Hal cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hal
Entrez Gene ID	15109
Full Name	histidine ammonia lyase
Synonyms	Hsd,his,histidase
General protein information	Preferred Names histidine ammonia lyase Names histidine ammonia-lyase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C2\|10 48.49 cM
Summary	This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010401.4	NP_034531.1	histidine ammonia-lyase

Pathways from BioSystems

Homologies

	HAL	XP_001107685.1
Gallus gallus (chicken)	HAL	NP_989735.1
Mus musculus (house mouse)	Hal	NP_034531.1
Rattus norvegicus (Norway rat)	Hal	NP_058855.1
Bos taurus (cattle)	HAL	NP_001098910.1
Danio rerio (zebrafish)	hal	NP_001082926.1
Caenorhabditis elegans (roundworm)	haly-1	NP_509820.1
Xenopus tropicalis (tropical clawed frog)	hal.1	NP_001120565.1
Canis lupus familiaris (dog)	HAL	XP_532657.2
Homo sapiens (human)	HAL	NP_002099.1
Pan troglodytes (chimpanzee)	HAL	XP_509282.3

Gene Ontology
Bibliography

Related articles in PubMed

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS
Nature cell biology18(5)467-79(2016 05)

Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.
Barresi C, Stremnitzer C, Mlitz V, Kezic S, Kammeyer A, Ghannadan M, Posa-Markaryan K, Selden C, Tschachler E, Eckhart L
The Journal of investigative dermatology131(1)188-94(2011 Jan)

Characteristics of murine histidinaemia and its potential for genetic manipulation.
Mellor N, Themis M, Selden C, Jones M, Hodgson HJ
Liver international : official journal of the International Association for the Study of the Liver24(4)354-60(2004 Aug)

Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan.
Dunlevy JR, Chakravarti S, Gyalzen P, Vergnes JP, Hassell JR
Mammalian genome : official journal of the International Mammalian Genome Society9(4)316-9(1998 Apr)

Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model.
Cabib S, Oliverio A, Ventura R, Lucchese F, Puglisi-Allegra S
Psychopharmacology132(2)153-60(1997 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

photoprotective role of endogenous urocanic acid in the murine skin using histidinemic mice, in which the gene encoding histidase is mutated
Title: Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.

The following Hal gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hal cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06110	NM_010401.4 Latest version!	Mus musculus histidine ammonia lyase (Hal), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$384.30 $549.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hal ( NM_010401.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034531.1 Mus musculus histidine ammonia lyase (Hal), mRNA.

Price & Availability↑

CloneID	OMu06110
Clone ID Related Accession (Same CDS sequence)	NM_010401.4
Accession Version	NM_010401.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	histidine ammonia-lyase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK014518.1 and AK028963.1. On Dec 4, 2015 this sequence version replaced NM_010401.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014518.1, BC157999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTAGGT ACACAGTGCA CGTGCGTGGG GAATGGCTGG CGGTGCCCTG TCAGGATGGG 
AAGCTCACTG TTGGCTGGCT GGGCCGTGAG GCTGTGCGAC GCTACATGAA GAACAAACCG 
GACAATGGTG GCTTCACTTC GGTGGATGAA GTGCAATTCC TTGTGCATCG GTGCAAGGGC 
CTGGGCCTGC TGGACAATGA GGACGAGCTG GAGGTGGCCT TAGAGGACAA TGAGTTCGTA 
GAAGTGGTGA TTGAAGGTGA TGTGATGTCT CCTGATTTCA TTCCGTCGCA GCCAGAAGGA 
GTTTTCCTAT ACAGCAAATA CCGGGAGCCT GAAAAATACA TTGCCCTAGA TGGGGACAGT 
CTGAGCACAG AGGATCTGGT CAACCTGGGC AAGGGACGTT ACAAGATAAA GCTCACTTCA 
ATTGCTGAGA AGAAAGTGCA GCAGTCCCGG GAGGTCATCG ACAGCATCAT CAAAGAAAGA 
ACAGTTGTTT ATGGCATCAC CACAGGTTTT GGAAAATTTG CTAGAACTGT AATCCCTGCC 
AATAAGCTAC AGGAGCTTCA AGTCAACTTA GTCCGTTCCC ATTCTTCAGG TGTTGGGAAA 
CCACTCAGTC CTGAGAGGTG TCGGATGCTC TTGGCTTTGA GGATCAACGT CTTAGCCAAA 
GGTTACAGTG GGATTTCCTT GGAGACGCTG AAACAAGTTA TTGAAGCATT TAATGCCTCC 
TGCCTGTCCT ATGTTCCAGA GAAAGGAACT GTGGGTGCCA GCGGAGACCT TGCCCCACTC 
TCTCATCTTG CTCTGGGGCT CATCGGAGAA GGAAAGATGT GGTCCCCGAA GAGTGGCTGG 
GCAGATGCTA AATATGTTCT AGAAGCCCAT GGACTGAAAC CAATTGTCTT GAAACCAAAA 
GAAGGCCTGG CACTCATCAA TGGGACACAG ATGATCACTT CCCTGGGCTG TGAAGCCCTG 
GAGCGAGCCA GCGCCATTGC CCGGCAAGCT GATATTGTGG CTGCCTTGAC CCTGGAGGTG 
CTGAAGGGCA CCACCAAAGC CTTCGATACC GACATCCATG CTGTCCGACC TCACCGTGGG 
CAAATTGAAG TTGCTTTCCG ATTCCGGTCC CTCCTGGACT CGGATCACCA CCCATCAGAA 
ATCGCAGAAA GCCACAGGTT CTGCGATCGT GTTCAGGACG CGTACACCTT ACGCTGCTGT 
CCACAGGTCC ACGGTGTGGT GAACGACACA ATAGCCTTTG TGAAGGACAT CATCACTACA 
GAACTGAACA GCGCCACAGA CAATCCTATG GTCTTTGCCA GTCGAGGGGA GACAATTTCA 
GGAGGAAACT TCCATGGTGA ATACCCAGCC AAAGCCCTGG ACTATTTGGC CATTGGTGTC 
CATGAACTTG CGGCAATTAG TGAAAGAAGA ATCGAAAGGC TGTGTAATCC TTCCCTCAGC 
GAGCTGCCTG CCTTCCTGGT GGCTGAAGGA GGTCTCAATT CTGGGTTCAT GATAGCCCAC 
TGCACCGCAG CAGCCCTGGT GTCTGAGAGC AAGGCTCTGT GCCACCCTTC ATCTGTGGAC 
TCACTCTCGA CCAGTGCTGC TACAGAAGAC CACGTCTCCA TGGGAGGATG GGCAGCCAGG 
AAAGCCCTCA GGGTCGTCGA GCACGTGGAA CAAGTGCTAG CCATTGAGCT TCTCGCGGCC 
TGCCAGGGTA TAGAGTTTCT GCGCCCCCTG AAAACAACCA CTCCGCTGGA GAAGGTGTAC 
GACCTGGTGC GCTCCGTAGT AAGGCCCTGG ATAAAAGATC GCTTCATGGC CCCGGACATT 
GAGGCAGCAC ACAGGTTGCT TCTTGACCAA AAGGTTTGGG AGGTTGCCGC ACCGTACATC 
GAGAAATACA GAATGGAGCA CATTCCGGAA TCCAGACCGC TTTCTCCAAC AGCGTTTTCA 
CTAGAATCTC TCCGAAAGAA CTCAGCCACA ATCCCAGAGT CTGACGATCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034531.1
CDS	364..2337
Translation	MPRYTVHVRGEWLAVPCQDGKLTVGWLGREAVRRYMKNKPDNGGFTSVDEVQFLVHRCKGLGLLDNEDELEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVFLYSKYREPEKYIALDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEAFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEALERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLESLRKNSATIPESDDL

Target ORF information:

RefSeq Version	NM_010401.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus histidine ammonia lyase (Hal), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010401.4

ORF Insert Sequence:

ATGCCTAGGT ACACAGTGCA CGTGCGTGGG GAATGGCTGG CGGTGCCCTG TCAGGATGGG 
AAGCTCACTG TTGGCTGGCT GGGCCGTGAG GCTGTGCGAC GCTACATGAA GAACAAACCG 
GACAATGGTG GCTTCACTTC GGTGGATGAA GTGCAATTCC TTGTGCATCG GTGCAAGGGC 
CTGGGCCTGC TGGACAATGA GGACGAGCTG GAGGTGGCCT TAGAGGACAA TGAGTTCGTA 
GAAGTGGTGA TTGAAGGTGA TGTGATGTCT CCTGATTTCA TTCCGTCGCA GCCAGAAGGA 
GTTTTCCTAT ACAGCAAATA CCGGGAGCCT GAAAAATACA TTGCCCTAGA TGGGGACAGT 
CTGAGCACAG AGGATCTGGT CAACCTGGGC AAGGGACGTT ACAAGATAAA GCTCACTTCA 
ATTGCTGAGA AGAAAGTGCA GCAGTCCCGG GAGGTCATCG ACAGCATCAT CAAAGAAAGA 
ACAGTTGTTT ATGGCATCAC CACAGGTTTT GGAAAATTTG CTAGAACTGT AATCCCTGCC 
AATAAGCTAC AGGAGCTTCA AGTCAACTTA GTCCGTTCCC ATTCTTCAGG TGTTGGGAAA 
CCACTCAGTC CTGAGAGGTG TCGGATGCTC TTGGCTTTGA GGATCAACGT CTTAGCCAAA 
GGTTACAGTG GGATTTCCTT GGAGACGCTG AAACAAGTTA TTGAAGCATT TAATGCCTCC 
TGCCTGTCCT ATGTTCCAGA GAAAGGAACT GTGGGTGCCA GCGGAGACCT TGCCCCACTC 
TCTCATCTTG CTCTGGGGCT CATCGGAGAA GGAAAGATGT GGTCCCCGAA GAGTGGCTGG 
GCAGATGCTA AATATGTTCT AGAAGCCCAT GGACTGAAAC CAATTGTCTT GAAACCAAAA 
GAAGGCCTGG CACTCATCAA TGGGACACAG ATGATCACTT CCCTGGGCTG TGAAGCCCTG 
GAGCGAGCCA GCGCCATTGC CCGGCAAGCT GATATTGTGG CTGCCTTGAC CCTGGAGGTG 
CTGAAGGGCA CCACCAAAGC CTTCGATACC GACATCCATG CTGTCCGACC TCACCGTGGG 
CAAATTGAAG TTGCTTTCCG ATTCCGGTCC CTCCTGGACT CGGATCACCA CCCATCAGAA 
ATCGCAGAAA GCCACAGGTT CTGCGATCGT GTTCAGGACG CGTACACCTT ACGCTGCTGT 
CCACAGGTCC ACGGTGTGGT GAACGACACA ATAGCCTTTG TGAAGGACAT CATCACTACA 
GAACTGAACA GCGCCACAGA CAATCCTATG GTCTTTGCCA GTCGAGGGGA GACAATTTCA 
GGAGGAAACT TCCATGGTGA ATACCCAGCC AAAGCCCTGG ACTATTTGGC CATTGGTGTC 
CATGAACTTG CGGCAATTAG TGAAAGAAGA ATCGAAAGGC TGTGTAATCC TTCCCTCAGC 
GAGCTGCCTG CCTTCCTGGT GGCTGAAGGA GGTCTCAATT CTGGGTTCAT GATAGCCCAC 
TGCACCGCAG CAGCCCTGGT GTCTGAGAGC AAGGCTCTGT GCCACCCTTC ATCTGTGGAC 
TCACTCTCGA CCAGTGCTGC TACAGAAGAC CACGTCTCCA TGGGAGGATG GGCAGCCAGG 
AAAGCCCTCA GGGTCGTCGA GCACGTGGAA CAAGTGCTAG CCATTGAGCT TCTCGCGGCC 
TGCCAGGGTA TAGAGTTTCT GCGCCCCCTG AAAACAACCA CTCCGCTGGA GAAGGTGTAC 
GACCTGGTGC GCTCCGTAGT AAGGCCCTGG ATAAAAGATC GCTTCATGGC CCCGGACATT 
GAGGCAGCAC ACAGGTTGCT TCTTGACCAA AAGGTTTGGG AGGTTGCCGC ACCGTACATC 
GAGAAATACA GAATGGAGCA CATTCCGGAA TCCAGACCGC TTTCTCCAAC AGCGTTTTCA 
CTAGAATCTC TCCGAAAGAA CTCAGCCACA ATCCCAGAGT CTGACGATCT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Nature cell biology18(5)467-79(2016 05)
Planas-Paz L,Orsini V,Boulter L,Calabrese D,Pikiolek M,Nigsch F,Xie Y,Roma G,Donovan A,Marti P,Beckmann N,Dill MT,Carbone W,Bergling S,Isken A,Mueller M,Kinzel B,Yang Y,Mao X,Nicholson TB,Zamponi R,Capodieci P,Valdez R,Rivera D,Loew A,Ukomadu C,Terracciano LM,Bouwmeester T,Cong F,Heim MH,Forbes SJ,Ruffner H,Tchorz JS

Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.
The Journal of investigative dermatology131(1)188-94(2011 Jan)
Barresi C,Stremnitzer C,Mlitz V,Kezic S,Kammeyer A,Ghannadan M,Posa-Markaryan K,Selden C,Tschachler E,Eckhart L

Characteristics of murine histidinaemia and its potential for genetic manipulation.
Liver international : official journal of the International Association for the Study of the Liver24(4)354-60(2004 Aug)
Mellor N,Themis M,Selden C,Jones M,Hodgson HJ

Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan.
Mammalian genome : official journal of the International Mammalian Genome Society9(4)316-9(1998 Apr)
Dunlevy JR,Chakravarti S,Gyalzen P,Vergnes JP,Hassell JR

Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model.
Psychopharmacology132(2)153-60(1997 Jul)
Cabib S,Oliverio A,Ventura R,Lucchese F,Puglisi-Allegra S

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Hal cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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