Hoxb4 cDNA ORF clone, Mus musculus(house mouse)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals
Title: Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus.

Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch-mediated lineage specification
Title: Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.

these studies define the transcriptional pathways involved in HOXB4 HSC expansion in vivo and identify repression of Prdm16 transcription as a mechanism by which expanding HSCs avoid leukemic transformation.
Title: Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.

Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.
Title: Molecular integration of HoxB4 and STAT3 for self-renewal of hematopoietic stem cells: a model of molecular convergence for stemness.

Hoxb4 favours the maintenance and increase of the CD4 central memory phenotype T cell population.
Title: Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation.