Hpgd cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hpgd
Entrez Gene ID	15446
Full Name	hydroxyprostaglandin dehydrogenase 15 (NAD)
Synonyms	15-PGDH,AV026552
General protein information	Preferred Names hydroxyprostaglandin dehydrogenase 15 (NAD) Names 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 15-hydroxyprostaglandin dehydrogenase PGDH prostaglandin dehydrogenase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B2

mRNA and Protein(s)

mRNA	Protein	Name
NM_008278.2	NP_032304.2	15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Pathways from BioSystems

Homologies

Homo sapiens (human)	HPGD	NP_000851.2
	HPGD	XP_001087957.1
Gallus gallus (chicken)	HPGD	NP_001264713.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001753	XP_321329.4
Mus musculus (house mouse)	Hpgd	NP_032304.2
Rattus norvegicus (Norway rat)	Hpgd	NP_077366.2
Xenopus tropicalis (tropical clawed frog)	hpgd	NP_001007992.1
Pan troglodytes (chimpanzee)	HPGD	XP_517542.2
Canis lupus familiaris (dog)	HPGD	XP_543199.1
Bos taurus (cattle)	HPGD	NP_001029591.1
Danio rerio (zebrafish)	LOC565975	XP_694331.5

Gene Ontology
Bibliography

Related articles in PubMed

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Kishore AH, Liang H, Kanchwala M, Xing C, Ganesh T, Akgul Y, Posner B, Ready JM, Markowitz SD, Word RA
Proceedings of the National Academy of Sciences of the United States of America114(31)E6427-E6436(2017 Aug)

Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.
Miyagishi H, Kosuge Y, Takano A, Endo M, Nango H, Yamagata-Murayama S, Hirose D, Kano R, Tanaka Y, Ishige K, Ito Y
Cellular and molecular neurobiology37(3)445-452(2017 Apr)

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.
Yao L, Chen W, Song K, Han C, Gandhi CR, Lim K, Wu T
PloS one12(4)e0176106(2017)

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD
Science (New York, N.Y.)348(6240)aaa2340(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.
Title: Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.

15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.
Title: 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.

15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies.
Title: Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.

Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.
Title: Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.

prostaglandin E synthase (cPGES/p23) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).
Title: Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH.

The following Hpgd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hpgd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01657	NM_008278.2 Latest version!	Mus musculus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hpgd ( NM_008278.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032304.2 Mus musculus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd), mRNA.

Price & Availability↑

CloneID	OMu01657
Clone ID Related Accession (Same CDS sequence)	NM_008278.2
Accession Version	NM_008278.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB870447.1, AK146038.1 and BY581851.1. On Feb 6, 2007 this sequence version replaced NM_008278.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146038.1, BC021157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCACGTGA ACGGCAAAGT GGCTCTGGTG ACCGGCGCGG CACAGGGCAT AGGCAAAGCC 
TTCGCTGAGG CTCTGCTGCT CCATGGCGCC AAGGTAGCAT TGGTGGATTG GAATCTTGAG 
GCAGGTGTAA AATGTAAAGC TGCCCTAGAT GAGCAGTTCG AACCTCAGAA GACACTGTTC 
GTCCAGTGTG ATGTGGCTGA CCAGAAACAA CTGAGAGATA CTTTTAGAAA AGTTGTAGAC 
CATTTCGGAA GATTGGATAT TTTGGTCAAC AATGCAGGCG TGAACAATGA GAAAAACTGG 
GAACAGACTC TACAAATTAA TTTGGTTTCT GTTATCAGTG GGACCTATCT TGGTTTGGAT 
TACATGAGTA AGCAAAACGG AGGTGAAGGC GGCATCATCA TCAATATGTC TTCATTAGCA 
GGGCTCATGC CTGTTGCGCA GCAACCTGTT TATTGTGCTT CGAAGCACGG CATCATCGGA 
TTCACACGCT CAGCAGCGAT GGCTGCTAAC CTCATGAAAA GCGGTGTAAG ACTGAATGTC 
ATTTGCCCAG GCTTTGTGGA CACACCCATC CTTGAATCCA TTGAAAAAGA AGAAAATATG 
GGCCAATATA TAGAATATAA GGACCAGATC AAGGCTATGA TGAAATTCTA TGGGGTTTTA 
CACCCATCAA CCATTGCCAA TGGATTAATA AATCTCATTG AAGATGATGC TCTCAATGGT 
GCCATTATGA AGATCACGGC ATCGAAAGGA ATTCATTTTC AAGATTATGA CATCTCTCCA 
TTACTCGTAA AAGCTCCATT AACCTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032304.2
CDS	69..878
Translation	MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS

Target ORF information:

RefSeq Version	NM_008278.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008278.2

ORF Insert Sequence:

ATGCACGTGA ACGGCAAAGT GGCTCTGGTG ACCGGCGCGG CACAGGGCAT AGGCAAAGCC 
TTCGCTGAGG CTCTGCTGCT CCATGGCGCC AAGGTAGCAT TGGTGGATTG GAATCTTGAG 
GCAGGTGTAA AATGTAAAGC TGCCCTAGAT GAGCAGTTCG AACCTCAGAA GACACTGTTC 
GTCCAGTGTG ATGTGGCTGA CCAGAAACAA CTGAGAGATA CTTTTAGAAA AGTTGTAGAC 
CATTTCGGAA GATTGGATAT TTTGGTCAAC AATGCAGGCG TGAACAATGA GAAAAACTGG 
GAACAGACTC TACAAATTAA TTTGGTTTCT GTTATCAGTG GGACCTATCT TGGTTTGGAT 
TACATGAGTA AGCAAAACGG AGGTGAAGGC GGCATCATCA TCAATATGTC TTCATTAGCA 
GGGCTCATGC CTGTTGCGCA GCAACCTGTT TATTGTGCTT CGAAGCACGG CATCATCGGA 
TTCACACGCT CAGCAGCGAT GGCTGCTAAC CTCATGAAAA GCGGTGTAAG ACTGAATGTC 
ATTTGCCCAG GCTTTGTGGA CACACCCATC CTTGAATCCA TTGAAAAAGA AGAAAATATG 
GGCCAATATA TAGAATATAA GGACCAGATC AAGGCTATGA TGAAATTCTA TGGGGTTTTA 
CACCCATCAA CCATTGCCAA TGGATTAATA AATCTCATTG AAGATGATGC TCTCAATGGT 
GCCATTATGA AGATCACGGC ATCGAAAGGA ATTCATTTTC AAGATTATGA CATCTCTCCA 
TTACTCGTAA AAGCTCCATT AACCTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Proceedings of the National Academy of Sciences of the United States of America114(31)E6427-E6436(2017 Aug)
Kishore AH,Liang H,Kanchwala M,Xing C,Ganesh T,Akgul Y,Posner B,Ready JM,Markowitz SD,Word RA

Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.
Cellular and molecular neurobiology37(3)445-452(2017 Apr)
Miyagishi H,Kosuge Y,Takano A,Endo M,Nango H,Yamagata-Murayama S,Hirose D,Kano R,Tanaka Y,Ishige K,Ito Y

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.
PloS one12(4)e0176106(2017)
Yao L,Chen W,Song K,Han C,Gandhi CR,Lim K,Wu T

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Science (New York, N.Y.)348(6240)aaa2340(2015 Jun)
Zhang Y,Desai A,Yang SY,Bae KB,Antczak MI,Fink SP,Tiwari S,Willis JE,Williams NS,Dawson DM,Wald D,Chen WD,Wang Z,Kasturi L,Larusch GA,He L,Cominelli F,Di Martino L,Djuric Z,Milne GL,Chance M,Sanabria J,Dealwis C,Mikkola D,Naidoo J,Wei S,Tai HH,Gerson SL,Ready JM,Posner B,Willson JK,Markowitz SD

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Hpgd cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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