Hmgn1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmgn1
Entrez Gene ID	15312
Full Name	high mobility group nucleosomal binding domain 1
Synonyms	HMG-14,Hmg14
General protein information	Preferred Names high mobility group nucleosomal binding domain 1 Names non-histone chromosomal protein HMG-14 high mobility group nucleosome-binding domain-containing protein 1 high mobility group protein 14
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 C4\|16 56.83 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008251.3	NP_032277.3	non-histone chromosomal protein HMG-14

Pathways from BioSystems

Homologies

	LOC722589	XP_001118717.2
Homo sapiens (human)	HMGN1	NP_004956.5
Rattus norvegicus (Norway rat)	LOC100911295	XP_003751077.1
Pan troglodytes (chimpanzee)	HMGN1	XP_514899.2
Canis lupus familiaris (dog)	HMGN1	XP_859756.2
Bos taurus (cattle)	HMGN1	NP_001029944.1
Mus musculus (house mouse)	Hmgn1	NP_032277.3
Gallus gallus (chicken)	HMGN1	NP_990437.1
Rattus norvegicus (Norway rat)	Hmgn1	NP_001013202.1

Gene Ontology
Bibliography

Related articles in PubMed

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
Deng T, Postnikov Y, Zhang S, Garrett L, Becker L, R?cz I, H?lter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Bustin M
Nucleic acids research45(6)3031-3045(2017 Apr)

HMGN proteins modulate chromatin regulatory sites and gene expression during activation of na?ve B cells.
Zhang S, Zhu I, Deng T, Furusawa T, Rochman M, Vacchio MS, Bosselut R, Yamane A, Casellas R, Landsman D, Bustin M
Nucleic acids research44(15)7144-58(2016 Sep)

Hmgn1 acts downstream of C/EBP? to regulate the decidualization of uterine stromal cells in mice.
Li DD, Yang ZQ, Guo CH, Yue L, Duan CC, Cao H, Guo B, Yue ZP
Cell cycle (Georgetown, Tex.)14(21)3461-74(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest Hmgn1/Cebpb signaling may play an important role during mouse decidualization.
Title: Hmgn1 acts downstream of C/EBP? to regulate the decidualization of uterine stromal cells in mice.

our findings show that HMGN1 contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines.
Title: The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.

HMGN1 is a nucleosome remodeling protein encoded on chromosome 21q22 that suppresses H3K27me3 and promotes both B cell proliferation in vitro and B-ALL in vivo
Title: Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.

in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice.
Title: Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.

HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Title: HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells.

The following Hmgn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18521	NM_008251.3 Latest version!	Mus musculus high mobility group nucleosomal binding domain 1 (Hmgn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmgn1 ( NM_008251.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032277.3 Mus musculus high mobility group nucleosomal binding domain 1 (Hmgn1), mRNA.

Price & Availability↑

CloneID	OMu18521
Clone ID Related Accession (Same CDS sequence)	NM_008251.3
Accession Version	NM_008251.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	non-histone chromosomal protein HMG-14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK010763.1 and BU923172.1. On Jan 30, 2004 this sequence version replaced NM_008251.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083138.1, AK010763.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGA GGAAGGTTAG CGCGGATGGA GCCGCCAAGG CGGAGCCCAA GCGCCGCTCC 
GCGAGGCTGT CGGCCAAGCC CGCCCCTGCC AAGGTGGACG CGAAGCCGAA AAAGGCCGCG 
GGAAAGGATA AAGCATCAGA CAAAAAAGTG CAGATAAAAG GGAAGAGGGG AGCGAAGGGC 
AAACAGGCTG ACGTGGCTGA CCAGCAAACC ACAGAGCTGC CTGCAGAAAA TGGAGAGACG 
GAAAACCAGA GTCCAGCCTC TGAAGAAGAG AAAGAAGCTA AGTCCGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032277.3
CDS	122..412
Translation	MPKRKVSADGAAKAEPKRRSARLSAKPAPAKVDAKPKKAAGKDKASDKKVQIKGKRGAKGKQADVADQQTTELPAENGETENQSPASEEEKEAKSD

Target ORF information:

RefSeq Version	NM_008251.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group nucleosomal binding domain 1 (Hmgn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008251.3

ORF Insert Sequence:

ATGCCCAAGA GGAAGGTTAG CGCGGATGGA GCCGCCAAGG CGGAGCCCAA GCGCCGCTCC 
GCGAGGCTGT CGGCCAAGCC CGCCCCTGCC AAGGTGGACG CGAAGCCGAA AAAGGCCGCG 
GGAAAGGATA AAGCATCAGA CAAAAAAGTG CAGATAAAAG GGAAGAGGGG AGCGAAGGGC 
AAACAGGCTG ACGTGGCTGA CCAGCAAACC ACAGAGCTGC CTGCAGAAAA TGGAGAGACG 
GAAAACCAGA GTCCAGCCTC TGAAGAAGAG AAAGAAGCTA AGTCCGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
Nucleic acids research45(6)3031-3045(2017 Apr)
Deng T,Postnikov Y,Zhang S,Garrett L,Becker L,R?cz I,H?lter SM,Wurst W,Fuchs H,Gailus-Durner V,de Angelis MH,Bustin M

HMGN proteins modulate chromatin regulatory sites and gene expression during activation of na?ve B cells.
Nucleic acids research44(15)7144-58(2016 Sep)
Zhang S,Zhu I,Deng T,Furusawa T,Rochman M,Vacchio MS,Bosselut R,Yamane A,Casellas R,Landsman D,Bustin M

Hmgn1 acts downstream of C/EBP? to regulate the decidualization of uterine stromal cells in mice.
Cell cycle (Georgetown, Tex.)14(21)3461-74(2015)
Li DD,Yang ZQ,Guo CH,Yue L,Duan CC,Cao H,Guo B,Yue ZP

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Hmgn1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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