Il5ra cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il5ra
Entrez Gene ID	16192
Full Name	interleukin 5 receptor, alpha
Synonyms	CD125,CDw125,Il5r
General protein information	Preferred Names interleukin 5 receptor, alpha Names interleukin-5 receptor subunit alpha IL-5 receptor alpha chain IL-5 receptor subunit alpha IL-5R subunit alpha IL-5R-alpha IL-5RA
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 E1\|6 49.19 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_030255194.1	XP_030111054.1	interleukin-5 receptor subunit alpha isoform X1
XM_017321406.1	XP_017176895.1	interleukin-5 receptor subunit alpha isoform X1
NM_008370.2	NP_032396.1	interleukin-5 receptor subunit alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL5RA	NP_783853.1
Pan troglodytes (chimpanzee)	IL5RA	XP_001139350.1
Mus musculus (house mouse)	Il5ra	NP_032396.1
Gallus gallus (chicken)	IL5RA	NP_001243081.1
Canis lupus familiaris (dog)	IL5RA	XP_005632301.1
Bos taurus (cattle)	IL5RA	XP_002697013.2
Xenopus tropicalis (tropical clawed frog)	il5ra	NP_001116934.1
Rattus norvegicus (Norway rat)	Il5ra	NP_446097.1

Gene Ontology
Bibliography

Related articles in PubMed

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH
Nature immunology16(8)829-37(2015 Aug)

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.
Schmitt F, Sch?ll D, Bucher K, Schindler TI, Hector A, Biedermann T, Zemlin M, Hartl D, Beer-Hammer S
European journal of immunology45(1)60-70(2015 Jan)

Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.
Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K
Journal of immunology (Baltimore, Md. : 1950)188(2)703-13(2012 Jan)

A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor ?.
Ishino T, Economou NJ, McFadden K, Zaks-Zilberman M, Jost M, Baxter S, Contarino MR, Harrington AE, Loll PJ, Pasut G, Lievens S, Tavernier J, Chaiken I
Biochemistry50(35)7546-56(2011 Sep)

Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development.
Kouro T, Ikutani M, Kariyone A, Takatsu K
Immunology letters123(2)169-78(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
Title: SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.

Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function.
Title: A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor ?.

We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver
Title: Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development.

Octamer Transcription Factor 2 (Oct2) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain.
Title: Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.

IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice
Title: Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo.

The following Il5ra gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il5ra cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu01803	NM_008370.2 Latest version!	Mus musculus interleukin 5 receptor, alpha (Il5ra), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu01803	XM_017321406.1 Latest version!	Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu01803	XM_030255194.1 Latest version!	Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il5ra ( NM_008370.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032396.1 Mus musculus interleukin 5 receptor, alpha (Il5ra), mRNA.

Price & Availability↑

CloneID	OMu01803
Clone ID Related Accession (Same CDS sequence)	XM_030255194.1 , XM_017321406.1 , NM_008370.2
Accession Version	NM_008370.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	interleukin-5 receptor subunit alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164169.8. On Nov 17, 2006 this sequence version replaced NM_008370.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D90205.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END##

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032396.1
CDS	303..1550
Translation	MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF

Target ORF information:

RefSeq Version	NM_008370.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 5 receptor, alpha (Il5ra), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008370.2

ORF Insert Sequence:

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il5ra ( XM_017321406.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017176895.1 Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu01803
Clone ID Related Accession (Same CDS sequence)	XM_030255194.1 , XM_017321406.1 , NM_008370.2
Accession Version	XM_017321406.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interleukin-5 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017176895.1
CDS	320..1567
Translation	MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF

Target ORF information:

RefSeq Version	XM_017321406.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017321406.1

ORF Insert Sequence:

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il5ra ( XM_030255194.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030111054.1 Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01803
Clone ID Related Accession (Same CDS sequence)	XM_030255194.1 , XM_017321406.1 , NM_008370.2
Accession Version	XM_030255194.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	interleukin-5 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030111054.1
CDS	157..1404
Translation	MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF

Target ORF information:

RefSeq Version	XM_030255194.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 5 receptor, alpha (Il5ra), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030255194.1

ORF Insert Sequence:

ATGGTGCCTG TGTTACTAAT TCTTGTGGGA GCTTTGGCAA CACTGCAAGC TGACTTACTT 
AATCACAAAA AGTTTTTACT TCTACCACCT GTCAATTTTA CCATTAAAGC CACTGGATTA 
GCTCAAGTTC TTTTACACTG GGACCCAAAT CCTGACCAAG AGCAAAGGCA TGTTGATCTA 
GAGTATCACG TGAAAATAAA TGCCCCACAA GAAGACGAAT ATGATACCAG AAAGACTGAA 
AGCAAATGTG TGACCCCCCT TCATGAAGGC TTTGCAGCTA GCGTGAGGAC CATTCTGAAG 
AGCAGCCATA CAACTCTGGC CAGCAGTTGG GTTTCTGCTG AACTCAAAGC TCCACCAGGA 
TCTCCTGGAA CCTCGGTTAC GAATTTAACT TGTACCACAC ACACTGTTGT AAGTAGCCAC 
ACCCACTTAA GGCCATACCA AGTGTCCCTT CGTTGCACCT GGCTTGTTGG GAAGGATGCC 
CCTGAGGACA CACAGTATTT CCTATACTAC AGGTTTGGTG TTTTGACTGA AAAATGCCAA 
GAATACAGCA GAGATGCACT GAACAGAAAT ACTGCATGCT GGTTTCCCAG GACATTTATC 
AACAGCAAAG GGTTTGAGCA GCTTGCTGTG CACATTAATG GCTCAAGCAA GCGTGCTGCA 
ATCAAGCCCT TTGATCAGCT GTTCAGTCCA CTTGCCATTG ACCAAGTGAA TCCTCCAAGG 
AATGTCACAG TGGAAATTGA AAGCAATTCT CTCTATATAC AGTGGGAGAA ACCACTTTCT 
GCCTTTCCAG ATCATTGCTT TAACTATGAG CTGAAAATTT ACAACACAAA AAATGGTCAC 
ATTCAGAAGG AAAAACTGAT CGCCAATAAG TTCATCTCAA AAATTGATGA TGTTTCTACA 
TATTCCATTC AAGTGAGAGC AGCTGTGAGC TCACCTTGCA GAATGCCAGG AAGGTGGGGC 
GAGTGGAGTC AACCTATTTA TGTGGGAAAG GAAAGGAAGT CCTTGGTAGA ATGGCATCTC 
ATTGTGCTCC CAACAGCCGC CTGCTTCGTC TTGTTAATCT TCTCACTCAT CTGCAGAGTG 
TGTCATCTAT GGACCAGGTT GTTTCCACCG GTTCCGGCCC CAAAGAGTAA CATCAAAGAT 
CTCCCTGTGG TTACTGAATA TGAGAAACCT TCGAATGAAA CCAAAATTGA AGTTGTACAT 
TGTGTGGAAG AGGTTGGATT TGAAGTCATG GGAAATTCCA CGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Nature immunology16(8)829-37(2015 Aug)
Bettigole SE,Lis R,Adoro S,Lee AH,Spencer LA,Weller PF,Glimcher LH

SLy2 controls the antibody response to pneumococcal vaccine through an IL-5R?-dependent mechanism in B-1 cells.
European journal of immunology45(1)60-70(2015 Jan)
Schmitt F,Sch?ll D,Bucher K,Schindler TI,Hector A,Biedermann T,Zemlin M,Hartl D,Beer-Hammer S

Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950)188(2)703-13(2012 Jan)
Ikutani M,Yanagibashi T,Ogasawara M,Tsuneyama K,Yamamoto S,Hattori Y,Kouro T,Itakura A,Nagai Y,Takaki S,Takatsu K

A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor ?.
Biochemistry50(35)7546-56(2011 Sep)
Ishino T,Economou NJ,McFadden K,Zaks-Zilberman M,Jost M,Baxter S,Contarino MR,Harrington AE,Loll PJ,Pasut G,Lievens S,Tavernier J,Chaiken I

Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development.
Immunology letters123(2)169-78(2009 Apr)
Kouro T,Ikutani M,Kariyone A,Takatsu K

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Il5ra cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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