Cxcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl1
Entrez Gene ID	14825
Full Name	chemokine (C-X-C motif) ligand 1
Synonyms	Fsp,Gro1,KC,Mgsa,N51,Scyb1,gro
General protein information	Preferred Names chemokine (C-X-C motif) ligand 1 Names growth-regulated alpha protein C-X-C motif chemokine 1 GRO1 oncogene KC/GR)-alpha KC/GRO-alpha alpha-chemokine platelet-derived growth factor-inducible protein KC secretory protein N51
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E1\|5 44.78 cM
Summary	This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008176.3	NP_032202.1	growth-regulated alpha protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCL2	XP_001155614.1
Bos taurus (cattle)	CXCL2	NP_776724.1
Bos taurus (cattle)	CXCL3	NP_001039978.1
Bos taurus (cattle)	GRO1	NP_783631.1
Homo sapiens (human)	CXCL2	NP_002080.1
	CXCL2	XP_001092240.1
Mus musculus (house mouse)	Cxcl1	NP_032202.1
Rattus norvegicus (Norway rat)	Cxcl1	NP_110472.1

Gene Ontology
Bibliography

Related articles in PubMed

Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice.
Batra S, Cai S, Balamayooran G, Jeyaseelan S
Journal of immunology (Baltimore, Md. : 1950)188(7)3458-68(2012 Apr)

Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities.
King AG, Johanson K, Frey CL, DeMarsh PL, White JR, McDevitt P, McNulty D, Balcarek J, Jonak ZL, Bhatnagar PK, Pelus LM
Journal of immunology (Baltimore, Md. : 1950)164(7)3774-82(2000 Apr)

The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski LF Jr, Conklyn MJ, Breslow R, Showell HJ, Gerard C
The Journal of biological chemistry269(47)29355-8(1994 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study demonstrates that in vivo blocking of CXCL1 and CXCL2 can significantly reduce the Mycobacterium tuberculosis-induced bioactive IL-1beta production
Title: CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2.

Interferon-gamma (IFN-gamma) up-regulated interleukin 6 (IL-6) and CXCL1 chemokine (CXCL1) production of bone marrow mesenchymal stem cells (mBM-MSC).
Title: IFN-? induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells.

Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1).
Title: MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.

Our work deciphers the mCXCL1-mTORC1 pathway as crucial in liver cancer stem cell maintenance
Title: Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma.

RelA has a role in regulating OIS in preneoplastic lesions; the RelA/CXCL1/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
Title: RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

The following Cxcl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18117	NM_008176.3 Latest version!	Mus musculus chemokine (C-X-C motif) ligand 1 (Cxcl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl1 ( NM_008176.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032202.1 Mus musculus chemokine (C-X-C motif) ligand 1 (Cxcl1), mRNA.

Price & Availability↑

CloneID	OMu18117
Clone ID Related Accession (Same CDS sequence)	NM_008176.3
Accession Version	NM_008176.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	growth-regulated alpha protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY335927.1 and BQ031102.1. On May 7, 2009 this sequence version replaced NM_008176.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037997.1, J04596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCCAG CCACCCGCTC GCTTCTCTGT GCAGCGCTGC TGCTGCTGGC CACCAGCCGC 
CTGGCCACAG GGGCGCCTAT CGCCAATGAG CTGCGCTGTC AGTGCCTGCA GACCATGGCT 
GGGATTCACC TCAAGAACAT CCAGAGCTTG AAGGTGTTGC CCTCAGGGCC CCACTGCACC 
CAAACCGAAG TCATAGCCAC ACTCAAGAAT GGTCGCGAGG CTTGCCTTGA CCCTGAAGCT 
CCCTTGGTTC AGAAAATTGT CCAAAAGATG CTAAAAGGTG TCCCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032202.1
CDS	67..357
Translation	MIPATRSLLCAALLLLATSRLATGAPIANELRCQCLQTMAGIHLKNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK

Target ORF information:

RefSeq Version	NM_008176.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) ligand 1 (Cxcl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008176.3

ORF Insert Sequence:

ATGATCCCAG CCACCCGCTC GCTTCTCTGT GCAGCGCTGC TGCTGCTGGC CACCAGCCGC 
CTGGCCACAG GGGCGCCTAT CGCCAATGAG CTGCGCTGTC AGTGCCTGCA GACCATGGCT 
GGGATTCACC TCAAGAACAT CCAGAGCTTG AAGGTGTTGC CCTCAGGGCC CCACTGCACC 
CAAACCGAAG TCATAGCCAC ACTCAAGAAT GGTCGCGAGG CTTGCCTTGA CCCTGAAGCT 
CCCTTGGTTC AGAAAATTGT CCAAAAGATG CTAAAAGGTG TCCCCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice.
Journal of immunology (Baltimore, Md. : 1950)188(7)3458-68(2012 Apr)
Batra S,Cai S,Balamayooran G,Jeyaseelan S

Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities.
Journal of immunology (Baltimore, Md. : 1950)164(7)3774-82(2000 Apr)
King AG,Johanson K,Frey CL,DeMarsh PL,White JR,McDevitt P,McNulty D,Balcarek J,Jonak ZL,Bhatnagar PK,Pelus LM

The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
The Journal of biological chemistry269(47)29355-8(1994 Nov)
Bozic CR,Gerard NP,von Uexkull-Guldenband C,Kolakowski LF Jr,Conklyn MJ,Breslow R,Showell HJ,Gerard C

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Cxcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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