Fabp6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp6
Entrez Gene ID	16204
Full Name	fatty acid binding protein 6, ileal (gastrotropin)
Synonyms	GT,I-15P,I-BABP,ILBP,ILBP3,Illbp
General protein information	Preferred Names fatty acid binding protein 6, ileal (gastrotropin) Names gastrotropin fatty acid-binding protein 6 ileal bile acid-binding protein ileal lipid-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B1.1\|11 25.81 cM
Summary	The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008375.2	NP_032401.1	gastrotropin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FABP6	NP_001069143.1
Mus musculus (house mouse)	Fabp6	NP_032401.1
Danio rerio (zebrafish)	fabp6	NP_001002076.1
Xenopus tropicalis (tropical clawed frog)	LOC100487630	XP_002940224.2
Homo sapiens (human)	FABP6	NP_001035532.1
Pan troglodytes (chimpanzee)	FABP6	XP_518071.3
	FABP6	XP_001083965.2
Canis lupus familiaris (dog)	FABP6	XP_536447.1
Rattus norvegicus (Norway rat)	Fabp6	NP_058794.1
Gallus gallus (chicken)	FABP6	NP_001264629.1

Gene Ontology
Bibliography

Related articles in PubMed

The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation.
Duggavathi R, Siddappa D, Schuermann Y, Pansera M, Menard IJ, Praslickova D, Agellon LB
The Journal of reproduction and development61(3)237-40(2015)

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Walker EM, Thompson CA, Battle MA
Developmental biology392(2)283-94(2014 Aug)

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K
Cell metabolism17(6)916-28(2013 Jun)

The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.
Praslickova D, Torchia EC, Sugiyama MG, Magrane EJ, Zwicker BL, Kolodzieyski L, Agellon LB
PloS one7(12)e50810(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression of the Fabp6 gene in granulosa cells serves an important and previously unrecognized function in fertility
Title: The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation.

The results demonstrate that ilbp is involved in the apical to basolateral transport of bile acids in ileal enterocytes, and is vital for the maintenance of bile acid homeostasis in the enterohepatic circulation (EHC) in mice.
Title: The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.

The lithogenic diet induced biliary hyperplasia and reduced bile salt transporter FABP6 expression in C57L mice.
Title: Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains.

The ligand binding activity of purified recombinant murine ILBP (mILBP) in vitro; mILBP exhibits a preference for certain species of bile and fatty acids.
Title: The relative ligand binding preference of the murine ileal lipid binding protein.

The following Fabp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19260	NM_008375.2 Latest version!	Mus musculus fatty acid binding protein 6 (Fabp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp6 ( NM_008375.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032401.1 Mus musculus fatty acid binding protein 6 (Fabp6), mRNA.

Price & Availability↑

CloneID	OMu19260
Clone ID Related Accession (Same CDS sequence)	NM_008375.2
Accession Version	NM_008375.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	gastrotropin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ043022.1 and BC119289.1. On Jan 12, 2013 this sequence version replaced NM_008375.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ043022.1, BX633352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTCA GTGGCAAATA TGAATTTGAG AGTGAGAAGA ATTACGATGA GTTCATGAAG 
CGCCTGGGTC TTCCAGGAGA CGTGATTGAA AGGGGACGTA ACTTCAAGAT CATCACAGAG 
GTCCAGCAGG ACGGACAGGA CTTCACCTGG TCCCAGTCTT ACTCTGGGGG CAACATTATG 
AGCAACAAGT TCACCATTGG CAAAGAATGT GAAATGCAGA CCATGGGGGG CAAGAAGTTC 
AAGGCTACCG TGAAGATGGA GGGTGGCAAG GTGGTGGCAG AGTTCCCCAA CTATCACCAG 
ACTTCGGAGG TCGTGGGTGA CAAGTTGGTG GAGATCTCCA CCATCGGGGA TGTGACCTAT 
GAGCGCGTAA GCAAGAGGCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032401.1
CDS	52..438
Translation	MAFSGKYEFESEKNYDEFMKRLGLPGDVIERGRNFKIITEVQQDGQDFTWSQSYSGGNIMSNKFTIGKECEMQTMGGKKFKATVKMEGGKVVAEFPNYHQTSEVVGDKLVEISTIGDVTYERVSKRLA

Target ORF information:

RefSeq Version	NM_008375.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fatty acid binding protein 6 (Fabp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008375.2

ORF Insert Sequence:

ATGGCCTTCA GTGGCAAATA TGAATTTGAG AGTGAGAAGA ATTACGATGA GTTCATGAAG 
CGCCTGGGTC TTCCAGGAGA CGTGATTGAA AGGGGACGTA ACTTCAAGAT CATCACAGAG 
GTCCAGCAGG ACGGACAGGA CTTCACCTGG TCCCAGTCTT ACTCTGGGGG CAACATTATG 
AGCAACAAGT TCACCATTGG CAAAGAATGT GAAATGCAGA CCATGGGGGG CAAGAAGTTC 
AAGGCTACCG TGAAGATGGA GGGTGGCAAG GTGGTGGCAG AGTTCCCCAA CTATCACCAG 
ACTTCGGAGG TCGTGGGTGA CAAGTTGGTG GAGATCTCCA CCATCGGGGA TGTGACCTAT 
GAGCGCGTAA GCAAGAGGCT GGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation.
The Journal of reproduction and development61(3)237-40(2015)
Duggavathi R,Siddappa D,Schuermann Y,Pansera M,Menard IJ,Praslickova D,Agellon LB

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Developmental biology392(2)283-94(2014 Aug)
Walker EM,Thompson CA,Battle MA

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Cell metabolism17(6)916-28(2013 Jun)
Vergnes L,Lee JM,Chin RG,Auwerx J,Reue K

The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.
PloS one7(12)e50810(2012)
Praslickova D,Torchia EC,Sugiyama MG,Magrane EJ,Zwicker BL,Kolodzieyski L,Agellon LB

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Fabp6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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