Hnrnpa1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hnrnpa1
Entrez Gene ID	15382
Full Name	heterogeneous nuclear ribonucleoprotein A1
Synonyms	HDP-1,Hdp,Hnrpa1,hnRNP A1,hnrnp-A1
General protein information	Preferred Names heterogeneous nuclear ribonucleoprotein A1 Names heterogeneous nuclear ribonucleoprotein A1 helix-destabilizing protein hnRNP core protein A1 single-strand-binding protein topoisomerase-inhibitor suppressed
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F3\|15 58.58 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039129.4	NP_001034218.1	heterogeneous nuclear ribonucleoprotein A1 isoform b
NM_010447.5	NP_034577.1	heterogeneous nuclear ribonucleoprotein A1 isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC737627	XP_001142796.2
Mus musculus (house mouse)	Hnrnpa1	NP_001034218.1
Gallus gallus (chicken)	HNRNPA3	XP_004950342.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.
Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G, Yang M, Dai B, Luong LA, Zhu J, Xu Q, Xiao Q
Arteriosclerosis, thrombosis, and vascular biology37(11)2182-2194(2017 Nov)

The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.
Mascarenhas JB, Tchourbanov AY, Danilov SM, Zhou T, Wang T, Garcia JGN
American journal of respiratory cell and molecular biology(2017 Oct)

Germline Chd8 haploinsufficiency alters brain development in mouse.
Gompers AL, Su-Feher L, Ellegood J, Copping NA, Riyadh MA, Stradleigh TW, Pride MC, Schaffler MD, Wade AA, Catta-Preta R, Zdilar I, Louis S, Kaushik G, Mannion BJ, Plajzer-Frick I, Afzal V, Visel A, Pennacchio LA, Dickel DE, Lerch JP, Crawley JN, Zarbalis KS, Silverman JL, Nord AS
Nature neuroscience20(8)1062-1073(2017 Aug)

Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation.
Kim HJ, Lee HR, Seo JY, Ryu HG, Lee KH, Kim DY, Kim KT
Scientific reports742882(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hnRNPA1 is a critical regulator of vascular smooth muscle cell function and behavior in the context of neointima hyperplasia via miR-124/IQGAP1 regulatory axis.
Title: Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.

PRMT5 regulates internal ribosome entry site-dependent translation via methylation of hnRNP A1.
Title: PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.
Title: Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.

this study identified hnRNPA1, an RNA-binding protein and auxiliary splicing factor, as a substrate of TRAF6; TRAF6 ubiquitination of hnRNPA1 regulated alternative splicing of Arhgap1, which resulted in activation of the GTP-binding Rho family protein Cdc42 and accounted for hematopoietic defects in TRAF6-expressing hematopoietic stem/ progenitor cells
Title: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Study demonstrated that hnRNPA1 plays a critical and irreplaceable role in embryonic muscle development by regulating the expression and alternative splicing of muscle-related genes.
Title: Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.

The following Hnrnpa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hnrnpa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19801	NM_001039129.4 Latest version!	Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu23321	NM_010447.5 Latest version!	Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hnrnpa1 ( NM_001039129.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001034218.1 Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19801
Clone ID Related Accession (Same CDS sequence)	NM_001039129.4
Accession Version	NM_001039129.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Mus musculus(house mouse)
Product	heterogeneous nuclear ribonucleoprotein A1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164069.9, BY067931.1, AK146630.1 and BE949469.1. On Nov 2, 2013 this sequence version replaced NM_001039129.3. Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146630.1, AK168733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAAGT CCGAGTCTCC CAAGGAGCCA GAACAGCTGC GGAAGCTCTT CATCGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTA 
ACAGACTGTG TGGTAATGAG AGATCCAAAC ACCAAGAGAT CCAGGGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAAGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTC TCAAGAGAAG ATTCTCAGCG ACCAGGTGCC 
CACTTAACTG TGAAAAAGAT CTTTGTTGGT GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAG ATTGAAGTGA TAGAAATTAT GACTGACAGA 
GGCAGTGGGA AAAAGAGGGG CTTTGCTTTT GTTACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAGC AAGAGATGGC TAGTGCTTCA TCCAGTCAGA GAGGTCGCAG TGGTTCTGGA 
AACTTTGGTG GTGGTCGTGG AGGCGGTTTT GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGTGGTTATG GAGGAGGCAG CCCTGGTTAC 
TCTGGAGGAA GCAGAGGCTA TGGAAGTGGT GGACAGGGTT ATGGAAACCA GGGCAGTGGC 
TATGGCGGGA GTGGCAGCTA TGACAGCTAT AACAACGGAG GAGGCGGAGG CGGCTTTGGC 
GGTGGTAGTG GAAGCAATTT TGGAGGTGGT GGAAGCTACA ATGATTTTGG CAATTACAAC 
AATCAGTCTT CCAATTTTGG GCCGATGAAG GGAGGAAACT TTGGAGGCAG GAGCTCTGGC 
CCTTATGGTG GTGGAGGCCA GTACTTTGCT AAACCACGGA ACCAAGGTGG CTATGGCGGT 
TCCAGCAGCA GCAGTAGCTA TGGCAGTGGC AGGAGGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034218.1
CDS	118..1239
Translation	MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGSPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF

Target ORF information:

RefSeq Version	NM_001039129.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039129.4

ORF Insert Sequence:

ATGTCTAAGT CCGAGTCTCC CAAGGAGCCA GAACAGCTGC GGAAGCTCTT CATCGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTA 
ACAGACTGTG TGGTAATGAG AGATCCAAAC ACCAAGAGAT CCAGGGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAAGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTC TCAAGAGAAG ATTCTCAGCG ACCAGGTGCC 
CACTTAACTG TGAAAAAGAT CTTTGTTGGT GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAG ATTGAAGTGA TAGAAATTAT GACTGACAGA 
GGCAGTGGGA AAAAGAGGGG CTTTGCTTTT GTTACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAGC AAGAGATGGC TAGTGCTTCA TCCAGTCAGA GAGGTCGCAG TGGTTCTGGA 
AACTTTGGTG GTGGTCGTGG AGGCGGTTTT GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGTGGTTATG GAGGAGGCAG CCCTGGTTAC 
TCTGGAGGAA GCAGAGGCTA TGGAAGTGGT GGACAGGGTT ATGGAAACCA GGGCAGTGGC 
TATGGCGGGA GTGGCAGCTA TGACAGCTAT AACAACGGAG GAGGCGGAGG CGGCTTTGGC 
GGTGGTAGTG GAAGCAATTT TGGAGGTGGT GGAAGCTACA ATGATTTTGG CAATTACAAC 
AATCAGTCTT CCAATTTTGG GCCGATGAAG GGAGGAAACT TTGGAGGCAG GAGCTCTGGC 
CCTTATGGTG GTGGAGGCCA GTACTTTGCT AAACCACGGA ACCAAGGTGG CTATGGCGGT 
TCCAGCAGCA GCAGTAGCTA TGGCAGTGGC AGGAGGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hnrnpa1 ( NM_010447.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034577.1 Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23321
Clone ID Related Accession (Same CDS sequence)	NM_010447.5
Accession Version	NM_010447.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	heterogeneous nuclear ribonucleoprotein A1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164069.9, BY067931.1, AK168531.1 and BE949469.1. On Nov 2, 2013 this sequence version replaced NM_010447.4. Transcript Variant: This variant (1) lacks an in-frame exon in the central coding region, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.221053.1, SRR1660815.236900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAAGT CCGAGTCTCC CAAGGAGCCA GAACAGCTGC GGAAGCTCTT CATCGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTA 
ACAGACTGTG TGGTAATGAG AGATCCAAAC ACCAAGAGAT CCAGGGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAAGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTC TCAAGAGAAG ATTCTCAGCG ACCAGGTGCC 
CACTTAACTG TGAAAAAGAT CTTTGTTGGT GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAG ATTGAAGTGA TAGAAATTAT GACTGACAGA 
GGCAGTGGGA AAAAGAGGGG CTTTGCTTTT GTTACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAGC AAGAGATGGC TAGTGCTTCA TCCAGTCAGA GAGGTCGCAG TGGTTCTGGA 
AACTTTGGTG GTGGTCGTGG AGGCGGTTTT GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGAAGCAATT TTGGAGGTGG TGGAAGCTAC 
AATGATTTTG GCAATTACAA CAATCAGTCT TCCAATTTTG GGCCGATGAA GGGAGGAAAC 
TTTGGAGGCA GGAGCTCTGG CCCTTATGGT GGTGGAGGCC AGTACTTTGC TAAACCACGG 
AACCAAGGTG GCTATGGCGG TTCCAGCAGC AGCAGTAGCT ATGGCAGTGG CAGGAGGTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034577.1
CDS	118..1080
Translation	MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF

Target ORF information:

RefSeq Version	NM_010447.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010447.5

ORF Insert Sequence:

ATGTCTAAGT CCGAGTCTCC CAAGGAGCCA GAACAGCTGC GGAAGCTCTT CATCGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTA 
ACAGACTGTG TGGTAATGAG AGATCCAAAC ACCAAGAGAT CCAGGGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAAGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTC TCAAGAGAAG ATTCTCAGCG ACCAGGTGCC 
CACTTAACTG TGAAAAAGAT CTTTGTTGGT GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAG ATTGAAGTGA TAGAAATTAT GACTGACAGA 
GGCAGTGGGA AAAAGAGGGG CTTTGCTTTT GTTACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAGC AAGAGATGGC TAGTGCTTCA TCCAGTCAGA GAGGTCGCAG TGGTTCTGGA 
AACTTTGGTG GTGGTCGTGG AGGCGGTTTT GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGAAGCAATT TTGGAGGTGG TGGAAGCTAC 
AATGATTTTG GCAATTACAA CAATCAGTCT TCCAATTTTG GGCCGATGAA GGGAGGAAAC 
TTTGGAGGCA GGAGCTCTGG CCCTTATGGT GGTGGAGGCC AGTACTTTGC TAAACCACGG 
AACCAAGGTG GCTATGGCGG TTCCAGCAGC AGCAGTAGCT ATGGCAGTGG CAGGAGGTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology37(11)2182-2194(2017 Nov)
Zhang L,Chen Q,An W,Yang F,Maguire EM,Chen D,Zhang C,Wen G,Yang M,Dai B,Luong LA,Zhu J,Xu Q,Xiao Q

The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.
American journal of respiratory cell and molecular biology(2017 Oct)
Mascarenhas JB,Tchourbanov AY,Danilov SM,Zhou T,Wang T,Garcia JGN

Germline Chd8 haploinsufficiency alters brain development in mouse.
Nature neuroscience20(8)1062-1073(2017 Aug)
Gompers AL,Su-Feher L,Ellegood J,Copping NA,Riyadh MA,Stradleigh TW,Pride MC,Schaffler MD,Wade AA,Catta-Preta R,Zdilar I,Louis S,Kaushik G,Mannion BJ,Plajzer-Frick I,Afzal V,Visel A,Pennacchio LA,Dickel DE,Lerch JP,Crawley JN,Zarbalis KS,Silverman JL,Nord AS

Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation.
Scientific reports742882(2017 Feb)
Kim HJ,Lee HR,Seo JY,Ryu HG,Lee KH,Kim DY,Kim KT

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Hnrnpa1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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