Gpx5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpx5
Entrez Gene ID	14780
Full Name	glutathione peroxidase 5
Synonyms	AV379049,Arep
General protein information	Preferred Names glutathione peroxidase 5 Names epididymal secretory glutathione peroxidase EGLP GPx-5 GSHPx-5 arMEP24 epididymis-specific glutathione peroxidase-like protein lysosomal trafficking regulator, long splice form major androgen-regulated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 A3.1\|13 7.73 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_011244283.2	XP_011242585.1	epididymal secretory glutathione peroxidase isoform X1
XM_011244283.3	XP_011242585.1	epididymal secretory glutathione peroxidase isoform X1
NM_010343.2	NP_034473.2	epididymal secretory glutathione peroxidase precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GPX5	NP_001003213.1
Caenorhabditis elegans (roundworm)	C11E4.2	NP_509616.1
Caenorhabditis elegans (roundworm)	Y94H6A.4	NP_500242.2
Rattus norvegicus (Norway rat)	Gpx5	NP_001099208.1
Caenorhabditis elegans (roundworm)	C11E4.1	NP_509615.3
Mus musculus (house mouse)	Gpx5	NP_034473.2
Homo sapiens (human)	GPX5	NP_001500.1
	GPX5	NP_001152774.1
Bos taurus (cattle)	GPX5	NP_001020506.2

Gene Ontology
Bibliography

Related articles in PubMed

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, J?gou B, Prevarskaya N, Bidaux G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(9)3155-70(2016 09)

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
Noblanc A, Peltier M, Damon-Soubeyrand C, Kerchkove N, Chabory E, Vernet P, Saez F, Cadet R, Janny L, Pons-Rejraji H, Conrad M, Drevet JR, Kocer A
PloS one7(6)e38565(2012)

Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice.
Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, Garrel C, Saez F, Cadet R, Henry-Berger J, Schoor M, Gottwald U, Habenicht U, Drevet JR, Vernet P
The Journal of clinical investigation119(7)2074-85(2009 Jul)

Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.
Choi YJ, Cho SK, Hwang KC, Park C, Kim JH, Park SB, Hwang S, Kim JH
FEBS letters583(8)1292-8(2009 Apr)

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Seiler A, Schneider M, F?rster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, R?dmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M
Cell metabolism8(3)237-48(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice
Title: Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.

GPX5 is a potent antioxidant scavenger in the luminal compartment of the mouse cauda epididymidis that protects spermatozoa from oxidative injuries.
Title: Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice.

results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species
Title: Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.

GPX5 gene is expressed in a temporally regulated manner during mouse embryonic development.
Title: GPX5, the selenium-independent glutathione peroxidase-encoding single copy gene is differentially expressed in mouse epididymis.

GPX5 is found in the caput & cauda epididymis lumen in 3 locations: as a soluble protein in the caput epididymal fluid, weakly bound to caput sperm membranes, or associated to lipid-containing structures causing a protective effect against proteolysis.
Title: GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations.

The following Gpx5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpx5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05992	NM_010343.2 Latest version!	Mus musculus glutathione peroxidase 5 (Gpx5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu67849	XM_011244283.3 Latest version!	Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu67849	XM_011244283.2	Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpx5 ( NM_010343.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034473.2 Mus musculus glutathione peroxidase 5 (Gpx5), mRNA.

Price & Availability↑

CloneID	OMu05992
Clone ID Related Accession (Same CDS sequence)	NM_010343.2
Accession Version	NM_010343.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	epididymal secretory glutathione peroxidase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC105648.1, AK029731.1 and AK033841.1. On Apr 1, 2008 this sequence version replaced NM_010343.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC103589.1, AK029731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGTTACAG AGTTAAGAGT CTTCTATCTT GTTCCACTTC TTCTAGCCAG CTATGTGCAG 
ACAACCCCCA GGCCGGAAAA GATGAAGATG GACTGCTACA AAGATGTGAA AGGCACCATC 
TACGACTATG AGGCTCTGTC TCTTAATGGG AAGGAACACA TTCCATTCAA GCAGTATGCA 
GGAAAGCACG TCCTCTTTGT CAATGTGGCT ACCTATTGCG GTCTGACAAT CCAGTACCCT 
GAGCTGAATG CACTCCAGGA GGATCTGAAG CCATTTGGCT TGGTTATATT GGGCTTTCCC 
TGCAACCAAT TTGGAAAGCA AGAACCAGGA GACAATTTAG AGATTCTTCC TGGGCTCAAG 
TATGTTCGTC CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA 
AATGGTGAAA ACGAGCAGAA AATCTTCACC TTCTTGAAGC GTTCTTGTCC TCACCCCTCA 
GAGACTGTGG TCATGAGCAA ACATACCTTC TGGGAGCCAA TAAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGACCC GATGGCATCC CTGTCATGCG CTGGTTCCAC 
CAGGCTCCTG TCAGCACTGT CAAGTCTGAC ATCATGGCGT ACCTGAGCCA TTTCAAAACC 
ATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034473.2
CDS	27..692
Translation	MVTELRVFYLVPLLLASYVQTTPRPEKMKMDCYKDVKGTIYDYEALSLNGKEHIPFKQYAGKHVLFVNVATYCGLTIQYPELNALQEDLKPFGLVILGFPCNQFGKQEPGDNLEILPGLKYVRPGKGFLPNFQLFAKGDVNGENEQKIFTFLKRSCPHPSETVVMSKHTFWEPIKVHDIRWNFEKFLVGPDGIPVMRWFHQAPVSTVKSDIMAYLSHFKTI

Target ORF information:

RefSeq Version	NM_010343.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 5 (Gpx5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010343.2

ORF Insert Sequence:

ATGGTTACAG AGTTAAGAGT CTTCTATCTT GTTCCACTTC TTCTAGCCAG CTATGTGCAG 
ACAACCCCCA GGCCGGAAAA GATGAAGATG GACTGCTACA AAGATGTGAA AGGCACCATC 
TACGACTATG AGGCTCTGTC TCTTAATGGG AAGGAACACA TTCCATTCAA GCAGTATGCA 
GGAAAGCACG TCCTCTTTGT CAATGTGGCT ACCTATTGCG GTCTGACAAT CCAGTACCCT 
GAGCTGAATG CACTCCAGGA GGATCTGAAG CCATTTGGCT TGGTTATATT GGGCTTTCCC 
TGCAACCAAT TTGGAAAGCA AGAACCAGGA GACAATTTAG AGATTCTTCC TGGGCTCAAG 
TATGTTCGTC CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA 
AATGGTGAAA ACGAGCAGAA AATCTTCACC TTCTTGAAGC GTTCTTGTCC TCACCCCTCA 
GAGACTGTGG TCATGAGCAA ACATACCTTC TGGGAGCCAA TAAAAGTCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGACCC GATGGCATCC CTGTCATGCG CTGGTTCCAC 
CAGGCTCCTG TCAGCACTGT CAAGTCTGAC ATCATGGCGT ACCTGAGCCA TTTCAAAACC 
ATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpx5 ( XM_011244283.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011242585.1 Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67849
Clone ID Related Accession (Same CDS sequence)	XM_011244283.2 , XM_011244283.3
Accession Version	XM_011244283.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	epididymal secretory glutathione peroxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011244283.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAG ACTGCAGGCC CTCAGACCAG AAATCGGCAG TACTAGTCAT GGTTACAGAG 
TTAAGAGTCT TCTATCTTGT TCCACTTCTT CTAGCCAGCT ATGTGCAGAC AACCCCCAGG 
CCGGAAAAGA TGAAGATGGA CTGCTACAAA GATGTGAAAG GCACCATCTA CGACTATGAG 
GCTCTGTCTC TTAATGGGAA GGAACACATT CCATTCAAGC AGTATGCAGG AAAGCACGTC 
CTCTTTGTCA ATGTGGCTAC CTATTGCGGT CTGACAATCC AGTACCCTGG TATGTTCGTC 
CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011242585.1
CDS	21..371
Translation	MSKDCRPSDQKSAVLVMVTELRVFYLVPLLLASYVQTTPRPEKMKMDCYKDVKGTIYDYEALSLNGKEHIPFKQYAGKHVLFVNVATYCGLTIQYPGMFVQEKGFYLTSSFLQKGM

Target ORF information:

RefSeq Version	XM_011244283.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011244283.2

ORF Insert Sequence:

ATGAGCAAAG ACTGCAGGCC CTCAGACCAG AAATCGGCAG TACTAGTCAT GGTTACAGAG 
TTAAGAGTCT TCTATCTTGT TCCACTTCTT CTAGCCAGCT ATGTGCAGAC AACCCCCAGG 
CCGGAAAAGA TGAAGATGGA CTGCTACAAA GATGTGAAAG GCACCATCTA CGACTATGAG 
GCTCTGTCTC TTAATGGGAA GGAACACATT CCATTCAAGC AGTATGCAGG AAAGCACGTC 
CTCTTTGTCA ATGTGGCTAC CTATTGCGGT CTGACAATCC AGTACCCTGG TATGTTCGTC 
CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpx5 ( XM_011244283.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011242585.1 Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67849
Clone ID Related Accession (Same CDS sequence)	XM_011244283.2 , XM_011244283.3
Accession Version	XM_011244283.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	epididymal secretory glutathione peroxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011244283.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAG ACTGCAGGCC CTCAGACCAG AAATCGGCAG TACTAGTCAT GGTTACAGAG 
TTAAGAGTCT TCTATCTTGT TCCACTTCTT CTAGCCAGCT ATGTGCAGAC AACCCCCAGG 
CCGGAAAAGA TGAAGATGGA CTGCTACAAA GATGTGAAAG GCACCATCTA CGACTATGAG 
GCTCTGTCTC TTAATGGGAA GGAACACATT CCATTCAAGC AGTATGCAGG AAAGCACGTC 
CTCTTTGTCA ATGTGGCTAC CTATTGCGGT CTGACAATCC AGTACCCTGG TATGTTCGTC 
CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011242585.1
CDS	20..370
Translation	MSKDCRPSDQKSAVLVMVTELRVFYLVPLLLASYVQTTPRPEKMKMDCYKDVKGTIYDYEALSLNGKEHIPFKQYAGKHVLFVNVATYCGLTIQYPGMFVQEKGFYLTSSFLQKGM

Target ORF information:

RefSeq Version	XM_011244283.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 5 (Gpx5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011244283.3

ORF Insert Sequence:

ATGAGCAAAG ACTGCAGGCC CTCAGACCAG AAATCGGCAG TACTAGTCAT GGTTACAGAG 
TTAAGAGTCT TCTATCTTGT TCCACTTCTT CTAGCCAGCT ATGTGCAGAC AACCCCCAGG 
CCGGAAAAGA TGAAGATGGA CTGCTACAAA GATGTGAAAG GCACCATCTA CGACTATGAG 
GCTCTGTCTC TTAATGGGAA GGAACACATT CCATTCAAGC AGTATGCAGG AAAGCACGTC 
CTCTTTGTCA ATGTGGCTAC CTATTGCGGT CTGACAATCC AGTACCCTGG TATGTTCGTC 
CAGGAAAAGG GTTTTTACCT AACTTCCAGC TTTTTGCAAA AGGGGATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(9)3155-70(2016 09)
Borowiec AS,Sion B,Chalmel F,D Rolland A,Lemonnier L,De Clerck T,Bokhobza A,Derouiche S,Dewailly E,Slomianny C,Mauduit C,Benahmed M,Roudbaraki M,J?gou B,Prevarskaya N,Bidaux G

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.
PloS one7(6)e38565(2012)
Noblanc A,Peltier M,Damon-Soubeyrand C,Kerchkove N,Chabory E,Vernet P,Saez F,Cadet R,Janny L,Pons-Rejraji H,Conrad M,Drevet JR,Kocer A

Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice.
The Journal of clinical investigation119(7)2074-85(2009 Jul)
Chabory E,Damon C,Lenoir A,Kauselmann G,Kern H,Zevnik B,Garrel C,Saez F,Cadet R,Henry-Berger J,Schoor M,Gottwald U,Habenicht U,Drevet JR,Vernet P

Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.
FEBS letters583(8)1292-8(2009 Apr)
Choi YJ,Cho SK,Hwang KC,Park C,Kim JH,Park SB,Hwang S,Kim JH

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Cell metabolism8(3)237-48(2008 Sep)
Seiler A,Schneider M,F?rster H,Roth S,Wirth EK,Culmsee C,Plesnila N,Kremmer E,R?dmark O,Wurst W,Bornkamm GW,Schweizer U,Conrad M

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Gpx5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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