Got2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Got2
Entrez Gene ID	14719
Full Name	glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms	AL022787,FABP-pm,Got-2,Kyat4,mAspAT
General protein information	Preferred Names glutamatic-oxaloacetic transaminase 2, mitochondrial Names aspartate aminotransferase, mitochondrial FABP-1 FABPpm fatty acid-binding protein glutamate oxaloacetate transaminase 2, mitochondrial kynurenine aminotransferase 4 kynurenine aminotransferase IV kynurenine--oxoglutarate transaminase 4 kynurenine--oxoglutarate transaminase IV mitochondrial aspartate aminotransferase plasma membrane fatty acid binding protein plasma membrane-associated fatty acid-binding protein transaminase A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 D1\|8 47.79 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010325.2	NP_034455.1	aspartate aminotransferase, mitochondrial
NM_010325.3	NP_034455.1	aspartate aminotransferase, mitochondrial

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GOT2	NP_777231.1
Gallus gallus (chicken)	GOT2	NP_990854.1
Caenorhabditis elegans (roundworm)	got-2.2	NP_741810.1
Caenorhabditis elegans (roundworm)	got-2.1	NP_491413.2
	GOT2	XP_001103601.1
Danio rerio (zebrafish)	got2a	NP_998544.1
Drosophila melanogaster (fruit fly)	Got2	NP_722745.1
Schizosaccharomyces pombe (fission yeast)	SPBC725.01	NP_595481.1
Neurospora crassa	NCU08411	XP_963283.2
Neurospora crassa	NCU10383	XP_001728110.1
Arabidopsis thaliana (thale cress)	ASP1	NP_001118421.1
Homo sapiens (human)	GOT2	NP_002071.2
Canis lupus familiaris (dog)	GOT2	XP_535278.3
Magnaporthe oryzae (rice blast fungus)	MGG_06530	XP_003717017.1
Rattus norvegicus (Norway rat)	Got2	NP_037309.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009685	XP_318743.3
Pan troglodytes (chimpanzee)	GOT2	XP_523381.2
Mus musculus (house mouse)	Got2	NP_034455.1
Danio rerio (zebrafish)	got2b	NP_956283.1
Oryza sativa (rice)	Os06g0548000	NP_001057825.1
Oryza sativa (rice)	Os02g0236000	NP_001046388.1
Xenopus tropicalis (tropical clawed frog)	got2	NP_001016933.1

Gene Ontology
Bibliography

Related articles in PubMed

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology216(3)675-693(2017 Mar)

Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
Honorat JA, Nakatsuji Y, Shimizu M, Kinoshita M, Sumi-Akamaru H, Sasaki T, Takata K, Koda T, Namba A, Yamashita K, Sanda E, Sakaguchi M, Kumanogoh A, Shirakura T, Tamura M, Sakoda S, Mochizuki H, Okuno T
PloS one12(11)e0187215(2017)

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Duteil D, Tosic M, Lausecker F, Nenseth HZ, M?ller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Br?ning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Sch?le R
Cell reports17(4)1008-1021(2016 10)

Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
Arun P, Abu-Taleb R, Oguntayo S, Wang Y, Valiyaveettil M, Long JB, Nambiar MP
Journal of neurotrauma30(19)1645-51(2013 Oct)

Adiponectin enhances mouse fetal fat deposition.
Qiao L, Yoo HS, Madon A, Kinney B, Hay WW Jr, Shao J
Diabetes61(12)3199-207(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GOT2-mediated ATP synthesis may be a pivotal mechanism underlying the protective effect of febuxostat against neurodegeneration in EA
Title: Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.

it is quite likely that the down regulation of GOT2 after blast exposure is playing a significant role in mitochondrial dysfunction after blast exposure
Title: Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.

The role of mAspAT in vivo is to control the levels of endogenous kynurenic acid (KYNA) through modulation of the mAspAt in the mouse brain.
Title: Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.

KAT IV inhibited by equimolar tryptophan and aspartate, and half-life is 6.5 minutes at 65 degree C.
Title: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.

FAT/CD36 and FABPpm protein content was increased in red muscles in IL-6(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG).
Title: IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle.

The following Got2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Got2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19326	NM_010325.3 Latest version!	Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu19326	NM_010325.2	Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Got2 ( NM_010325.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034455.1 Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.

Price & Availability↑

CloneID	OMu19326
Clone ID Related Accession (Same CDS sequence)	NM_010325.2 , NM_010325.3
Accession Version	NM_010325.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-14
Organism	Mus musculus(house mouse)
Product	aspartate aminotransferase, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC127300.3. On Mar 21, 2007 this sequence version replaced NM_010325.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J02622.1, BC089015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTCC TGCACTCCAG CCGCATCCTC TCCGGGATGG CTGCTGCCTT TCACCCAGGC 
CTAGCTGCTG CAGCCTCTGC CAGAGCCAGC TCCTGGTGGA CCCATGTTGA AATGGGACCT 
CCAGATCCCA TCCTGGGCGT TACCGAAGCC TTCAAGAGAG ATACCAACAG CAAGAAGATG 
AACCTGGGAG TTGGTGCCTA CCGGGATGAT AACGGAAAAC CTTACGTGCT CCCCAGTGTC 
CGGAAGGCAG AGGCCCAGAT TGCTGCAAAA AATTTGGACA AAGAATACCT GCCCATTGGG 
GGACTGGCTG AATTCTGTAA GGCTTCTGCA GAACTGGCCC TGGGCGAGAA CAATGAAGTG 
TTGAAAAGCG GCCGGTTCGT CACTGTGCAG ACCATTTCCG GGACTGGAGC CTTAAGGGTC 
GGGGCCAGTT TTCTGCAAAG GTTTTTTAAG TTCAGCCGAG ATGTCTTTCT GCCCAAACCA 
TCCTGGGGAA ATCACACGCC CATCTTCAGG GATGCCGGCA TGCAGCTCCA AGGTTATCGC 
TACTATGACC CCAAGACTTG CGGTTTTGAC TTCTCTGGAG CCCTAGAAGA CATATCAAAA 
ATCCCAGAGC AGAGTGTCCT CCTCCTGCAT GCCTGCGCTC ACAACCCCAC CGGCGTGGAC 
CCGCGTCCCG AGCAGTGGAA GGAGATAGCG TCCGTGGTGA AGAAAAAGAA TCTCTTCGCA 
TTCTTTGACA TGGCCTACCA AGGCTTTGCC AGCGGTGATG GTGATAAGGA TGCCTGGGCC 
GTGCGGCACT TCATCGAGCA GGGCATCAAT GTCTGCCTCT GCCAATCGTA TGCCAAGAAC 
ATGGGCCTGT ACGGTGAGCG TGTGGGAGCC TTCACGGTGG TCTGCAAAGA TGCAGAAGAA 
GCCAAAAGGG TGGAGTCACA GCTGAAGATC TTGATCCGTC CCCTGTATTC CAACCCACCT 
CTCAATGGGG CCCGGATCGC AGCAACCATC CTGACTTCTC CAGACTTGCG GAAGCAATGG 
TTGCAAGAGG TGAAAGGCAT GGCTGACCGC ATCATCAGCA TGAGGACCCA GCTGGTCTCC 
AACCTGAAGA AAGAGGGCTC TTCCCACAAC TGGCAGCACA TCACCGACCA GATCGGCATG 
TTCTGTTTCA CCGGCCTAAA GCCAGAGCAG GTAGAGCGGC TGACCAAGGA GTTCTCGGTC 
TACATGACAA AGGATGGCCG AATCTCCGTG GCAGGGGTCA CCTCTGGCAA TGTGGGCTAC 
CTTGCCCATG CCATTCACCA GGTCACCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034455.1
CDS	61..1353
Translation	MALLHSSRILSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK

Target ORF information:

RefSeq Version	NM_010325.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010325.2

ORF Insert Sequence:

ATGGCCCTCC TGCACTCCAG CCGCATCCTC TCCGGGATGG CTGCTGCCTT TCACCCAGGC 
CTAGCTGCTG CAGCCTCTGC CAGAGCCAGC TCCTGGTGGA CCCATGTTGA AATGGGACCT 
CCAGATCCCA TCCTGGGCGT TACCGAAGCC TTCAAGAGAG ATACCAACAG CAAGAAGATG 
AACCTGGGAG TTGGTGCCTA CCGGGATGAT AACGGAAAAC CTTACGTGCT CCCCAGTGTC 
CGGAAGGCAG AGGCCCAGAT TGCTGCAAAA AATTTGGACA AAGAATACCT GCCCATTGGG 
GGACTGGCTG AATTCTGTAA GGCTTCTGCA GAACTGGCCC TGGGCGAGAA CAATGAAGTG 
TTGAAAAGCG GCCGGTTCGT CACTGTGCAG ACCATTTCCG GGACTGGAGC CTTAAGGGTC 
GGGGCCAGTT TTCTGCAAAG GTTTTTTAAG TTCAGCCGAG ATGTCTTTCT GCCCAAACCA 
TCCTGGGGAA ATCACACGCC CATCTTCAGG GATGCCGGCA TGCAGCTCCA AGGTTATCGC 
TACTATGACC CCAAGACTTG CGGTTTTGAC TTCTCTGGAG CCCTAGAAGA CATATCAAAA 
ATCCCAGAGC AGAGTGTCCT CCTCCTGCAT GCCTGCGCTC ACAACCCCAC CGGCGTGGAC 
CCGCGTCCCG AGCAGTGGAA GGAGATAGCG TCCGTGGTGA AGAAAAAGAA TCTCTTCGCA 
TTCTTTGACA TGGCCTACCA AGGCTTTGCC AGCGGTGATG GTGATAAGGA TGCCTGGGCC 
GTGCGGCACT TCATCGAGCA GGGCATCAAT GTCTGCCTCT GCCAATCGTA TGCCAAGAAC 
ATGGGCCTGT ACGGTGAGCG TGTGGGAGCC TTCACGGTGG TCTGCAAAGA TGCAGAAGAA 
GCCAAAAGGG TGGAGTCACA GCTGAAGATC TTGATCCGTC CCCTGTATTC CAACCCACCT 
CTCAATGGGG CCCGGATCGC AGCAACCATC CTGACTTCTC CAGACTTGCG GAAGCAATGG 
TTGCAAGAGG TGAAAGGCAT GGCTGACCGC ATCATCAGCA TGAGGACCCA GCTGGTCTCC 
AACCTGAAGA AAGAGGGCTC TTCCCACAAC TGGCAGCACA TCACCGACCA GATCGGCATG 
TTCTGTTTCA CCGGCCTAAA GCCAGAGCAG GTAGAGCGGC TGACCAAGGA GTTCTCGGTC 
TACATGACAA AGGATGGCCG AATCTCCGTG GCAGGGGTCA CCTCTGGCAA TGTGGGCTAC 
CTTGCCCATG CCATTCACCA GGTCACCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Got2 ( NM_010325.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034455.1 Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.

Price & Availability↑

CloneID	OMu19326
Clone ID Related Accession (Same CDS sequence)	NM_010325.2 , NM_010325.3
Accession Version	NM_010325.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Mus musculus(house mouse)
Product	aspartate aminotransferase, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127300.3. On Feb 5, 2019 this sequence version replaced NM_010325.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152921.1, AK136556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCCCTCC TGCACTCCAG CCGCATCCTC TCCGGGATGG CTGCTGCCTT TCACCCAGGC 
CTAGCTGCTG CAGCCTCTGC CAGAGCCAGC TCCTGGTGGA CCCATGTTGA AATGGGACCT 
CCAGATCCCA TCCTGGGCGT TACCGAAGCC TTCAAGAGAG ATACCAACAG CAAGAAGATG 
AACCTGGGAG TTGGTGCCTA CCGGGATGAT AACGGAAAAC CTTACGTGCT CCCCAGTGTC 
CGGAAGGCAG AGGCCCAGAT TGCTGCAAAA AATTTGGACA AAGAATACCT GCCCATTGGG 
GGACTGGCTG AATTCTGTAA GGCTTCTGCA GAACTGGCCC TGGGCGAGAA CAATGAAGTG 
TTGAAAAGCG GCCGGTTCGT CACTGTGCAG ACCATTTCCG GGACTGGAGC CTTAAGGGTC 
GGGGCCAGTT TTCTGCAAAG GTTTTTTAAG TTCAGCCGAG ATGTCTTTCT GCCCAAACCA 
TCCTGGGGAA ATCACACGCC CATCTTCAGG GATGCCGGCA TGCAGCTCCA AGGTTATCGC 
TACTATGACC CCAAGACTTG CGGTTTTGAC TTCTCTGGAG CCCTAGAAGA CATATCAAAA 
ATCCCAGAGC AGAGTGTCCT CCTCCTGCAT GCCTGCGCTC ACAACCCCAC CGGCGTGGAC 
CCGCGTCCCG AGCAGTGGAA GGAGATAGCG TCCGTGGTGA AGAAAAAGAA TCTCTTCGCA 
TTCTTTGACA TGGCCTACCA AGGCTTTGCC AGCGGTGATG GTGATAAGGA TGCCTGGGCC 
GTGCGGCACT TCATCGAGCA GGGCATCAAT GTCTGCCTCT GCCAATCGTA TGCCAAGAAC 
ATGGGCCTGT ACGGTGAGCG TGTGGGAGCC TTCACGGTGG TCTGCAAAGA TGCAGAAGAA 
GCCAAAAGGG TGGAGTCACA GCTGAAGATC TTGATCCGTC CCCTGTATTC CAACCCACCT 
CTCAATGGGG CCCGGATCGC AGCAACCATC CTGACTTCTC CAGACTTGCG GAAGCAATGG 
TTGCAAGAGG TGAAAGGCAT GGCTGACCGC ATCATCAGCA TGAGGACCCA GCTGGTCTCC 
AACCTGAAGA AAGAGGGCTC TTCCCACAAC TGGCAGCACA TCACCGACCA GATCGGCATG 
TTCTGTTTCA CCGGCCTAAA GCCAGAGCAG GTAGAGCGGC TGACCAAGGA GTTCTCGGTC 
TACATGACAA AGGATGGCCG AATCTCCGTG GCAGGGGTCA CCTCTGGCAA TGTGGGCTAC 
CTTGCCCATG CCATTCACCA GGTCACCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034455.1
CDS	97..1389
Translation	MALLHSSRILSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK

Target ORF information:

RefSeq Version	NM_010325.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial (Got2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010325.3

ORF Insert Sequence:

ATGGCCCTCC TGCACTCCAG CCGCATCCTC TCCGGGATGG CTGCTGCCTT TCACCCAGGC 
CTAGCTGCTG CAGCCTCTGC CAGAGCCAGC TCCTGGTGGA CCCATGTTGA AATGGGACCT 
CCAGATCCCA TCCTGGGCGT TACCGAAGCC TTCAAGAGAG ATACCAACAG CAAGAAGATG 
AACCTGGGAG TTGGTGCCTA CCGGGATGAT AACGGAAAAC CTTACGTGCT CCCCAGTGTC 
CGGAAGGCAG AGGCCCAGAT TGCTGCAAAA AATTTGGACA AAGAATACCT GCCCATTGGG 
GGACTGGCTG AATTCTGTAA GGCTTCTGCA GAACTGGCCC TGGGCGAGAA CAATGAAGTG 
TTGAAAAGCG GCCGGTTCGT CACTGTGCAG ACCATTTCCG GGACTGGAGC CTTAAGGGTC 
GGGGCCAGTT TTCTGCAAAG GTTTTTTAAG TTCAGCCGAG ATGTCTTTCT GCCCAAACCA 
TCCTGGGGAA ATCACACGCC CATCTTCAGG GATGCCGGCA TGCAGCTCCA AGGTTATCGC 
TACTATGACC CCAAGACTTG CGGTTTTGAC TTCTCTGGAG CCCTAGAAGA CATATCAAAA 
ATCCCAGAGC AGAGTGTCCT CCTCCTGCAT GCCTGCGCTC ACAACCCCAC CGGCGTGGAC 
CCGCGTCCCG AGCAGTGGAA GGAGATAGCG TCCGTGGTGA AGAAAAAGAA TCTCTTCGCA 
TTCTTTGACA TGGCCTACCA AGGCTTTGCC AGCGGTGATG GTGATAAGGA TGCCTGGGCC 
GTGCGGCACT TCATCGAGCA GGGCATCAAT GTCTGCCTCT GCCAATCGTA TGCCAAGAAC 
ATGGGCCTGT ACGGTGAGCG TGTGGGAGCC TTCACGGTGG TCTGCAAAGA TGCAGAAGAA 
GCCAAAAGGG TGGAGTCACA GCTGAAGATC TTGATCCGTC CCCTGTATTC CAACCCACCT 
CTCAATGGGG CCCGGATCGC AGCAACCATC CTGACTTCTC CAGACTTGCG GAAGCAATGG 
TTGCAAGAGG TGAAAGGCAT GGCTGACCGC ATCATCAGCA TGAGGACCCA GCTGGTCTCC 
AACCTGAAGA AAGAGGGCTC TTCCCACAAC TGGCAGCACA TCACCGACCA GATCGGCATG 
TTCTGTTTCA CCGGCCTAAA GCCAGAGCAG GTAGAGCGGC TGACCAAGGA GTTCTCGGTC 
TACATGACAA AGGATGGCCG AATCTCCGTG GCAGGGGTCA CCTCTGGCAA TGTGGGCTAC 
CTTGCCCATG CCATTCACCA GGTCACCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
The Journal of cell biology216(3)675-693(2017 Mar)
Schatton D,Pla-Martin D,Marx MC,Hansen H,Mourier A,Nemazanyy I,Pessia A,Zentis P,Corona T,Kondylis V,Barth E,Schauss AC,Velagapudi V,Rugarli EI

Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
PloS one12(11)e0187215(2017)
Honorat JA,Nakatsuji Y,Shimizu M,Kinoshita M,Sumi-Akamaru H,Sasaki T,Takata K,Koda T,Namba A,Yamashita K,Sanda E,Sakaguchi M,Kumanogoh A,Shirakura T,Tamura M,Sakoda S,Mochizuki H,Okuno T

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Cell reports17(4)1008-1021(2016 10)
Duteil D,Tosic M,Lausecker F,Nenseth HZ,M?ller JM,Urban S,Willmann D,Petroll K,Messaddeq N,Arrigoni L,Manke T,Kornfeld JW,Br?ning JC,Zagoriy V,Meret M,Dengjel J,Kanouni T,Sch?le R

Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
Journal of neurotrauma30(19)1645-51(2013 Oct)
Arun P,Abu-Taleb R,Oguntayo S,Wang Y,Valiyaveettil M,Long JB,Nambiar MP

Adiponectin enhances mouse fetal fat deposition.
Diabetes61(12)3199-207(2012 Dec)
Qiao L,Yoo HS,Madon A,Kinney B,Hay WW Jr,Shao J

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Got2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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