Hnrnpab cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hnrnpab
Entrez Gene ID	15384
Full Name	heterogeneous nuclear ribonucleoprotein A/B
Synonyms	3010025C11Rik,CBF-A,Cgbfa,Hnrpab
General protein information	Preferred Names heterogeneous nuclear ribonucleoprotein A/B Names heterogeneous nuclear ribonucleoprotein A/B CArG-binding factor-A S1 protein D2 hnRNP A/B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.3
Summary	This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010448.3	NP_034578.1	heterogeneous nuclear ribonucleoprotein A/B isoform 2
NM_001048061.1	NP_001041526.1	heterogeneous nuclear ribonucleoprotein A/B isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HNRNPAB	NP_001035612.1
Danio rerio (zebrafish)	hnrnpaba	NP_997752.2
	HNRNPAB	XP_001096907.1
Rattus norvegicus (Norway rat)	LOC100910156	XP_003750865.1
Mus musculus (house mouse)	Hnrnpab	NP_001041526.1
Gallus gallus (chicken)	HNRNPAB	NP_990659.1
Xenopus tropicalis (tropical clawed frog)	hnrnpab	NP_001039236.1
Homo sapiens (human)	HNRNPAB	NP_112556.2
Danio rerio (zebrafish)	hnrnpabb	NP_998467.1

Gene Ontology
Bibliography

Related articles in PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

A long noncoding RNA mediates both activation and repression of immune response genes.
Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA
Science (New York, N.Y.)341(6147)789-92(2013 Aug)

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H
PloS one8(10)e75754(2013)

The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis.
Fukuda N, Fukuda T, Sinnamon J, Hernandez-Hernandez A, Izadi M, Raju CS, Czaplinski K, Percipalle P
PLoS genetics9(10)e1003858(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We suggest that CBF-A plays an important role in spermatogenesis by regulating stage-specific translation of testicular mRNAs.
Title: The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis.

Hnrpab(-/-) neural stem and progenitor cells undergo altered differentiation patterns in culture, and mature Hnrpab(-/-) neurons demonstrate increased sensitivity to glutamate-induced excitotoxicity
Title: Hnrpab regulates neural development and neuron cell survival after glutamate stimulation.

Expressing Hnrpab into two different cell lines, their growth was suppressed, demonstrating that this protein has cytostatic activity.
Title: Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.

Although CRP2 expression during development is independent of CArG box, its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors.
Title: Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature.

role of S-nitrosylation in osteopontin transcription regulation in macrophages
Title: S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.

The following Hnrnpab gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hnrnpab cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14891	NM_010448.3 Latest version!	Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
OMu15093	NM_001048061.1 Latest version!	Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hnrnpab ( NM_010448.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034578.1 Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu14891
Clone ID Related Accession (Same CDS sequence)	NM_010448.3
Accession Version	NM_010448.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	heterogeneous nuclear ribonucleoprotein A/B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ166869.1 and AK013384.1. On Sep 14, 2006 this sequence version replaced NM_010448.2. Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK013384.1, D90151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGACG CGGCTGAGGA GCAGCCCATG GAGACGACGG GCGCCACCGA GAACGGACAC 
GAGGCCGCCC CCGAAGGCGA GGCCCCGGTC GAGCCCAGCG CGGCTGCCGC GGCCCCCGCG 
GCCTCGGCCG GGTCTGGGGG CGGGACCACG ACCGCACCGA GCGGGAACCA GAACGGCGCG 
GAGGGCGACC AGATCAACGC CAGCAAGAAC GAGGAGGACG CGGGAAAAAT GTTCGTTGGT 
GGTCTGAGCT GGGATACCAG CAAAAAAGAC TTAAAGGATT ATTTTACTAA GTTTGGAGAG 
GTTGTTGACT GTACAATAAA AATGGATCCC AACACTGGAC GATCAAGAGG GTTTGGGTTT 
ATTCTCTTCA AAGATTCTTC TAGTGTGGAA AAGGTCTTAG ATCAGAAGGA GCACAGGCTG 
GATGGTCGTG TCATTGACCC TAAAAAGGCT ATGGCTATGA AGAAGGACCC TGTGAAGAAA 
ATCTTTGTGG GAGGTCTAAA CCCTGAAGCC ACAGAGGAAA AGATCAGAGA ATACTTCGGC 
CAGTTTGGGG AGATTGAGGC CATTGAGCTT CCAATAGATC CCAAGTTGAA CAAAAGACGG 
GGTTTTGTTT TTATTACATT TAAAGAGGAA GATCCTGTGA AGAAAGTTCT GGAGAAGAAA 
TTTCATACTG TCAGTGGAAG CAAGTGTGAA ATCAAGGTTG CCCAGCCCAA AGAGGTGTAT 
CAGCAACAGC AGTATGGCTC TGGGGGCAGA GGAAATCGCA ATCGAGGGAA CCGAGGCAGT 
GGTGGAGGTC AGGGTAGTAC AAATTACGGA AAGAGCCAGC GACGTGGTGG TCATCAGAAT 
AACTACAAGC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034578.1
CDS	239..1096
Translation	MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSAAAAAPAASAGSGGGTTTAPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQGSTNYGKSQRRGGHQNNYKPY

Target ORF information:

RefSeq Version	NM_010448.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010448.3

ORF Insert Sequence:

ATGTCGGACG CGGCTGAGGA GCAGCCCATG GAGACGACGG GCGCCACCGA GAACGGACAC 
GAGGCCGCCC CCGAAGGCGA GGCCCCGGTC GAGCCCAGCG CGGCTGCCGC GGCCCCCGCG 
GCCTCGGCCG GGTCTGGGGG CGGGACCACG ACCGCACCGA GCGGGAACCA GAACGGCGCG 
GAGGGCGACC AGATCAACGC CAGCAAGAAC GAGGAGGACG CGGGAAAAAT GTTCGTTGGT 
GGTCTGAGCT GGGATACCAG CAAAAAAGAC TTAAAGGATT ATTTTACTAA GTTTGGAGAG 
GTTGTTGACT GTACAATAAA AATGGATCCC AACACTGGAC GATCAAGAGG GTTTGGGTTT 
ATTCTCTTCA AAGATTCTTC TAGTGTGGAA AAGGTCTTAG ATCAGAAGGA GCACAGGCTG 
GATGGTCGTG TCATTGACCC TAAAAAGGCT ATGGCTATGA AGAAGGACCC TGTGAAGAAA 
ATCTTTGTGG GAGGTCTAAA CCCTGAAGCC ACAGAGGAAA AGATCAGAGA ATACTTCGGC 
CAGTTTGGGG AGATTGAGGC CATTGAGCTT CCAATAGATC CCAAGTTGAA CAAAAGACGG 
GGTTTTGTTT TTATTACATT TAAAGAGGAA GATCCTGTGA AGAAAGTTCT GGAGAAGAAA 
TTTCATACTG TCAGTGGAAG CAAGTGTGAA ATCAAGGTTG CCCAGCCCAA AGAGGTGTAT 
CAGCAACAGC AGTATGGCTC TGGGGGCAGA GGAAATCGCA ATCGAGGGAA CCGAGGCAGT 
GGTGGAGGTC AGGGTAGTAC AAATTACGGA AAGAGCCAGC GACGTGGTGG TCATCAGAAT 
AACTACAAGC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hnrnpab ( NM_001048061.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001041526.1 Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15093
Clone ID Related Accession (Same CDS sequence)	NM_001048061.1
Accession Version	NM_001048061.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	heterogeneous nuclear ribonucleoprotein A/B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ166869.1, CA325334.1, BQ445737.1, CF751043.1 and AL645602.14. Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK165609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGACG CGGCTGAGGA GCAGCCCATG GAGACGACGG GCGCCACCGA GAACGGACAC 
GAGGCCGCCC CCGAAGGCGA GGCCCCGGTC GAGCCCAGCG CGGCTGCCGC GGCCCCCGCG 
GCCTCGGCCG GGTCTGGGGG CGGGACCACG ACCGCACCGA GCGGGAACCA GAACGGCGCG 
GAGGGCGACC AGATCAACGC CAGCAAGAAC GAGGAGGACG CGGGAAAAAT GTTCGTTGGT 
GGTCTGAGCT GGGATACCAG CAAAAAAGAC TTAAAGGATT ATTTTACTAA GTTTGGAGAG 
GTTGTTGACT GTACAATAAA AATGGATCCC AACACTGGAC GATCAAGAGG GTTTGGGTTT 
ATTCTCTTCA AAGATTCTTC TAGTGTGGAA AAGGTCTTAG ATCAGAAGGA GCACAGGCTG 
GATGGTCGTG TCATTGACCC TAAAAAGGCT ATGGCTATGA AGAAGGACCC TGTGAAGAAA 
ATCTTTGTGG GAGGTCTAAA CCCTGAAGCC ACAGAGGAAA AGATCAGAGA ATACTTCGGC 
CAGTTTGGGG AGATTGAGGC CATTGAGCTT CCAATAGATC CCAAGTTGAA CAAAAGACGG 
GGTTTTGTTT TTATTACATT TAAAGAGGAA GATCCTGTGA AGAAAGTTCT GGAGAAGAAA 
TTTCATACTG TCAGTGGAAG CAAGTGTGAA ATCAAGGTTG CCCAGCCCAA AGAGGTGTAT 
CAGCAACAGC AGTATGGCTC TGGGGGCAGA GGAAATCGCA ATCGAGGGAA CCGAGGCAGT 
GGTGGAGGTC AGAGTCAGAG TTGGAATCAG GGCTACGGCA ACTACTGGAA CCAGGGCTAC 
GGCTACCAGC AGGGCTACGG GCCGGGCTAT GGCGGCTACG ACTACTCGCC CTATGGCTAT 
TACGGCTACG GCCCCGGCTA CGACTACAGT CAGGGTAGTA CAAATTACGG AAAGAGCCAG 
CGACGTGGTG GTCATCAGAA TAACTACAAG CCATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041526.1
CDS	239..1237
Translation	MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSAAAAAPAASAGSGGGTTTAPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY

Target ORF information:

RefSeq Version	NM_001048061.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048061.1

ORF Insert Sequence:

ATGTCGGACG CGGCTGAGGA GCAGCCCATG GAGACGACGG GCGCCACCGA GAACGGACAC 
GAGGCCGCCC CCGAAGGCGA GGCCCCGGTC GAGCCCAGCG CGGCTGCCGC GGCCCCCGCG 
GCCTCGGCCG GGTCTGGGGG CGGGACCACG ACCGCACCGA GCGGGAACCA GAACGGCGCG 
GAGGGCGACC AGATCAACGC CAGCAAGAAC GAGGAGGACG CGGGAAAAAT GTTCGTTGGT 
GGTCTGAGCT GGGATACCAG CAAAAAAGAC TTAAAGGATT ATTTTACTAA GTTTGGAGAG 
GTTGTTGACT GTACAATAAA AATGGATCCC AACACTGGAC GATCAAGAGG GTTTGGGTTT 
ATTCTCTTCA AAGATTCTTC TAGTGTGGAA AAGGTCTTAG ATCAGAAGGA GCACAGGCTG 
GATGGTCGTG TCATTGACCC TAAAAAGGCT ATGGCTATGA AGAAGGACCC TGTGAAGAAA 
ATCTTTGTGG GAGGTCTAAA CCCTGAAGCC ACAGAGGAAA AGATCAGAGA ATACTTCGGC 
CAGTTTGGGG AGATTGAGGC CATTGAGCTT CCAATAGATC CCAAGTTGAA CAAAAGACGG 
GGTTTTGTTT TTATTACATT TAAAGAGGAA GATCCTGTGA AGAAAGTTCT GGAGAAGAAA 
TTTCATACTG TCAGTGGAAG CAAGTGTGAA ATCAAGGTTG CCCAGCCCAA AGAGGTGTAT 
CAGCAACAGC AGTATGGCTC TGGGGGCAGA GGAAATCGCA ATCGAGGGAA CCGAGGCAGT 
GGTGGAGGTC AGAGTCAGAG TTGGAATCAG GGCTACGGCA ACTACTGGAA CCAGGGCTAC 
GGCTACCAGC AGGGCTACGG GCCGGGCTAT GGCGGCTACG ACTACTCGCC CTATGGCTAT 
TACGGCTACG GCCCCGGCTA CGACTACAGT CAGGGTAGTA CAAATTACGG AAAGAGCCAG 
CGACGTGGTG GTCATCAGAA TAACTACAAG CCATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

A long noncoding RNA mediates both activation and repression of immune response genes.
Science (New York, N.Y.)341(6147)789-92(2013 Aug)
Carpenter S,Aiello D,Atianand MK,Ricci EP,Gandhi P,Hall LL,Byron M,Monks B,Henry-Bezy M,Lawrence JB,O'Neill LA,Moore MJ,Caffrey DR,Fitzgerald KA

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
PloS one8(10)e75754(2013)
Shimizu H,Kubo A,Uchibe K,Hashimoto M,Yokoyama S,Takada S,Mitsuoka K,Asahara H

The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis.
PLoS genetics9(10)e1003858(2013)
Fukuda N,Fukuda T,Sinnamon J,Hernandez-Hernandez A,Izadi M,Raju CS,Czaplinski K,Percipalle P

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Hnrnpab cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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