Hbb-b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hbb-b1
Entrez Gene ID	15129
Full Name	hemoglobin, beta adult major chain
Synonyms	AA409645,Hbb1,Hbbt1,Hbbt2,MommeD7,beta1
General protein information	Preferred Names hemoglobin, beta adult major chain Names hemoglobin subunit beta-1 beta maj beta major globin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 E3\|7 54.85 cM
Summary	This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-major adult gene found in the 'diffuse' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278161.1	NP_001265090.1	hemoglobin subunit beta-1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.
Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH
Proceedings of the National Academy of Sciences of the United States of America96(9)5129-34(1999 Apr)

The adult beta-globin genes of the "single" type mouse C57BL.
Weaver S, Comer MB, Jahn CL, Hutchison CA 3rd, Edgell MH
Cell24(2)403-11(1981 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results revealed iron deficiency induced expression changes in two genes which have never before been implicated in an iron-dopamine pathway, Cxcl12 and hemoglobin, beta adult chain
Title: Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice.

Dynamic changes in chromatin structure of the beta-globin locus, were examined.
Title: Super-resolution imaging reveals three-dimensional folding dynamics of the ?-globin locus upon gene activation.

The limiting effect on RNA levels occurs after beta-globin genes associate with transcription factories, at which time hypersensitivity sites contribute to the RNA arising from each burst of transcription by stimulating transcriptional elongation.
Title: The hypersensitive sites of the murine ?-globin locus control region act independently to affect nuclear localization and transcriptional elongation.

cerebral microvasculature is rendered vulnerable to thrombus formation in beta(s) mice via a neutrophil-dependent mechanism that is associated with an increased formation of and enhanced platelet sensitivity to thrombin
Title: Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.

GATA1-HS2 enhancer allows persistent and position-independent expression of a beta-globin transgene
Title: The GATA1-HS2 enhancer allows persistent and position-independent expression of a ?-globin transgene.

The following Hbb-b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hbb-b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16359	NM_001278161.1 Latest version!	Mus musculus hemoglobin, beta adult major chain (Hbb-b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hbb-b1 ( NM_001278161.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001265090.1 Mus musculus hemoglobin, beta adult major chain (Hbb-b1), mRNA.

Price & Availability↑

CloneID	OMu16359
Clone ID Related Accession (Same CDS sequence)	NM_001278161.1
Accession Version	NM_001278161.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	hemoglobin subunit beta-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X14061.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the alternate haplotype that this gene represents. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGTGCACC TGACTGATGC TGAGAAGGCT GCTGTCTCTT GCCTGTGGGG AAAGGTGAAC 
TCCGATGAAG TTGGTGGTGA GGCCCTGGGC AGGCTGCTGG TTGTCTACCC TTGGACCCAG 
CGGTACTTTG ATAGCTTTGG AGACCTATCC TCTGCCTCTG CTATCATGGG TAATGCCAAA 
GTGAAGGCCC ATGGCAAGAA GGTGATAACT GCCTTTAACG ATGGCCTGAA TCACTTGGAC 
AGCCTCAAGG GCACCTTTGC CAGCCTCAGT GAGCTCCACT GTGACAAGCT GCATGTGGAT 
CCTGAGAACT TCAGGCTCCT GGGCAATATG ATCGTGATTG TGCTGGGCCA CCACCTGGGC 
AAGGATTTCA CCCCCGCTGC ACAGGCTGCC TTCCAGAAGG TGGTGGCTGG AGTGGCCACT 
GCCCTGGCTC ACAAGTACCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265090.1
CDS	55..498
Translation	MVHLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH

Target ORF information:

RefSeq Version	NM_001278161.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hemoglobin, beta adult major chain (Hbb-b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278161.1

ORF Insert Sequence:

ATGGTGCACC TGACTGATGC TGAGAAGGCT GCTGTCTCTT GCCTGTGGGG AAAGGTGAAC 
TCCGATGAAG TTGGTGGTGA GGCCCTGGGC AGGCTGCTGG TTGTCTACCC TTGGACCCAG 
CGGTACTTTG ATAGCTTTGG AGACCTATCC TCTGCCTCTG CTATCATGGG TAATGCCAAA 
GTGAAGGCCC ATGGCAAGAA GGTGATAACT GCCTTTAACG ATGGCCTGAA TCACTTGGAC 
AGCCTCAAGG GCACCTTTGC CAGCCTCAGT GAGCTCCACT GTGACAAGCT GCATGTGGAT 
CCTGAGAACT TCAGGCTCCT GGGCAATATG ATCGTGATTG TGCTGGGCCA CCACCTGGGC 
AAGGATTTCA CCCCCGCTGC ACAGGCTGCC TTCCAGAAGG TGGTGGCTGG AGTGGCCACT 
GCCCTGGCTC ACAAGTACCA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.
Proceedings of the National Academy of Sciences of the United States of America96(9)5129-34(1999 Apr)
Bulger M,van Doorninck JH,Saitoh N,Telling A,Farrell C,Bender MA,Felsenfeld G,Axel R,Groudine M,von Doorninck JH

The adult beta-globin genes of the "single" type mouse C57BL.
Cell24(2)403-11(1981 May)
Weaver S,Comer MB,Jahn CL,Hutchison CA 3rd,Edgell MH

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Hbb-b1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報