Klk1b5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klk1b5
Entrez Gene ID	16622
Full Name	kallikrein 1-related peptidase b5
Synonyms	Klk5,kallikrein,mGK-5
General protein information	Preferred Names kallikrein 1-related peptidase b5 Names kallikrein 1-related peptidase b5 glandular kallikrein K5 tissue kallikrein-5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.73 cM
Summary	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008456.3	NP_032482.1	kallikrein 1-related peptidase b5 precursor
NM_008456.4	NP_032482.1	kallikrein 1-related peptidase b5 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klk1b5	NP_032482.1
Mus musculus (house mouse)	Klk1b1	NP_034775.1
Mus musculus (house mouse)	Klk1b3	NP_032719.1
Mus musculus (house mouse)	Klk1b24	NP_034773.1
Mus musculus (house mouse)	Klk1b26	NP_034774.1
Mus musculus (house mouse)	Klk1b4	NP_035045.2
Mus musculus (house mouse)	Klk1b22	NP_034244.1
Mus musculus (house mouse)	Klk1b8	NP_032483.1
Mus musculus (house mouse)	Klk1b21	NP_034772.1
Mus musculus (house mouse)	Klk1b27	NP_064664.1
Homo sapiens (human)	KLK3	NP_001639.1
Mus musculus (house mouse)	Klk1b16	NP_032480.1
Mus musculus (house mouse)	Klk1b11	NP_034770.1
	KLK3	NP_001036241.1
Mus musculus (house mouse)	Klk1	NP_034769.4
Mus musculus (house mouse)	Klk1b9	NP_034246.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury.
Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, Ahrens K, Graumann N, Baurecht H, Reiss K, Schr?der JM, Proksch E, Meyer-Hoffert U
The Journal of investigative dermatology134(5)1305-1312(2014 May)

MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.
Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M
Physiological genomics44(4)259-67(2012 Feb)

Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS
BMC biology515(2007 Apr)

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM
Biological chemistry387(6)637-41(2006 Jun)

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Angata T, Margulies EH, Green ED, Varki A
Proceedings of the National Academy of Sciences of the United States of America101(36)13251-6(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data support a completely novel mechanism in which miR-382 targets kallikrein 5 and contributes to the development of renal inner medullary interstitial fibrosis.
Title: MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.

The following Klk1b5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk1b5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu01966	NM_008456.4 Latest version!	Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu01966	NM_008456.3	Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klk1b5 ( NM_008456.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032482.1 Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.

Price & Availability↑

CloneID	OMu01966
Clone ID Related Accession (Same CDS sequence)	NM_008456.3 , NM_008456.4
Accession Version	NM_008456.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	kallikrein 1-related peptidase b5 precursor
Comment

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATTTTTGG AGGATTTAAC TGTGAGAAGA ACTCCCAACC CTGGCAAGTG 
GCTGTGTACC GCTTCACCAA ATATCAATGC GGGGGAGTCC TGCTGAACGC CAACTGGGTT 
CTCACTGCTG CCCACTGCCA TAATGACAAG TACCAGGTTT GGCTGGGCAA AAACAACTTT 
TTTGAGGATG AACCCTCTGC CCAACACCGG CTTGTCAGCA AAGCCATCCC TCACCCTGAC 
TTCAACATGA GCCTCCTGAA TGAGCACACC CCACAACCTG AGGACGACTA CAGCAATGAC 
CTGATGCTGC TCCGCCTCAA AAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGAC 
CTGCCCACTG AGGAGCCCAA GCTGGGGAGC ACATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCGTCA TATACGAACC CGCAGATGAT CTCCAGTGTG TGAACTTCAA GCTCCTGCCT 
AATGAGGACT GTGTCAAAGC CCACATAGAG AAGGTGACAG ATGTTATGTT GTGTGCAGGA 
GATATGGATG GAGGCAAAGA CACTTGTATG GGTGACTCAG GAGGCCCACT GATCTGTGAT 
GGTGTTCTCC ACGGTATCAC ATCATGGGGC CCTAGCCCTT GCGGTAAACC CAATGTGCCA 
GGTATCTACA CCAAACTTAT TAAGTTTAAC TCTTGGATAA AAGACACTAT AGCTAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032482.1
Translation	MWFLILFLALSLGGIDAAPPVQSRIFGGFNCEKNSQPWQVAVYRFTKYQCGGVLLNANWVLTAAHCHNDKYQVWLGKNNFFEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVIYEPADDLQCVNFKLLPNEDCVKAHIEKVTDVMLCAGDMDGGKDTCMGDSGGPLICDGVLHGITSWGPSPCGKPNVPGIYTKLIKFNSWIKDTIAKNA

Target ORF information:

RefSeq Version	NM_008456.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008456.3

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATTTTTGG AGGATTTAAC TGTGAGAAGA ACTCCCAACC CTGGCAAGTG 
GCTGTGTACC GCTTCACCAA ATATCAATGC GGGGGAGTCC TGCTGAACGC CAACTGGGTT 
CTCACTGCTG CCCACTGCCA TAATGACAAG TACCAGGTTT GGCTGGGCAA AAACAACTTT 
TTTGAGGATG AACCCTCTGC CCAACACCGG CTTGTCAGCA AAGCCATCCC TCACCCTGAC 
TTCAACATGA GCCTCCTGAA TGAGCACACC CCACAACCTG AGGACGACTA CAGCAATGAC 
CTGATGCTGC TCCGCCTCAA AAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGAC 
CTGCCCACTG AGGAGCCCAA GCTGGGGAGC ACATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCGTCA TATACGAACC CGCAGATGAT CTCCAGTGTG TGAACTTCAA GCTCCTGCCT 
AATGAGGACT GTGTCAAAGC CCACATAGAG AAGGTGACAG ATGTTATGTT GTGTGCAGGA 
GATATGGATG GAGGCAAAGA CACTTGTATG GGTGACTCAG GAGGCCCACT GATCTGTGAT 
GGTGTTCTCC ACGGTATCAC ATCATGGGGC CCTAGCCCTT GCGGTAAACC CAATGTGCCA 
GGTATCTACA CCAAACTTAT TAAGTTTAAC TCTTGGATAA AAGACACTAT AGCTAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klk1b5 ( NM_008456.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032482.1 Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.

Price & Availability↑

CloneID	OMu01966
Clone ID Related Accession (Same CDS sequence)	NM_008456.3 , NM_008456.4
Accession Version	NM_008456.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	kallikrein 1-related peptidase b5 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124176.3. On Feb 23, 2016 this sequence version replaced NM_008456.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094281.1, BG870715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATTTTTGG AGGATTTAAC TGTGAGAAGA ACTCCCAACC CTGGCAAGTG 
GCTGTGTACC GCTTCACCAA ATATCAATGC GGGGGAGTCC TGCTGAACGC CAACTGGGTT 
CTCACTGCTG CCCACTGCCA TAATGACAAG TACCAGGTTT GGCTGGGCAA AAACAACTTT 
TTTGAGGATG AACCCTCTGC CCAACACCGG CTTGTCAGCA AAGCCATCCC TCACCCTGAC 
TTCAACATGA GCCTCCTGAA TGAGCACACC CCACAACCTG AGGACGACTA CAGCAATGAC 
CTGATGCTGC TCCGCCTCAA AAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGAC 
CTGCCCACTG AGGAGCCCAA GCTGGGGAGC ACATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCGTCA TATACGAACC CGCAGATGAT CTCCAGTGTG TGAACTTCAA GCTCCTGCCT 
AATGAGGACT GTGTCAAAGC CCACATAGAG AAGGTGACAG ATGTTATGTT GTGTGCAGGA 
GATATGGATG GAGGCAAAGA CACTTGTATG GGTGACTCAG GAGGCCCACT GATCTGTGAT 
GGTGTTCTCC ACGGTATCAC ATCATGGGGC CCTAGCCCTT GCGGTAAACC CAATGTGCCA 
GGTATCTACA CCAAACTTAT TAAGTTTAAC TCTTGGATAA AAGACACTAT AGCTAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032482.1
CDS	28..813
Translation	MWFLILFLALSLGGIDAAPPVQSRIFGGFNCEKNSQPWQVAVYRFTKYQCGGVLLNANWVLTAAHCHNDKYQVWLGKNNFFEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVIYEPADDLQCVNFKLLPNEDCVKAHIEKVTDVMLCAGDMDGGKDTCMGDSGGPLICDGVLHGITSWGPSPCGKPNVPGIYTKLIKFNSWIKDTIAKNA

Target ORF information:

RefSeq Version	NM_008456.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008456.4

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTAGCCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATTTTTGG AGGATTTAAC TGTGAGAAGA ACTCCCAACC CTGGCAAGTG 
GCTGTGTACC GCTTCACCAA ATATCAATGC GGGGGAGTCC TGCTGAACGC CAACTGGGTT 
CTCACTGCTG CCCACTGCCA TAATGACAAG TACCAGGTTT GGCTGGGCAA AAACAACTTT 
TTTGAGGATG AACCCTCTGC CCAACACCGG CTTGTCAGCA AAGCCATCCC TCACCCTGAC 
TTCAACATGA GCCTCCTGAA TGAGCACACC CCACAACCTG AGGACGACTA CAGCAATGAC 
CTGATGCTGC TCCGCCTCAA AAAGCCTGCT GACATCACAG ATGTTGTGAA GCCCATCGAC 
CTGCCCACTG AGGAGCCCAA GCTGGGGAGC ACATGCCTAG CCTCAGGCTG GGGCAGCATT 
ACACCCGTCA TATACGAACC CGCAGATGAT CTCCAGTGTG TGAACTTCAA GCTCCTGCCT 
AATGAGGACT GTGTCAAAGC CCACATAGAG AAGGTGACAG ATGTTATGTT GTGTGCAGGA 
GATATGGATG GAGGCAAAGA CACTTGTATG GGTGACTCAG GAGGCCCACT GATCTGTGAT 
GGTGTTCTCC ACGGTATCAC ATCATGGGGC CCTAGCCCTT GCGGTAAACC CAATGTGCCA 
GGTATCTACA CCAAACTTAT TAAGTTTAAC TCTTGGATAA AAGACACTAT AGCTAAAAAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury.
The Journal of investigative dermatology134(5)1305-1312(2014 May)
Fischer J,Wu Z,Kantyka T,Sperrhacke M,Dimitrieva O,Koblyakova Y,Ahrens K,Graumann N,Baurecht H,Reiss K,Schr?der JM,Proksch E,Meyer-Hoffert U

MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.
Physiological genomics44(4)259-67(2012 Feb)
Kriegel AJ,Liu Y,Cohen B,Usa K,Liu Y,Liang M

Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
BMC biology515(2007 Apr)
Schwab KR,Patterson LT,Hartman HA,Song N,Lang RA,Lin X,Potter SS

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Biological chemistry387(6)637-41(2006 Jun)
Lundwall A,Band V,Blaber M,Clements JA,Courty Y,Diamandis EP,Fritz H,Lilja H,Malm J,Maltais LJ,Olsson AY,Petraki C,Scorilas A,Sotiropoulou G,Stenman UH,Stephan C,Talieri M,Yousef GM

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Proceedings of the National Academy of Sciences of the United States of America101(36)13251-6(2004 Sep)
Angata T,Margulies EH,Green ED,Varki A

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Klk1b5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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