Hoxa2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxa2
Entrez Gene ID	15399
Full Name	homeobox A2
Synonyms	AI324701,HOX1.11,Hox-1.11
General protein information	Preferred Names homeobox A2 Names homeobox protein Hox-A2 homeo box A2 homeobox protein Hox-1.11
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B3\|6 25.4 cM
Summary	This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010451.2	NP_034581.1	homeobox protein Hox-A2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HOXA2	XP_851905.1
Bos taurus (cattle)	HOXA2	NP_001069322.1
Rattus norvegicus (Norway rat)	LOC100911443	XP_003752225.1
Gallus gallus (chicken)	HOXA2	NP_990481.1
Xenopus tropicalis (tropical clawed frog)	hoxa2	XP_004915456.1
Pan troglodytes (chimpanzee)	HOXA2	XP_527697.2
Mus musculus (house mouse)	Hoxa2	NP_034581.1
Homo sapiens (human)	HOXA2	NP_006726.1
	HOXA2	XP_001092920.1
Rattus norvegicus (Norway rat)	Hoxa2	NP_036713.2
Danio rerio (zebrafish)	hoxa2b	NP_571181.1

Gene Ontology
Bibliography

Related articles in PubMed

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.
Rijli FM, Mark M, Lakkaraju S, Dierich A, Doll? P, Chambon P
Cell75(7)1333-49(1993 Dec)

Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest.
Gendron-Maguire M, Mallo M, Zhang M, Gridley T
Cell75(7)1317-31(1993 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit.
Title: Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.

Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.
Title: A distal 594?bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex.

our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm.
Title: KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity.

Ectopic Hoxa2 expression results in the transformation of the proximal Meckel's cartilage and the malleus into a supernumerary styloid process (SP), a second pharyngeal arch-derived mammalian-specific skeletal structure.
Title: Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.

Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the second arch with its anatomical identity
Title: Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.

The following Hoxa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19853	NM_010451.2 Latest version!	Mus musculus homeobox A2 (Hoxa2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxa2 ( NM_010451.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034581.1 Mus musculus homeobox A2 (Hoxa2), mRNA.

Price & Availability↑

CloneID	OMu19853
Clone ID Related Accession (Same CDS sequence)	NM_010451.2
Accession Version	NM_010451.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	homeobox protein Hox-A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M95599.1 and AK157713.1. On Mar 23, 2013 this sequence version replaced NM_010451.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M95599.1, BC117105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATTACG AATTTGAGCG AGAGATTGGT TTTATCAATA GCCAGCCGTC GCTCGCTGAG 
TGCCTGACAT CTTTTCCCCC TGTCGCTGAT ACATTTCAAA GTTCATCAAT CAAGACCTCG 
ACGCTTTCAC ACTCGACACT GATTCCTCCT CCTTTTGAGC AGACCATTCC CAGCCTGAAC 
CCGGGCAGTC ACCCTCGCCA CGGCGCTGGC GTTGGCGGCC GCCCCAAGTC GAGCCCCGCG 
GGCAGTCGCG GCAGCCCGGT GCCTGCCGGC GCCCTGCAGC CGCCTGAGTA TCCCTGGATG 
AAGGAGAAGA AGGCGGCCAA GAAAACCGCG CTGCCGCCCG CCGCCGCCTC CACGGGCCCT 
GCCTGCCTCG GCCACAAAGA ATCCCTGGAA ATAGCTGATG GCAGCGGCGG GGGATCCAGG 
CGTCTGAGAA CCGCGTACAC CAACACTCAG CTTTTGGAGC TGGAAAAGGA ATTTCATTTC 
AACAAGTACC TTTGCAGACC CCGCAGGGTG GAAATCGCCG CGCTGCTGGA TTTGACCGAG 
AGACAAGTGA AAGTGTGGTT TCAGAACCGG AGAATGAAGC ATAAGAGGCA AACCCAGTGC 
AAGGAGAACC AAAACAGCGA AGGGAAATTT AAAAACCTGG AGGACTCGGA CAAAGTGGAG 
GAAGACGAGG AAGAGAAGTC ACTCTTTGAG CAAGCCCTCA GTGTCTCCGG GGCCCTTCTG 
GAGAGGGAAG GGTACACTTT TCAGCAAAAT GCGCTCTCTC AACAGCAGGC TCCCAATGGA 
CACAATGGCG ACTCCCAAAC TTTCCCAGTT TCGCCTTTAA CCAGCAATGA GAAAAATTTG 
AAACATTTTC AGCACCAGTC ACCCACTGTT CCTAACTGCT TGTCAACAAT GGGCCAGAAC 
TGTGGAGCTG GCCTAAACAA TGACAGTCCC GAGGCCATCG AGGTCCCCTC TTTGCAGGAC 
TTCAATGTTT TCTCCACAGA TTCCTGCCTG CAGCTTTCAG ATGCACTGTC GCCCAGCTTG 
CCTGGCTCCC TGGACAGTCC TGTAGATATC TCAGCTGACA GCTTTGACTT TTTTACAGAC 
ACACTCACCA CAATCGACCT ACAGCATCTG AATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034581.1
CDS	188..1306
Translation	MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGVGGRPKSSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALPPAAASTGPACLGHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKFKNLEDSDKVEEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQTFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEAIEVPSLQDFNVFSTDSCLQLSDALSPSLPGSLDSPVDISADSFDFFTDTLTTIDLQHLNY

Target ORF information:

RefSeq Version	NM_010451.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox A2 (Hoxa2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010451.2

ORF Insert Sequence:

ATGAATTACG AATTTGAGCG AGAGATTGGT TTTATCAATA GCCAGCCGTC GCTCGCTGAG 
TGCCTGACAT CTTTTCCCCC TGTCGCTGAT ACATTTCAAA GTTCATCAAT CAAGACCTCG 
ACGCTTTCAC ACTCGACACT GATTCCTCCT CCTTTTGAGC AGACCATTCC CAGCCTGAAC 
CCGGGCAGTC ACCCTCGCCA CGGCGCTGGC GTTGGCGGCC GCCCCAAGTC GAGCCCCGCG 
GGCAGTCGCG GCAGCCCGGT GCCTGCCGGC GCCCTGCAGC CGCCTGAGTA TCCCTGGATG 
AAGGAGAAGA AGGCGGCCAA GAAAACCGCG CTGCCGCCCG CCGCCGCCTC CACGGGCCCT 
GCCTGCCTCG GCCACAAAGA ATCCCTGGAA ATAGCTGATG GCAGCGGCGG GGGATCCAGG 
CGTCTGAGAA CCGCGTACAC CAACACTCAG CTTTTGGAGC TGGAAAAGGA ATTTCATTTC 
AACAAGTACC TTTGCAGACC CCGCAGGGTG GAAATCGCCG CGCTGCTGGA TTTGACCGAG 
AGACAAGTGA AAGTGTGGTT TCAGAACCGG AGAATGAAGC ATAAGAGGCA AACCCAGTGC 
AAGGAGAACC AAAACAGCGA AGGGAAATTT AAAAACCTGG AGGACTCGGA CAAAGTGGAG 
GAAGACGAGG AAGAGAAGTC ACTCTTTGAG CAAGCCCTCA GTGTCTCCGG GGCCCTTCTG 
GAGAGGGAAG GGTACACTTT TCAGCAAAAT GCGCTCTCTC AACAGCAGGC TCCCAATGGA 
CACAATGGCG ACTCCCAAAC TTTCCCAGTT TCGCCTTTAA CCAGCAATGA GAAAAATTTG 
AAACATTTTC AGCACCAGTC ACCCACTGTT CCTAACTGCT TGTCAACAAT GGGCCAGAAC 
TGTGGAGCTG GCCTAAACAA TGACAGTCCC GAGGCCATCG AGGTCCCCTC TTTGCAGGAC 
TTCAATGTTT TCTCCACAGA TTCCTGCCTG CAGCTTTCAG ATGCACTGTC GCCCAGCTTG 
CCTGGCTCCC TGGACAGTCC TGTAGATATC TCAGCTGACA GCTTTGACTT TTTTACAGAC 
ACACTCACCA CAATCGACCT ACAGCATCTG AATTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.
Cell75(7)1333-49(1993 Dec)
Rijli FM,Mark M,Lakkaraju S,Dierich A,Doll? P,Chambon P

Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest.
Cell75(7)1317-31(1993 Dec)
Gendron-Maguire M,Mallo M,Zhang M,Gridley T

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Hoxa2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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