H60a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H60a
Entrez Gene ID	15101
Full Name	histocompatibility 60a
Synonyms	H60
General protein information	Preferred Names histocompatibility 60a Names histocompatibility 60a histocompatibility 60
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10

mRNA and Protein(s)

mRNA	Protein	Name
NM_010400.2	NP_034530.1	histocompatibility 60a precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen.
Ju JM, Jung MH, Nam G, Kim W, Oh S, Kim HD, Kim JY, Chang J, Lee SH, Park GS, Min CK, Lee DS, Kim MG, Choi K, Choi EY
Nature communications9(1)225(2018 Jan)

Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H
Anticancer research37(8)4093-4101(2017 08)

Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help.
Kim J, Ryu SJ, Oh K, Ju JM, Jeon JY, Nam G, Lee DS, Kim HR, Kim JY, Chang J, Sproule T, Choi K, Roopenian D, Choi EY
Nature communications67994(2015 Aug)

Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.
Nam G, Lee YK, Lee HY, Ma MJ, Araki M, Araki K, Lee S, Lee IS, Choi EY
Journal of immunology (Baltimore, Md. : 1950)191(11)5730-42(2013 Dec)

A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment.
Ryu SJ, Jeon JY, Chang J, Sproule TJ, Roopenian DC, Choi EY
Molecules and cells33(4)393-9(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After PSK administration, INF-g production in CD8(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model
Title: Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.

Our studies show that the expression of H60a on tumors cells can be actively modulated by the immune system
Title: Cancer immunoediting of the NK group 2D ligand H60a.

tumour cells that constitutively express H60a at the cell surface can be recognized by H60a-specific T cells
Title: Studies on the antigenicity of the NKG2D ligand H60a in tumour cells.

The genomic locus of H60a in 129/Sv and C57BL/6 strains, was examined.
Title: Studies of the H60a locus in C57BL/6 and 129/Sv mouse strains identify the H60a 3'UTR as a regulator of H60a expression.

Embryonic stem cell-derived hematopoietic progenitor cells (HPCs) express high levels of H60, rendering HPCs susceptible to natural killer (NK) cell killing in vitro and in vivo.
Title: HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells.

The following H60a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H60a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22396	NM_010400.2 Latest version!	Mus musculus histocompatibility 60a (H60a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H60a ( NM_010400.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034530.1 Mus musculus histocompatibility 60a (H60a), mRNA.

Price & Availability↑

CloneID	OMu22396
Clone ID Related Accession (Same CDS sequence)	NM_010400.2
Accession Version	NM_010400.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histocompatibility 60a precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK169909.1. On Apr 6, 2007 this sequence version replaced NM_010400.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169909.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCAAAGG GAGCCACCAG CAAGAGCAAC CATTGCCTGA TTCTGAGCCT TTTCATTCTG 
CTGAGCTATC TGGGGACCAT ACTGGCAGAT GGTACAGACT CTCTAAGTTG TGAATTAACT 
TTCAACTATC GTAATCTACA TGGACAGTGC TCAGTGAATG GAAAGACTCT CCTTGATTTT 
GGTGATAAAA AACATGAGGA AAATGCTACT AAGATGTGTG CTGATTTGTC CCAAAACCTG 
AGAGAGATTT CAGAAGAGAT GTGGAAGTTA CAATCAGGTA ATGATACCTT GAATGTCACA 
ACACAATCTC AGTATAATCA AGGAAAATTC ATTGATGGAT TCTGGGCCAT CAACACTGAT 
GAACAGCATA GCATCTACTT TTATCCACTT AATATGACCT GGAGAGAAAG TCATTCTGAT 
AACAGCAGTG CCATGGAGCA GTGGAAGAAC AAGAACCTAG AGAAAGATAT GAGGAATTTC 
CTCATCACAT ATTTCAGTCA CTGCCTCAAC AAATCGTCAT CACACTTTAG AGAAATGCCA 
AAATCAACAT TAAAGGTGCC GGATACCACC CAACGTACAA ATGCCACTCA GATTCATCCT 
ACAGTGAATA ACTTCCGACA TAATTCTGAC AACCAGGGTC TGAGTGTCAC CTGGATTGTG 
ATTATATGTA TAGGAGGATT AGTGTCTTTC ATGGCATTCA TGGTATTCGC TTGGTGTATG 
CTGAAGAAAA AAAAAAAAAG GTGCTCCCTG CTGCTCCTCT TCTTCTGCAG TCCTCATTAC 
CAGCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034530.1
CDS	204..992
Translation	MAKGATSKSNHCLILSLFILLSYLGTILADGTDSLSCELTFNYRNLHGQCSVNGKTLLDFGDKKHEENATKMCADLSQNLREISEEMWKLQSGNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEQWKNKNLEKDMRNFLITYFSHCLNKSSSHFREMPKSTLKVPDTTQRTNATQIHPTVNNFRHNSDNQGLSVTWIVIICIGGLVSFMAFMVFAWCMLKKKKKRCSLLLLFFCSPHYQL

Target ORF information:

RefSeq Version	NM_010400.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 60a (H60a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010400.2

ORF Insert Sequence:

ATGGCAAAGG GAGCCACCAG CAAGAGCAAC CATTGCCTGA TTCTGAGCCT TTTCATTCTG 
CTGAGCTATC TGGGGACCAT ACTGGCAGAT GGTACAGACT CTCTAAGTTG TGAATTAACT 
TTCAACTATC GTAATCTACA TGGACAGTGC TCAGTGAATG GAAAGACTCT CCTTGATTTT 
GGTGATAAAA AACATGAGGA AAATGCTACT AAGATGTGTG CTGATTTGTC CCAAAACCTG 
AGAGAGATTT CAGAAGAGAT GTGGAAGTTA CAATCAGGTA ATGATACCTT GAATGTCACA 
ACACAATCTC AGTATAATCA AGGAAAATTC ATTGATGGAT TCTGGGCCAT CAACACTGAT 
GAACAGCATA GCATCTACTT TTATCCACTT AATATGACCT GGAGAGAAAG TCATTCTGAT 
AACAGCAGTG CCATGGAGCA GTGGAAGAAC AAGAACCTAG AGAAAGATAT GAGGAATTTC 
CTCATCACAT ATTTCAGTCA CTGCCTCAAC AAATCGTCAT CACACTTTAG AGAAATGCCA 
AAATCAACAT TAAAGGTGCC GGATACCACC CAACGTACAA ATGCCACTCA GATTCATCCT 
ACAGTGAATA ACTTCCGACA TAATTCTGAC AACCAGGGTC TGAGTGTCAC CTGGATTGTG 
ATTATATGTA TAGGAGGATT AGTGTCTTTC ATGGCATTCA TGGTATTCGC TTGGTGTATG 
CTGAAGAAAA AAAAAAAAAG GTGCTCCCTG CTGCTCCTCT TCTTCTGCAG TCCTCATTAC 
CAGCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen.
Nature communications9(1)225(2018 Jan)
Ju JM,Jung MH,Nam G,Kim W,Oh S,Kim HD,Kim JY,Chang J,Lee SH,Park GS,Min CK,Lee DS,Kim MG,Choi K,Choi EY

Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Anticancer research37(8)4093-4101(2017 08)
Konagai A,Yoshimura K,Hazama S,Yamamoto N,Aoki K,Ueno T,Fujioka M,Iijima H,Kato M,Uchida M,Wada T,Inoue M,Asao T,Fuse M,Wada S,Kuramasu A,Kamei R,Takeda S,Yamamoto S,Yoshino S,Oka M,Nagano H

Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help.
Nature communications67994(2015 Aug)
Kim J,Ryu SJ,Oh K,Ju JM,Jeon JY,Nam G,Lee DS,Kim HR,Kim JY,Chang J,Sproule T,Choi K,Roopenian D,Choi EY

Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.
Journal of immunology (Baltimore, Md. : 1950)191(11)5730-42(2013 Dec)
Nam G,Lee YK,Lee HY,Ma MJ,Araki M,Araki K,Lee S,Lee IS,Choi EY

A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment.
Molecules and cells33(4)393-9(2012 Apr)
Ryu SJ,Jeon JY,Chang J,Sproule TJ,Roopenian DC,Choi EY

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H60a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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