Il17a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il17a
Entrez Gene ID	16171
Full Name	interleukin 17A
Synonyms	Ctla-8,Ctla8,IL-17,IL-17A,Il17
General protein information	Preferred Names interleukin 17A Names interleukin-17A cytotoxic T-lymphocyte-associated antigen 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 A4
Summary	This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010552.3	NP_034682.1	interleukin-17A precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL17A	NP_002181.1
Canis lupus familiaris (dog)	IL17A	NP_001159350.1
Mus musculus (house mouse)	Il17a	NP_034682.1
Xenopus tropicalis (tropical clawed frog)	LOC101734167	XP_004915038.1
Pan troglodytes (chimpanzee)	IL17A	XP_527408.2
Bos taurus (cattle)	IL17A	NP_001008412.1
	IL17A	XP_001106391.1
Rattus norvegicus (Norway rat)	Il17a	NP_001100367.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction and molecular signature of pathogenic TH17 cells.
Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK
Nature immunology13(10)991-9(2012 Oct)

Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.
Torchinsky MB, Garaude J, Martin AP, Blander JM
Nature458(7234)78-82(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study unveiled the role of IL-23-dependent IL-17 induction in LdCen-/- parasite-induced immunity and subsequent protection against visceral leishmaniasis
Title: Live Attenuated

These data support the conclusion that IL-17A contributes to middle ear injury through the p38 MAPK signaling pathway.
Title: Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway.

these results identify a distinct pathway in which IL-17 production by splenic LSK- cells supports their differentiation into B cells in response to acute Plasmodium infection
Title: IL-17 Promotes Differentiation of Splenic LSK

These data thus reveal that HDAC6 represses IL-17 production in T cells, providing novel insights into the role of HDAC6 in the immune system.
Title: HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies.

MMP-9 mediates IL-17's capacity to inhibit myoblast differentiation during inflammatory diseases
Title: Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation.

The following Il17a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il17a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18115	NM_010552.3 Latest version!	Mus musculus interleukin 17A (Il17a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il17a ( NM_010552.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034682.1 Mus musculus interleukin 17A (Il17a), mRNA.

Price & Availability↑

CloneID	OMu18115
Clone ID Related Accession (Same CDS sequence)	NM_010552.3
Accession Version	NM_010552.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	interleukin-17A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK040420.1. On Apr 6, 2007 this sequence version replaced NM_010552.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK040420.1, U43088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGAGTCCAG GGAGAGCTTC ATCTGTGTCT CTGATGCTGT TGCTGCTGCT GAGCCTGGCG 
GCTACAGTGA AGGCAGCAGC GATCATCCCT CAAAGCTCAG CGTGTCCAAA CACTGAGGCC 
AAGGACTTCC TCCAGAATGT GAAGGTCAAC CTCAAAGTCT TTAACTCCCT TGGCGCAAAA 
GTGAGCTCCA GAAGGCCCTC AGACTACCTC AACCGTTCCA CGTCACCCTG GACTCTCCAC 
CGCAATGAAG ACCCTGATAG ATATCCCTCT GTGATCTGGG AAGCTCAGTG CCGCCACCAG 
CGCTGTGTCA ATGCGGAGGG AAAGCTGGAC CACCACATGA ATTCTGTTCT CATCCAGCAA 
GAGATCCTGG TCCTGAAGAG GGAGCCTGAG AGCTGCCCCT TCACTTTCAG GGTCGAGAAG 
ATGCTGGTGG GTGTGGGCTG CACCTGCGTG GCCTCGATTG TCCGCCAGGC AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034682.1
CDS	58..534
Translation	MSPGRASSVSLMLLLLLSLAATVKAAAIIPQSSACPNTEAKDFLQNVKVNLKVFNSLGAKVSSRRPSDYLNRSTSPWTLHRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPESCPFTFRVEKMLVGVGCTCVASIVRQAA

Target ORF information:

RefSeq Version	NM_010552.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 17A (Il17a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010552.3

ORF Insert Sequence:

ATGAGTCCAG GGAGAGCTTC ATCTGTGTCT CTGATGCTGT TGCTGCTGCT GAGCCTGGCG 
GCTACAGTGA AGGCAGCAGC GATCATCCCT CAAAGCTCAG CGTGTCCAAA CACTGAGGCC 
AAGGACTTCC TCCAGAATGT GAAGGTCAAC CTCAAAGTCT TTAACTCCCT TGGCGCAAAA 
GTGAGCTCCA GAAGGCCCTC AGACTACCTC AACCGTTCCA CGTCACCCTG GACTCTCCAC 
CGCAATGAAG ACCCTGATAG ATATCCCTCT GTGATCTGGG AAGCTCAGTG CCGCCACCAG 
CGCTGTGTCA ATGCGGAGGG AAAGCTGGAC CACCACATGA ATTCTGTTCT CATCCAGCAA 
GAGATCCTGG TCCTGAAGAG GGAGCCTGAG AGCTGCCCCT TCACTTTCAG GGTCGAGAAG 
ATGCTGGTGG GTGTGGGCTG CACCTGCGTG GCCTCGATTG TCCGCCAGGC AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction and molecular signature of pathogenic TH17 cells.
Nature immunology13(10)991-9(2012 Oct)
Lee Y,Awasthi A,Yosef N,Quintana FJ,Xiao S,Peters A,Wu C,Kleinewietfeld M,Kunder S,Hafler DA,Sobel RA,Regev A,Kuchroo VK

Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.
Nature458(7234)78-82(2009 Mar)
Torchinsky MB,Garaude J,Martin AP,Blander JM

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Il17a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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