Fabp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp5
Entrez Gene ID	16592
Full Name	fatty acid binding protein 5, epidermal
Synonyms	E-FABP,Fabpe,Klbp,PA-FABP,mal1
General protein information	Preferred Names fatty acid binding protein 5, epidermal Names fatty acid-binding protein, epidermal uncharacterized protein LOC16592 epidermal-type fatty acid-binding protein epithelial fatty acid-binding protein keratinocyte lipid-binding protein psoriasis-associated fatty acid-binding protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 A1
Summary	The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010634.3	NP_034764.1	fatty acid-binding protein 5 isoform 1
NM_001272097.1	NP_001259026.1	fatty acid-binding protein 5 isoform 2
NM_001272098.1	NP_001259027.1	uncharacterized protein LOC16592 isoform 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fabp5	NP_034764.1
Rattus norvegicus (Norway rat)	Fabp5	NP_665885.1
Homo sapiens (human)	FABP5	NP_001435.1
	FABP5	XP_001091773.1
Pan troglodytes (chimpanzee)	FABP5	XP_003311829.1
Bos taurus (cattle)	FABP5	NP_776740.1
Gallus gallus (chicken)	FABP5	NP_001006346.1
Canis lupus familiaris (dog)	FABP5	XP_535112.4
Canis lupus familiaris (dog)	LOC102155424	XP_005642139.1

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.
Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J
Journal of immunology (Baltimore, Md. : 1950)179(1)313-21(2007 Jul)

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS
Cell metabolism1(2)107-19(2005 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A 42.1 +/- 12.6% decrease in the BBB transport of (14) C-DHA in 8-month-old AD transgenic mice relative to wild-type mice was associated with a 34.5 +/- 6.7% reduction in FABP5 expression in isolated brain capillaries. Short-term spatial and recognition memory deficits were seen in AD mice on a 6-month n-3 fatty acid-depleted diet, but not those on control diet.
Title: Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets.

Using a yeast two-hybrid screen, immunoprecipitation, microscale thermophoresis analysis and cellular fractionation, we discovered that Fabp5 interacts with the calnexin cytoplasmic C-tail domain at the endoplasmic reticulum. These observations identify Fabp5 as a previously unrecognized calnexin binding partner.
Title: Fatty acid binding protein (Fabp) 5 interacts with the calnexin cytoplasmic domain at the endoplasmic reticulum.

Lack of PPARbeta/delta-expression, TUNEL reaction, RA receptor (RAR)beta, and cellular retinoic acid-binding protein (CRABP)-II were induced in E-FABP-positive septoclasts under RA excess, suggesting the growth arrest/cell-death of septoclasts, whereas cartilage-derived retinoic acid-sensitive protein (CD-RAP) inducing the cell growth arrest or morphological changes was induced in septoclasts under VA deficiency.
Title: Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice.

Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA. Therefore, FABP5 in the brain endothelial cell is a crucial contributor to the brain levels of DHA. Critically, lowered brain DHA levels in FABP5(-/-) mice occurred in tandem with cognitive deficits
Title: Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function.

Following infection with Listeria monocytogenes, we observed similar clonal expansion, contraction and formation of memory CD8 T cells in WT and E-FABP-/- mice. Analysis of Listeria-specific CD4 T cells revealed no defect in the expansion, contraction, and formation of memory CD4 T cells in E-FABP-/- mice. Our data demonstrate that E-FABP is dispensable for antigen-specific T cell response following bacterial infection.
Title: Epidermal Fatty Acid Binding Protein (E-FABP) Is Not Required for the Generation or Maintenance of Effector and Memory T Cells following Infection with Listeria monocytogenes.

The following Fabp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19256	NM_001272097.1 Latest version!	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu19516	NM_010634.3 Latest version!	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu19544	NM_001272098.1 Latest version!	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp5 ( NM_001272097.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001259026.1 Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19256
Clone ID Related Accession (Same CDS sequence)	NM_001272097.1
Accession Version	NM_001272097.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	fatty acid-binding protein 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC157379.7. Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (by one amino acid; isoform 2), compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV451451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGG AGTAGGACTG GCTCTTAGGA AGATGGCTGC CATGGCCAAG 
CCAGACTGTA TCATTACGTG TGATGGCAAC AACATCACGG TCAAAACCGA GAGCACAGTG 
AAGACGACTG TGTTCTCTTG TAACCTGGGA GAGAAGTTTG ATGAAACGAC AGCTGATGGC 
AGAAAAACTG AGACGGTCTG CACCTTCCAA GACGGTGCCC TGGTCCAGCA CCAGCAATGG 
GACGGGAAGG AGAGCACGAT AACAAGAAAA CTGAAGGATG GGAAGATGAT CGTGTGTGTC 
ATGAACAATG CCACCTGCAC TCGGGTCTAT GAGAAGGTGC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259026.1
CDS	56..460
Translation	MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCIITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDGKESTITRKLKDGKMIVCVMNNATCTRVYEKVQ

Target ORF information:

RefSeq Version	NM_001272097.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272097.1

ORF Insert Sequence:

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGG AGTAGGACTG GCTCTTAGGA AGATGGCTGC CATGGCCAAG 
CCAGACTGTA TCATTACGTG TGATGGCAAC AACATCACGG TCAAAACCGA GAGCACAGTG 
AAGACGACTG TGTTCTCTTG TAACCTGGGA GAGAAGTTTG ATGAAACGAC AGCTGATGGC 
AGAAAAACTG AGACGGTCTG CACCTTCCAA GACGGTGCCC TGGTCCAGCA CCAGCAATGG 
GACGGGAAGG AGAGCACGAT AACAAGAAAA CTGAAGGATG GGAAGATGAT CGTGTGTGTC 
ATGAACAATG CCACCTGCAC TCGGGTCTAT GAGAAGGTGC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fabp5 ( NM_010634.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034764.1 Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19516
Clone ID Related Accession (Same CDS sequence)	NM_010634.3
Accession Version	NM_010634.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	fatty acid-binding protein 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC157379.7, AK011551.1 and BE987062.1. On Jan 15, 2013 this sequence version replaced NM_010634.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X70100.1, AK011551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGG AGTAGGACTG GCTCTTAGGA AGATGGCTGC CATGGCCAAG 
CCAGACTGTA TCATTACGTG TGATGGCAAC AACATCACGG TCAAAACCGA GAGCACAGTG 
AAGACGACTG TGTTCTCTTG TAACCTGGGA GAGAAGTTTG ATGAAACGAC AGCTGATGGC 
AGAAAAACTG AGACGGTCTG CACCTTCCAA GACGGTGCCC TGGTCCAGCA CCAGCAATGG 
GACGGGAAGG AGAGCACGAT AACAAGAAAA CTGAAGGATG GGAAGATGAT CGTGGAGTGT 
GTCATGAACA ATGCCACCTG CACTCGGGTC TATGAGAAGG TGCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034764.1
CDS	56..463
Translation	MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCIITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDGKESTITRKLKDGKMIVECVMNNATCTRVYEKVQ

Target ORF information:

RefSeq Version	NM_010634.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010634.3

ORF Insert Sequence:

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGG AGTAGGACTG GCTCTTAGGA AGATGGCTGC CATGGCCAAG 
CCAGACTGTA TCATTACGTG TGATGGCAAC AACATCACGG TCAAAACCGA GAGCACAGTG 
AAGACGACTG TGTTCTCTTG TAACCTGGGA GAGAAGTTTG ATGAAACGAC AGCTGATGGC 
AGAAAAACTG AGACGGTCTG CACCTTCCAA GACGGTGCCC TGGTCCAGCA CCAGCAATGG 
GACGGGAAGG AGAGCACGAT AACAAGAAAA CTGAAGGATG GGAAGATGAT CGTGGAGTGT 
GTCATGAACA ATGCCACCTG CACTCGGGTC TATGAGAAGG TGCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fabp5 ( NM_001272098.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001259027.1 Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu19544
Clone ID Related Accession (Same CDS sequence)	NM_001272098.1
Accession Version	NM_001272098.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Mus musculus(house mouse)
Product	uncharacterized protein LOC16592 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC157379.7, W54445.1 and BE987062.1. Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. Variant 3 lacks a large portion of the central coding region found in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform lacks the lipocalin domain found in isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W54445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGA CGGTCTGCAC CTTCCAAGAC GGTGCCCTGG TCCAGCACCA 
GCAATGGGAC GGGAAGGAGA GCACGATAAC AAGAAAACTG AAGGATGGGA AGATGATCGT 
GGAGTGTGTC ATGAACAATG CCACCTGCAC TCGGGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259027.1
CDS	56..277
Translation	MASLKDLEGKWRLMESHGFEEYMKELDGLHLPRRCPGPAPAMGREGEHDNKKTEGWEDDRGVCHEQCHLHSGL

Target ORF information:

RefSeq Version	NM_001272098.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fatty acid binding protein 5, epidermal (Fabp5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272098.1

ORF Insert Sequence:

ATGGCCAGTC TTAAGGATCT CGAAGGGAAG TGGCGCCTGA TGGAAAGCCA CGGCTTTGAG 
GAGTACATGA AAGAGCTAGA CGGTCTGCAC CTTCCAAGAC GGTGCCCTGG TCCAGCACCA 
GCAATGGGAC GGGAAGGAGA GCACGATAAC AAGAAAACTG AAGGATGGGA AGATGATCGT 
GGAGTGTGTC ATGAACAATG CCACCTGCAC TCGGGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)179(1)313-21(2007 Jul)
Reynolds JM,Liu Q,Brittingham KC,Liu Y,Gruenthal M,Gorgun CZ,Hotamisligil GS,Stout RD,Suttles J

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Cell metabolism1(2)107-19(2005 Feb)
Maeda K,Cao H,Kono K,Gorgun CZ,Furuhashi M,Uysal KT,Cao Q,Atsumi G,Malone H,Krishnan B,Minokoshi Y,Kahn BB,Parker RA,Hotamisligil GS

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Fabp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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