Hpx cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hpx
Entrez Gene ID	15458
Full Name	hemopexin
Synonyms	Hpxn,hx
General protein information	Preferred Names hemopexin Names hemopexin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_017371.2	NP_059067.2	hemopexin precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HPX	XP_417267.3
Pan troglodytes (chimpanzee)	HPX	XP_508255.1
Canis lupus familiaris (dog)	HPX	XP_853676.1
Xenopus tropicalis (tropical clawed frog)	LOC100495728	XP_002944396.2
	HPX	XP_001109797.1
Mus musculus (house mouse)	Hpx	NP_059067.2
Rattus norvegicus (Norway rat)	Hpx	NP_445770.1
Danio rerio (zebrafish)	hpx	NP_001104617.1
Homo sapiens (human)	HPX	NP_000604.1
Bos taurus (cattle)	HPX	NP_001029784.1

Gene Ontology
Bibliography

Related articles in PubMed

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.
Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E
Free radical biology & medicine108452-464(2017 Jul)

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.
Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, N??ez G
Science immunology2(8)(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hemopexin plays a novel protective role in alleviating heme-induced oxidative stress, improving inflammatory properties of high-density lipoprotein, macrophage phenotype and function, and inhibiting the development of atherosclerosis in apoE(-/-) mice.
Title: Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.

This study demonstrated that Deletion of the hemopexin aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.

In models for sepsis or burns, mean plasma hemopexin levels were increased above baseline.
Title: Hemopexin in severe inflammation and infection: mouse models and human diseases.

negative regulatory role in Th17-mediated autoimmune inflammation
Title: Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

The findings suggest that hemopexin can modulate the role of hemoglobin in sterile and infectious inflammation
Title: Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation.

The following Hpx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hpx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13120	NM_017371.2 Latest version!	Mus musculus hemopexin (Hpx), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hpx ( NM_017371.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059067.2 Mus musculus hemopexin (Hpx), mRNA.

Price & Availability↑

CloneID	OMu13120
Clone ID Related Accession (Same CDS sequence)	NM_017371.2
Accession Version	NM_017371.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	hemopexin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY088352.1, AK145928.1 and AA985967.1. On Nov 16, 2007 this sequence version replaced NM_017371.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011246.1, AK145928.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTAGGA CAGCAGTGGC GCTAAATATC CTGGTGTTGC TGGGCCTGTG CTGGTCCCTG 
GCTGTTGCCA GCCCTCTTCC TACTGCCAAC GGGAGAGTTG CCGAAGTTGA AAATGGGACC 
AAGCCAGATT CAGATGTACC CGAACACTGC TTGGATACCT GGAGCTTTGA TGCTGCGACC 
ATGGATCACA ATGGGACCAT GCTGTTCTTT AAAGGGGAGT TTGTGTGGAG GGGTCACTCA 
GGGACCCGGG AGTTGATCTC AGCGAGGTGG AAGAATCCCA TCACCTCAGT GGATGCTGCA 
TTCCGTGGTC CTGACAGTGT CTTCCTGATC AAGGAAGACA AAGTCTGGGT GTACCCTCCT 
GAAAAGAAGG AAAACGGGTA TCCAAAGTTG TTCCAAGAAG AGTTTCCTGG AATCCCATAC 
CCACCAGACG CAGCTGTGGA ATGCCACCGT GGAGAGTGCC AGAGTGAAGG CGTCCTTTTC 
TTCCAAGGTA ACCGCAAGTG GTTCTGGGAC TTTGCCACAA GAACCCAAAA GGAACGTTCC 
TGGTCAACTG TTGGGAATTG CACTGCGGCC TTGAGGTGGC TTGAACGCTA CTACTGCTTC 
CAGGGTAACA AGTTCCTGCG ATTCAACCCT GTCACAGGAG AGGTGCCTCC CAGATACCCT 
CTGGATGCCC GTGACTACTT CGTATCCTGC CCTGGCAGAG GCCATGGTAG ACCCAGAAAT 
GGAACTGCTC ATGGAAATAG CACCCATCCT ATGCATTCAC GTTGTAGCCC AGATCCTGGC 
CTGACTGCAC TGCTGTCTGA CCATCGCGGT GCCACCTATG CCTTCACTGG CTCCCACTAC 
TGGCGTCTGG ACTCCAGCCG TGATGGATGG CATAGCTGGC CCATTGCTCA TCACTGGCCT 
CAGGGTCCTT CAACAGTAGA TGCTGCCTTT TCCTGGGATG ATAAAGTCTA TCTGATCCAG 
GGCACTCAAG TGTATGTCTT CCTGACAAAG GGAGGCAATA ACCTAGTAAG TGGTTATCCA 
AAGCGGCTGG AGAAGGAACT TGGGAGCCCT CCTGGGATCA GCCTTGAGAC CATAGATGCA 
GCCTTTTCCT GCCCTGGTTC TTCCAGGCTC TATGTCTCAT CAGGACGGCG GCTTTGGTGG 
CTGGACCTGA AGTCAGGAGC CCAGGCAACA TGGACAGAGG TTTCCTGGCC CCATGAGAAA 
GTTGATGGGG CCCTGTGTTT GGACAAGTCT CTTGGCCCCA ACACATGTTC TTCCAATGGT 
TCCAGCTTGT ACTTTATCCA TGGGCCCAAT TTGTACTGCT ATAGCAGTAT AGACAAACTG 
AATGCAGCCA AGAGTCTGCC TCAGCCTCAG AAGGTGAACA GCATCCTTGG CTGCAGTCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059067.2
CDS	27..1409
Translation	MARTAVALNILVLLGLCWSLAVASPLPTANGRVAEVENGTKPDSDVPEHCLDTWSFDAATMDHNGTMLFFKGEFVWRGHSGTRELISARWKNPITSVDAAFRGPDSVFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIPYPPDAAVECHRGECQSEGVLFFQGNRKWFWDFATRTQKERSWSTVGNCTAALRWLERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFVSCPGRGHGRPRNGTAHGNSTHPMHSRCSPDPGLTALLSDHRGATYAFTGSHYWRLDSSRDGWHSWPIAHHWPQGPSTVDAAFSWDDKVYLIQGTQVYVFLTKGGNNLVSGYPKRLEKELGSPPGISLETIDAAFSCPGSSRLYVSSGRRLWWLDLKSGAQATWTEVSWPHEKVDGALCLDKSLGPNTCSSNGSSLYFIHGPNLYCYSSIDKLNAAKSLPQPQKVNSILGCSQ

Target ORF information:

RefSeq Version	NM_017371.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hemopexin (Hpx), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017371.2

ORF Insert Sequence:

ATGGCTAGGA CAGCAGTGGC GCTAAATATC CTGGTGTTGC TGGGCCTGTG CTGGTCCCTG 
GCTGTTGCCA GCCCTCTTCC TACTGCCAAC GGGAGAGTTG CCGAAGTTGA AAATGGGACC 
AAGCCAGATT CAGATGTACC CGAACACTGC TTGGATACCT GGAGCTTTGA TGCTGCGACC 
ATGGATCACA ATGGGACCAT GCTGTTCTTT AAAGGGGAGT TTGTGTGGAG GGGTCACTCA 
GGGACCCGGG AGTTGATCTC AGCGAGGTGG AAGAATCCCA TCACCTCAGT GGATGCTGCA 
TTCCGTGGTC CTGACAGTGT CTTCCTGATC AAGGAAGACA AAGTCTGGGT GTACCCTCCT 
GAAAAGAAGG AAAACGGGTA TCCAAAGTTG TTCCAAGAAG AGTTTCCTGG AATCCCATAC 
CCACCAGACG CAGCTGTGGA ATGCCACCGT GGAGAGTGCC AGAGTGAAGG CGTCCTTTTC 
TTCCAAGGTA ACCGCAAGTG GTTCTGGGAC TTTGCCACAA GAACCCAAAA GGAACGTTCC 
TGGTCAACTG TTGGGAATTG CACTGCGGCC TTGAGGTGGC TTGAACGCTA CTACTGCTTC 
CAGGGTAACA AGTTCCTGCG ATTCAACCCT GTCACAGGAG AGGTGCCTCC CAGATACCCT 
CTGGATGCCC GTGACTACTT CGTATCCTGC CCTGGCAGAG GCCATGGTAG ACCCAGAAAT 
GGAACTGCTC ATGGAAATAG CACCCATCCT ATGCATTCAC GTTGTAGCCC AGATCCTGGC 
CTGACTGCAC TGCTGTCTGA CCATCGCGGT GCCACCTATG CCTTCACTGG CTCCCACTAC 
TGGCGTCTGG ACTCCAGCCG TGATGGATGG CATAGCTGGC CCATTGCTCA TCACTGGCCT 
CAGGGTCCTT CAACAGTAGA TGCTGCCTTT TCCTGGGATG ATAAAGTCTA TCTGATCCAG 
GGCACTCAAG TGTATGTCTT CCTGACAAAG GGAGGCAATA ACCTAGTAAG TGGTTATCCA 
AAGCGGCTGG AGAAGGAACT TGGGAGCCCT CCTGGGATCA GCCTTGAGAC CATAGATGCA 
GCCTTTTCCT GCCCTGGTTC TTCCAGGCTC TATGTCTCAT CAGGACGGCG GCTTTGGTGG 
CTGGACCTGA AGTCAGGAGC CCAGGCAACA TGGACAGAGG TTTCCTGGCC CCATGAGAAA 
GTTGATGGGG CCCTGTGTTT GGACAAGTCT CTTGGCCCCA ACACATGTTC TTCCAATGGT 
TCCAGCTTGT ACTTTATCCA TGGGCCCAAT TTGTACTGCT ATAGCAGTAT AGACAAACTG 
AATGCAGCCA AGAGTCTGCC TCAGCCTCAG AAGGTGAACA GCATCCTTGG CTGCAGTCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.
Free radical biology & medicine108452-464(2017 Jul)
Ingoglia G,Sag CM,Rex N,De Franceschi L,Vinchi F,Cimino J,Petrillo S,Wagner S,Kreitmeier K,Silengo L,Altruda F,Maier LS,Hirsch E,Ghigo A,Tolosano E

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.
Science immunology2(8)(2017 Feb)
Sakamoto K,Kim YG,Hara H,Kamada N,Caballero-Flores G,Tolosano E,Soares MP,Puente JL,Inohara N,N??ez G

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Hpx cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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