Kcnd2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnd2
Entrez Gene ID	16508
Full Name	potassium voltage-gated channel, Shal-related family, member 2
Synonyms	AI839615,AW555701,Kv4.2,R75121,mKIAA1044
General protein information	Preferred Names potassium voltage-gated channel, Shal-related family, member 2 Names potassium voltage-gated channel subfamily D member 2 potassium channel Kv4.2 voltage-gated potassium channel subunit Kv4.2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 A2-A3.1\|6 8.49 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019697.4	NP_062671.1	potassium voltage-gated channel subfamily D member 2 precursor
NM_019697.3	NP_062671.1	potassium voltage-gated channel subfamily D member 2 precursor

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Shal	NP_001097646.1
Caenorhabditis elegans (roundworm)	shl-1	NP_500975.2
Pan troglodytes (chimpanzee)	KCND2	XP_001141749.1
	KCND2	XP_001082011.2
Mus musculus (house mouse)	Kcnd2	NP_062671.1
Rattus norvegicus (Norway rat)	Kcnd2	NP_113918.2
Gallus gallus (chicken)	KCND2	NP_989610.1
Xenopus tropicalis (tropical clawed frog)	kcnd2	XP_002935005.1
Bos taurus (cattle)	KCND2	NP_001178113.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007046	XP_308716.2
Homo sapiens (human)	KCND2	NP_036413.1
Canis lupus familiaris (dog)	KCND2	XP_852736.1
Danio rerio (zebrafish)	kcnd2	NP_001076336.1

Gene Ontology
Bibliography

Related articles in PubMed

Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.
Mendon?a PRF, Kyle V, Yeo SH, Colledge WH, Robinson HPC
The Journal of physiology(2017 Dec)

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
Vysotskaya Z, Chidipi B, Rodgers JL, Tang X, Samal E, Kolliputi N, Mohapatra S, Bennett ES, Panguluri SK
Journal of cellular physiology(2017 Nov)

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.
Toib A, Zhang C, Borghetti G, Zhang X, Wallner M, Yang Y, Troupes CD, Kubo H, Sharp TE, Feldsott E, Berretta RM, Zalavadia N, Trappanese DM, Harper S, Gross P, Chen X, Mohsin S, Houser SR
American journal of physiology. Heart and circulatory physiology313(3)H620-H630(2017 Sep)

Neuron subset-specific Pten deletion induces abnormal skeletal activity in mice.
Lugo JN, Thompson MH, Huber P, Smith G, Kwon RY
Experimental neurology29198-105(2017 May)

Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents.
Khandekar A, Springer S, Wang W, Hicks S, Weinheimer C, Diaz-Trelles R, Nerbonne JM, Rentschler S
Circulation research119(12)1324-1338(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results reveal an important role for miR-324-5p-mediated silencing of Kv4.2 in seizure onset.
Title: MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.

Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Title: Neuritin Up-regulates Kv4.2 ?-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.

Result suggests that the memory type supported by neurons may depend critically on the phosphorylation of specific K+ channels at single residues.
Title: Phosphorylation of K+ channels at single residues regulates memory formation.

Data show that suprachiasmatic nucleus (SCN) explants from potassium channel Kv1.4(-/-)period2 protein Per2(Luc) and potassium channel Kv4.2(-/-) period2 protein Per2(Luc) mice have significantly shorter circadian periods in PER2 rhythms.
Title: IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.

Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).
Title: Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

The following Kcnd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11644	NM_019697.4 Latest version!	Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$370.30 $529.00
View Old Accession Versions >>
OMu11644	NM_019697.3	Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$370.30 $529.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnd2 ( NM_019697.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062671.1 Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.

Price & Availability↑

CloneID	OMu11644
Clone ID Related Accession (Same CDS sequence)	NM_019697.4 , NM_019697.3
Accession Version	NM_019697.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	potassium voltage-gated channel subfamily D member 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY279027.1, CB520748.1 and BC079667.1. On May 29, 2018 this sequence version replaced NM_019697.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB045326.1, BC079667.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCG GTGTTGCAGC ATGGCTGCCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCTT CGGGGCCTAT GCCTGCGCCC CCAAGACAGG AGAGAAAAAG GACTCAGGAC 
GCTCTGATAG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGTAGTTCT GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATACT TCTTTGACCG TGACCCGGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAACTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCTGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCGCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGCGGG CCTTTGAGAA TCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACTGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAGA GGTATGCGGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTC 
ACAGTTGAGT ACTTGCTTCG CCTGGCCGCA GCACCTAGTC GTTACCGTTT CGTGCGCAGT 
GTCATGAGTA TCATCGACGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG AGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGGCTG CGTATACTGG GGTACACCCT GAAGAGCTGT 
GCATCAGAAC TGGGCTTCTT GCTCTTTTCT CTCACAATGG CTATCATCAT TTTCGCTACC 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCGGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTTGG GTCCATCTGC TCACTGAGCG GAGTCTTGGT CATTGCGCTA 
CCCGTGCCTG TGATCGTGTC GAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCAGAC 
AAACGAAGGG CACAGAAGAA AGCCAGGCTG GCCAGGATCC GAGCAGCCAA AAGCGGGAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGCTACTGA GCAACCAGCT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCAT AAGCAAATCT GGATCCAGCT TTGAGACACA GCACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TCGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTTGC CACCGTCAAT CGCCCATCAA GTCACAGTCC CTCTCTCTCC 
TCACAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAGAC TTTCCGCATT 
CCTAATGCCA ATGTGTCGGG AAGCCATAGA GGCAGTGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TTAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATAAGCATC 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAATA TCGTCAGGGT GTCTGCCTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062671.1
CDS	954..2846
Translation	MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFISKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL

Target ORF information:

RefSeq Version	NM_019697.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019697.4

ORF Insert Sequence:

ATGGCAGCCG GTGTTGCAGC ATGGCTGCCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCTT CGGGGCCTAT GCCTGCGCCC CCAAGACAGG AGAGAAAAAG GACTCAGGAC 
GCTCTGATAG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGTAGTTCT GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATACT TCTTTGACCG TGACCCGGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAACTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCTGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCGCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGCGGG CCTTTGAGAA TCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACTGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAGA GGTATGCGGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTC 
ACAGTTGAGT ACTTGCTTCG CCTGGCCGCA GCACCTAGTC GTTACCGTTT CGTGCGCAGT 
GTCATGAGTA TCATCGACGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG AGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGGCTG CGTATACTGG GGTACACCCT GAAGAGCTGT 
GCATCAGAAC TGGGCTTCTT GCTCTTTTCT CTCACAATGG CTATCATCAT TTTCGCTACC 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCGGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTTGG GTCCATCTGC TCACTGAGCG GAGTCTTGGT CATTGCGCTA 
CCCGTGCCTG TGATCGTGTC GAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCAGAC 
AAACGAAGGG CACAGAAGAA AGCCAGGCTG GCCAGGATCC GAGCAGCCAA AAGCGGGAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGCTACTGA GCAACCAGCT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCAT AAGCAAATCT GGATCCAGCT TTGAGACACA GCACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TCGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTTGC CACCGTCAAT CGCCCATCAA GTCACAGTCC CTCTCTCTCC 
TCACAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAGAC TTTCCGCATT 
CCTAATGCCA ATGTGTCGGG AAGCCATAGA GGCAGTGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TTAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATAAGCATC 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAATA TCGTCAGGGT GTCTGCCTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnd2 ( NM_019697.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062671.1 Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.

Price & Availability↑

CloneID	OMu11644
Clone ID Related Accession (Same CDS sequence)	NM_019697.4 , NM_019697.3
Accession Version	NM_019697.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-30
Organism	Mus musculus(house mouse)
Product	potassium voltage-gated channel subfamily D member 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079667.1. On Aug 8, 2004 this sequence version replaced NM_019697.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079667.1, AB093280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849390 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCCG GTGTTGCAGC ATGGCTGCCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCTT CGGGGCCTAT GCCTGCGCCC CCAAGACAGG AGAGAAAAAG GACTCAGGAC 
GCTCTGATAG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGTAGTTCT GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATACT TCTTTGACCG TGACCCGGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAACTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCTGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCGCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGCGGG CCTTTGAGAA TCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACTGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAGA GGTATGCGGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTC 
ACAGTTGAGT ACTTGCTTCG CCTGGCCGCA GCACCTAGTC GTTACCGTTT CGTGCGCAGT 
GTCATGAGTA TCATCGACGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG AGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGGCTG CGTATACTGG GGTACACCCT GAAGAGCTGT 
GCATCAGAAC TGGGCTTCTT GCTCTTTTCT CTCACAATGG CTATCATCAT TTTCGCTACC 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCGGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTTGG GTCCATCTGC TCACTGAGCG GAGTCTTGGT CATTGCGCTA 
CCCGTGCCTG TGATCGTGTC GAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCAGAC 
AAACGAAGGG CACAGAAGAA AGCCAGGCTG GCCAGGATCC GAGCAGCCAA AAGCGGGAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGCTACTGA GCAACCAGCT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCAT AAGCAAATCT GGATCCAGCT TTGAGACACA GCACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TCGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTTGC CACCGTCAAT CGCCCATCAA GTCACAGTCC CTCTCTCTCC 
TCACAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAGAC TTTCCGCATT 
CCTAATGCCA ATGTGTCGGG AAGCCATAGA GGCAGTGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TTAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATAAGCATC 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAATA TCGTCAGGGT GTCTGCCTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062671.1
CDS	191..2083
Translation	MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFISKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL

Target ORF information:

RefSeq Version	NM_019697.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium voltage-gated channel, Shal-related family, member 2 (Kcnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019697.3

ORF Insert Sequence:

ATGGCAGCCG GTGTTGCAGC ATGGCTGCCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCTT CGGGGCCTAT GCCTGCGCCC CCAAGACAGG AGAGAAAAAG GACTCAGGAC 
GCTCTGATAG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGTAGTTCT GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATACT TCTTTGACCG TGACCCGGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAACTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCTGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCGCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGCGGG CCTTTGAGAA TCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACTGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAGA GGTATGCGGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTC 
ACAGTTGAGT ACTTGCTTCG CCTGGCCGCA GCACCTAGTC GTTACCGTTT CGTGCGCAGT 
GTCATGAGTA TCATCGACGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG AGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGGCTG CGTATACTGG GGTACACCCT GAAGAGCTGT 
GCATCAGAAC TGGGCTTCTT GCTCTTTTCT CTCACAATGG CTATCATCAT TTTCGCTACC 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCGGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTTGG GTCCATCTGC TCACTGAGCG GAGTCTTGGT CATTGCGCTA 
CCCGTGCCTG TGATCGTGTC GAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCAGAC 
AAACGAAGGG CACAGAAGAA AGCCAGGCTG GCCAGGATCC GAGCAGCCAA AAGCGGGAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGCTACTGA GCAACCAGCT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCAT AAGCAAATCT GGATCCAGCT TTGAGACACA GCACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TCGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTTGC CACCGTCAAT CGCCCATCAA GTCACAGTCC CTCTCTCTCC 
TCACAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAGAC TTTCCGCATT 
CCTAATGCCA ATGTGTCGGG AAGCCATAGA GGCAGTGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TTAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATAAGCATC 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAATA TCGTCAGGGT GTCTGCCTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.
The Journal of physiology(2017 Dec)
Mendon?a PRF,Kyle V,Yeo SH,Colledge WH,Robinson HPC

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
Journal of cellular physiology(2017 Nov)
Vysotskaya Z,Chidipi B,Rodgers JL,Tang X,Samal E,Kolliputi N,Mohapatra S,Bennett ES,Panguluri SK

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.
American journal of physiology. Heart and circulatory physiology313(3)H620-H630(2017 Sep)
Toib A,Zhang C,Borghetti G,Zhang X,Wallner M,Yang Y,Troupes CD,Kubo H,Sharp TE,Feldsott E,Berretta RM,Zalavadia N,Trappanese DM,Harper S,Gross P,Chen X,Mohsin S,Houser SR

Neuron subset-specific Pten deletion induces abnormal skeletal activity in mice.
Experimental neurology29198-105(2017 May)
Lugo JN,Thompson MH,Huber P,Smith G,Kwon RY

Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents.
Circulation research119(12)1324-1338(2016 Dec)
Khandekar A,Springer S,Wang W,Hicks S,Weinheimer C,Diaz-Trelles R,Nerbonne JM,Rentschler S

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Kcnd2 cDNA ORF clone, Mus musculus(house mouse)

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