GSTO1 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSTO1
Entrez Gene ID	14873
Full Name	glutathione S-transferase omega 1
Synonyms	AA407097,AI194287,AU018802,Gsto-1,Gstx,Spg-r,p28
General protein information	Preferred Names glutathione S-transferase omega 1 Names glutathione S-transferase omega-1 Glutathione transferase omega 1 (GSTO 1-1) (p28) MMA(V) reductase S-(Phenacyl)glutathione reductase glutathione S-transferase omega 1-1 glutathione-S-transferase like glutathione-dependent dehydroascorbate reductase monomethylarsonic acid reductase
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 19 Map Location: 19\|19 D1
Summary	This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010362.3	NP_034492.1	glutathione S-transferase omega-1
NM_010362.2	NP_034492.1	glutathione S-transferase omega-1

Pathways from BioSystems

Homologies

	GSTO1	XP_002805857.1
Canis lupus familiaris (dog)	GSTO1	XP_535007.2
Drosophila melanogaster (fruit fly)	se	NP_648235.1
Homo sapiens (human)	GSTO1	NP_004823.1
Bos taurus (cattle)	GSTO1	NP_001068682.2
Rattus norvegicus (Norway rat)	Gsto1	NP_001007603.1
Drosophila melanogaster (fruit fly)	GstO1	NP_648237.1
Drosophila melanogaster (fruit fly)	GstO3	NP_648234.1
Caenorhabditis elegans (roundworm)	gsto-1	NP_498728.1
Caenorhabditis elegans (roundworm)	gsto-2	NP_871705.3
Magnaporthe oryzae (rice blast fungus)	MGG_05367	XP_003710212.1
Danio rerio (zebrafish)	gsto1	NP_001002621.1
Danio rerio (zebrafish)	gsto2	NP_001007373.1
Caenorhabditis elegans (roundworm)	gst-44	NP_507142.2
Caenorhabditis elegans (roundworm)	gsto-3	NP_741069.1
Pan troglodytes (chimpanzee)	GSTO1	NP_001233486.1
Bos taurus (cattle)	LOC785216	XP_005225748.1
Mus musculus (house mouse)	Gsto1	NP_034492.1
Gallus gallus (chicken)	GSTO1	NP_001264304.1
Anopheles gambiae (African malaria mosquito)	GSTO1	XP_315763.2
Caenorhabditis elegans (roundworm)	C02D5.4	NP_001254962.1
Neurospora crassa	NCU00549	XP_964710.2

Gene Ontology
Bibliography

Related articles in PubMed

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Br?stle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG
Scientific reports7(1)17832(2017 Dec)

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.
Menon D, Coll R, O'Neill LA, Board PG
Journal of cell science128(10)1982-90(2015 May)

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.
Menon D, Coll R, O'Neill LA, Board PG
Free radical biology & medicine73318-27(2014 Aug)

Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM
Nature medicine17(11)1466-72(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that GSTO1-1 is required for LPS-mediated signalling in macrophages and that it acts early in the LPS-TLR4 pro-inflammatory pathway.
Title: GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.

shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
Title: Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.

Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
Title: Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.

The following GSTO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSTO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06043	NM_010362.3 Latest version!	Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu06043	NM_010362.2	Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSTO1 ( NM_010362.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_034492.1 Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.

Price & Availability↑

CloneID	OMu06043
Clone ID Related Accession (Same CDS sequence)	NM_010362.3 , NM_010362.2
Accession Version	NM_010362.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Mus musculus(house mouse)
Product	glutathione S-transferase omega-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC126679.2, BE860946.1, AK146834.1 and AI846704.1. On Dec 4, 2015 this sequence version replaced NM_010362.2. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U80819.1, AK146834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGAG AATCCTCCAG GAGCCTGGGG AAGGGAAGCG CGCCCCCCGG CCCGGTCCCG 
GAGGGCCAGA TCCGCGTCTA CAGCATGAGG TTCTGCCCCT TCGCTCAGAG GACGCTGATG 
GTCCTGAAGG CCAAGGGAAT CCGGCACGAA GTCATCAATA TCAACCTGAA GAATAAGCCC 
GAGTGGTTCT TTGAGAAGAA TCCCCTTGGG CTGGTGCCGG TTCTGGAGAA CAGCCAGGGT 
CACTTGGTCA CCGAATCTGT CATCACTTGT GAGTACCTGG ATGAGGCCTA CCCAGAGAAG 
AAGTTATTTC CAGATGACCC GTACAAGAAG GCACGTCAGA AGATGACCCT TGAGTCATTC 
TCTAAGGTGC CGCCTTTGAT TGCAAGCTTT GTTAGGTCGA AGAGAAAGGA AGACTCTCCG 
AACCTAAGGG AAGCGTTGGA GAACGAATTC AAAAAGCTAG AGGAGGGCAT GGATAATTAC 
AAGAGCTTCC TTGGTGGGGA TTCTCCTTCT ATGGTTGATT ATCTTACTTG GCCTTGGTTT 
CAGCGACTGG AAGCATTGGA GCTCAAGGAG TGTCTAGCCC ACACCCCCAA GCTCAAGCTC 
TGGATGGCGG CCATGCAGCA AGACCCTGTG GCATCCTCTC ACAAAATTGA TGCCAAGACC 
TACCGCGAGT ACTTAAATCT CTACCTACAG GACAGCCCCG AGGCCTGTGA TTATGGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034492.1
CDS	117..839
Translation	MSGESSRSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKAKGIRHEVININLKNKPEWFFEKNPLGLVPVLENSQGHLVTESVITCEYLDEAYPEKKLFPDDPYKKARQKMTLESFSKVPPLIASFVRSKRKEDSPNLREALENEFKKLEEGMDNYKSFLGGDSPSMVDYLTWPWFQRLEALELKECLAHTPKLKLWMAAMQQDPVASSHKIDAKTYREYLNLYLQDSPEACDYGL

Target ORF information:

RefSeq Version	NM_010362.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010362.3

ORF Insert Sequence:

ATGTCGGGAG AATCCTCCAG GAGCCTGGGG AAGGGAAGCG CGCCCCCCGG CCCGGTCCCG 
GAGGGCCAGA TCCGCGTCTA CAGCATGAGG TTCTGCCCCT TCGCTCAGAG GACGCTGATG 
GTCCTGAAGG CCAAGGGAAT CCGGCACGAA GTCATCAATA TCAACCTGAA GAATAAGCCC 
GAGTGGTTCT TTGAGAAGAA TCCCCTTGGG CTGGTGCCGG TTCTGGAGAA CAGCCAGGGT 
CACTTGGTCA CCGAATCTGT CATCACTTGT GAGTACCTGG ATGAGGCCTA CCCAGAGAAG 
AAGTTATTTC CAGATGACCC GTACAAGAAG GCACGTCAGA AGATGACCCT TGAGTCATTC 
TCTAAGGTGC CGCCTTTGAT TGCAAGCTTT GTTAGGTCGA AGAGAAAGGA AGACTCTCCG 
AACCTAAGGG AAGCGTTGGA GAACGAATTC AAAAAGCTAG AGGAGGGCAT GGATAATTAC 
AAGAGCTTCC TTGGTGGGGA TTCTCCTTCT ATGGTTGATT ATCTTACTTG GCCTTGGTTT 
CAGCGACTGG AAGCATTGGA GCTCAAGGAG TGTCTAGCCC ACACCCCCAA GCTCAAGCTC 
TGGATGGCGG CCATGCAGCA AGACCCTGTG GCATCCTCTC ACAAAATTGA TGCCAAGACC 
TACCGCGAGT ACTTAAATCT CTACCTACAG GACAGCCCCG AGGCCTGTGA TTATGGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSTO1 ( NM_010362.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_034492.1 Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.

Price & Availability↑

CloneID	OMu06043
Clone ID Related Accession (Same CDS sequence)	NM_010362.3 , NM_010362.2
Accession Version	NM_010362.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	glutathione S-transferase omega-1
Comment

ATGTCGGGAG AATCCTCCAG GAGCCTGGGG AAGGGAAGCG CGCCCCCCGG CCCGGTCCCG 
GAGGGCCAGA TCCGCGTCTA CAGCATGAGG TTCTGCCCCT TCGCTCAGAG GACGCTGATG 
GTCCTGAAGG CCAAGGGAAT CCGGCACGAA GTCATCAATA TCAACCTGAA GAATAAGCCC 
GAGTGGTTCT TTGAGAAGAA TCCCCTTGGG CTGGTGCCGG TTCTGGAGAA CAGCCAGGGT 
CACTTGGTCA CCGAATCTGT CATCACTTGT GAGTACCTGG ATGAGGCCTA CCCAGAGAAG 
AAGTTATTTC CAGATGACCC GTACAAGAAG GCACGTCAGA AGATGACCCT TGAGTCATTC 
TCTAAGGTGC CGCCTTTGAT TGCAAGCTTT GTTAGGTCGA AGAGAAAGGA AGACTCTCCG 
AACCTAAGGG AAGCGTTGGA GAACGAATTC AAAAAGCTAG AGGAGGGCAT GGATAATTAC 
AAGAGCTTCC TTGGTGGGGA TTCTCCTTCT ATGGTTGATT ATCTTACTTG GCCTTGGTTT 
CAGCGACTGG AAGCATTGGA GCTCAAGGAG TGTCTAGCCC ACACCCCCAA GCTCAAGCTC 
TGGATGGCGG CCATGCAGCA AGACCCTGTG GCATCCTCTC ACAAAATTGA TGCCAAGACC 
TACCGCGAGT ACTTAAATCT CTACCTACAG GACAGCCCCG AGGCCTGTGA TTATGGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034492.1
Translation	MSGESSRSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKAKGIRHEVININLKNKPEWFFEKNPLGLVPVLENSQGHLVTESVITCEYLDEAYPEKKLFPDDPYKKARQKMTLESFSKVPPLIASFVRSKRKEDSPNLREALENEFKKLEEGMDNYKSFLGGDSPSMVDYLTWPWFQRLEALELKECLAHTPKLKLWMAAMQQDPVASSHKIDAKTYREYLNLYLQDSPEACDYGL

Target ORF information:

RefSeq Version	NM_010362.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus glutathione S-transferase omega 1 (Gsto1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010362.2

ORF Insert Sequence:

ATGTCGGGAG AATCCTCCAG GAGCCTGGGG AAGGGAAGCG CGCCCCCCGG CCCGGTCCCG 
GAGGGCCAGA TCCGCGTCTA CAGCATGAGG TTCTGCCCCT TCGCTCAGAG GACGCTGATG 
GTCCTGAAGG CCAAGGGAAT CCGGCACGAA GTCATCAATA TCAACCTGAA GAATAAGCCC 
GAGTGGTTCT TTGAGAAGAA TCCCCTTGGG CTGGTGCCGG TTCTGGAGAA CAGCCAGGGT 
CACTTGGTCA CCGAATCTGT CATCACTTGT GAGTACCTGG ATGAGGCCTA CCCAGAGAAG 
AAGTTATTTC CAGATGACCC GTACAAGAAG GCACGTCAGA AGATGACCCT TGAGTCATTC 
TCTAAGGTGC CGCCTTTGAT TGCAAGCTTT GTTAGGTCGA AGAGAAAGGA AGACTCTCCG 
AACCTAAGGG AAGCGTTGGA GAACGAATTC AAAAAGCTAG AGGAGGGCAT GGATAATTAC 
AAGAGCTTCC TTGGTGGGGA TTCTCCTTCT ATGGTTGATT ATCTTACTTG GCCTTGGTTT 
CAGCGACTGG AAGCATTGGA GCTCAAGGAG TGTCTAGCCC ACACCCCCAA GCTCAAGCTC 
TGGATGGCGG CCATGCAGCA AGACCCTGTG GCATCCTCTC ACAAAATTGA TGCCAAGACC 
TACCGCGAGT ACTTAAATCT CTACCTACAG GACAGCCCCG AGGCCTGTGA TTATGGGCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
Scientific reports7(1)17832(2017 Dec)
Menon D,Innes A,Oakley AJ,Dahlstrom JE,Jensen LM,Br?stle A,Tummala P,Rooke M,Casarotto MG,Baell JB,Nguyen N,Xie Y,Cuellar M,Strasser J,Dahlin JL,Walters MA,Burgio G,O'Neill LAJ,Board PG

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.
Journal of cell science128(10)1982-90(2015 May)
Menon D,Coll R,O'Neill LA,Board PG

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.
Free radical biology & medicine73318-27(2014 Aug)
Menon D,Coll R,O'Neill LA,Board PG

Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Nature medicine17(11)1466-72(2011 Oct)
Pei L,Leblanc M,Barish G,Atkins A,Nofsinger R,Whyte J,Gold D,He M,Kawamura K,Li HR,Downes M,Yu RT,Powell HC,Lingrel JB,Evans RM

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GSTO1 cDNA ORF clone, Mus musculus(House mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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