HPSE cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	HPSE
Entrez Gene ID	15442
Full Name	heparanase
Synonyms	HSE1,Hpa,Hpr1
General protein information	Preferred Names heparanase Names heparanase endo-glucoronidase endoglycosidase heparanase
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E4
Summary	This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_152803.5	NP_690016.1	heparanase preproprotein
NM_152803.4	NP_690016.1	heparanase precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HPSE	NP_776507.1
Danio rerio (zebrafish)	hpse	NP_001038470.1
Canis lupus familiaris (dog)	HPSE	XP_850908.1
Mus musculus (house mouse)	Hpse	NP_690016.1
Gallus gallus (chicken)	HPSE	NP_989498.1
Oryza sativa (rice)	Os06g0179000	NP_001056967.1
Xenopus tropicalis (tropical clawed frog)	hpse	NP_001120267.1
Rattus norvegicus (Norway rat)	Hpse	NP_072127.1
Arabidopsis thaliana (thale cress)	GUS3	NP_851093.1
Oryza sativa (rice)	Os02g0802200	NP_001048420.1
Homo sapiens (human)	HPSE	NP_006656.2
Pan troglodytes (chimpanzee)	HPSE	XP_517183.2
	HPSE	XP_001104975.1

Gene Ontology
Bibliography

Related articles in PubMed

Heparanase and macrophage interplay in the onset of liver fibrosis.
Secchi MF, Crescenzi M, Masola V, Russo FP, Floreani A, Onisto M
Scientific reports7(1)14956(2017 Nov)

Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury.
Masola V, Zaza G, Bellin G, Dall'Olmo L, Granata S, Vischini G, Secchi MF, Lupo A, Gambaro G, Onisto M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Sep)

NK cell heparanase controls tumor invasion and immune surveillance.
Putz EM, Mayfosh AJ, Kos K, Barkauskas DS, Nakamura K, Town L, Goodall KJ, Yee DY, Poon IK, Baschuk N, Souza-Fonseca-Guimaraes F, Hulett MD, Smyth MJ
The Journal of clinical investigation127(7)2777-2788(2017 Jun)

The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-?B signaling pathway.
An X, Zhang L, Yao Q, Li L, Wang B, Zhang J, He M, Zhang J
Molecular and cellular endocrinology(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the activation of intestinal heparanase contributes to intestinal injury during early sepsis by facilitating the destruction of mucosal epithelial glycocalyx and promoting inflammatory responses.
Title: Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis.

Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.
Title: Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.

Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE-NF-kappaB pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.
Title: Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.

Heparanase has a role in upregulating platelet adhesion activity and thrombogenicity
Title: Heparanase expression upregulates platelet adhesion activity and thrombogenicity.

eNOS prevents heparanase induction and the development of proteinuria
Title: Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.

The following HPSE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPSE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22423	NM_152803.5 Latest version!	Mus musculus heparanase (Hpse), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OMu22423	NM_152803.4	Mus musculus heparanase (Hpse), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HPSE ( NM_152803.5 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_690016.1 Mus musculus heparanase (Hpse), mRNA.

Price & Availability↑

CloneID	OMu22423
Clone ID Related Accession (Same CDS sequence)	NM_152803.5 , NM_152803.4
Accession Version	NM_152803.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	heparanase preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY014662.1, AK040471.1, AC161510.10 and BC099521.1. On Aug 11, 2016 this sequence version replaced NM_152803.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154628.1, SRR1660817.32164.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGGC TGCTGCTGCT GTGGCTCTGG GGGCCGCTCG GTGCCCTGGC CCAGGGCGCC 
CCCGCGGGGA CCGCGCCGAC CGACGACGTG GTAGACTTGG AGTTTTACAC CAAGCGGCCG 
CTCCGAAGCG TGAGTCCCTC GTTCCTGTCC ATCACCATCG ACGCCAGCCT GGCCACCGAC 
CCGCGCTTCC TCACCTTCCT GGGCTCTCCA AGGCTCCGTG CTCTGGCTAG AGGCTTATCT 
CCTGCATACT TGAGATTTGG CGGCACAAAG ACTGACTTCC TTATTTTTGA TCCGGACAAG 
GAACCGACTT CCGAAGAAAG AAGTTACTGG AAATCTCAAG TCAACCATGA TATTTGCAGG 
TCTGAGCCGG TCTCTGCTGC GGTGTTGAGG AAACTCCAGG TGGAATGGCC CTTCCAGGAG 
CTGTTGCTGC TCCGAGAGCA GTACCAAAAG GAGTTCAAGA ACAGCACCTA CTCAAGAAGC 
TCAGTGGACA TGCTCTACAG TTTTGCCAAG TGCTCGGGGT TAGACCTGAT CTTTGGTCTA 
AATGCGTTAC TACGAACCCC AGACTTACGG TGGAACAGCT CCAACGCCCA GCTTCTCCTT 
GACTACTGCT CTTCCAAGGG TTATAACATC TCCTGGGAAC TGGGCAATGA GCCCAACAGT 
TTCTGGAAGA AAGCTCACAT TCTCATCGAT GGGTTGCAGT TAGGAGAAGA CTTTGTGGAG 
TTGCATAAAC TTCTACAAAG GTCAGCTTTC CAAAATGCAA AACTCTATGG TCCTGACATC 
GGTCAGCCTC GAGGGAAGAC AGTTAAACTG CTGAGGAGTT TCCTGAAGGC TGGCGGAGAA 
GTGATCGACT CTCTTACATG GCATCACTAT TACTTGAATG GACGCATCGC TACCAAAGAA 
GATTTTCTGA GCTCTGATGT GCTGGACACT TTTATTCTCT CTGTGCAAAA AATTCTGAAG 
GTCACTAAAG AGATCACACC TGGCAAGAAG GTCTGGTTGG GAGAGACGAG CTCAGCTTAC 
GGTGGCGGTG CACCCTTGCT GTCCAACACC TTTGCAGCTG GCTTTATGTG GCTGGATAAA 
TTGGGCCTGT CAGCCCAGAT GGGCATAGAA GTCGTGATGA GGCAGGTGTT CTTCGGAGCA 
GGCAACTACC ACTTAGTGGA TGAAAACTTT GAGCCTTTAC CTGATTACTG GCTCTCTCTT 
CTGTTCAAGA AACTGGTAGG TCCCAGGGTG TTACTGTCAA GAGTGAAAGG CCCAGACAGG 
AGCAAACTCC GAGTGTATCT CCACTGCACT AACGTCTATC ACCCACGATA TCAGGAAGGA 
GATCTAACTC TGTATGTCCT GAACCTCCAT AATGTCACCA AGCACTTGAA GGTACCGCCT 
CCGTTGTTCA GGAAACCAGT GGATACGTAC CTTCTGAAGC CTTCGGGGCC GGATGGATTA 
CTTTCCAAAT CTGTCCAACT GAACGGTCAA ATTCTGAAGA TGGTGGATGA GCAGACCCTG 
CCAGCTTTGA CAGAAAAACC TCTCCCCGCA GGAAGTGCAC TAAGCCTGCC TGCCTTTTCC 
TATGGTTTTT TTGTCATAAG AAATGCCAAA ATCGCTGCTT GTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690016.1
CDS	123..1730
Translation	MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI

Target ORF information:

RefSeq Version	NM_152803.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus heparanase (Hpse), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152803.5

ORF Insert Sequence:

ATGCTGAGGC TGCTGCTGCT GTGGCTCTGG GGGCCGCTCG GTGCCCTGGC CCAGGGCGCC 
CCCGCGGGGA CCGCGCCGAC CGACGACGTG GTAGACTTGG AGTTTTACAC CAAGCGGCCG 
CTCCGAAGCG TGAGTCCCTC GTTCCTGTCC ATCACCATCG ACGCCAGCCT GGCCACCGAC 
CCGCGCTTCC TCACCTTCCT GGGCTCTCCA AGGCTCCGTG CTCTGGCTAG AGGCTTATCT 
CCTGCATACT TGAGATTTGG CGGCACAAAG ACTGACTTCC TTATTTTTGA TCCGGACAAG 
GAACCGACTT CCGAAGAAAG AAGTTACTGG AAATCTCAAG TCAACCATGA TATTTGCAGG 
TCTGAGCCGG TCTCTGCTGC GGTGTTGAGG AAACTCCAGG TGGAATGGCC CTTCCAGGAG 
CTGTTGCTGC TCCGAGAGCA GTACCAAAAG GAGTTCAAGA ACAGCACCTA CTCAAGAAGC 
TCAGTGGACA TGCTCTACAG TTTTGCCAAG TGCTCGGGGT TAGACCTGAT CTTTGGTCTA 
AATGCGTTAC TACGAACCCC AGACTTACGG TGGAACAGCT CCAACGCCCA GCTTCTCCTT 
GACTACTGCT CTTCCAAGGG TTATAACATC TCCTGGGAAC TGGGCAATGA GCCCAACAGT 
TTCTGGAAGA AAGCTCACAT TCTCATCGAT GGGTTGCAGT TAGGAGAAGA CTTTGTGGAG 
TTGCATAAAC TTCTACAAAG GTCAGCTTTC CAAAATGCAA AACTCTATGG TCCTGACATC 
GGTCAGCCTC GAGGGAAGAC AGTTAAACTG CTGAGGAGTT TCCTGAAGGC TGGCGGAGAA 
GTGATCGACT CTCTTACATG GCATCACTAT TACTTGAATG GACGCATCGC TACCAAAGAA 
GATTTTCTGA GCTCTGATGT GCTGGACACT TTTATTCTCT CTGTGCAAAA AATTCTGAAG 
GTCACTAAAG AGATCACACC TGGCAAGAAG GTCTGGTTGG GAGAGACGAG CTCAGCTTAC 
GGTGGCGGTG CACCCTTGCT GTCCAACACC TTTGCAGCTG GCTTTATGTG GCTGGATAAA 
TTGGGCCTGT CAGCCCAGAT GGGCATAGAA GTCGTGATGA GGCAGGTGTT CTTCGGAGCA 
GGCAACTACC ACTTAGTGGA TGAAAACTTT GAGCCTTTAC CTGATTACTG GCTCTCTCTT 
CTGTTCAAGA AACTGGTAGG TCCCAGGGTG TTACTGTCAA GAGTGAAAGG CCCAGACAGG 
AGCAAACTCC GAGTGTATCT CCACTGCACT AACGTCTATC ACCCACGATA TCAGGAAGGA 
GATCTAACTC TGTATGTCCT GAACCTCCAT AATGTCACCA AGCACTTGAA GGTACCGCCT 
CCGTTGTTCA GGAAACCAGT GGATACGTAC CTTCTGAAGC CTTCGGGGCC GGATGGATTA 
CTTTCCAAAT CTGTCCAACT GAACGGTCAA ATTCTGAAGA TGGTGGATGA GCAGACCCTG 
CCAGCTTTGA CAGAAAAACC TCTCCCCGCA GGAAGTGCAC TAAGCCTGCC TGCCTTTTCC 
TATGGTTTTT TTGTCATAAG AAATGCCAAA ATCGCTGCTT GTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPSE ( NM_152803.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_690016.1 Mus musculus heparanase (Hpse), mRNA.

Price & Availability↑

CloneID	OMu22423
Clone ID Related Accession (Same CDS sequence)	NM_152803.5 , NM_152803.4
Accession Version	NM_152803.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	heparanase precursor
Comment

ATGCTGAGGC TGCTGCTGCT GTGGCTCTGG GGGCCGCTCG GTGCCCTGGC CCAGGGCGCC 
CCCGCGGGGA CCGCGCCGAC CGACGACGTG GTAGACTTGG AGTTTTACAC CAAGCGGCCG 
CTCCGAAGCG TGAGTCCCTC GTTCCTGTCC ATCACCATCG ACGCCAGCCT GGCCACCGAC 
CCGCGCTTCC TCACCTTCCT GGGCTCTCCA AGGCTCCGTG CTCTGGCTAG AGGCTTATCT 
CCTGCATACT TGAGATTTGG CGGCACAAAG ACTGACTTCC TTATTTTTGA TCCGGACAAG 
GAACCGACTT CCGAAGAAAG AAGTTACTGG AAATCTCAAG TCAACCATGA TATTTGCAGG 
TCTGAGCCGG TCTCTGCTGC GGTGTTGAGG AAACTCCAGG TGGAATGGCC CTTCCAGGAG 
CTGTTGCTGC TCCGAGAGCA GTACCAAAAG GAGTTCAAGA ACAGCACCTA CTCAAGAAGC 
TCAGTGGACA TGCTCTACAG TTTTGCCAAG TGCTCGGGGT TAGACCTGAT CTTTGGTCTA 
AATGCGTTAC TACGAACCCC AGACTTACGG TGGAACAGCT CCAACGCCCA GCTTCTCCTT 
GACTACTGCT CTTCCAAGGG TTATAACATC TCCTGGGAAC TGGGCAATGA GCCCAACAGT 
TTCTGGAAGA AAGCTCACAT TCTCATCGAT GGGTTGCAGT TAGGAGAAGA CTTTGTGGAG 
TTGCATAAAC TTCTACAAAG GTCAGCTTTC CAAAATGCAA AACTCTATGG TCCTGACATC 
GGTCAGCCTC GAGGGAAGAC AGTTAAACTG CTGAGGAGTT TCCTGAAGGC TGGCGGAGAA 
GTGATCGACT CTCTTACATG GCATCACTAT TACTTGAATG GACGCATCGC TACCAAAGAA 
GATTTTCTGA GCTCTGATGT GCTGGACACT TTTATTCTCT CTGTGCAAAA AATTCTGAAG 
GTCACTAAAG AGATCACACC TGGCAAGAAG GTCTGGTTGG GAGAGACGAG CTCAGCTTAC 
GGTGGCGGTG CACCCTTGCT GTCCAACACC TTTGCAGCTG GCTTTATGTG GCTGGATAAA 
TTGGGCCTGT CAGCCCAGAT GGGCATAGAA GTCGTGATGA GGCAGGTGTT CTTCGGAGCA 
GGCAACTACC ACTTAGTGGA TGAAAACTTT GAGCCTTTAC CTGATTACTG GCTCTCTCTT 
CTGTTCAAGA AACTGGTAGG TCCCAGGGTG TTACTGTCAA GAGTGAAAGG CCCAGACAGG 
AGCAAACTCC GAGTGTATCT CCACTGCACT AACGTCTATC ACCCACGATA TCAGGAAGGA 
GATCTAACTC TGTATGTCCT GAACCTCCAT AATGTCACCA AGCACTTGAA GGTACCGCCT 
CCGTTGTTCA GGAAACCAGT GGATACGTAC CTTCTGAAGC CTTCGGGGCC GGATGGATTA 
CTTTCCAAAT CTGTCCAACT GAACGGTCAA ATTCTGAAGA TGGTGGATGA GCAGACCCTG 
CCAGCTTTGA CAGAAAAACC TCTCCCCGCA GGAAGTGCAC TAAGCCTGCC TGCCTTTTCC 
TATGGTTTTT TTGTCATAAG AAATGCCAAA ATCGCTGCTT GTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_690016.1

Translation

MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI

Target ORF information:

RefSeq Version	NM_152803.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus heparanase (Hpse), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152803.4

ORF Insert Sequence:

ATGCTGAGGC TGCTGCTGCT GTGGCTCTGG GGGCCGCTCG GTGCCCTGGC CCAGGGCGCC 
CCCGCGGGGA CCGCGCCGAC CGACGACGTG GTAGACTTGG AGTTTTACAC CAAGCGGCCG 
CTCCGAAGCG TGAGTCCCTC GTTCCTGTCC ATCACCATCG ACGCCAGCCT GGCCACCGAC 
CCGCGCTTCC TCACCTTCCT GGGCTCTCCA AGGCTCCGTG CTCTGGCTAG AGGCTTATCT 
CCTGCATACT TGAGATTTGG CGGCACAAAG ACTGACTTCC TTATTTTTGA TCCGGACAAG 
GAACCGACTT CCGAAGAAAG AAGTTACTGG AAATCTCAAG TCAACCATGA TATTTGCAGG 
TCTGAGCCGG TCTCTGCTGC GGTGTTGAGG AAACTCCAGG TGGAATGGCC CTTCCAGGAG 
CTGTTGCTGC TCCGAGAGCA GTACCAAAAG GAGTTCAAGA ACAGCACCTA CTCAAGAAGC 
TCAGTGGACA TGCTCTACAG TTTTGCCAAG TGCTCGGGGT TAGACCTGAT CTTTGGTCTA 
AATGCGTTAC TACGAACCCC AGACTTACGG TGGAACAGCT CCAACGCCCA GCTTCTCCTT 
GACTACTGCT CTTCCAAGGG TTATAACATC TCCTGGGAAC TGGGCAATGA GCCCAACAGT 
TTCTGGAAGA AAGCTCACAT TCTCATCGAT GGGTTGCAGT TAGGAGAAGA CTTTGTGGAG 
TTGCATAAAC TTCTACAAAG GTCAGCTTTC CAAAATGCAA AACTCTATGG TCCTGACATC 
GGTCAGCCTC GAGGGAAGAC AGTTAAACTG CTGAGGAGTT TCCTGAAGGC TGGCGGAGAA 
GTGATCGACT CTCTTACATG GCATCACTAT TACTTGAATG GACGCATCGC TACCAAAGAA 
GATTTTCTGA GCTCTGATGT GCTGGACACT TTTATTCTCT CTGTGCAAAA AATTCTGAAG 
GTCACTAAAG AGATCACACC TGGCAAGAAG GTCTGGTTGG GAGAGACGAG CTCAGCTTAC 
GGTGGCGGTG CACCCTTGCT GTCCAACACC TTTGCAGCTG GCTTTATGTG GCTGGATAAA 
TTGGGCCTGT CAGCCCAGAT GGGCATAGAA GTCGTGATGA GGCAGGTGTT CTTCGGAGCA 
GGCAACTACC ACTTAGTGGA TGAAAACTTT GAGCCTTTAC CTGATTACTG GCTCTCTCTT 
CTGTTCAAGA AACTGGTAGG TCCCAGGGTG TTACTGTCAA GAGTGAAAGG CCCAGACAGG 
AGCAAACTCC GAGTGTATCT CCACTGCACT AACGTCTATC ACCCACGATA TCAGGAAGGA 
GATCTAACTC TGTATGTCCT GAACCTCCAT AATGTCACCA AGCACTTGAA GGTACCGCCT 
CCGTTGTTCA GGAAACCAGT GGATACGTAC CTTCTGAAGC CTTCGGGGCC GGATGGATTA 
CTTTCCAAAT CTGTCCAACT GAACGGTCAA ATTCTGAAGA TGGTGGATGA GCAGACCCTG 
CCAGCTTTGA CAGAAAAACC TCTCCCCGCA GGAAGTGCAC TAAGCCTGCC TGCCTTTTCC 
TATGGTTTTT TTGTCATAAG AAATGCCAAA ATCGCTGCTT GTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heparanase and macrophage interplay in the onset of liver fibrosis.
Scientific reports7(1)14956(2017 Nov)
Secchi MF,Crescenzi M,Masola V,Russo FP,Floreani A,Onisto M

Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Sep)
Masola V,Zaza G,Bellin G,Dall'Olmo L,Granata S,Vischini G,Secchi MF,Lupo A,Gambaro G,Onisto M

NK cell heparanase controls tumor invasion and immune surveillance.
The Journal of clinical investigation127(7)2777-2788(2017 Jun)
Putz EM,Mayfosh AJ,Kos K,Barkauskas DS,Nakamura K,Town L,Goodall KJ,Yee DY,Poon IK,Baschuk N,Souza-Fonseca-Guimaraes F,Hulett MD,Smyth MJ

The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-?B signaling pathway.
Molecular and cellular endocrinology(2017 May)
An X,Zhang L,Yao Q,Li L,Wang B,Zhang J,He M,Zhang J

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HPSE cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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