Insl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Insl3
Entrez Gene ID	16336
Full Name	insulin-like 3
Synonyms	Rlf,Rlnl
General protein information	Preferred Names insulin-like 3 Names insulin-like 3 Ley I-L ley-I-L leydig insulin-like peptide relaxin-like factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B3.3\|8 34.43 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013564.7	NP_038592.3	insulin-like 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	INSL3	NP_005534.2
Mus musculus (house mouse)	Insl3	NP_038592.3
Rattus norvegicus (Norway rat)	Insl3	NP_446132.1
Pan troglodytes (chimpanzee)	INSL3	NP_001171286.1
Canis lupus familiaris (dog)	INSL3	NP_001002962.1
Bos taurus (cattle)	INSL3	NP_776790.1

Gene Ontology
Bibliography

Related articles in PubMed

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S
PloS one13(1)e0190800(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results displayed that INSL3 changed RXFP2 expression in mouse gubernaculum testis cells in vitro
Title: An insight into insulin-like factor 3 regulate its receptor RXFP2 in mouse gubernaculum testis cells.

Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 in GDX-induced adrenocortical tumors of the mouse.
Title: Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.

COUP-TFII cooperates with the nuclear receptor steroidogenic factor 1 (SF1) to further enhance Insl3 promoter activity in Leydig cells.
Title: The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.

Our data suggest that beta-catenin and NOTCH1 pathways are potential targets of INSL3 signaling during gubernacular development.
Title: Mechanisms of INSL3 signaling in male reproductive organs.

Data suggest that Insl3/Rxfp2 (insulin-like peptide 3/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility.
Title: Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.

The following Insl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Insl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19409	NM_013564.7 Latest version!	Mus musculus insulin-like 3 (Insl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Insl3 ( NM_013564.7 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038592.3 Mus musculus insulin-like 3 (Insl3), mRNA.

Price & Availability↑

CloneID	OMu19409
Clone ID Related Accession (Same CDS sequence)	NM_013564.7
Accession Version	NM_013564.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Mus musculus(house mouse)
Product	insulin-like 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132857.1 and AC162033.11. On Dec 22, 2011 this sequence version replaced NM_013564.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049540.1, CN842510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGCGC CGCTGCTACT GATGCTCCTG GCTCTGGGGT CCGCGCTGCG CTCCCCGCAG 
CCCCCCGAGG CACGCGCCAA GCTCTGCGGC CACCACCTGG TGCGCACGCT GGTGCGGGTG 
TGCGGCGGCC CACGCTGGTC GCCCGAGGCC ACGCAGCCTG TGGAGACCCG GGACCGGGAG 
CTGCTGCAGT GGCTAGAGCA GAGACATCTC CTGCACGCGC TGGTGGCCGA CGTGGACCCA 
GCGCTAGACC CGCAGCTTCC TCTCCAGGCT TCTCAGCGCC AGCGCCGCAG TGCCGCCACC 
AACGCTGTGC ACCGCTGCTG TCTTACTGGC TGCACCCAGC AAGACCTGTT GGGTCTGTGT 
CCCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038592.3
CDS	7..375
Translation	MRAPLLLMLLALGSALRSPQPPEARAKLCGHHLVRTLVRVCGGPRWSPEATQPVETRDRELLQWLEQRHLLHALVADVDPALDPQLPLQASQRQRRSAATNAVHRCCLTGCTQQDLLGLCPH

Target ORF information:

RefSeq Version	NM_013564.7
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like 3 (Insl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013564.7

ORF Insert Sequence:

ATGCGCGCGC CGCTGCTACT GATGCTCCTG GCTCTGGGGT CCGCGCTGCG CTCCCCGCAG 
CCCCCCGAGG CACGCGCCAA GCTCTGCGGC CACCACCTGG TGCGCACGCT GGTGCGGGTG 
TGCGGCGGCC CACGCTGGTC GCCCGAGGCC ACGCAGCCTG TGGAGACCCG GGACCGGGAG 
CTGCTGCAGT GGCTAGAGCA GAGACATCTC CTGCACGCGC TGGTGGCCGA CGTGGACCCA 
GCGCTAGACC CGCAGCTTCC TCTCCAGGCT TCTCAGCGCC AGCGCCGCAG TGCCGCCACC 
AACGCTGTGC ACCGCTGCTG TCTTACTGGC TGCACCCAGC AAGACCTGTT GGGTCTGTGT 
CCCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
PloS one13(1)e0190800(2018)
Shawki HH,Oishi H,Usui T,Kitadate Y,Basha WA,Abdellatif AM,Hasegawa K,Okada R,Mochida K,El-Shemy HA,Muratani M,Ogura A,Yoshida S,Takahashi S

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Insl3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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