F11r cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F11r
Entrez Gene ID	16456
Full Name	F11 receptor
Synonyms	9130004G24,AA638916,ESTM33,JAM,JAM-1,JAM-A,Jcam,Jcam1,Ly106
General protein information	Preferred Names F11 receptor Names junctional adhesion molecule A BV11 antigen F11 receptor/F11R junction cell adhesion molecule A junction cell adhesion molecule1 junctional adhesion molecule 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.43 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_172647.2	NP_766235.1	junctional adhesion molecule A precursor

Pathways from BioSystems

Homologies

	F11R	XP_001117664.1
Rattus norvegicus (Norway rat)	F11r	NP_446248.1
Danio rerio (zebrafish)	f11r	NP_001004667.1
Bos taurus (cattle)	F11R	NP_776520.1
Homo sapiens (human)	F11R	NP_058642.1
Pan troglodytes (chimpanzee)	F11R	XP_001172741.1
Canis lupus familiaris (dog)	F11R	XP_005640936.1
Mus musculus (house mouse)	F11r	NP_766235.1
Danio rerio (zebrafish)	f11rl	NP_001076451.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation.
Curaj A, Wu Z, Rix A, Gresch O, Sternkopf M, Alampour-Rajabi S, Lammers T, van Zandvoort M, Weber C, Koenen RR, Liehn EA, Kiessling F
Arteriosclerosis, thrombosis, and vascular biology38(1)40-48(2018 Jan)

Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.
Zhao Z, Vajen T, Karshovska E, Dickhout A, Schmitt MM, Megens RTA, von Hundelshausen P, Koeppel TA, Hackeng TM, Weber C, Koenen RR
Journal of cellular and molecular medicine21(8)1523-1531(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects
Title: JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells.

Deletion of JAM-A causes a gain-of-function in platelets, with lower activation thresholds and increased inflammatory activities. This leads to an increase of plaque formation, particularly in early stages of the disease.
Title: Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice.

Endothelial JAM-A but not hematopoietic JAM-A facilitates reovirus T1L bloodstream entry and egress.
Title: Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination.

Soluble JAM-A secreted from cardiac progenitor cells reduces infiltration of neutrophils after myocardial infarction and ameliorates tissue damage through prevention of excess inflammation.
Title: Anti-inflammatory peptides from cardiac progenitors ameliorate dysfunction after myocardial infarction.

The F11r gene is directly regulated by retinoic acid in the embryonic mesoderm.
Title: Identification of novel retinoic acid target genes.

The following F11r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F11r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19196	NM_172647.2 Latest version!	Mus musculus F11 receptor (F11r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F11r ( NM_172647.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766235.1 Mus musculus F11 receptor (F11r), mRNA.

Price & Availability↑

CloneID	OMu19196
Clone ID Related Accession (Same CDS sequence)	NM_172647.2
Accession Version	NM_172647.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	junctional adhesion molecule A precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK033574.1 and CJ317566.1. On Feb 10, 2006 this sequence version replaced NM_172647.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021876.1, AK033574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGCACCG AGGGGAAAGC CGGGAGGAAA CTGTTGTTTC TCTTCACGTC TATGATCCTG 
GGCTCTTTGG TACAAGGCAA GGGTTCGGTG TACACTGCTC AATCTGACGT CCAGGTTCCC 
GAGAACGAGT CCATCAAATT GACCTGCACC TACTCTGGCT TCTCCTCTCC CCGAGTGGAG 
TGGAAGTTCG TCCAAGGCAG CACAACTGCA CTTGTGTGTT ATAACAGCCA GATCACAGCT 
CCCTATGCGG ACCGAGTCAC CTTCTCATCC AGTGGCATCA CGTTCAGTTC TGTGACCCGG 
AAGGACAATG GAGAGTATAC TTGCATGGTC TCCGAGGAAG GTGGCCAGAA CTACGGGGAG 
GTCAGCATCC ACCTCACTGT GCTTGTACCT CCATCCAAGC CGACGATCAG TGTCCCCTCC 
TCTGTCACCA TTGGGAACAG GGCAGTGCTG ACCTGCTCAG AGCATGATGG TTCCCCACCC 
TCTGAATATT CCTGGTTCAA GGACGGGATA TCCATGCTTA CAGCAGATGC CAAGAAAACC 
CGGGCCTTCA TGAATTCTTC ATTCACTATT GATCCAAAGT CGGGGGATCT GATCTTTGAC 
CCCGTGACAG CCTTTGATAG TGGTGAATAC TACTGCCAGG CCCAGAATGG ATATGGGACA 
GCCATGAGGT CAGAGGCTGC ACACATGGAT GCTGTGGAGC TGAATGTGGG GGGCATCGTG 
GCAGCTGTCC TGGTAACACT GATTCTCCTT GGACTCTTGA TTTTTGGCGT CTGGTTTGCC 
TATAGCCGTG GATACTTTGA AAGAACAAAG AAAGGGACTG CACCGGGTAA GAAGGTCATT 
TACAGCCAGC CCAGTACTCG AAGTGAGGGG GAATTCAAAC AGACCTCGTC GTTCCTGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766235.1
CDS	81..983
Translation	MGTEGKAGRKLLFLFTSMILGSLVQGKGSVYTAQSDVQVPENESIKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGYGTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPGKKVIYSQPSTRSEGEFKQTSSFLV

Target ORF information:

RefSeq Version	NM_172647.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus F11 receptor (F11r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172647.2

ORF Insert Sequence:

ATGGGCACCG AGGGGAAAGC CGGGAGGAAA CTGTTGTTTC TCTTCACGTC TATGATCCTG 
GGCTCTTTGG TACAAGGCAA GGGTTCGGTG TACACTGCTC AATCTGACGT CCAGGTTCCC 
GAGAACGAGT CCATCAAATT GACCTGCACC TACTCTGGCT TCTCCTCTCC CCGAGTGGAG 
TGGAAGTTCG TCCAAGGCAG CACAACTGCA CTTGTGTGTT ATAACAGCCA GATCACAGCT 
CCCTATGCGG ACCGAGTCAC CTTCTCATCC AGTGGCATCA CGTTCAGTTC TGTGACCCGG 
AAGGACAATG GAGAGTATAC TTGCATGGTC TCCGAGGAAG GTGGCCAGAA CTACGGGGAG 
GTCAGCATCC ACCTCACTGT GCTTGTACCT CCATCCAAGC CGACGATCAG TGTCCCCTCC 
TCTGTCACCA TTGGGAACAG GGCAGTGCTG ACCTGCTCAG AGCATGATGG TTCCCCACCC 
TCTGAATATT CCTGGTTCAA GGACGGGATA TCCATGCTTA CAGCAGATGC CAAGAAAACC 
CGGGCCTTCA TGAATTCTTC ATTCACTATT GATCCAAAGT CGGGGGATCT GATCTTTGAC 
CCCGTGACAG CCTTTGATAG TGGTGAATAC TACTGCCAGG CCCAGAATGG ATATGGGACA 
GCCATGAGGT CAGAGGCTGC ACACATGGAT GCTGTGGAGC TGAATGTGGG GGGCATCGTG 
GCAGCTGTCC TGGTAACACT GATTCTCCTT GGACTCTTGA TTTTTGGCGT CTGGTTTGCC 
TATAGCCGTG GATACTTTGA AAGAACAAAG AAAGGGACTG CACCGGGTAA GAAGGTCATT 
TACAGCCAGC CCAGTACTCG AAGTGAGGGG GAATTCAAAC AGACCTCGTC GTTCCTGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation.
Arteriosclerosis, thrombosis, and vascular biology38(1)40-48(2018 Jan)
Curaj A,Wu Z,Rix A,Gresch O,Sternkopf M,Alampour-Rajabi S,Lammers T,van Zandvoort M,Weber C,Koenen RR,Liehn EA,Kiessling F

Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.
Journal of cellular and molecular medicine21(8)1523-1531(2017 Aug)
Zhao Z,Vajen T,Karshovska E,Dickhout A,Schmitt MM,Megens RTA,von Hundelshausen P,Koeppel TA,Hackeng TM,Weber C,Koenen RR

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F11r cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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