Sdc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sdc2
Entrez Gene ID	15529
Full Name	syndecan 2
Synonyms	4833414L08Rik,AA960457,Hspg1,Synd2,syndecan-2
General protein information	Preferred Names syndecan 2 Names syndecan-2 HSPG fibroglycan heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan) heparan sulfate proteoglycan core protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 B3.1\|15 13.74 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008304.2	NP_032330.1	syndecan-2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SDC2	NP_002989.2
Rattus norvegicus (Norway rat)	Sdc2	NP_037214.1
Pan troglodytes (chimpanzee)	SDC2	XP_003311905.1
Bos taurus (cattle)	SDC2	NP_001029960.2
Canis lupus familiaris (dog)	SDC2	XP_005638221.1
Gallus gallus (chicken)	SDC2	NP_001001462.1
Danio rerio (zebrafish)	sdc2	NP_775330.2
Xenopus tropicalis (tropical clawed frog)	sdc2	NP_001017163.1
	SDC2	XP_002805455.1
Mus musculus (house mouse)	Sdc2	NP_032330.1

Gene Ontology
Bibliography

Related articles in PubMed

Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.
Mansouri R, Jouan Y, Hay E, Blin-Wakkach C, Frain M, Ostertag A, Le Henaff C, Marty C, Geoffroy V, Marie PJ, Cohen-Solal M, Modrowski D
Cell death & disease8(6)e2902(2017 Jun)

Inflammatory hypoxia induces syndecan-2 expression through IL-1?-mediated FOXO3a activation in colonic epithelia.
Choi S, Chung H, Hong H, Kim SY, Kim SE, Seoh JY, Moon CM, Yang EG, Oh ES
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(4)1516-1530(2017 04)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.
Dierker T, Bachvarova V, Krause Y, Li JP, Kjell?n L, Seidler DG, Vortkamp A
Matrix biology : journal of the International Society for Matrix Biology4982-92(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Syndecan-2 expression is upregulated in colonic epithelia of mice with DSS-induced colitis via FOXO3 activation.
Title: Inflammatory hypoxia induces syndecan-2 expression through IL-1?-mediated FOXO3a activation in colonic epithelia.

In mouse melanoma cells, siRNA-mediated knockdown of syndecan-2 was associated with reduced melanin synthesis, whereas overexpression of syndecan-2 increased melanin synthesis.
Title: Syndecan-2 regulates melanin synthesis via protein kinase C ?II-mediated tyrosinase activation.

The N-terminal growth-factor-like domain of amyloid-beta precursor protein is necessary for protein-receptor binding, whereas the E2-domain mediates interaction with membrane-anchored syndecan 2 and glypican 1.
Title: Soluble amyloid-? precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans.

The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin.
Title: Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice.

MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression.
Title: Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.

The following Sdc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sdc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01692	NM_008304.2 Latest version!	Mus musculus syndecan 2 (Sdc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sdc2 ( NM_008304.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032330.1 Mus musculus syndecan 2 (Sdc2), mRNA.

Price & Availability↑

CloneID	OMu01692
Clone ID Related Accession (Same CDS sequence)	NM_008304.2
Accession Version	NM_008304.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	syndecan-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC139845.19 and AC129537.8. On Nov 17, 2006 this sequence version replaced NM_008304.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U00674.1, AK011042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCGCG CGTGGATCCT GCTCACCTTG GGCTTGATGG CCTGTGTGTC CGCAGAGACG 
AGAACAGAGC TGACATCCGA TAAGGATATG TACCTTGACA ATAGCTCCAT TGAGGAAGCT 
TCAGGAGTAT ATCCTATTGA TGATGATGAC TATTCTTCTG CCTCAGGCTC AGGAGCTGAT 
GAAGACATAG AGAGTCCAGT TCTGACAACA TCCCAACTGA TTCCAAGAAT CCCACTCACT 
AGTGCTGCTT CCCCCAAAGT GGAAACCATG ACGTTGAAGA CACAAAGCAT TACACCTGCT 
CAGACTGAGT CACCTGAAGA AACTGACAAG GAGGAAGTTG ACATTTCTGA GGCAGAAGAG 
AAGCTGGGCC CTGCTATAAA AAGCACAGAT GTGTACACGG AGAAACATTC AGACAATCTG 
TTTAAACGGA CAGAAGTTCT AGCAGCCGTC ATTGCTGGTG GTGTGATCGG CTTTCTCTTT 
GCCATTTTCC TCATCCTGCT ATTGGTGTAC CGCATGCGGA AGAAAGATGA AGGAAGCTAC 
GACCTTGGAG AACGCAAACC ATCCAGCGCA GCTTACCAGA AGGCACCCAC TAAGGAGTTT 
TATGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032330.1
CDS	524..1132
Translation	MQRAWILLTLGLMACVSAETRTELTSDKDMYLDNSSIEEASGVYPIDDDDYSSASGSGADEDIESPVLTTSQLIPRIPLTSAASPKVETMTLKTQSITPAQTESPEETDKEEVDISEAEEKLGPAIKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA

Target ORF information:

RefSeq Version	NM_008304.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus syndecan 2 (Sdc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008304.2

ORF Insert Sequence:

ATGCAGCGCG CGTGGATCCT GCTCACCTTG GGCTTGATGG CCTGTGTGTC CGCAGAGACG 
AGAACAGAGC TGACATCCGA TAAGGATATG TACCTTGACA ATAGCTCCAT TGAGGAAGCT 
TCAGGAGTAT ATCCTATTGA TGATGATGAC TATTCTTCTG CCTCAGGCTC AGGAGCTGAT 
GAAGACATAG AGAGTCCAGT TCTGACAACA TCCCAACTGA TTCCAAGAAT CCCACTCACT 
AGTGCTGCTT CCCCCAAAGT GGAAACCATG ACGTTGAAGA CACAAAGCAT TACACCTGCT 
CAGACTGAGT CACCTGAAGA AACTGACAAG GAGGAAGTTG ACATTTCTGA GGCAGAAGAG 
AAGCTGGGCC CTGCTATAAA AAGCACAGAT GTGTACACGG AGAAACATTC AGACAATCTG 
TTTAAACGGA CAGAAGTTCT AGCAGCCGTC ATTGCTGGTG GTGTGATCGG CTTTCTCTTT 
GCCATTTTCC TCATCCTGCT ATTGGTGTAC CGCATGCGGA AGAAAGATGA AGGAAGCTAC 
GACCTTGGAG AACGCAAACC ATCCAGCGCA GCTTACCAGA AGGCACCCAC TAAGGAGTTT 
TATGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.
Cell death & disease8(6)e2902(2017 Jun)
Mansouri R,Jouan Y,Hay E,Blin-Wakkach C,Frain M,Ostertag A,Le Henaff C,Marty C,Geoffroy V,Marie PJ,Cohen-Solal M,Modrowski D

Inflammatory hypoxia induces syndecan-2 expression through IL-1?-mediated FOXO3a activation in colonic epithelia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(4)1516-1530(2017 04)
Choi S,Chung H,Hong H,Kim SY,Kim SE,Seoh JY,Moon CM,Yang EG,Oh ES

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.
Matrix biology : journal of the International Society for Matrix Biology4982-92(2016 Jan)
Dierker T,Bachvarova V,Krause Y,Li JP,Kjell?n L,Seidler DG,Vortkamp A

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Sdc2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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