Gnb3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gnb3
Entrez Gene ID	14695
Full Name	guanine nucleotide binding protein (G protein), beta 3
Synonyms	Gnb-3
General protein information	Preferred Names guanine nucleotide binding protein (G protein), beta 3 Names guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 guanine nucleotide binding protein, beta 3 transducin beta chain 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F2\|6 59.17 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_013530.1	NP_038558.1	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GNB3	XP_003313511.1
Danio rerio (zebrafish)	gnb3a	NP_001002437.1
	GNB3	XP_001110494.1
Rattus norvegicus (Norway rat)	Gnb3	NP_068630.1
Xenopus tropicalis (tropical clawed frog)	gnb3	NP_001011107.1
Homo sapiens (human)	GNB3	NP_002066.1
Canis lupus familiaris (dog)	GNB3	NP_001003004.1
Bos taurus (cattle)	GNB3	NP_001179276.1
Mus musculus (house mouse)	Gnb3	NP_038558.1
Gallus gallus (chicken)	GNB3	XP_004938175.1

Gene Ontology
Bibliography

Related articles in PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M, McGillewie L, B?r S, Minocha S, Chevalier C, Po C, , Chelly J, Mandel JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, H?rault Y, Collins SC, Friant S, Godin JD, Yalcin B
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)

G?2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.
Guo Y, He X, Zhao L, Liu L, Song H, Wang X, Xu J, Ju X, Guo W, Zhu X
Cerebral cortex (New York, N.Y. : 1991)27(6)3414-3426(2017 Jun)

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.
Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S
Cellular signalling26(11)2514-20(2014 Nov)

Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Tummala SR, Neinstein A, Fina ME, Dhingra A, Vardi N
Investigative ophthalmology & visual science55(3)1483-92(2014 Mar)

Onecut1 and Onecut2 play critical roles in the development of the mouse retina.
Goetz JJ, Martin GM, Chowdhury R, Trimarchi JM
PloS one9(10)e110194(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.
Title: Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

A transgenic model carries an extra copy of GNB3, weighs significantly more than wild-type littermates, and has excess fat accumulation. GNB3 is highly expressed in the brain, consistent with G-protein signaling involved in satiety and/or metabolism.
Title: Mouse model implicates GNB3 duplication in a childhood obesity syndrome.

These results suggest that the main role of Gbeta3 in cones is to establish optimal levels of transducin heteromer in the outer segment, thereby indirectly contributing to robust response properties.
Title: Cones respond to light in the absence of transducin ? subunit.

The results of this study showed that Gbeta(3) may play a role in synaptic maintenance since in its absence, the number of invaginating rod bipolar dendrites is greatly reduced, a deficit that was not observed at 3 weeks, the end of the developmental period.
Title: G?3 is required for normal light ON responses and synaptic maintenance.

Gbeta3 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta4 but is not present in OFF-type bipolar cells.
Title: G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.

The following Gnb3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gnb3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14570	NM_013530.1 Latest version!	Mus musculus guanine nucleotide binding protein (G protein), beta 3 (Gnb3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gnb3 ( NM_013530.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038558.1 Mus musculus guanine nucleotide binding protein (G protein), beta 3 (Gnb3), mRNA.

Price & Availability↑

CloneID	OMu14570
Clone ID Related Accession (Same CDS sequence)	NM_013530.1
Accession Version	NM_013530.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC018239.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018239.1, AK014789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGA TGGAGCAGCT GAGGCAGGAG GCGGAGCAAC TCAAGAAGCA GATTGCTGAT 
GCCAGGAAAG CCTGTGCGGA CATCACTCTG GCTGAGCTTG TGTCTGGCCT GGAGGTGGTG 
GGCCGAGTCC AGATGCGGAC ACGGAGGACA TTAAGGGGAC ATCTGGCCAA GATCTATGCC 
ATGCACTGGG CCACTGACTC TAAGCTGCTC GTAAGTGCCT CGCAGGATGG GAAGCTGATC 
GTGTGGGACA CTTATACCAC CAATAAGGTG CATGCAATCC CGCTGCGTTC CTCCTGGGTC 
ATGACCTGTG CCTATGCACC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG 
TGTTCAATCT ACAACCTCAA ATCCCGCGAG GGCAATGTCA AGGTCAGCCG GGAGCTCTCT 
GCTCACACAG GTTATCTCTC CTGTTGCCGC TTCCTGGATG ACAACAACAT CGTGACTAGC 
TCTGGGGACA CCACATGTGC CTTGTGGGAC ATTGAGACAG GACAGCAGAA GACAGTGTTT 
GTGGGACACA CTGGTGACTG CATGAGCCTG GCTGTGTCCC CAGACTACAA ACTCTTCATT 
TCGGGAGCTT GCGATGCTAG CGCGAAGCTC TGGGATGTGA GGGAAGGGAC CTGTCGTCAG 
ACTTTCACTG GCCATGAGTC AGACATCAAT GCCATCTGTT TCTTTCCCAA CGGGGAGGCC 
ATCTGCACTG GCTCAGATGA CGCCTCCTGC CGCCTCTTTG ACCTGAGGGC AGACCAGGAA 
CTGACTGCCT ATTCCCAGGA GAGCATCATC TGCGGCATCA CTTCAGTAGC CTTCTCGCTC 
AGTGGGCGCC TGCTCTTTGC AGGCTATGAT GACTTCAACT GCAATGTCTG GGACTCTCTG 
AAGTGCGAGC GTGTAGGCAT ACTCTCTGGC CATGACAACA GAGTCAGCTG CCTGGGGGTC 
ACTGCTGACG GCATGGCTGT GGCCACTGGT TCCTGGGACA GCTTCCTCAA AATCTGGAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038558.1
CDS	387..1409
Translation	MGEMEQLRQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Target ORF information:

RefSeq Version	NM_013530.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein (G protein), beta 3 (Gnb3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013530.1

ORF Insert Sequence:

ATGGGGGAGA TGGAGCAGCT GAGGCAGGAG GCGGAGCAAC TCAAGAAGCA GATTGCTGAT 
GCCAGGAAAG CCTGTGCGGA CATCACTCTG GCTGAGCTTG TGTCTGGCCT GGAGGTGGTG 
GGCCGAGTCC AGATGCGGAC ACGGAGGACA TTAAGGGGAC ATCTGGCCAA GATCTATGCC 
ATGCACTGGG CCACTGACTC TAAGCTGCTC GTAAGTGCCT CGCAGGATGG GAAGCTGATC 
GTGTGGGACA CTTATACCAC CAATAAGGTG CATGCAATCC CGCTGCGTTC CTCCTGGGTC 
ATGACCTGTG CCTATGCACC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG 
TGTTCAATCT ACAACCTCAA ATCCCGCGAG GGCAATGTCA AGGTCAGCCG GGAGCTCTCT 
GCTCACACAG GTTATCTCTC CTGTTGCCGC TTCCTGGATG ACAACAACAT CGTGACTAGC 
TCTGGGGACA CCACATGTGC CTTGTGGGAC ATTGAGACAG GACAGCAGAA GACAGTGTTT 
GTGGGACACA CTGGTGACTG CATGAGCCTG GCTGTGTCCC CAGACTACAA ACTCTTCATT 
TCGGGAGCTT GCGATGCTAG CGCGAAGCTC TGGGATGTGA GGGAAGGGAC CTGTCGTCAG 
ACTTTCACTG GCCATGAGTC AGACATCAAT GCCATCTGTT TCTTTCCCAA CGGGGAGGCC 
ATCTGCACTG GCTCAGATGA CGCCTCCTGC CGCCTCTTTG ACCTGAGGGC AGACCAGGAA 
CTGACTGCCT ATTCCCAGGA GAGCATCATC TGCGGCATCA CTTCAGTAGC CTTCTCGCTC 
AGTGGGCGCC TGCTCTTTGC AGGCTATGAT GACTTCAACT GCAATGTCTG GGACTCTCTG 
AAGTGCGAGC GTGTAGGCAT ACTCTCTGGC CATGACAACA GAGTCAGCTG CCTGGGGGTC 
ACTGCTGACG GCATGGCTGT GGCCACTGGT TCCTGGGACA GCTTCCTCAA AATCTGGAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)
Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,B?r S,Minocha S,Chevalier C,Po C,,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,H?rault Y,Collins SC,Friant S,Godin JD,Yalcin B

G?2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.
Cerebral cortex (New York, N.Y. : 1991)27(6)3414-3426(2017 Jun)
Guo Y,He X,Zhao L,Liu L,Song H,Wang X,Xu J,Ju X,Guo W,Zhu X

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.
Cellular signalling26(11)2514-20(2014 Nov)
Ye Y,Sun Z,Guo A,Song LS,Grobe JL,Chen S

Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
Investigative ophthalmology & visual science55(3)1483-92(2014 Mar)
Tummala SR,Neinstein A,Fina ME,Dhingra A,Vardi N

Onecut1 and Onecut2 play critical roles in the development of the mouse retina.
PloS one9(10)e110194(2014)
Goetz JJ,Martin GM,Chowdhury R,Trimarchi JM

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Gnb3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報