Hp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hp
Entrez Gene ID	15439
Full Name	haptoglobin
Synonyms	HP-1,preHP2
General protein information	Preferred Names haptoglobin Names haptoglobin zonulin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 D3\|8 57.11 cM
Summary	This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017370.2	NP_059066.1	haptoglobin isoform 1 preproprotein
NM_001329965.1	NP_001316894.1	haptoglobin isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HP	NP_001190987.1
Canis lupus familiaris (dog)	LOC479668	XP_850996.1
Homo sapiens (human)	HP	NP_001119574.1
Mus musculus (house mouse)	Hp	NP_059066.1
Rattus norvegicus (Norway rat)	Hp	NP_036714.2
	HP	XP_001103863.1
Bos taurus (cattle)	HP	NP_001035560.1

Gene Ontology
Bibliography

Related articles in PubMed

The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.
Yang H, Wang H, Wang Y, Addorisio M, Li J, Postiglione MJ, Chavan SS, Al-Abed Y, Antoine DJ, Andersson U, Tracey KJ
Journal of internal medicine282(1)76-93(2017 Jul)

Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.
Murphy S, Dowling P, Zweyer M, Henry M, Meleady P, Mundegar RR, Swandulla D, Ohlendieck K
International journal of molecular medicine39(6)1357-1370(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs).
Title: Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model.

Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection.
Title: Haptoglobin enhances cardiac transplant rejection.

Exogenous haptoglobin attenuated the HbA-induced HO-1 expression in vitro and in mouse model of sickle cell disease.
Title: Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.

the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability
Title: Pharmacogenomic interaction between the Haptoglobin genotype and vitamin E on atherosclerotic plaque progression and stability.

Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI.
Title: Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system.

The following Hp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23407	NM_017370.2 Latest version!	Mus musculus haptoglobin (Hp), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu83342	NM_001329965.1 Latest version!	Mus musculus haptoglobin (Hp), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hp ( NM_017370.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059066.1 Mus musculus haptoglobin (Hp), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23407
Clone ID Related Accession (Same CDS sequence)	NM_017370.2
Accession Version	NM_017370.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	haptoglobin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125162.4, AK152698.1 and M96827.1. On Jul 30, 2009 this sequence version replaced NM_017370.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M96827.1, AK150430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAGCCC TGGGAGCTGT TGTCACTCTC CTGCTCTGGG GTCAGCTTTT TGCTGTGGAG 
TTGGGCAATG ATGCCATGGA CTTTGAAGAT GACAGCTGCC CAAAGCCCCC AGAGATTGCA 
AACGGCTATG TGGAGCACTT GGTTCGCTAT CGCTGCCGAC AGTTCTACAG ACTACGGGCC 
GAAGGAGATG GGGTGTACAC CTTAAACGAC GAGAAGCAAT GGGTGAACAC AGTCGCTGGA 
GAGAAACTCC CCGAATGTGA GGCAGTGTGT GGGAAGCCCA AGCACCCTGT GGACCAGGTG 
CAGCGCATCA TCGGTGGCTC TATGGATGCC AAAGGCAGCT TTCCTTGGCA GGCCAAGATG 
ATCTCCCGCC ACGGACTCAC CACCGGGGCC ACGTTGATCA GTGACCAGTG GCTGCTGACC 
ACGGCCAAAA ACCTCTTCCT GAACCACAGC GAGACGGCGT CAGCCAAGGA CATCACCCCC 
ACCCTAACGC TCTACGTGGG GAAAAACCAG CTGGTGGAGA TTGAGAAGGT CGTTCTCCAC 
CCCAACCACT CCGTGGTGGA TATCGGGCTA ATCAAACTCA AGCAGAGGGT GCTTGTAACC 
GAGAGAGTCA TGCCTATCTG CCTGCCTTCC AAAGACTACA TAGCACCAGG CCGTGTGGGC 
TACGTGTCTG GCTGGGGGCG GAACGCCAAC TTTAGATTTA CCGATCGTCT CAAGTATGTC 
ATGCTGCCTG TGGCCGACCA GGACAAGTGT GTGGTGCACT ATGAGAATAG TACAGTGCCC 
GAGAAGAAAA ACTTGACGAG TCCCGTTGGG GTCCAGCCTA TCTTGAACGA GCACACCTTC 
TGTGCTGGCC TCACCAAGTA CCAGGAAGAC ACCTGCTACG GTGACGCCGG CAGTGCCTTT 
GCCATTCATG ACATGGAGGA GGACACCTGG TACGCAGCTG GGATCCTGAG CTTTGACAAG 
AGCTGCGCTG TCGCTGAGTA TGGTGTGTAC GTGAGGGCGA CCGACCTGAA GGACTGGGTT 
CAGGAAACCA TGGCCAAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059066.1
CDS	159..1202
Translation	MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN

Target ORF information:

RefSeq Version	NM_017370.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus haptoglobin (Hp), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017370.2

ORF Insert Sequence:

ATGAGAGCCC TGGGAGCTGT TGTCACTCTC CTGCTCTGGG GTCAGCTTTT TGCTGTGGAG 
TTGGGCAATG ATGCCATGGA CTTTGAAGAT GACAGCTGCC CAAAGCCCCC AGAGATTGCA 
AACGGCTATG TGGAGCACTT GGTTCGCTAT CGCTGCCGAC AGTTCTACAG ACTACGGGCC 
GAAGGAGATG GGGTGTACAC CTTAAACGAC GAGAAGCAAT GGGTGAACAC AGTCGCTGGA 
GAGAAACTCC CCGAATGTGA GGCAGTGTGT GGGAAGCCCA AGCACCCTGT GGACCAGGTG 
CAGCGCATCA TCGGTGGCTC TATGGATGCC AAAGGCAGCT TTCCTTGGCA GGCCAAGATG 
ATCTCCCGCC ACGGACTCAC CACCGGGGCC ACGTTGATCA GTGACCAGTG GCTGCTGACC 
ACGGCCAAAA ACCTCTTCCT GAACCACAGC GAGACGGCGT CAGCCAAGGA CATCACCCCC 
ACCCTAACGC TCTACGTGGG GAAAAACCAG CTGGTGGAGA TTGAGAAGGT CGTTCTCCAC 
CCCAACCACT CCGTGGTGGA TATCGGGCTA ATCAAACTCA AGCAGAGGGT GCTTGTAACC 
GAGAGAGTCA TGCCTATCTG CCTGCCTTCC AAAGACTACA TAGCACCAGG CCGTGTGGGC 
TACGTGTCTG GCTGGGGGCG GAACGCCAAC TTTAGATTTA CCGATCGTCT CAAGTATGTC 
ATGCTGCCTG TGGCCGACCA GGACAAGTGT GTGGTGCACT ATGAGAATAG TACAGTGCCC 
GAGAAGAAAA ACTTGACGAG TCCCGTTGGG GTCCAGCCTA TCTTGAACGA GCACACCTTC 
TGTGCTGGCC TCACCAAGTA CCAGGAAGAC ACCTGCTACG GTGACGCCGG CAGTGCCTTT 
GCCATTCATG ACATGGAGGA GGACACCTGG TACGCAGCTG GGATCCTGAG CTTTGACAAG 
AGCTGCGCTG TCGCTGAGTA TGGTGTGTAC GTGAGGGCGA CCGACCTGAA GGACTGGGTT 
CAGGAAACCA TGGCCAAGAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hp ( NM_001329965.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001316894.1 Mus musculus haptoglobin (Hp), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83342
Clone ID Related Accession (Same CDS sequence)	NM_001329965.1
Accession Version	NM_001329965.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	haptoglobin isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125162.4 and BY166781.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB950684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAGCCC TGGGAGCTGT TGTCACTCTC CTGCTCTGGG GTCAGCTTTT TGCTGTGGAG 
TTGGGCAATG ATGCCATGGA CTTTGAAGAT GACAGCTGCC CAAAGCCCCC AGAGATTGCA 
AACGGCTATG TGGAGCACTT GGTTCGCTAT CGCTGCCGAC AGTTCTACAG ACTACGGGCC 
GAAGGAGATG GGGTGTACAC CTTAAACGAC GAGAAGCAAT GGGTGAACAC AGTCGCTGGA 
GAGAAACTCC CCGAATGTGA GGCAGGCCAA GATGATCTCC CGCCACGGAC TCACCACCGG 
GGCCACGTTG ATCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316894.1
CDS	159..476
Translation	MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAGQDDLPPRTHHRGHVDQ

Target ORF information:

RefSeq Version	NM_001329965.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus haptoglobin (Hp), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329965.1

ORF Insert Sequence:

ATGAGAGCCC TGGGAGCTGT TGTCACTCTC CTGCTCTGGG GTCAGCTTTT TGCTGTGGAG 
TTGGGCAATG ATGCCATGGA CTTTGAAGAT GACAGCTGCC CAAAGCCCCC AGAGATTGCA 
AACGGCTATG TGGAGCACTT GGTTCGCTAT CGCTGCCGAC AGTTCTACAG ACTACGGGCC 
GAAGGAGATG GGGTGTACAC CTTAAACGAC GAGAAGCAAT GGGTGAACAC AGTCGCTGGA 
GAGAAACTCC CCGAATGTGA GGCAGGCCAA GATGATCTCC CGCCACGGAC TCACCACCGG 
GGCCACGTTG ATCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.
Journal of internal medicine282(1)76-93(2017 Jul)
Yang H,Wang H,Wang Y,Addorisio M,Li J,Postiglione MJ,Chavan SS,Al-Abed Y,Antoine DJ,Andersson U,Tracey KJ

Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.
International journal of molecular medicine39(6)1357-1370(2017 Jun)
Murphy S,Dowling P,Zweyer M,Henry M,Meleady P,Mundegar RR,Swandulla D,Ohlendieck K

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Hp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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