Cuzd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cuzd1
Entrez Gene ID	16433
Full Name	CUB and zona pellucida-like domains 1
Synonyms	Erg-1,Itmap1,Uo-44,Usg,Utczp
General protein information	Preferred Names CUB and zona pellucida-like domains 1 Names CUB and zona pellucida-like domain-containing protein 1 CUB and ZP domain-containing protein 1 cuzd1 integral membrane-associated protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_008411.3	NP_032437.3	CUB and zona pellucida-like domain-containing protein 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CUZD1	NP_071317.2
Mus musculus (house mouse)	Cuzd1	NP_032437.3
Rattus norvegicus (Norway rat)	Cuzd1	NP_446457.1
Danio rerio (zebrafish)	wu:fb66a12	XP_684059.2
Xenopus tropicalis (tropical clawed frog)	LOC101733966	XP_004920959.1
	CUZD1	XP_001103890.1
Canis lupus familiaris (dog)	CUZD1	XP_544054.2
Danio rerio (zebrafish)	LOC555768	XP_683476.4
Xenopus tropicalis (tropical clawed frog)	LOC100485179	XP_002937840.2
Pan troglodytes (chimpanzee)	CUZD1	XP_001160209.2
Danio rerio (zebrafish)	LOC101886384	XP_005158771.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
Mapes J, Anandan L, Li Q, Neff A, Clevenger CV, Bagchi IC, Bagchi MK
The Journal of biological chemistry(2018 Jan)

CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.
Mapes J, Li Q, Kannan A, Anandan L, Laws M, Lydon JP, Bagchi IC, Bagchi MK
PLoS genetics13(3)e1006654(2017 Mar)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages.
Xiang F, Bai M, Jin Y, Ma W, Xin J
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban27(1)13-6(2007 Feb)

Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.
Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ
The Journal of biological chemistry277(52)50725-33(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that CUZD1 interacts with a complex containing JAK1/JAK2 and STAT5, downstream transducers of prolactin signaling in the mammary gland.
Title: CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.

ERG-1 mediates SiO(2)-driven transcription of Mmp14 in macrophages.
Title: Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages.

plays an essential role in trypsinogen activation and both impaired and augmented trypsinogen activation can be associated with increased severity of pancreatitis
Title: Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.

The following Cuzd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cuzd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15033	NM_008411.3 Latest version!	Mus musculus CUB and zona pellucida-like domains 1 (Cuzd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cuzd1 ( NM_008411.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032437.3 Mus musculus CUB and zona pellucida-like domains 1 (Cuzd1), mRNA.

Price & Availability↑

CloneID	OMu15033
Clone ID Related Accession (Same CDS sequence)	NM_008411.3
Accession Version	NM_008411.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	CUB and zona pellucida-like domain-containing protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156606.12, BY707834.1, AC110885.14 and BY707920.1. On Mar 20, 2007 this sequence version replaced NM_008411.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. An in-frame AUG is located 33 codons upstream of the annotated translation start site but is not being annotated as a start site since it would disrupt the signal peptide on NP_032437.3. ##Evidence-Data-START## Transcript exon combination :: U69699.2, BC140992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGTCA CTGGAAGGCT GTTCATCTGG GCTATTTTAG CTGTCTCCTG TGGGGCACAG 
CTGAATTCTA CAGAGGCTGA AGGCAAATCA AGATGCACAG CCAGTCTGGG AGGGGCCAAT 
CTGGGAGAGA CCCATAAAGC CCTGGTCCTA CAGCTCAGTG CGAATGAGAA CTGCACTTGG 
ACCATAGAGA GACCTGAAAA CAGGAGCATC AGAATCATCT TCTCCTACAT CAAGTTGGAT 
CCAGGCAGCA GGTGTGAAAC TGAAAACATT AAGGTGTTTG ATGGAAGCTC CACCAGTGGG 
CCTCTGCTAG GGAAGGCCTG CAGCAGAAAT GATTTCGTGC CTGTGTTTGA ATCATCATCC 
AACTCGATGA CATTTCAGAT AGTCACTGGC TTGACAAAGT TCCCAAGGAG TGTCTTTATC 
TTCTACTATT TTTTCTCCGC TGCTACCGTT ATTCCAAACT GCGGTGGTGA CCTGCGAGCA 
TTGGAAGGGT CCTTCAGCAG CCCCAATTAT CCAAAGCCGC ACCCTGAGCT GGCATATTGT 
GTCTGGCACA TACAAGTGGG GAAAGGCTAT AAGATACAAT TGAAGTTTAC AGATCTCTTA 
CTAGAGATGG ATGAAAACTG CAAGTTTGAT TTCATCGCAG TCTACGATGG CCCCTCCACC 
ACGGCAGGCC TGCTCAAACA ACTCTGCGGC CGTGGGAAGC CTACCTTAGA ATCTTCCTCT 
GACGCCATGA CTGTCGTGCT ATCTACAGAT TATGCCAATT CCTACAAAGG CTTTTCTGCT 
TCCTACACTT CAATTTACAT CCACGATGTC AACACTACAT CTCTAAGTTG TGTTTCTGAC 
AAGATGAGAG TCATCATAAG CAAATCATAC CTACCGGCAC TCAACTACAA TGAGAGCAAT 
TTGCAGCTAA ATGACCCAAC TTGCAGACCG AATGTATCAA ATGTCATAGA GTTCTCTATC 
CCTCTGCACG AATGCGGTAC AGTCAAAAAG ATAGAGGACC ACGCGATCAG CTATACCAAC 
AGGATCACCT TCATCGAGTC TCCGGTCTCT GCTGTGATCA CCCGACAGAA GCTCCTCCAG 
ATCGTGGTGA CCTGTGAGAT GGAGTATAAC TCTACCGTGG AGATTATGTA CATAACTGAA 
GACGACATCA TACAGAACCA GAGTGTCCTG GGCAAATACA ACACCAGCCT GGCTCTCTAT 
GAGTCCGACT CATTTGAAAA CCTCGTACAG GAGTCACCAT ATTATGTAGA CTTGAACCAG 
ACTCTCTTTG TCCAAGCCAC CTTGCACACC TCGGATCCAA GCCTGGTGGT GTTTCTGGAT 
ACTTGCAGAG CCTCGCCTAC GTCTGACTTT GCATCTCCAA CCTACGACTT AATCAGCAGC 
GGATGTTGTC AAGATGAGAC CTGTAAGGTG TATCCCTTAT TTGGGCACTA TGGAAGGTTC 
CAGTTTAATG CCTTTAAATT CTTGAAACAT CTCAACTCTG TGTATCTCAA GTGTAAGATT 
TTGATATGTG ATAACAATGA CCAAACATCT CGCTGCAATC AAGGCTGTGT CCCAAGAAGG 
AAACGGGATA TTCCTTCCTA CAAATGGAAG ACTGACTCTG TTATAGGACC CATTCGCCTG 
AAGAGGGACC GAAGTGCAAG TAGAGATTCA GGACTTCTGC CTCAAATACA TGAAGCAGAA 
ATTTCAAACC AGCCCCTCAG TCGCCTGTAC CTGTTTTCCT TCATGGTTCT TGCGCTAAAT 
GTGGTGATTG TGGCGATAAC CACAGTGAAG CATTTCCTAA ATCGGTGGAT GGATCACAGA 
TACCAGAAGC TGCAGGTCTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032437.3
CDS	246..2069
Translation	MEVTGRLFIWAILAVSCGAQLNSTEAEGKSRCTASLGGANLGETHKALVLQLSANENCTWTIERPENRSIRIIFSYIKLDPGSRCETENIKVFDGSSTSGPLLGKACSRNDFVPVFESSSNSMTFQIVTGLTKFPRSVFIFYYFFSAATVIPNCGGDLRALEGSFSSPNYPKPHPELAYCVWHIQVGKGYKIQLKFTDLLLEMDENCKFDFIAVYDGPSTTAGLLKQLCGRGKPTLESSSDAMTVVLSTDYANSYKGFSASYTSIYIHDVNTTSLSCVSDKMRVIISKSYLPALNYNESNLQLNDPTCRPNVSNVIEFSIPLHECGTVKKIEDHAISYTNRITFIESPVSAVITRQKLLQIVVTCEMEYNSTVEIMYITEDDIIQNQSVLGKYNTSLALYESDSFENLVQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCCQDETCKVYPLFGHYGRFQFNAFKFLKHLNSVYLKCKILICDNNDQTSRCNQGCVPRRKRDIPSYKWKTDSVIGPIRLKRDRSASRDSGLLPQIHEAEISNQPLSRLYLFSFMVLALNVVIVAITTVKHFLNRWMDHRYQKLQVY

Target ORF information:

RefSeq Version	NM_008411.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CUB and zona pellucida-like domains 1 (Cuzd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008411.3

ORF Insert Sequence:

ATGGAGGTCA CTGGAAGGCT GTTCATCTGG GCTATTTTAG CTGTCTCCTG TGGGGCACAG 
CTGAATTCTA CAGAGGCTGA AGGCAAATCA AGATGCACAG CCAGTCTGGG AGGGGCCAAT 
CTGGGAGAGA CCCATAAAGC CCTGGTCCTA CAGCTCAGTG CGAATGAGAA CTGCACTTGG 
ACCATAGAGA GACCTGAAAA CAGGAGCATC AGAATCATCT TCTCCTACAT CAAGTTGGAT 
CCAGGCAGCA GGTGTGAAAC TGAAAACATT AAGGTGTTTG ATGGAAGCTC CACCAGTGGG 
CCTCTGCTAG GGAAGGCCTG CAGCAGAAAT GATTTCGTGC CTGTGTTTGA ATCATCATCC 
AACTCGATGA CATTTCAGAT AGTCACTGGC TTGACAAAGT TCCCAAGGAG TGTCTTTATC 
TTCTACTATT TTTTCTCCGC TGCTACCGTT ATTCCAAACT GCGGTGGTGA CCTGCGAGCA 
TTGGAAGGGT CCTTCAGCAG CCCCAATTAT CCAAAGCCGC ACCCTGAGCT GGCATATTGT 
GTCTGGCACA TACAAGTGGG GAAAGGCTAT AAGATACAAT TGAAGTTTAC AGATCTCTTA 
CTAGAGATGG ATGAAAACTG CAAGTTTGAT TTCATCGCAG TCTACGATGG CCCCTCCACC 
ACGGCAGGCC TGCTCAAACA ACTCTGCGGC CGTGGGAAGC CTACCTTAGA ATCTTCCTCT 
GACGCCATGA CTGTCGTGCT ATCTACAGAT TATGCCAATT CCTACAAAGG CTTTTCTGCT 
TCCTACACTT CAATTTACAT CCACGATGTC AACACTACAT CTCTAAGTTG TGTTTCTGAC 
AAGATGAGAG TCATCATAAG CAAATCATAC CTACCGGCAC TCAACTACAA TGAGAGCAAT 
TTGCAGCTAA ATGACCCAAC TTGCAGACCG AATGTATCAA ATGTCATAGA GTTCTCTATC 
CCTCTGCACG AATGCGGTAC AGTCAAAAAG ATAGAGGACC ACGCGATCAG CTATACCAAC 
AGGATCACCT TCATCGAGTC TCCGGTCTCT GCTGTGATCA CCCGACAGAA GCTCCTCCAG 
ATCGTGGTGA CCTGTGAGAT GGAGTATAAC TCTACCGTGG AGATTATGTA CATAACTGAA 
GACGACATCA TACAGAACCA GAGTGTCCTG GGCAAATACA ACACCAGCCT GGCTCTCTAT 
GAGTCCGACT CATTTGAAAA CCTCGTACAG GAGTCACCAT ATTATGTAGA CTTGAACCAG 
ACTCTCTTTG TCCAAGCCAC CTTGCACACC TCGGATCCAA GCCTGGTGGT GTTTCTGGAT 
ACTTGCAGAG CCTCGCCTAC GTCTGACTTT GCATCTCCAA CCTACGACTT AATCAGCAGC 
GGATGTTGTC AAGATGAGAC CTGTAAGGTG TATCCCTTAT TTGGGCACTA TGGAAGGTTC 
CAGTTTAATG CCTTTAAATT CTTGAAACAT CTCAACTCTG TGTATCTCAA GTGTAAGATT 
TTGATATGTG ATAACAATGA CCAAACATCT CGCTGCAATC AAGGCTGTGT CCCAAGAAGG 
AAACGGGATA TTCCTTCCTA CAAATGGAAG ACTGACTCTG TTATAGGACC CATTCGCCTG 
AAGAGGGACC GAAGTGCAAG TAGAGATTCA GGACTTCTGC CTCAAATACA TGAAGCAGAA 
ATTTCAAACC AGCCCCTCAG TCGCCTGTAC CTGTTTTCCT TCATGGTTCT TGCGCTAAAT 
GTGGTGATTG TGGCGATAAC CACAGTGAAG CATTTCCTAA ATCGGTGGAT GGATCACAGA 
TACCAGAAGC TGCAGGTCTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
The Journal of biological chemistry(2018 Jan)
Mapes J,Anandan L,Li Q,Neff A,Clevenger CV,Bagchi IC,Bagchi MK

CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.
PLoS genetics13(3)e1006654(2017 Mar)
Mapes J,Li Q,Kannan A,Anandan L,Laws M,Lydon JP,Bagchi IC,Bagchi MK

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Egr-1 mediates Si0(2)-driven transcription of membrane type I matrix metalloproteinase in macrophages.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban27(1)13-6(2007 Feb)
Xiang F,Bai M,Jin Y,Ma W,Xin J

Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.
The Journal of biological chemistry277(52)50725-33(2002 Dec)
Imamura T,Asada M,Vogt SK,Rudnick DA,Lowe ME,Muglia LJ

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Cuzd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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