Klra1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra1
Entrez Gene ID	16627
Full Name	killer cell lectin-like receptor, subfamily A, member 1
Synonyms	A1,CH29-493D4.3,Klra22,Ly49a,Ly49o<129>,Ly49v
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 1 Names T-cell surface glycoprotein YE1/48 class I MHC receptor KLRA22 ly-49a lymphocyte antigen 49a natural killer cell receptor Ly49A novel killer cell lectin-like receptor subfamily A protein t lymphocyte antigen A1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 63.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_016659.3	NP_057868.2	T-cell surface glycoprotein YE1/48

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klra9	NP_034781.2
Mus musculus (house mouse)	Klra21	NP_444381.1
Mus musculus (house mouse)	Klra3	NP_034778.2
Mus musculus (house mouse)	Klra1	NP_057868.2
Mus musculus (house mouse)	Klra4	NP_034779.1
Mus musculus (house mouse)	Gm15854	XP_003688868.1
Mus musculus (house mouse)	Klra6	NP_032490.1
Mus musculus (house mouse)	Klra10	NP_032485.2
Mus musculus (house mouse)	Klra7	NP_001103793.1
Mus musculus (house mouse)	Klra5	NP_032489.1
Mus musculus (house mouse)	Klra8	NP_034780.1
Rattus norvegicus (Norway rat)	Klra2	NP_001009718.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.
Bern MD, Beckman DL, Ebihara T, Taffner SM, Poursine-Laurent J, White JM, Yokoyama WM
Proceedings of the National Academy of Sciences of the United States of America114(40)E8440-E8447(2017 Oct)

Natural killer cell licensing in mice with inducible expression of MHC class I.
Ebihara T, Jonsson AH, Yokoyama WM
Proceedings of the National Academy of Sciences of the United States of America110(45)E4232-7(2013 Nov)

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, Jiang M, Wu Y, Xu T, Cao X
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Schenkel AR, Kingry LC, Slayden RA
Frontiers in immunology490(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study found the receptor Ly49A bound the MHC class I molecule H2-M3 with an affinity similar to its affinity for H-2D(d); specific recognition of H2-M3 by Ly49A regulated 'licensing' of NK cells and mediated 'missing-self' recognition of H2-M3-deficient bone marrow
Title: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

The difference in frequency of Ly49A-specific natural killer (NK) cells between H2-Dd+/+ and H2-Dd+/2 mice is reflected by a skewed balance between proliferation and apoptosis in this subset.
Title: Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.

The membrane proximal nonligand binding ecto-domain (the stalk region) of Ly49A is critical to ligand binding and signaling.
Title: Essential role of the Ly49A stalk region for immunological synapse formation and signaling.

The association with MHC-I in cis sequestered wild-type Ly49A, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A
Title: A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Ly49A blocks Zap70, extracellular signal-regulated kinase 1/2 and c-Jun activation but leaves unique components of the CD28 signaling pathway intact.
Title: Engagement of transgenic Ly49A inhibits mouse CD4 cell activation by disrupting T cell receptor, but not CD28, signaling.

The following Klra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10413	NM_016659.3 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 1 (Klra1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra1 ( NM_016659.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_057868.2 Mus musculus killer cell lectin-like receptor, subfamily A, member 1 (Klra1), mRNA.

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CloneID	OMu10413
Clone ID Related Accession (Same CDS sequence)	NM_016659.3
Accession Version	NM_016659.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	T-cell surface glycoprotein YE1/48
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087336.5 and AK080158.1. On or before Nov 15, 2007 this sequence version replaced XM_001471779.1, XM_001471680.1, NM_016659.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY078436.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849380 [ECO:0000350] ##Evidence-Data-END##

ATGAGTGAGC AGGAGGTCAC TTATTCAATG GTGAGATTTC ATAAATCTGC AGGATTGCAG 
AAACAAGTGA GACCTGAGGA GACTAAAGGG CCCAGAGAAG CTGGCTACAG AAGGTGTTCA 
TTCCACTGGA AGTTCATTGT GATAGCTCTT GGCATCTTCT GTTTCCTTCT TCTGGTAGCT 
GTTTCAGTGT TGGCAATAAA AATTTTTCAG TATGATCAAC AAAAAAAACT GCAGGAATTT 
CTAAACCACC ACAATAACTG CAGCAACATG CAAAGTGACA TCAACTTGAA GGATGAAATG 
CTGAAAAATA AGTCTATAGA GTGTGATCTT CTGGAATCCC TCAACAGGGA TCAGAACAGA 
TTGTATAATA AAACCAAGAC TGTTTTAGAT TCCTTACAGC ACACAGGCAG AGGTGATAAA 
GTATACTGGT TCTGCTATGG TATGAAATGT TATTATTTCG TCATGGACAG AAAAACATGG 
AGTGGATGTA AACAGACCTG CCAGAGTTCC AGTTTATCCC TTCTGAAGAT AGATGATGAG 
GATGAACTGA AGTTCCTTCA GCTCGTGGTT CCTTCAGACA GTTGCTGGGT TGGATTGTCA 
TATGATAATA AGAAAAAAGA TTGGGCATGG ATTGACAATC GCCCATCTAA ACTTGCCTTG 
AACACAAGGA AATACAATAT AAGAGATGGG GGATGTATGT TGTTATCTAA AACAAGACTA 
GACAATGGTA ACTGTGATCA AGTATTCATC TGTATTTGTG GGAAGAGACT GGATAAATTC 
CCTCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057868.2
CDS	577..1365
Translation	MSEQEVTYSMVRFHKSAGLQKQVRPEETKGPREAGYRRCSFHWKFIVIALGIFCFLLLVAVSVLAIKIFQYDQQKKLQEFLNHHNNCSNMQSDINLKDEMLKNKSIECDLLESLNRDQNRLYNKTKTVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKTWSGCKQTCQSSSLSLLKIDDEDELKFLQLVVPSDSCWVGLSYDNKKKDWAWIDNRPSKLALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICGKRLDKFPH

Target ORF information:

RefSeq Version	NM_016659.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 1 (Klra1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016659.3

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTATTCAATG GTGAGATTTC ATAAATCTGC AGGATTGCAG 
AAACAAGTGA GACCTGAGGA GACTAAAGGG CCCAGAGAAG CTGGCTACAG AAGGTGTTCA 
TTCCACTGGA AGTTCATTGT GATAGCTCTT GGCATCTTCT GTTTCCTTCT TCTGGTAGCT 
GTTTCAGTGT TGGCAATAAA AATTTTTCAG TATGATCAAC AAAAAAAACT GCAGGAATTT 
CTAAACCACC ACAATAACTG CAGCAACATG CAAAGTGACA TCAACTTGAA GGATGAAATG 
CTGAAAAATA AGTCTATAGA GTGTGATCTT CTGGAATCCC TCAACAGGGA TCAGAACAGA 
TTGTATAATA AAACCAAGAC TGTTTTAGAT TCCTTACAGC ACACAGGCAG AGGTGATAAA 
GTATACTGGT TCTGCTATGG TATGAAATGT TATTATTTCG TCATGGACAG AAAAACATGG 
AGTGGATGTA AACAGACCTG CCAGAGTTCC AGTTTATCCC TTCTGAAGAT AGATGATGAG 
GATGAACTGA AGTTCCTTCA GCTCGTGGTT CCTTCAGACA GTTGCTGGGT TGGATTGTCA 
TATGATAATA AGAAAAAAGA TTGGGCATGG ATTGACAATC GCCCATCTAA ACTTGCCTTG 
AACACAAGGA AATACAATAT AAGAGATGGG GGATGTATGT TGTTATCTAA AACAAGACTA 
GACAATGGTA ACTGTGATCA AGTATTCATC TGTATTTGTG GGAAGAGACT GGATAAATTC 
CCTCATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.
Proceedings of the National Academy of Sciences of the United States of America114(40)E8440-E8447(2017 Oct)
Bern MD,Beckman DL,Ebihara T,Taffner SM,Poursine-Laurent J,White JM,Yokoyama WM

Natural killer cell licensing in mice with inducible expression of MHC class I.
Proceedings of the National Academy of Sciences of the United States of America110(45)E4232-7(2013 Nov)
Ebihara T,Jonsson AH,Yokoyama WM

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Proceedings of the National Academy of Sciences of the United States of America110(19)7814-9(2013 May)
Liu J,Liu S,Xia M,Xu S,Wang C,Bao Y,Jiang M,Wu Y,Xu T,Cao X

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Frontiers in immunology490(2013)
Schenkel AR,Kingry LC,Slayden RA

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Klra1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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