Hesx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hesx1
Entrez Gene ID	15209
Full Name	homeobox gene expressed in ES cells
Synonyms	HES-1,Rpx
General protein information	Preferred Names homeobox gene expressed in ES cells Names homeobox expressed in ES cells 1 anterior-restricted homeobox protein homeo box gene expressed in ES cells homeobox protein ANF rathke pouch homeo box
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006518570.3	XP_006518633.1	homeobox expressed in ES cells 1 isoform X1
XM_006518570.2	XP_006518633.1	homeobox expressed in ES cells 1 isoform X1
XM_006518570.4	XP_006518633.1	homeobox expressed in ES cells 1 isoform X1
NM_010420.2	NP_034550.2	homeobox expressed in ES cells 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HESX1	NP_001178069.1
Mus musculus (house mouse)	Hesx1	NP_034550.2
Gallus gallus (chicken)	HESX1	NP_990343.1
Rattus norvegicus (Norway rat)	Hesx1	NP_001102576.1
	HESX1	XP_001100209.1
Canis lupus familiaris (dog)	HESX1	XP_541834.1
Pan troglodytes (chimpanzee)	HESX1	NP_001075039.1
Danio rerio (zebrafish)	hesx1	NP_571424.1
Homo sapiens (human)	HESX1	NP_003856.1
Xenopus tropicalis (tropical clawed frog)	hesx1	NP_001016712.1

Gene Ontology
Bibliography

Related articles in PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J
Nature communications8(1)1819(2017 Nov)

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J
eLife6(2017 Nov)

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP
Development (Cambridge, England)144(18)3289-3302(2017 09)

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP
Development (Cambridge, England)144(12)2141-2152(2017 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.
Title: Hesx1 enhances pluripotency by working downstream of multiple pluripotency-associated signaling pathways.

Wnt inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt inhibition caused by Dkk1 contributes greatly in the establishment of the anterior forebrain precursor.
Title: Dkk1-dependent inhibition of Wnt signaling activates Hesx1 expression through its 5' enhancer and directs forebrain precursor development.

Variability in Hes1 expression therefore helps to explain why STAT3 responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..
Title: Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.

Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt/beta-catenin target activation.
Title: HESX1- and TCF3-mediated repression of Wnt/?-catenin targets is required for normal development of the anterior forebrain.

Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.
Title: Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.

The following Hesx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hesx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19283	NM_010420.2 Latest version!	Mus musculus homeobox gene expressed in ES cells (Hesx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu19283	XM_006518570.4 Latest version!	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu19283	XM_006518570.2	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu19283	XM_006518570.3	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hesx1 ( NM_010420.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034550.2 Mus musculus homeobox gene expressed in ES cells (Hesx1), mRNA.

Price & Availability↑

CloneID	OMu19283
Clone ID Related Accession (Same CDS sequence)	XM_006518570.3 , XM_006518570.2 , XM_006518570.4 , NM_010420.2
Accession Version	NM_010420.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	homeobox expressed in ES cells 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124603.5, BC132051.1 and U40720.1. On Mar 21, 2009 this sequence version replaced NM_010420.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U40720.1, X80040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034550.2
CDS	359..916
Translation	MSPSLREGAQLRESKPAPCSFSIESILGLDQKKDCTTSVRPHRPWTDTCGDSEKGGNPPLHAPDLPSETSFPCPVDHPRPEERAPKYENYFSASETRSLKRELSWYRGRRPRTAFTQNQVEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKMKRSRRESQFLMAKKPFNPDLLK

Target ORF information:

RefSeq Version	NM_010420.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox gene expressed in ES cells (Hesx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010420.2

ORF Insert Sequence:

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hesx1 ( XM_006518570.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006518633.1 Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19283
Clone ID Related Accession (Same CDS sequence)	XM_006518570.3 , XM_006518570.2 , XM_006518570.4 , NM_010420.2
Accession Version	XM_006518570.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	homeobox expressed in ES cells 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006518570.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518633.1
CDS	226..783
Translation	MSPSLREGAQLRESKPAPCSFSIESILGLDQKKDCTTSVRPHRPWTDTCGDSEKGGNPPLHAPDLPSETSFPCPVDHPRPEERAPKYENYFSASETRSLKRELSWYRGRRPRTAFTQNQVEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKMKRSRRESQFLMAKKPFNPDLLK

Target ORF information:

RefSeq Version	XM_006518570.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518570.3

ORF Insert Sequence:

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hesx1 ( XM_006518570.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006518633.1 Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19283
Clone ID Related Accession (Same CDS sequence)	XM_006518570.3 , XM_006518570.2 , XM_006518570.4 , NM_010420.2
Accession Version	XM_006518570.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	homeobox expressed in ES cells 1 isoform X1
Comment

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518633.1
Translation	MSPSLREGAQLRESKPAPCSFSIESILGLDQKKDCTTSVRPHRPWTDTCGDSEKGGNPPLHAPDLPSETSFPCPVDHPRPEERAPKYENYFSASETRSLKRELSWYRGRRPRTAFTQNQVEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKMKRSRRESQFLMAKKPFNPDLLK

Target ORF information:

RefSeq Version	XM_006518570.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518570.2

ORF Insert Sequence:

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hesx1 ( XM_006518570.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006518633.1 Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19283
Clone ID Related Accession (Same CDS sequence)	XM_006518570.3 , XM_006518570.2 , XM_006518570.4 , NM_010420.2
Accession Version	XM_006518570.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	homeobox expressed in ES cells 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006518570.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518633.1
CDS	231..788
Translation	MSPSLREGAQLRESKPAPCSFSIESILGLDQKKDCTTSVRPHRPWTDTCGDSEKGGNPPLHAPDLPSETSFPCPVDHPRPEERAPKYENYFSASETRSLKRELSWYRGRRPRTAFTQNQVEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKMKRSRRESQFLMAKKPFNPDLLK

Target ORF information:

RefSeq Version	XM_006518570.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox gene expressed in ES cells (Hesx1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518570.4

ORF Insert Sequence:

ATGTCTCCCA GCCTTCGGGA AGGTGCTCAG CTCCGGGAAA GCAAGCCCGC GCCCTGCTCC 
TTCTCAATTG AGAGCATTTT AGGACTGGAC CAGAAAAAAG ATTGTACAAC GTCAGTAAGA 
CCCCACAGAC CCTGGACAGA CACCTGCGGT GACTCAGAGA AAGGTGGCAA CCCACCCCTA 
CATGCCCCAG ATCTTCCCAG TGAGACTTCA TTTCCTTGTC CAGTGGATCA TCCAAGGCCA 
GAAGAAAGGG CTCCGAAATA TGAAAATTAT TTTTCAGCCT CCGAAACACG CTCTTTGAAA 
AGAGAATTGA GTTGGTACCG AGGACGAAGG CCAAGAACCG CTTTCACCCA GAACCAGGTC 
GAAGTATTGG AAAATGTCTT TAGAGTGAAC TGCTACCCTG GCATTGACAT CAGAGAGGAC 
CTAGCTCAAA AGCTGAACTT AGAGGAAGAC AGAATCCAGA TTTGGTTCCA AAATCGCCGA 
GCAAAGATGA AAAGGTCCCG TAGAGAATCA CAGTTTCTAA TGGCGAAAAA ACCCTTCAAC 
CCAGATCTTC TGAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Nature communications8(1)1819(2017 Nov)
Mario Gonzalez-Meljem J,Haston S,Carreno G,Apps JR,Pozzi S,Stache C,Kaushal G,Virasami A,Panousopoulos L,Neda Mousavy-Gharavy S,Guerrero A,Rashid M,Jani N,Goding CR,Jacques TS,Adams DJ,Gil J,Andoniadou CL,Pedro Martinez-Barbera J

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
eLife6(2017 Nov)
Huang X,Balmer S,Yang F,Fidalgo M,Li D,Guallar D,Hadjantonakis AK,Wang J

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Development (Cambridge, England)144(18)3289-3302(2017 09)
Carreno G,Apps JR,Lodge EJ,Panousopoulos L,Haston S,Gonzalez-Meljem JM,Hahn H,Andoniadou CL,Martinez-Barbera JP

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
Development (Cambridge, England)144(12)2141-2152(2017 06)
Haston S,Pozzi S,Carreno G,Manshaei S,Panousopoulos L,Gonzalez-Meljem JM,Apps JR,Virasami A,Thavaraj S,Gutteridge A,Forshew T,Marais R,Brandner S,Jacques TS,Andoniadou CL,Martinez-Barbera JP

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Hesx1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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