Gna11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gna11
Entrez Gene ID	14672
Full Name	guanine nucleotide binding protein, alpha 11
Synonyms	Dsk7,E430025L19
General protein information	Preferred Names guanine nucleotide binding protein, alpha 11 Names guanine nucleotide-binding protein subunit alpha-11 G-protein subunit alpha-11 g alpha-11
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.72 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010301.3	NP_034431.1	guanine nucleotide-binding protein subunit alpha-11
NM_010301.4	NP_034431.1	guanine nucleotide-binding protein subunit alpha-11

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gna11	NP_034431.1
Danio rerio (zebrafish)	gna11b	NP_001007774.1
Caenorhabditis elegans (roundworm)	egl-30	NP_740789.1
Xenopus tropicalis (tropical clawed frog)	gna11	NP_989150.1
Pan troglodytes (chimpanzee)	GNA11	XP_003954570.1
	GNA11	XP_001117841.2
Bos taurus (cattle)	GNA11	NP_776747.1
Homo sapiens (human)	GNA11	NP_002058.2
Rattus norvegicus (Norway rat)	Gna11	NP_112295.1
Gallus gallus (chicken)	GNA11	NP_989565.1

Gene Ontology
Bibliography

Related articles in PubMed

Cinacalcet corrects hypercalcemia in mice with an inactivating G?11 mutation.
Howles SA, Hannan FM, Gorvin CM, Piret SE, Paudyal A, Stewart M, Hough TA, Nesbit MA, Wells S, Brown SD, Cox RD, Thakker RV
JCI insight2(20)(2017 Oct)

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
M?ller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M
Nature communications8(1)484(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
Title: Loss of epithelial Gq and G11 signaling inhibits TGF? production but promotes IL-33-mediated macrophage polarization and emphysema.

Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone and exercise
Title: Overexpression of G?11 in Osteoblast Lineage Cells Suppresses the Osteoanabolic Response to Intermittent PTH and Exercise.

the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
Title: Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.

In Galpha11-knock-out mice there is a decreased heart rate and increased ejection fraction.
Title: Cardiac remodeling in G?q and G?11 knockout mice.

claudin-3 and claudin-5 expression is increased by DHEAS and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
Title: Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gn?11-Coupled Receptor in Sertoli Cells.

The following Gna11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gna11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15772	NM_010301.4 Latest version!	Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OMu15772	NM_010301.3	Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gna11 ( NM_010301.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034431.1 Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.

Price & Availability↑

CloneID	OMu15772
Clone ID Related Accession (Same CDS sequence)	NM_010301.3 , NM_010301.4
Accession Version	NM_010301.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein subunit alpha-11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK143685.1. On Apr 6, 2007 this sequence version replaced NM_010301.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143685.1, BC011169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACTCTGG AGTCCATGAT GGCGTGTTGC CTGAGCGACG AGGTGAAGGA GTCGAAGCGC 
ATCAACGCGG AGATCGAGAA ACAGCTGCGG CGGGACAAGC GCGACGCCCG GCGCGAGCTC 
AAGCTGCTGC TACTTGGCAC TGGCGAGAGC GGGAAGAGTA CCTTCATCAA GCAGATGCGC 
ATCATCCACG GGGCCGGCTA CTCGGAGGAG GACAAGCGCG GCTTCACCAA GTTGGTGTAC 
CAGAACATCT TTACCGCCAT GCAGGCCATG GTGCGCGCCA TGGAGACGCT CAAGATCCTC 
TACAAGTATG AGCAGAACAA GGCCAATGCA CTCCTGATCC GGGAGGTCGA TGTGGAGAAG 
GTCACAACTT TTGAGCACCA GTATGTGAAT GCCATCAAGA CGCTGTGGAG TGACCCTGGT 
GTCCAGGAGT GTTACGATCG CAGGCGGGAG TTCCAGCTAT CTGACTCGGC TAAGTACTAC 
TTGACGGACG TGGACCGCAT CGCCACAGTA GGCTACCTGC CCACCCAGCA GGATGTGCTG 
CGGGTACGCG TGCCCACCAC TGGCATCATC GAGTACCCGT TTGACCTGGA GAACATCATC 
TTCAGGATGG TGGATGTGGG CGGGCAGAGG TCAGAGCGCA GGAAGTGGAT CCATTGCTTT 
GAGAACGTGA CTTCCATCAT GTTCTTGGTG GCACTAAGCG AGTATGACCA AGTCCTGGTG 
GAGTCAGACA ATGAGAACCG CATGGAGGAG AGCAAGGCCC TGTTCCGCAC AATCATCACC 
TACCCCTGGT TCCAGAACTC GTCTGTCATT CTCTTCCTCA ACAAGAAGGA CCTTCTAGAA 
GACAAGATCC TGCACTCACA CTTGGTCGAT TACTTCCCTG AGTTTGATGG GCCACAGAGG 
GATGCACAGG CCGCACGCGA GTTCATTCTG AAGATGTTTG TGGACCTGAA CCCTGACAGC 
GACAAAATCA TCTACTCCCA CTTCACGTGT GCCACCGACA CCGAGAACAT CCGCTTTGTG 
TTCGCAGCTG TGAAGGACAC CATCCTGCAG CTGAACCTGA AGGAGTACAA CCTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034431.1
CDS	120..1199
Translation	MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMVRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

Target ORF information:

RefSeq Version	NM_010301.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010301.3

ORF Insert Sequence:

ATGACTCTGG AGTCCATGAT GGCGTGTTGC CTGAGCGACG AGGTGAAGGA GTCGAAGCGC 
ATCAACGCGG AGATCGAGAA ACAGCTGCGG CGGGACAAGC GCGACGCCCG GCGCGAGCTC 
AAGCTGCTGC TACTTGGCAC TGGCGAGAGC GGGAAGAGTA CCTTCATCAA GCAGATGCGC 
ATCATCCACG GGGCCGGCTA CTCGGAGGAG GACAAGCGCG GCTTCACCAA GTTGGTGTAC 
CAGAACATCT TTACCGCCAT GCAGGCCATG GTGCGCGCCA TGGAGACGCT CAAGATCCTC 
TACAAGTATG AGCAGAACAA GGCCAATGCA CTCCTGATCC GGGAGGTCGA TGTGGAGAAG 
GTCACAACTT TTGAGCACCA GTATGTGAAT GCCATCAAGA CGCTGTGGAG TGACCCTGGT 
GTCCAGGAGT GTTACGATCG CAGGCGGGAG TTCCAGCTAT CTGACTCGGC TAAGTACTAC 
TTGACGGACG TGGACCGCAT CGCCACAGTA GGCTACCTGC CCACCCAGCA GGATGTGCTG 
CGGGTACGCG TGCCCACCAC TGGCATCATC GAGTACCCGT TTGACCTGGA GAACATCATC 
TTCAGGATGG TGGATGTGGG CGGGCAGAGG TCAGAGCGCA GGAAGTGGAT CCATTGCTTT 
GAGAACGTGA CTTCCATCAT GTTCTTGGTG GCACTAAGCG AGTATGACCA AGTCCTGGTG 
GAGTCAGACA ATGAGAACCG CATGGAGGAG AGCAAGGCCC TGTTCCGCAC AATCATCACC 
TACCCCTGGT TCCAGAACTC GTCTGTCATT CTCTTCCTCA ACAAGAAGGA CCTTCTAGAA 
GACAAGATCC TGCACTCACA CTTGGTCGAT TACTTCCCTG AGTTTGATGG GCCACAGAGG 
GATGCACAGG CCGCACGCGA GTTCATTCTG AAGATGTTTG TGGACCTGAA CCCTGACAGC 
GACAAAATCA TCTACTCCCA CTTCACGTGT GCCACCGACA CCGAGAACAT CCGCTTTGTG 
TTCGCAGCTG TGAAGGACAC CATCCTGCAG CTGAACCTGA AGGAGTACAA CCTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gna11 ( NM_010301.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034431.1 Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.

Price & Availability↑

CloneID	OMu15772
Clone ID Related Accession (Same CDS sequence)	NM_010301.3 , NM_010301.4
Accession Version	NM_010301.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein subunit alpha-11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159474.9, AK143685.1 and CD741377.1. On Jun 23, 2018 this sequence version replaced NM_010301.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143685.1, BC011169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCTGG AGTCCATGAT GGCGTGTTGC CTGAGCGACG AGGTGAAGGA GTCGAAGCGC 
ATCAACGCGG AGATCGAGAA ACAGCTGCGG CGGGACAAGC GCGACGCCCG GCGCGAGCTC 
AAGCTGCTGC TACTTGGCAC TGGCGAGAGC GGGAAGAGTA CCTTCATCAA GCAGATGCGC 
ATCATCCACG GGGCCGGCTA CTCGGAGGAG GACAAGCGCG GCTTCACCAA GTTGGTGTAC 
CAGAACATCT TTACCGCCAT GCAGGCCATG GTGCGCGCCA TGGAGACGCT CAAGATCCTC 
TACAAGTATG AGCAGAACAA GGCCAATGCA CTCCTGATCC GGGAGGTCGA TGTGGAGAAG 
GTCACAACTT TTGAGCACCA GTATGTGAAT GCCATCAAGA CGCTGTGGAG TGACCCTGGT 
GTCCAGGAGT GTTACGATCG CAGGCGGGAG TTCCAGCTAT CTGACTCGGC TAAGTACTAC 
TTGACGGACG TGGACCGCAT CGCCACAGTA GGCTACCTGC CCACCCAGCA GGATGTGCTG 
CGGGTACGCG TGCCCACCAC TGGCATCATC GAGTACCCGT TTGACCTGGA GAACATCATC 
TTCAGGATGG TGGATGTGGG CGGGCAGAGG TCAGAGCGCA GGAAGTGGAT CCATTGCTTT 
GAGAACGTGA CTTCCATCAT GTTCTTGGTG GCACTAAGCG AGTATGACCA AGTCCTGGTG 
GAGTCAGACA ATGAGAACCG CATGGAGGAG AGCAAGGCCC TGTTCCGCAC AATCATCACC 
TACCCCTGGT TCCAGAACTC GTCTGTCATT CTCTTCCTCA ACAAGAAGGA CCTTCTAGAA 
GACAAGATCC TGCACTCACA CTTGGTCGAT TACTTCCCTG AGTTTGATGG GCCACAGAGG 
GATGCACAGG CCGCACGCGA GTTCATTCTG AAGATGTTTG TGGACCTGAA CCCTGACAGC 
GACAAAATCA TCTACTCCCA CTTCACGTGT GCCACCGACA CCGAGAACAT CCGCTTTGTG 
TTCGCAGCTG TGAAGGACAC CATCCTGCAG CTGAACCTGA AGGAGTACAA CCTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034431.1
CDS	236..1315
Translation	MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMVRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

Target ORF information:

RefSeq Version	NM_010301.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein, alpha 11 (Gna11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010301.4

ORF Insert Sequence:

ATGACTCTGG AGTCCATGAT GGCGTGTTGC CTGAGCGACG AGGTGAAGGA GTCGAAGCGC 
ATCAACGCGG AGATCGAGAA ACAGCTGCGG CGGGACAAGC GCGACGCCCG GCGCGAGCTC 
AAGCTGCTGC TACTTGGCAC TGGCGAGAGC GGGAAGAGTA CCTTCATCAA GCAGATGCGC 
ATCATCCACG GGGCCGGCTA CTCGGAGGAG GACAAGCGCG GCTTCACCAA GTTGGTGTAC 
CAGAACATCT TTACCGCCAT GCAGGCCATG GTGCGCGCCA TGGAGACGCT CAAGATCCTC 
TACAAGTATG AGCAGAACAA GGCCAATGCA CTCCTGATCC GGGAGGTCGA TGTGGAGAAG 
GTCACAACTT TTGAGCACCA GTATGTGAAT GCCATCAAGA CGCTGTGGAG TGACCCTGGT 
GTCCAGGAGT GTTACGATCG CAGGCGGGAG TTCCAGCTAT CTGACTCGGC TAAGTACTAC 
TTGACGGACG TGGACCGCAT CGCCACAGTA GGCTACCTGC CCACCCAGCA GGATGTGCTG 
CGGGTACGCG TGCCCACCAC TGGCATCATC GAGTACCCGT TTGACCTGGA GAACATCATC 
TTCAGGATGG TGGATGTGGG CGGGCAGAGG TCAGAGCGCA GGAAGTGGAT CCATTGCTTT 
GAGAACGTGA CTTCCATCAT GTTCTTGGTG GCACTAAGCG AGTATGACCA AGTCCTGGTG 
GAGTCAGACA ATGAGAACCG CATGGAGGAG AGCAAGGCCC TGTTCCGCAC AATCATCACC 
TACCCCTGGT TCCAGAACTC GTCTGTCATT CTCTTCCTCA ACAAGAAGGA CCTTCTAGAA 
GACAAGATCC TGCACTCACA CTTGGTCGAT TACTTCCCTG AGTTTGATGG GCCACAGAGG 
GATGCACAGG CCGCACGCGA GTTCATTCTG AAGATGTTTG TGGACCTGAA CCCTGACAGC 
GACAAAATCA TCTACTCCCA CTTCACGTGT GCCACCGACA CCGAGAACAT CCGCTTTGTG 
TTCGCAGCTG TGAAGGACAC CATCCTGCAG CTGAACCTGA AGGAGTACAA CCTGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cinacalcet corrects hypercalcemia in mice with an inactivating G?11 mutation.
JCI insight2(20)(2017 Oct)
Howles SA,Hannan FM,Gorvin CM,Piret SE,Paudyal A,Stewart M,Hough TA,Nesbit MA,Wells S,Brown SD,Cox RD,Thakker RV

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
Nature communications8(1)484(2017 09)
M?ller-Fielitz H,Stahr M,Bernau M,Richter M,Abele S,Krajka V,Benzin A,Wenzel J,Kalies K,Mittag J,Heuer H,Offermanns S,Schwaninger M

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Gna11 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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