Klra8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra8
Entrez Gene ID	16639
Full Name	killer cell lectin-like receptor, subfamily A, member 8
Synonyms	Cmv-1,Cmv1,Ly49h,Ly49u<129>
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 8 Names killer cell lectin-like receptor 8 T-cell surface glycoprotein Ly-49H cytomegalovirus resistance 1 ly-49h lymphocyte antigen 49h
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 63.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010650.3	NP_034780.1	killer cell lectin-like receptor 8 isoform 2
NM_001101620.1	NP_001095090.1	killer cell lectin-like receptor 8 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klra9	NP_034781.2
Mus musculus (house mouse)	Klra21	NP_444381.1
Mus musculus (house mouse)	Klra3	NP_034778.2
Mus musculus (house mouse)	Klra1	NP_057868.2
Mus musculus (house mouse)	Klra4	NP_034779.1
Mus musculus (house mouse)	Gm15854	XP_003688868.1
Mus musculus (house mouse)	Klra6	NP_032490.1
Mus musculus (house mouse)	Klra10	NP_032485.2
Mus musculus (house mouse)	Klra7	NP_001103793.1
Mus musculus (house mouse)	Klra5	NP_032489.1
Mus musculus (house mouse)	Klra8	NP_034780.1
Rattus norvegicus (Norway rat)	Klra2	NP_001009718.1

Gene Ontology
Bibliography

Related articles in PubMed

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popovi? B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpoti? A, Allan DSJ, Makrigiannis AP, Jonji? S, Rossjohn J, Carlyle JR
Cell169(1)58-71.e14(2017 Mar)

Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.
Romasanta PN, Curto LM, Sarratea MB, Noli Truant S, Antonoglou MB, Fern?ndez Lynch MJ, Delfino JM, Mariuzza RA, Fern?ndez MM, Malchiodi EL
The Biochemical journal474(1)179-194(2017 01)

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
Nabekura T, Lanier LL
Immunity45(1)74-82(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven.
Title: Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.

Ly49H has a role in antiviral activity.
Title: Targeting of a natural killer cell receptor family by a viral immunoevasin.

Signaling through the Ly49H receptor is necessary to induce transient Ly49H-mediated natural killer (NK) cell tolerance during chronic viral infection.
Title: Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.

m157 gene(G1F)-Ly49C interactions cause no apparent attenuating effect on clearance of murine cytomegalovirus from natural killer (NK) cells.
Title: Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation.

NK cell expansion is increased through an Ly49H-dependent pathway to promote alternative beneficial effects.
Title: Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection.

The following Klra8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06535	NM_010650.3 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu03634	NM_001101620.1 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra8 ( NM_010650.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034780.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu06535
Clone ID Related Accession (Same CDS sequence)	NM_010650.3
Accession Version	NM_010650.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-24
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 8 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK143236.1. On Mar 22, 2007 this sequence version replaced NM_010650.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein(isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGAGC AGGAGGTCAC TTTCCCAACT ATGAGATTCC ACAAGTCTTC AGGGTTGAAC 
AGCCAGGTGA GACTTGAGGG GACTCAGAGA TCTAGAAAAG CTGGCCTAAG AGTCCCTTGG 
CAGCTCATTG TGATAGCTCT TGGAATCCTC TGTTCCCTTC GGCTGGTAAT TGTTGCAGTG 
TTTGTGACAA AGTTTTTTCA GTATAGTCAA CACAAACAAG AAATCAATGA AACTCTCAAC 
CACCGCCATA ACTGCAGCAA CATGCAAAGG GATTTCAACT TAAAGGAAGA AATGTTGACA 
AATAAGTCTA TAGATTGTAG GCCAAGCTAT GAACTTCTGG AATACATCAA AAGAGAACAG 
GAGAGATGGG ACAGTGAAAC CAAGAGTGTT TCAGATTCTT CACGAGACAC AGGCAGAGGT 
GTTAAATACT GGTTCTGCTA TGGTACTAAA TGTTATTATT TCATCATGAA TAAAACTACA 
TGGAGTGGAT GTAAAGCGAA CTGCCAGCAT TACAGCGTTC CCATTGTGAA GATAGAAGAT 
GAAGATGAAC TGAAATTCCT TCAACGCCAT GTTATTCTAG AGAGTTACTG GATTGGATTG 
TCATATGATA AGAAAAAAAA GGAATGGGCA TGGATTCACA ATGGCCAATC TAAACTTGAC 
ATGAAAATAA AGAAAATGAA CTTTACGTCT AGAGGATGTG TATTTTTATC TAAAGCAAGA 
ATAGAAGATA CTGACTGTAA TACTCCCTAC TACTGTATTT GTGGGAAGAA ACTGGATAAA 
TTCCCTGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034780.1
CDS	83..874
Translation	MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVPWQLIVIALGILCSLRLVIVAVFVTKFFQYSQHKQEINETLNHRHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQERWDSETKSVSDSSRDTGRGVKYWFCYGTKCYYFIMNKTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVILESYWIGLSYDKKKKEWAWIHNGQSKLDMKIKKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD

Target ORF information:

RefSeq Version	NM_010650.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010650.3

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTTCCCAACT ATGAGATTCC ACAAGTCTTC AGGGTTGAAC 
AGCCAGGTGA GACTTGAGGG GACTCAGAGA TCTAGAAAAG CTGGCCTAAG AGTCCCTTGG 
CAGCTCATTG TGATAGCTCT TGGAATCCTC TGTTCCCTTC GGCTGGTAAT TGTTGCAGTG 
TTTGTGACAA AGTTTTTTCA GTATAGTCAA CACAAACAAG AAATCAATGA AACTCTCAAC 
CACCGCCATA ACTGCAGCAA CATGCAAAGG GATTTCAACT TAAAGGAAGA AATGTTGACA 
AATAAGTCTA TAGATTGTAG GCCAAGCTAT GAACTTCTGG AATACATCAA AAGAGAACAG 
GAGAGATGGG ACAGTGAAAC CAAGAGTGTT TCAGATTCTT CACGAGACAC AGGCAGAGGT 
GTTAAATACT GGTTCTGCTA TGGTACTAAA TGTTATTATT TCATCATGAA TAAAACTACA 
TGGAGTGGAT GTAAAGCGAA CTGCCAGCAT TACAGCGTTC CCATTGTGAA GATAGAAGAT 
GAAGATGAAC TGAAATTCCT TCAACGCCAT GTTATTCTAG AGAGTTACTG GATTGGATTG 
TCATATGATA AGAAAAAAAA GGAATGGGCA TGGATTCACA ATGGCCAATC TAAACTTGAC 
ATGAAAATAA AGAAAATGAA CTTTACGTCT AGAGGATGTG TATTTTTATC TAAAGCAAGA 
ATAGAAGATA CTGACTGTAA TACTCCCTAC TACTGTATTT GTGGGAAGAA ACTGGATAAA 
TTCCCTGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra8 ( NM_001101620.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001095090.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu03634
Clone ID Related Accession (Same CDS sequence)	NM_001101620.1
Accession Version	NM_001101620.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-24
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 8 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090127.11. On Sep 4, 2008 this sequence version replaced XM_001471777.1. Transcript Variant: represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAGTGAGC AGGAGGTCAC TTTCCCAACT ATGAGATTCC ACAAGTCTTC AGGGTTGAAC 
AGCCAGGTGA GACTTGAGGG GACTCAGAGA TCTAGAAAAG CTGGCCTAAG AGTGTGTTCA 
GTCCCTTGGC AGCTCATTGT GATAGCTCTT GGAATCCTCT GTTCCCTTCG GCTGGTAATT 
GTTGCAGTGT TTGTGACAAA GTTTTTTCAG TATAGTCAAC ACAAACAAGA AATCAATGAA 
ACTCTCAACC ACCGCCATAA CTGCAGCAAC ATGCAAAGGG ATTTCAACTT AAAGGAAGAA 
ATGTTGACAA ATAAGTCTAT AGATTGTAGG CCAAGCTATG AACTTCTGGA ATACATCAAA 
AGAGAACAGG AGAGATGGGA CAGTGAAACC AAGAGTGTTT CAGATTCTTC ACGAGACACA 
GGCAGAGGTG TTAAATACTG GTTCTGCTAT GGTACTAAAT GTTATTATTT CATCATGAAT 
AAAACTACAT GGAGTGGATG TAAAGCGAAC TGCCAGCATT ACAGCGTTCC CATTGTGAAG 
ATAGAAGATG AAGATGAACT GAAATTCCTT CAACGCCATG TTATTCTAGA GAGTTACTGG 
ATTGGATTGT CATATGATAA GAAAAAAAAG GAATGGGCAT GGATTCACAA TGGCCAATCT 
AAACTTGACA TGAAAATAAA GAAAATGAAC TTTACGTCTA GAGGATGTGT ATTTTTATCT 
AAAGCAAGAA TAGAAGATAC TGACTGTAAT ACTCCCTACT ACTGTATTTG TGGGAAGAAA 
CTGGATAAAT TCCCTGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095090.1
CDS	146..946
Translation	MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQLIVIALGILCSLRLVIVAVFVTKFFQYSQHKQEINETLNHRHNCSNMQRDFNLKEEMLTNKSIDCRPSYELLEYIKREQERWDSETKSVSDSSRDTGRGVKYWFCYGTKCYYFIMNKTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVILESYWIGLSYDKKKKEWAWIHNGQSKLDMKIKKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD

Target ORF information:

RefSeq Version	NM_001101620.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 8 (Klra8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001101620.1

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTTCCCAACT ATGAGATTCC ACAAGTCTTC AGGGTTGAAC 
AGCCAGGTGA GACTTGAGGG GACTCAGAGA TCTAGAAAAG CTGGCCTAAG AGTGTGTTCA 
GTCCCTTGGC AGCTCATTGT GATAGCTCTT GGAATCCTCT GTTCCCTTCG GCTGGTAATT 
GTTGCAGTGT TTGTGACAAA GTTTTTTCAG TATAGTCAAC ACAAACAAGA AATCAATGAA 
ACTCTCAACC ACCGCCATAA CTGCAGCAAC ATGCAAAGGG ATTTCAACTT AAAGGAAGAA 
ATGTTGACAA ATAAGTCTAT AGATTGTAGG CCAAGCTATG AACTTCTGGA ATACATCAAA 
AGAGAACAGG AGAGATGGGA CAGTGAAACC AAGAGTGTTT CAGATTCTTC ACGAGACACA 
GGCAGAGGTG TTAAATACTG GTTCTGCTAT GGTACTAAAT GTTATTATTT CATCATGAAT 
AAAACTACAT GGAGTGGATG TAAAGCGAAC TGCCAGCATT ACAGCGTTCC CATTGTGAAG 
ATAGAAGATG AAGATGAACT GAAATTCCTT CAACGCCATG TTATTCTAGA GAGTTACTGG 
ATTGGATTGT CATATGATAA GAAAAAAAAG GAATGGGCAT GGATTCACAA TGGCCAATCT 
AAACTTGACA TGAAAATAAA GAAAATGAAC TTTACGTCTA GAGGATGTGT ATTTTTATCT 
AAAGCAAGAA TAGAAGATAC TGACTGTAAT ACTCCCTACT ACTGTATTTG TGGGAAGAAA 
CTGGATAAAT TCCCTGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Cell169(1)58-71.e14(2017 Mar)
Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popovi? B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpoti? A,Allan DSJ,Makrigiannis AP,Jonji? S,Rossjohn J,Carlyle JR

Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.
The Biochemical journal474(1)179-194(2017 01)
Romasanta PN,Curto LM,Sarratea MB,Noli Truant S,Antonoglou MB,Fern?ndez Lynch MJ,Delfino JM,Mariuzza RA,Fern?ndez MM,Malchiodi EL

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
Immunity45(1)74-82(2016 07)
Nabekura T,Lanier LL

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Klra8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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