Gpr3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr3
Entrez Gene ID	14748
Full Name	G-protein coupled receptor 3
Synonyms	Gpcr20,Gpcr21,Gpcr3
General protein information	Preferred Names G-protein coupled receptor 3 Names G-protein coupled receptor 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D2.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_008154.3	NP_032180.1	G-protein coupled receptor 3

Pathways from BioSystems

Homologies

	GPR3	XP_001111240.1
Canis lupus familiaris (dog)	GPR3	XP_544470.1
Rattus norvegicus (Norway rat)	Gpr3	NP_714949.1
Homo sapiens (human)	GPR3	NP_005272.1
Mus musculus (house mouse)	Gpr3	NP_032180.1
Pan troglodytes (chimpanzee)	GPR3	XP_001148989.1
Bos taurus (cattle)	GPR3	XP_005203355.1

Gene Ontology
Bibliography

Related articles in PubMed

The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes.
Firmani LD, Uliasz TF, Mehlmann LM
Developmental biology(2017 Dec)

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons.
Miyagi T, Tanaka S, Hide I, Shirafuji T, Sakai N
PloS one11(1)e0147466(2016)

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Godlewski G, Jourdan T, Szanda G, Tam J, Cinar R, Harvey-White J, Liu J, Mukhopadhyay B, Pacher P, Ming Mo F, Osei-Hyiaman D, Kunos G
Scientific reports514953(2015 Oct)

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.
Huang Y, Skwarek-Maruszewska A, Horr? K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A
Science translational medicine7(309)309ra164(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPR3 appears to have a key role in the thermogenic response of interscapular brown adipose tissue and may represent a new therapeutic target in age-related obesity.
Title: Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.

This study found that the expression of GPR3 in CGNs exerted prosurvival effects against apoptosis-inducing stimuli, such as potassium deprivation, hypoxia, and ROS.
Title: Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.

Altered signalling pathways of GPR3 could contribute to the neurobiological substrate involved in developing addiction to cocaine
Title: The orphan receptor GPR3 modulates the early phases of cocaine reinforcement.

Involvement of the orphan GPR3 receptor is demonstrated for the first time in expression and development of neuropathic pain and in analgesia induced by morphine.
Title: GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception.

GPR3 is a novel antiproliferative mediator of CGPs in the postnatal development of murine cerebellu
Title: The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development.

The following Gpr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01439	NM_008154.3 Latest version!	Mus musculus G-protein coupled receptor 3 (Gpr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr3 ( NM_008154.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032180.1 Mus musculus G-protein coupled receptor 3 (Gpr3), mRNA.

Price & Availability↑

CloneID	OMu01439
Clone ID Related Accession (Same CDS sequence)	NM_008154.3
Accession Version	NM_008154.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Mus musculus(house mouse)
Product	G-protein coupled receptor 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB851645.1, AK140302.1 and AI854631.1. On May 23, 2007 this sequence version replaced NM_008154.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK140302.1, AK158917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTGGG GAGCAGGAAG CTCTATGGCC TGGTTCTCAG CTGGCTCAGG CAGTGTGAAC 
GTGAGCAGCG TGGACCCAGT AGAGGAACCC ACAGGCCCAG CTACACTGCT GCCCTCTCCC 
AGGGCCTGGG ATGTGGTGCT GTGCATCTCA GGCACCCTGG TGTCCTGCGA GAACGCGCTG 
GTGGTGGCCA TCATTGTGGG CACTCCTGCC TTCCGCGCCC CCATGTTCCT GCTGGTGGGT 
AGCTTGGCCG TAGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCGGCTGAC 
TTCTGCATTG GCTCACCAGA GATGAGCTTG ATGCTGGTCG GCGTGCTAGC AATGGCCTTC 
ACTGCCAGCA TCGGCAGCCT GCTGGCCATT ACCGTTGACC GCTACCTTTC CCTGTACAAT 
GCTCTCACTT ACTACTCAGA GACAACGGTA ACTCGGACTT ATGTGATGCT GGCCTTGGTG 
TGGGTGGGTG CCCTGGGCCT GGGGCTGGTT CCCGTGCTGG CCTGGAACTG CCGGGATGGC 
CTGACCACGT GTGGTGTGGT CTATCCACTC TCCAAGAACC ATCTGGTGGT TCTGGCCATC 
GCCTTCTTCA TGGTGTTTGG CATCATGTTG CAGCTCTATG CCCAGATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT CGCCCTCCAA CGACACCTGC TGCCTGCCTC TCACTACGTG 
GCCACCCGCA AGGGCATCGC CACATTGGCT GTGGTGCTTG GCGCCTTTGC TGCCTGTTGG 
TTGCCCTTCA CTGTCTACTG CCTCCTGGGA GATGCCGACT CTCCCCGTCT CTACACCTAT 
CTTACCCTGC TCCCAGCCAC CTACAACTCC ATGATCAACC CTGTCATCTA CGCCTTTCGC 
AACCAAGATG TGCAGAAGGT GCTGTGGGCC ATCTGCTGCT GCTGTTCCAC TTCCAAGATT 
CCATTCCGGT CCCGGTCCCC TAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032180.1
CDS	124..1116
Translation	MMWGAGSSMAWFSAGSGSVNVSSVDPVEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCIGSPEMSLMLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDADSPRLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV

Target ORF information:

RefSeq Version	NM_008154.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus G-protein coupled receptor 3 (Gpr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008154.3

ORF Insert Sequence:

ATGATGTGGG GAGCAGGAAG CTCTATGGCC TGGTTCTCAG CTGGCTCAGG CAGTGTGAAC 
GTGAGCAGCG TGGACCCAGT AGAGGAACCC ACAGGCCCAG CTACACTGCT GCCCTCTCCC 
AGGGCCTGGG ATGTGGTGCT GTGCATCTCA GGCACCCTGG TGTCCTGCGA GAACGCGCTG 
GTGGTGGCCA TCATTGTGGG CACTCCTGCC TTCCGCGCCC CCATGTTCCT GCTGGTGGGT 
AGCTTGGCCG TAGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCGGCTGAC 
TTCTGCATTG GCTCACCAGA GATGAGCTTG ATGCTGGTCG GCGTGCTAGC AATGGCCTTC 
ACTGCCAGCA TCGGCAGCCT GCTGGCCATT ACCGTTGACC GCTACCTTTC CCTGTACAAT 
GCTCTCACTT ACTACTCAGA GACAACGGTA ACTCGGACTT ATGTGATGCT GGCCTTGGTG 
TGGGTGGGTG CCCTGGGCCT GGGGCTGGTT CCCGTGCTGG CCTGGAACTG CCGGGATGGC 
CTGACCACGT GTGGTGTGGT CTATCCACTC TCCAAGAACC ATCTGGTGGT TCTGGCCATC 
GCCTTCTTCA TGGTGTTTGG CATCATGTTG CAGCTCTATG CCCAGATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT CGCCCTCCAA CGACACCTGC TGCCTGCCTC TCACTACGTG 
GCCACCCGCA AGGGCATCGC CACATTGGCT GTGGTGCTTG GCGCCTTTGC TGCCTGTTGG 
TTGCCCTTCA CTGTCTACTG CCTCCTGGGA GATGCCGACT CTCCCCGTCT CTACACCTAT 
CTTACCCTGC TCCCAGCCAC CTACAACTCC ATGATCAACC CTGTCATCTA CGCCTTTCGC 
AACCAAGATG TGCAGAAGGT GCTGTGGGCC ATCTGCTGCT GCTGTTCCAC TTCCAAGATT 
CCATTCCGGT CCCGGTCCCC TAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes.
Developmental biology(2017 Dec)
Firmani LD,Uliasz TF,Mehlmann LM

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons.
PloS one11(1)e0147466(2016)
Miyagi T,Tanaka S,Hide I,Shirafuji T,Sakai N

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Scientific reports514953(2015 Oct)
Godlewski G,Jourdan T,Szanda G,Tam J,Cinar R,Harvey-White J,Liu J,Mukhopadhyay B,Pacher P,Ming Mo F,Osei-Hyiaman D,Kunos G

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.
Science translational medicine7(309)309ra164(2015 Oct)
Huang Y,Skwarek-Maruszewska A,Horr? K,Vandewyer E,Wolfs L,Snellinx A,Saito T,Radaelli E,Corthout N,Colombelli J,Lo AC,Van Aerschot L,Callaerts-Vegh Z,Trabzuni D,Bossers K,Verhaagen J,Ryten M,Munck S,D'Hooge R,Swaab DF,Hardy J,Saido TC,De Strooper B,Thathiah A

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Gpr3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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