Gys1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gys1
Entrez Gene ID	14936
Full Name	glycogen synthase 1, muscle
Synonyms	Gys3,MGS
General protein information	Preferred Names glycogen synthase 1, muscle Names glycogen [starch] synthase, muscle glycogen synthase 3, brain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 29.31 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_030678.3	NP_109603.2	glycogen [starch] synthase, muscle

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gys1	NP_001103085.1
Drosophila melanogaster (fruit fly)	CG6904	NP_731967.2
Saccharomyces cerevisiae (baker's yeast)	GSY1	NP_116670.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002586	XP_312352.3
Xenopus tropicalis (tropical clawed frog)	LOC100490155	XP_004916359.1
Homo sapiens (human)	GYS1	NP_002094.2
Danio rerio (zebrafish)	gys1	NP_957474.1
Caenorhabditis elegans (roundworm)	gsy-1	NP_496736.1
Kluyveromyces lactis	KLLA0F23133g	XP_456111.1
Neurospora crassa	NCU06687	XP_961002.1
Pan troglodytes (chimpanzee)	GYS1	XP_003316534.1
	GYS1	NP_001028058.1
Bos taurus (cattle)	GYS1	NP_001094769.1
Mus musculus (house mouse)	Gys1	NP_109603.2
Saccharomyces cerevisiae (baker's yeast)	GSY2	NP_013359.1
Canis lupus familiaris (dog)	GYS1	XP_854809.3
Eremothecium gossypii	AGOS_AAR008W	NP_982549.2
Magnaporthe oryzae (rice blast fungus)	MGG_07289	XP_003715517.1

Gene Ontology
Bibliography

Related articles in PubMed

AJS1669, a novel small-molecule muscle glycogen synthase activator, improves glucose metabolism and reduces body fat mass in mice.
Nakano K, Takeshita S, Kawasaki N, Miyanaga W, Okamatsu Y, Dohi M, Nakagawa T
International journal of molecular medicine39(4)841-850(2017 Apr)

Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta.
Tunster SJ, McNamara GI, Creeth HDJ, John RM
Developmental biology418(1)55-65(2016 10)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrate that pharmacological agents that activate GYS1, the main GS subtype found in skeletal muscle, have potential for use as novel treatments for diabetes that improve glucose metabolism in skeletal muscle.
Title: AJS1669, a novel small-molecule muscle glycogen synthase activator, improves glucose metabolism and reduces body fat mass in mice.

We show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity
Title: Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance.

Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: glycogen overproduction induces apoptosis in male germ cells.
Title: Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: glycogen overproduction induces apoptosis in male germ cells.

Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1(Nestin-KO) mice.
Title: Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain.

Neurodegeneration and functional impairments are associated with glycogen synthase accumulation in the mouse model of Lafora disease.
Title: Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease.

The following Gys1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gys1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20781	NM_030678.3 Latest version!	Mus musculus glycogen synthase 1, muscle (Gys1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gys1 ( NM_030678.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_109603.2 Mus musculus glycogen synthase 1, muscle (Gys1), mRNA.

Price & Availability↑

CloneID	OMu20781
Clone ID Related Accession (Same CDS sequence)	NM_030678.3
Accession Version	NM_030678.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	glycogen [starch] synthase, muscle
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB853436.1, AK169344.1 and AK171426.1. On Dec 20, 2006 this sequence version replaced NM_030678.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK170404.1, AK171148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCTCTCA GCCGCAGTCT CTCTGTGTCC TCGCTTCCAG GATTGGAAGA CTGGGAGGAT 
GAATTCGACC CCGAGAACGC AGTGCTTTTC GAGGTGGCCT GGGAGGTGGC CAACAAGGTG 
GGTGGCATCT ACACTGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGATGA ATGGGGTGAC 
AACTACTATC TGGTGGGACC ATACACGGAG CAGGGTGTGA GGACGCAGGT AGAGCTCCTG 
GAGCCCCCAA CTCCGGAACT GAAGAGGACT TTGGATTCCA TGAACAGCAA GGGTTGTAAG 
GTGTATTTTG GGCGTTGGCT GATCGAGGGG GGACCCCTAG TGGTGCTCCT GGATGTAGGA 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGTGAGCTTT GGGACACCTG CAACATCGGG 
GTACCCTGGT ACGACCGCGA GGCCAATGAC GCTGTCCTGT TCGGCTTCCT CACCACCTGG 
TTCCTGGGTG AGTTCCTGGC CCAGAACGAA GAGAAGCCGT ATGTGGTTGC CCACTTCCAC 
GAATGGTTGG CTGGCGTTGG TCTGTGTCTG TGCCGTGCCC GGCGCTTGCC GGTGGCAACC 
ATCTTCACCA CTCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCTGGCGC TGTGGACTTC 
TACAACAACC TGGAGAATTT CAATGTAGAC AAGGAAGCAG GAGAGAGGCA GATCTATCAC 
CGGTACTGCA TGGAGCGTGC AGCAGCTCAC TGTGCCCATG TCTTCACTAC CGTATCCCAG 
ATCACCGCAA TCGAGGCTCA ACACCTCCTT AAGAGAAAAC CAGATATTGT GACCCCCAAC 
GGGCTGAATG TGAAGAAGTT CTCTGCTATG CACGAATTCC AGAACCTTCA TGCTCAGAGC 
AAAGCACGAA TCCAGGAATT TGTGCGTGGC CATTTTTATG GGCACCTGGA CTTCAACCTA 
GACAAGACTT TGTATTTCTT TATCGCTGGC CGCTATGAGT TTTCCAACAA GGGAGCTGAT 
GTGTTCCTGG AGGCATTGGC CCGGCTCAAC TATCTGCTCA GAGTGAATGG CAGTGAGCAA 
ACAGTTGTCG CATTCTTCAT CATGCCGGCC CGGACCAATA ATTTCAACGT GGAAACCCTG 
AAGGGCCAAG CCGTGCGCAA ACAACTATGG GACACAGCCA ATACAGTCAA GGAGAAATTT 
GGGAGGAAGC TCTACGAATC CCTTTTAGTG GGGAGCCTCC CGGACATGAA CAAGATGCTG 
GACAAGGAGG ACTTCACTAT GATGAAGAGA GCCATCTTTG CCACTCAGCG GCAGTCTTTC 
CCACCAGTGT GCACCCACAA CATGCTGGAC GACTCCTCAG ACCCCATCTT GACCACCATC 
CGCCGAATTG GCCTTTTCAA CAGCAGTGCC GACCGTGTGA AGGTGATTTT TCACCCAGAA 
TTCCTTTCTT CCACAAGCCC TCTCCTCCCC GTGGATTATG AGGAATTTGT CCGCGGCTGT 
CACCTTGGGG TCTTCCCCTC CTACTATGAG CCCTGGGGCT ACACACCAGC GGAGTGCACT 
GTCATGGGCA TCCCCAGCAT CTCCACCAAC CTCTCCGGCT TTGGCTGCTT TATGGAGGAA 
CACATCGCAG ATCCCTCAGC TTACGGCATT TACATTCTGG ATCGGAGGTT CCGCAGCCTG 
GATGATTCAT GCTCACAGCT CACCTCCTTC CTGTACAGCT TCTGCCAGCA GAGCCGGCGA 
CAGCGCATCA TCCAGCGGAA CCGCACAGAA CGGTTGTCGG ACTTGCTAGA TTGGAAGTAC 
CTGGGCCGGT ACTACATGTC TGCGCGCCAC ATGGCTCTGG CCAAGGCCTT TCCAGACCAC 
TTCACCTATG AACCCCATGA GGTAGATGCG ACCCAGGGGT ACCGGTACCC ACGACCAGCC 
TCCGTCCCGC CGTCGCCCTC ACTGTCTCGA CACTCCAGCC CACACCAGAG TGAGGATGAG 
GAAGAGCCAC GGGATGGACC CCTGGGGGAA GACAGTGAGC GTTATGATGA GGAAGAGGAG 
GCTGCCAAGG ACCGCCGCAA CATCCGGGCA CCTGAGTGGC CACGCAGGGC CTCCTGTTCC 
TCCTCCACAG GTGGCAGCAA GAGAAGCAAC TCGGTGGACA CTGGGCCCTC CAGCTCACTC 
AGCACACCCA CTGAGCCCCT GAGTCCTACC AGTTCCCTGG GTGAGGAGCG CAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109603.2
CDS	215..2431
Translation	MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN

Target ORF information:

RefSeq Version	NM_030678.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycogen synthase 1, muscle (Gys1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030678.3

ORF Insert Sequence:

ATGCCTCTCA GCCGCAGTCT CTCTGTGTCC TCGCTTCCAG GATTGGAAGA CTGGGAGGAT 
GAATTCGACC CCGAGAACGC AGTGCTTTTC GAGGTGGCCT GGGAGGTGGC CAACAAGGTG 
GGTGGCATCT ACACTGTGCT GCAGACGAAG GCGAAGGTGA CAGGGGATGA ATGGGGTGAC 
AACTACTATC TGGTGGGACC ATACACGGAG CAGGGTGTGA GGACGCAGGT AGAGCTCCTG 
GAGCCCCCAA CTCCGGAACT GAAGAGGACT TTGGATTCCA TGAACAGCAA GGGTTGTAAG 
GTGTATTTTG GGCGTTGGCT GATCGAGGGG GGACCCCTAG TGGTGCTCCT GGATGTAGGA 
GCCTCAGCTT GGGCCCTGGA GCGCTGGAAG GGTGAGCTTT GGGACACCTG CAACATCGGG 
GTACCCTGGT ACGACCGCGA GGCCAATGAC GCTGTCCTGT TCGGCTTCCT CACCACCTGG 
TTCCTGGGTG AGTTCCTGGC CCAGAACGAA GAGAAGCCGT ATGTGGTTGC CCACTTCCAC 
GAATGGTTGG CTGGCGTTGG TCTGTGTCTG TGCCGTGCCC GGCGCTTGCC GGTGGCAACC 
ATCTTCACCA CTCATGCCAC GCTGCTGGGG CGCTACCTGT GTGCTGGCGC TGTGGACTTC 
TACAACAACC TGGAGAATTT CAATGTAGAC AAGGAAGCAG GAGAGAGGCA GATCTATCAC 
CGGTACTGCA TGGAGCGTGC AGCAGCTCAC TGTGCCCATG TCTTCACTAC CGTATCCCAG 
ATCACCGCAA TCGAGGCTCA ACACCTCCTT AAGAGAAAAC CAGATATTGT GACCCCCAAC 
GGGCTGAATG TGAAGAAGTT CTCTGCTATG CACGAATTCC AGAACCTTCA TGCTCAGAGC 
AAAGCACGAA TCCAGGAATT TGTGCGTGGC CATTTTTATG GGCACCTGGA CTTCAACCTA 
GACAAGACTT TGTATTTCTT TATCGCTGGC CGCTATGAGT TTTCCAACAA GGGAGCTGAT 
GTGTTCCTGG AGGCATTGGC CCGGCTCAAC TATCTGCTCA GAGTGAATGG CAGTGAGCAA 
ACAGTTGTCG CATTCTTCAT CATGCCGGCC CGGACCAATA ATTTCAACGT GGAAACCCTG 
AAGGGCCAAG CCGTGCGCAA ACAACTATGG GACACAGCCA ATACAGTCAA GGAGAAATTT 
GGGAGGAAGC TCTACGAATC CCTTTTAGTG GGGAGCCTCC CGGACATGAA CAAGATGCTG 
GACAAGGAGG ACTTCACTAT GATGAAGAGA GCCATCTTTG CCACTCAGCG GCAGTCTTTC 
CCACCAGTGT GCACCCACAA CATGCTGGAC GACTCCTCAG ACCCCATCTT GACCACCATC 
CGCCGAATTG GCCTTTTCAA CAGCAGTGCC GACCGTGTGA AGGTGATTTT TCACCCAGAA 
TTCCTTTCTT CCACAAGCCC TCTCCTCCCC GTGGATTATG AGGAATTTGT CCGCGGCTGT 
CACCTTGGGG TCTTCCCCTC CTACTATGAG CCCTGGGGCT ACACACCAGC GGAGTGCACT 
GTCATGGGCA TCCCCAGCAT CTCCACCAAC CTCTCCGGCT TTGGCTGCTT TATGGAGGAA 
CACATCGCAG ATCCCTCAGC TTACGGCATT TACATTCTGG ATCGGAGGTT CCGCAGCCTG 
GATGATTCAT GCTCACAGCT CACCTCCTTC CTGTACAGCT TCTGCCAGCA GAGCCGGCGA 
CAGCGCATCA TCCAGCGGAA CCGCACAGAA CGGTTGTCGG ACTTGCTAGA TTGGAAGTAC 
CTGGGCCGGT ACTACATGTC TGCGCGCCAC ATGGCTCTGG CCAAGGCCTT TCCAGACCAC 
TTCACCTATG AACCCCATGA GGTAGATGCG ACCCAGGGGT ACCGGTACCC ACGACCAGCC 
TCCGTCCCGC CGTCGCCCTC ACTGTCTCGA CACTCCAGCC CACACCAGAG TGAGGATGAG 
GAAGAGCCAC GGGATGGACC CCTGGGGGAA GACAGTGAGC GTTATGATGA GGAAGAGGAG 
GCTGCCAAGG ACCGCCGCAA CATCCGGGCA CCTGAGTGGC CACGCAGGGC CTCCTGTTCC 
TCCTCCACAG GTGGCAGCAA GAGAAGCAAC TCGGTGGACA CTGGGCCCTC CAGCTCACTC 
AGCACACCCA CTGAGCCCCT GAGTCCTACC AGTTCCCTGG GTGAGGAGCG CAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AJS1669, a novel small-molecule muscle glycogen synthase activator, improves glucose metabolism and reduces body fat mass in mice.
International journal of molecular medicine39(4)841-850(2017 Apr)
Nakano K,Takeshita S,Kawasaki N,Miyanaga W,Okamatsu Y,Dohi M,Nakagawa T

Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta.
Developmental biology418(1)55-65(2016 10)
Tunster SJ,McNamara GI,Creeth HDJ,John RM

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

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Gys1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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