Klk1b27 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klk1b27
Entrez Gene ID	16619
Full Name	kallikrein 1-related peptidase b27
Synonyms	Gk27,Klk21l,Klk27,mGK-27
General protein information	Preferred Names kallikrein 1-related peptidase b27 Names kallikrein 1-related peptidase b27 glandular kallikrein 27 glandular kallikrein K27 tissue kallikrein 27
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.54 cM
Summary	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020268.3	NP_064664.1	kallikrein 1-related peptidase b27 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klk1b5	NP_032482.1
Mus musculus (house mouse)	Klk1b1	NP_034775.1
Mus musculus (house mouse)	Klk1b3	NP_032719.1
Mus musculus (house mouse)	Klk1b24	NP_034773.1
Mus musculus (house mouse)	Klk1b26	NP_034774.1
Mus musculus (house mouse)	Klk1b4	NP_035045.2
Mus musculus (house mouse)	Klk1b22	NP_034244.1
Mus musculus (house mouse)	Klk1b8	NP_032483.1
Mus musculus (house mouse)	Klk1b21	NP_034772.1
Mus musculus (house mouse)	Klk1b27	NP_064664.1
Homo sapiens (human)	KLK3	NP_001639.1
Mus musculus (house mouse)	Klk1b16	NP_032480.1
Mus musculus (house mouse)	Klk1b11	NP_034770.1
	KLK3	NP_001036241.1
Mus musculus (house mouse)	Klk1	NP_034769.4
Mus musculus (house mouse)	Klk1b9	NP_034246.1

Gene Ontology
Bibliography

Related articles in PubMed

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
Isbel L, Srivastava R, Oey H, Spurling A, Daxinger L, Puthalakath H, Whitelaw E
PLoS genetics11(12)e1005693(2015 Dec)

Androgen receptor binding sites identified in mouse testis.
Hu S, Yao G, Li X, Chen Z, Sun Y
Acta biochimica et biophysica Sinica45(9)795-7(2013 Sep)

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM
Biological chemistry387(6)637-41(2006 Jun)

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Olsson AY, Lilja H, Lundwall A
Genomics84(1)147-56(2004 Jul)

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Olsson AY, Lundwall A
Biochemical and biophysical research communications299(2)305-11(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.

The following Klk1b27 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk1b27 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16657	NM_020268.3 Latest version!	Mus musculus kallikrein 1-related peptidase b27 (Klk1b27), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klk1b27 ( NM_020268.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064664.1 Mus musculus kallikrein 1-related peptidase b27 (Klk1b27), mRNA.

Price & Availability↑

CloneID	OMu16657
Clone ID Related Accession (Same CDS sequence)	NM_020268.3
Accession Version	NM_020268.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	kallikrein 1-related peptidase b27 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC151051.2. On Jun 22, 2007 this sequence version replaced NM_020268.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AB039275.1, BC132090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCC TGATCCTGTT CCTTGCCCTG TCCCTAGGAG GGATTGATGC TGCGCCTCCT 
GTCCAGTCTA GAATAATTGG AGGATTTAAA TGTAAGAAGA ATTCTCAACC CTGGCATGTG 
GCTGTGCTCC GCTCCAACAA ATATATATGC GGGGGAGTCC TGTTGGACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAATGAC ACCAGCCAGC ATAATGTTTG GCTGGGCAAA 
AACAAGCTAT TCCAACGTGA ACCCTCTGCT CAGCACCGAT GGGTCAGCAA AAGCTTCCCC 
CACCCTGACT ACAACATGAG CCTCCTGAAT GACCACATCC CACATCCTGA GGACAAGAGC 
AATGACCTGA TGCTGCTCCG TCTCAGCAAG CCTGCTGACA TCACAGATGC TGTGAAGCCC 
ATCGACCTGC CCACTGAGGA GCCCAAGCTG GGGAGCACAT GCCTAGCCTC AGGCTGGGGC 
AGCATTACAC CCACAAAATA CCAAATCCCA AATGATCTTC AGTGTGTGTT CATCAAGCTC 
CTGCCCAATG AGAACTGTGC CAAAGCCTAC GTACATAAAG TCACAGATGT CATGCTGTGT 
GTAGGAGAGA CGGGTGGAGG CAAAGGCACT TGCAAGGGTG ACTCAGGAGG CCCACTGATC 
TGTGATGGTG TTCTCCACGG TATCACATCA TGGGGCTCTA TCCCATGCGC TAAACCCAAT 
GCGCCAGGCG TCTTCACAAA ACTTATTAAG TTTACCTCCT GGATAAAAGA CACTATGGCA 
AAAAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064664.1
CDS	52..843
Translation	MRFLILFLALSLGGIDAAPPVQSRIIGGFKCKKNSQPWHVAVLRSNKYICGGVLLDPNWVLTAAHCYGNDTSQHNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDHIPHPEDKSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKYQIPNDLQCVFIKLLPNENCAKAYVHKVTDVMLCVGETGGGKGTCKGDSGGPLICDGVLHGITSWGSIPCAKPNAPGVFTKLIKFTSWIKDTMAKNP

Target ORF information:

RefSeq Version	NM_020268.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein 1-related peptidase b27 (Klk1b27), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020268.3

ORF Insert Sequence:

ATGAGGTTCC TGATCCTGTT CCTTGCCCTG TCCCTAGGAG GGATTGATGC TGCGCCTCCT 
GTCCAGTCTA GAATAATTGG AGGATTTAAA TGTAAGAAGA ATTCTCAACC CTGGCATGTG 
GCTGTGCTCC GCTCCAACAA ATATATATGC GGGGGAGTCC TGTTGGACCC CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGGCAATGAC ACCAGCCAGC ATAATGTTTG GCTGGGCAAA 
AACAAGCTAT TCCAACGTGA ACCCTCTGCT CAGCACCGAT GGGTCAGCAA AAGCTTCCCC 
CACCCTGACT ACAACATGAG CCTCCTGAAT GACCACATCC CACATCCTGA GGACAAGAGC 
AATGACCTGA TGCTGCTCCG TCTCAGCAAG CCTGCTGACA TCACAGATGC TGTGAAGCCC 
ATCGACCTGC CCACTGAGGA GCCCAAGCTG GGGAGCACAT GCCTAGCCTC AGGCTGGGGC 
AGCATTACAC CCACAAAATA CCAAATCCCA AATGATCTTC AGTGTGTGTT CATCAAGCTC 
CTGCCCAATG AGAACTGTGC CAAAGCCTAC GTACATAAAG TCACAGATGT CATGCTGTGT 
GTAGGAGAGA CGGGTGGAGG CAAAGGCACT TGCAAGGGTG ACTCAGGAGG CCCACTGATC 
TGTGATGGTG TTCTCCACGG TATCACATCA TGGGGCTCTA TCCCATGCGC TAAACCCAAT 
GCGCCAGGCG TCTTCACAAA ACTTATTAAG TTTACCTCCT GGATAAAAGA CACTATGGCA 
AAAAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics11(12)e1005693(2015 Dec)
Isbel L,Srivastava R,Oey H,Spurling A,Daxinger L,Puthalakath H,Whitelaw E

Androgen receptor binding sites identified in mouse testis.
Acta biochimica et biophysica Sinica45(9)795-7(2013 Sep)
Hu S,Yao G,Li X,Chen Z,Sun Y

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Biological chemistry387(6)637-41(2006 Jun)
Lundwall A,Band V,Blaber M,Clements JA,Courty Y,Diamandis EP,Fritz H,Lilja H,Malm J,Maltais LJ,Olsson AY,Petraki C,Scorilas A,Sotiropoulou G,Stenman UH,Stephan C,Talieri M,Yousef GM

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Genomics84(1)147-56(2004 Jul)
Olsson AY,Lilja H,Lundwall A

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Biochemical and biophysical research communications299(2)305-11(2002 Nov)
Olsson AY,Lundwall A

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Klk1b27 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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