 
ATCCAGAAGT CTGTGACCTC TGACCTGCAG CCTTATCTCC AGACTCTGCC AGTCACAGCA 
GAGATCGACA ATGTCCTGGG CATTGACTAC AGTTTGGTGG CGGCTCCCCA AGCGAAGGCC 
CAGGTGCTGG ATGTCATGTT TAAGGGTGAA ATTTTTAATC GGAATCACCG CTCTCCAGTT 
GCTACCCCCA CTCCGACCAT GAGCCTACCT GAGGACAGTA AGCAAATGGT CTACTTTGCC 
ATCTCAGATT ATGCCTTCAA CATAGCCAGC CGGGTTTATC ACCAGGCTGG GTACCTGAAT 
TTTTCCATCA CAGATGACAT GTTACCACAT GACTCCGGCA TCCGGTTGAA CACCAAGGCC 
TTCCGTCCCT TCACTCCCCA GATATACAAA AAGTATCCCG ACATGAAATT GGAGCTCCTT 
GGAACAGTGG TCTCTGCCCC GATTCTGAAT GTCAGTCCTG GGAATCTGTC CTTGGCCCCA 
CAGATGGAGA TCGAAGGCTT TGTGATCCTG CCCACCTCCG CCCGGGAACC TGTCTTCCGG 
CTTGGCGTGG TCACTAATGT ATTTGCCTCA TTAACTTTCA ACAACAGCAA GGTTACCGGG 
ATGCTGCATC CAGACAAGGC ACAAGTGAGA CTGATCGAAT CCAAAGTCGG CATGTTCAAT 
GTGAACCTGT TCCAGGCATT CCTTAACTAC TACCTTCTCA ACAGCCTCTA CCCTGATGTC 
AATGCTGAGC TGGCCCAGGG CTTCCCCCTC CCTCTGCCAA GGCATATTCA GCTCCACGAC 
CTCGACTTCC AGATCCGCAA GGACTTCTTA TACTTGGGTG CCAATGTCCA GTATATGAGA 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice.
Journal of gastroenterology and hepatology32(3)708-715(2017 Mar)
Jin CJ,Engstler AJ,Ziegenhardt D,Bischoff SC,Trautwein C,Bergheim I

Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans.
Diabetologia59(10)2208-18(2016 Oct)
Gavald?-Navarro A,Moreno-Navarrete JM,Quesada-L?pez T,Cair? M,Giralt M,Fern?ndez-Real JM,Villarroya F

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Immunity43(4)739-50(2015 Oct)
Maxwell JR,Zhang Y,Brown WA,Smith CL,Byrne FR,Fiorino M,Stevens E,Bigler J,Davis JA,Rottman JB,Budelsky AL,Symons A,Towne JE

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.
Alcoholism, clinical and experimental research39(10)1917-29(2015 Oct)
Summa KC,Jiang P,Fitzpatrick K,Voigt RM,Bowers SJ,Forsyth CB,Vitaterna MH,Keshavarzian A,Turek FW

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Lbp cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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