Kcnd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnd1
Entrez Gene ID	16506
Full Name	potassium voltage-gated channel, Shal-related family, member 1
Synonyms	1110037K09Rik,Kca2-1,Kv4.1,Shal,Shal1,mShal1
General protein information	Preferred Names potassium voltage-gated channel, Shal-related family, member 1 Names potassium voltage-gated channel subfamily D member 1 voltage-gated potassium channel subunit Kv4.1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A1.1\|X 3.53 cM
Summary	This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008423.2	NP_032449.1	potassium voltage-gated channel subfamily D member 1 precursor

Pathways from BioSystems

Homologies

	KCND1	XP_001104621.1
Canis lupus familiaris (dog)	KCND1	XP_855372.1
Rattus norvegicus (Norway rat)	Kcnd1	NP_001099218.1
Danio rerio (zebrafish)	kcnd1	NP_001119942.1
Homo sapiens (human)	KCND1	NP_004970.3
Pan troglodytes (chimpanzee)	KCND1	XP_521053.3
Bos taurus (cattle)	KCND1	NP_001019724.1
Mus musculus (house mouse)	Kcnd1	NP_032449.1
Xenopus tropicalis (tropical clawed frog)	LOC100488387	XP_004920307.1

Gene Ontology
Bibliography

Related articles in PubMed

Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.
Hermanstyne TO, Granados-Fuentes D, Mellor RL, Herzog ED, Nerbonne JM
eNeuro4(3)(2017 May-Jun)

Overexpression of tau downregulated the mRNA levels of Kv channels and improved proliferation in N2A cells.
Li X, Hu X, Li X, Hao X
PloS one10(1)e0116628(2015)

Heteropoda toxin 2 interaction with Kv4.3 and Kv4.1 reveals differences in gating modification.
DeSimone CV, Zarayskiy VV, Bondarenko VE, Morales MJ
Molecular pharmacology80(2)345-55(2011 Aug)

Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus.
Itri JN, Vosko AM, Schroeder A, Dragich JM, Michel S, Colwell CS
Journal of neurophysiology103(2)632-40(2010 Feb)

Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.
Kollo M, Holderith N, Antal M, Nusser Z
The European journal of neuroscience27(7)1686-99(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The complex voltage-dependent gating rearrangements of eukaryotic Kv channels are not limited to the membrane-spanning core but must include the intracellular T1-T1 interface.
Title: Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.

The following Kcnd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01893	NM_008423.2 Latest version!	Mus musculus potassium voltage-gated channel, Shal-related family, member 1 (Kcnd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnd1 ( NM_008423.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032449.1 Mus musculus potassium voltage-gated channel, Shal-related family, member 1 (Kcnd1), mRNA.

Price & Availability↑

CloneID	OMu01893
Clone ID Related Accession (Same CDS sequence)	NM_008423.2
Accession Version	NM_008423.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1956bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	potassium voltage-gated channel subfamily D member 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC139325.1 and AK033805.1. On May 9, 2015 this sequence version replaced NM_008423.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033805.1, SRR1660819.7259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG GTGTGGCCAC ATGGCTACCA TTTGCAAGGG CCGCAGCAGT GGGCTGGCTG 
CCCTTAGCCC AGCAGCCCCT ACCCCCTGCA CCGGAGGTGA AGGCATCCCG AGGGGATGAG 
GTTCTGGTGG TGAATGTGAG TGGTCGGCGC TTTGAGACCT GGAAAAACAC ACTGGATCGC 
TACCCAGACA CATTGCTGGG CAGCTCGGAG AAGGAATTCT TCTATGATGC TGAATCTGGC 
GAGTACTTCT TTGATCGTGA CCCAGACATG TTCCGGCACG TGCTGAACTT TTATCGCACT 
GGCCGGCTGC ACTGCCCCAG GCAGGAGTGC ATCCAGGCCT TTGATGAGGA GCTGGCCTTC 
TATGGCTTGG TCCCAGAGCT GGTTGGTGAC TGCTGTCTTG AAGAGTACAG GGACCGTAAG 
AAGGAAAACG CAGAGCGCCT GGCAGAAGAT GAGGAGGCTG AGCAGGCCGG GGAAGGTCCA 
GCCCTTCCAG CAGGCAGCTC CCTGCGACAG CGACTCTGGA GGGCCTTTGA GAACCCCCAC 
ACGAGCACTG CAGCCCTGGT TTTCTACTAT GTGACTGGCT TCTTCATAGC TGTGTCAGTC 
ATTGCCAACG TCGTGGAGAC CATCCCATGT CGTGGTACCC CACGATGGCC CTCCAAAGAG 
CAGTCGTGTG GTGACCGCTT CCCTACAGCC TTTTTCTGTA TGGACACAGC CTGTGTACTC 
ATATTCACAG GGGAGTACCT GCTGCGGCTC TTCGCAGCCC CCAGCCGTTG TCGCTTCCTG 
CGGAGTGTGA TGAGCCTTAT CGATGTGGTG GCCATCCTAC CCTACTATAT TGGGCTGTTC 
GTGCCCAAGA ATGATGATGT CTCTGGTGCC TTTGTCACCC TCCGTGTGTT CCGGGTCTTC 
CGAATCTTCA AGTTCTCCAG GCACTCGCAG GGCCTGAGGA TTCTGGGCTA CACCCTCAAG 
AGCTGTGCCT CTGAGCTAGG CTTTCTCCTC TTTTCCCTCA CCATGGCCAT CATCATCTTT 
GCCACTGTCA TGTTCTATGC TGAGAAGGGC ACGAGCAAGA CCAACTTCAC AAGCATCCCT 
GCTGCCTTCT GGTATACCAT TGTCACCATG ACCACACTTG GGTATGGAGA TATGGTACCT 
AGCACCATTG CAGGCAAAAT TTTTGGGTCC ATCTGCTCAC TTAGCGGTGT CTTGGTCATT 
GCCTTGCCTG TGCCAGTCAT TGTATCCAAC TTCAGCCGCA TCTACCACCA GAACCAGCGT 
GCTGACAAGC GCCGGGCACA GCAGAAAGTG CGCCTGGCAA GAATCCGTTT GGCAAAGAGT 
GGTACCACCA ATGCCTTCCT GCAGTATAAG CAAAATGGGG GCCTCGAGGA CAGTGGCAGT 
GGCGACGGAC AAATGCTGTG CGTTAGGAGC CGCTCTGCTT TTGAACAACA GCATCACCAT 
CTGCTGCATT GTCTGGAGAA GACTACGTGT CACGAGTTCA CAGACGAGCT AACTTTCAGT 
GAGGCCCTTG GAGCAGTCTC ACTGGGTGGT CGCACCAGCC GCAGTACCTC AGTATCATCC 
CAACCAATGG GGCCTGGGAG CCTGTTCTCA TCCTGCTGCT CTCGAAGGGT CAATCGCAGA 
GCCATCCGCC TTGCCAACTC TACTGCCTCT GTCAGCCGTG GCAGCATGCA GGAGCTAGAC 
ACACTAGCAG GTCTTCGGAG GAGCCCTGCC CCTCAAACCC GCTCAAGCCT CAATGCCAAG 
CCCCACGACA GCCTTGACCT GAACTGTGAC AGCCGGGACT TCGTGGCCGC CATCATCAGT 
ATCCCCACCC CCCCTGCCAA CACGCCAGAT GAAAGTCAAC CTTCCTCCCC TAGTGGTGGT 
GGCGGCAGTG GTGGCACACC CAACACCACT CTCAGGAACT CCAGCTTGGG TACTCCGTGC 
CTCCTCCCTG AGACTGTCAA GATCTCTTCC CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032449.1
CDS	85..2040
Translation	MAAGVATWLPFARAAAVGWLPLAQQPLPPAPEVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSGGTPNTTLRNSSLGTPCLLPETVKISSL

Target ORF information:

RefSeq Version	NM_008423.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium voltage-gated channel, Shal-related family, member 1 (Kcnd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008423.2

ORF Insert Sequence:

ATGGCGGCAG GTGTGGCCAC ATGGCTACCA TTTGCAAGGG CCGCAGCAGT GGGCTGGCTG 
CCCTTAGCCC AGCAGCCCCT ACCCCCTGCA CCGGAGGTGA AGGCATCCCG AGGGGATGAG 
GTTCTGGTGG TGAATGTGAG TGGTCGGCGC TTTGAGACCT GGAAAAACAC ACTGGATCGC 
TACCCAGACA CATTGCTGGG CAGCTCGGAG AAGGAATTCT TCTATGATGC TGAATCTGGC 
GAGTACTTCT TTGATCGTGA CCCAGACATG TTCCGGCACG TGCTGAACTT TTATCGCACT 
GGCCGGCTGC ACTGCCCCAG GCAGGAGTGC ATCCAGGCCT TTGATGAGGA GCTGGCCTTC 
TATGGCTTGG TCCCAGAGCT GGTTGGTGAC TGCTGTCTTG AAGAGTACAG GGACCGTAAG 
AAGGAAAACG CAGAGCGCCT GGCAGAAGAT GAGGAGGCTG AGCAGGCCGG GGAAGGTCCA 
GCCCTTCCAG CAGGCAGCTC CCTGCGACAG CGACTCTGGA GGGCCTTTGA GAACCCCCAC 
ACGAGCACTG CAGCCCTGGT TTTCTACTAT GTGACTGGCT TCTTCATAGC TGTGTCAGTC 
ATTGCCAACG TCGTGGAGAC CATCCCATGT CGTGGTACCC CACGATGGCC CTCCAAAGAG 
CAGTCGTGTG GTGACCGCTT CCCTACAGCC TTTTTCTGTA TGGACACAGC CTGTGTACTC 
ATATTCACAG GGGAGTACCT GCTGCGGCTC TTCGCAGCCC CCAGCCGTTG TCGCTTCCTG 
CGGAGTGTGA TGAGCCTTAT CGATGTGGTG GCCATCCTAC CCTACTATAT TGGGCTGTTC 
GTGCCCAAGA ATGATGATGT CTCTGGTGCC TTTGTCACCC TCCGTGTGTT CCGGGTCTTC 
CGAATCTTCA AGTTCTCCAG GCACTCGCAG GGCCTGAGGA TTCTGGGCTA CACCCTCAAG 
AGCTGTGCCT CTGAGCTAGG CTTTCTCCTC TTTTCCCTCA CCATGGCCAT CATCATCTTT 
GCCACTGTCA TGTTCTATGC TGAGAAGGGC ACGAGCAAGA CCAACTTCAC AAGCATCCCT 
GCTGCCTTCT GGTATACCAT TGTCACCATG ACCACACTTG GGTATGGAGA TATGGTACCT 
AGCACCATTG CAGGCAAAAT TTTTGGGTCC ATCTGCTCAC TTAGCGGTGT CTTGGTCATT 
GCCTTGCCTG TGCCAGTCAT TGTATCCAAC TTCAGCCGCA TCTACCACCA GAACCAGCGT 
GCTGACAAGC GCCGGGCACA GCAGAAAGTG CGCCTGGCAA GAATCCGTTT GGCAAAGAGT 
GGTACCACCA ATGCCTTCCT GCAGTATAAG CAAAATGGGG GCCTCGAGGA CAGTGGCAGT 
GGCGACGGAC AAATGCTGTG CGTTAGGAGC CGCTCTGCTT TTGAACAACA GCATCACCAT 
CTGCTGCATT GTCTGGAGAA GACTACGTGT CACGAGTTCA CAGACGAGCT AACTTTCAGT 
GAGGCCCTTG GAGCAGTCTC ACTGGGTGGT CGCACCAGCC GCAGTACCTC AGTATCATCC 
CAACCAATGG GGCCTGGGAG CCTGTTCTCA TCCTGCTGCT CTCGAAGGGT CAATCGCAGA 
GCCATCCGCC TTGCCAACTC TACTGCCTCT GTCAGCCGTG GCAGCATGCA GGAGCTAGAC 
ACACTAGCAG GTCTTCGGAG GAGCCCTGCC CCTCAAACCC GCTCAAGCCT CAATGCCAAG 
CCCCACGACA GCCTTGACCT GAACTGTGAC AGCCGGGACT TCGTGGCCGC CATCATCAGT 
ATCCCCACCC CCCCTGCCAA CACGCCAGAT GAAAGTCAAC CTTCCTCCCC TAGTGGTGGT 
GGCGGCAGTG GTGGCACACC CAACACCACT CTCAGGAACT CCAGCTTGGG TACTCCGTGC 
CTCCTCCCTG AGACTGTCAA GATCTCTTCC CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.
eNeuro4(3)(2017 May-Jun)
Hermanstyne TO,Granados-Fuentes D,Mellor RL,Herzog ED,Nerbonne JM

Overexpression of tau downregulated the mRNA levels of Kv channels and improved proliferation in N2A cells.
PloS one10(1)e0116628(2015)
Li X,Hu X,Li X,Hao X

Heteropoda toxin 2 interaction with Kv4.3 and Kv4.1 reveals differences in gating modification.
Molecular pharmacology80(2)345-55(2011 Aug)
DeSimone CV,Zarayskiy VV,Bondarenko VE,Morales MJ

Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus.
Journal of neurophysiology103(2)632-40(2010 Feb)
Itri JN,Vosko AM,Schroeder A,Dragich JM,Michel S,Colwell CS

Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.
The European journal of neuroscience27(7)1686-99(2008 Apr)
Kollo M,Holderith N,Antal M,Nusser Z

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Kcnd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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