H2-Eb1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-Eb1
Entrez Gene ID	14969
Full Name	histocompatibility 2, class II antigen E beta
Synonyms	Eb,H-2Eb,H2Eb,Ia-4,Ia4
General protein information	Preferred Names histocompatibility 2, class II antigen E beta Names H-2 class II histocompatibility antigen, I-E beta chain I-E beta MHC class II MHC H2-IE-beta cell surface glycoprotein MHC class II IE-b cell surface glycoprotein major histocompatibility complex H-2E beta chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010382.2	NP_034512.2	H-2 class II histocompatibility antigen, I-E beta chain precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HLA-DRB1	NP_001014768.1
Homo sapiens (human)	HLA-DRB5	NP_002116.2
Pan troglodytes (chimpanzee)	PATR-DRB5	XP_001165809.3
	MAMU-DRB1	NP_001037726.1
Bos taurus (cattle)	LOC101903005	XP_005201033.1
Mus musculus (house mouse)	H2-Eb1	NP_034512.2
Rattus norvegicus (Norway rat)	RT1-Db1	NP_001008884.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.
McIntyre RE, Nicod J, Robles-Espinoza CD, Maciejowski J, Cai N, Hill J, Verstraten R, Iyer V, Rust AG, Balmus G, Mott R, Flint J, Adams DJ
G3 (Bethesda, Md.)6(8)2343-54(2016 08)

H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
Li L, Hu B, Feng J, Zhang Y, Shou X, Tian Y, Jiang C, Zhang H
Iranian journal of immunology : IJI12(4)263-73(2015 Dec)

Molecular mechanism and cellular function of MHCII ubiquitination.
Oh J, Shin JS
Immunological reviews266(1)134-44(2015 Jul)

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
Pelletier AN, Aliesky HA, Banuelos B, Chabot-Roy G, Rapoport B, Lesage S, McLachlan SM
Genes and immunity16(4)268-74(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

may play an important role in regulating Th1/Th2 balance during the pathogenesis of allergic rhinitis
Title: H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
Title: Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.

H2-Eb1 expression was significantly upregulated in the nasal mucosa of our successfully established allergic rhinitis mouse model
Title: H2-Eb1 expression is upregulated in the nasal mucosa of allergic rhinitis.

Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.

The following H2-Eb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-Eb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06081	NM_010382.2 Latest version!	Mus musculus histocompatibility 2, class II antigen E beta (H2-Eb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-Eb1 ( NM_010382.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034512.2 Mus musculus histocompatibility 2, class II antigen E beta (H2-Eb1), mRNA.

Price & Availability↑

CloneID	OMu06081
Clone ID Related Accession (Same CDS sequence)	NM_010382.2
Accession Version	NM_010382.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	H-2 class II histocompatibility antigen, I-E beta chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY202562.1, AK160485.1 and CAAA01111730.1. On Sep 15, 2006 this sequence version replaced NM_010382.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155968.1, AK005018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTGGC TCCCCAGAGT TCCCTGTGTG GCAGCTGTGA TCCTGTTGCT GACAGTGCTG 
AGCCCTCCAG TGGCTTTGGT CAGAGACTCC AGACCATGGT TTTTGGAATA CTGTAAATCT 
GAGTGTCATT TCTACAACGG GACGCAGCGC GTGCGGCTTC TGGAAAGATA CTTCTACAAC 
CTGGAGGAGA ACCTGCGCTT CGACAGCGAC GTGGGCGAGT TCCGCGCGGT GACCGAGCTG 
GGGCGGCCAG ACGCCGAGAA CTGGAACAGC CAGCCGGAGT TCCTGGAGCA AAAGCGGGCC 
GAGGTGGACA CGGTGTGCAG ACACAACTAT GAGATCTCGG ATAAATTCCT TGTGCGGCGG 
AGAGTTGAGC CTACGGTGAC TGTGTACCCC ACAAAGACAC AGCCCCTGGA ACACCACAAC 
CTCCTGGTCT GCTCTGTGAG TGACTTCTAC CCTGGCAACA TTGAAGTCAG ATGGTTCCGG 
AATGGCAAGG AGGAGAAAAC AGGAATTGTG TCCACGGGCC TGGTCCGAAA TGGAGACTGG 
ACCTTCCAGA CACTGGTGAT GCTGGAGACG GTTCCTCAGA GTGGAGAGGT TTACACCTGC 
CAGGTGGAGC ATCCCAGCCT GACCGACCCT GTCACGGTCG AGTGGAAAGC ACAATCCACA 
TCTGCACAGA ACAAGATGTT GAGTGGAGTT GGGGGCTTCG TGCTGGGCCT GCTCTTCCTG 
GGAGCGGGGC TGTTCATCTA CTTCAGGAAC CAGAAAGGAC AGTCTGGACT TCAGCCAACA 
GGACTCCTGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034512.2
CDS	88..882
Translation	MVWLPRVPCVAAVILLLTVLSPPVALVRDSRPWFLEYCKSECHFYNGTQRVRLLERYFYNLEENLRFDSDVGEFRAVTELGRPDAENWNSQPEFLEQKRAEVDTVCRHNYEISDKFLVRRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFYPGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLETVPQSGEVYTCQVEHPSLTDPVTVEWKAQSTSAQNKMLSGVGGFVLGLLFLGAGLFIYFRNQKGQSGLQPTGLLS

Target ORF information:

RefSeq Version	NM_010382.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen E beta (H2-Eb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010382.2

ORF Insert Sequence:

ATGGTGTGGC TCCCCAGAGT TCCCTGTGTG GCAGCTGTGA TCCTGTTGCT GACAGTGCTG 
AGCCCTCCAG TGGCTTTGGT CAGAGACTCC AGACCATGGT TTTTGGAATA CTGTAAATCT 
GAGTGTCATT TCTACAACGG GACGCAGCGC GTGCGGCTTC TGGAAAGATA CTTCTACAAC 
CTGGAGGAGA ACCTGCGCTT CGACAGCGAC GTGGGCGAGT TCCGCGCGGT GACCGAGCTG 
GGGCGGCCAG ACGCCGAGAA CTGGAACAGC CAGCCGGAGT TCCTGGAGCA AAAGCGGGCC 
GAGGTGGACA CGGTGTGCAG ACACAACTAT GAGATCTCGG ATAAATTCCT TGTGCGGCGG 
AGAGTTGAGC CTACGGTGAC TGTGTACCCC ACAAAGACAC AGCCCCTGGA ACACCACAAC 
CTCCTGGTCT GCTCTGTGAG TGACTTCTAC CCTGGCAACA TTGAAGTCAG ATGGTTCCGG 
AATGGCAAGG AGGAGAAAAC AGGAATTGTG TCCACGGGCC TGGTCCGAAA TGGAGACTGG 
ACCTTCCAGA CACTGGTGAT GCTGGAGACG GTTCCTCAGA GTGGAGAGGT TTACACCTGC 
CAGGTGGAGC ATCCCAGCCT GACCGACCCT GTCACGGTCG AGTGGAAAGC ACAATCCACA 
TCTGCACAGA ACAAGATGTT GAGTGGAGTT GGGGGCTTCG TGCTGGGCCT GCTCTTCCTG 
GGAGCGGGGC TGTTCATCTA CTTCAGGAAC CAGAAAGGAC AGTCTGGACT TCAGCCAACA 
GGACTCCTGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.
G3 (Bethesda, Md.)6(8)2343-54(2016 08)
McIntyre RE,Nicod J,Robles-Espinoza CD,Maciejowski J,Cai N,Hill J,Verstraten R,Iyer V,Rust AG,Balmus G,Mott R,Flint J,Adams DJ

H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
ian journal of immunology : IJI12(4)263-73(2015 Dec)
Li L,Hu B,Feng J,Zhang Y,Shou X,Tian Y,Jiang C,Zhang H

Molecular mechanism and cellular function of MHCII ubiquitination.
Immunological reviews266(1)134-44(2015 Jul)
Oh J,Shin JS

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice.
Genes and immunity16(4)268-74(2015 Jun)
Pelletier AN,Aliesky HA,Banuelos B,Chabot-Roy G,Rapoport B,Lesage S,McLachlan SM

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H2-Eb1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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