Gdi1 cDNA ORF clone, Mus musculus(house mouse)

Altered fronto-striatal functions in the Gdi1-null mouse model of X-linked Intellectual Disability.
Mor? L, K?nnecke B, Yekhlef L, Bruns A, Marte A, Fedele E, Bianchi V, Taverna S, Gatti S, D'Adamo P
Neuroscience344346-359(2017 Mar)

RabGDI? is a negative regulator of interferon-?-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M
Proceedings of the National Academy of Sciences of the United States of America112(33)E4581-90(2015 Aug)

Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.
Kiyota A, Iwama S, Sugimura Y, Takeuchi S, Takagi H, Iwata N, Nakashima K, Suzuki H, Nishioka T, Kato T, Enomoto A, Arima H, Kaibuchi K, Oiso Y
Endocrine journal62(2)153-60(2015)

Forebrain deletion of ?GDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.
Bianchi V, Gambino F, Muzio L, Toniolo D, Humeau Y, D'Adamo P
PloS one7(1)e29763(2012)

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.
Chen Y, Deng Y, Zhang J, Yang L, Xie X, Xu T
The Biochemical journal422(2)229-35(2009 Aug)

Study used cognitive protocols with high translational validity to human condition that target the functionality of cortico-striatal circuitry such as attention and stimulus selection ability with progressive degree of complexity; showed that that Gdi1-null mice are impaired in attention and associative learning processes.
Title: Altered fronto-striatal functions in the Gdi1-null mouse model of X-linked Intellectual Disability.

Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA/Gdi1 (human or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA/Gdi1.
Title: Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.

A pivotal role of alphaGDI via specific RAB GTPases acting specifically in forebrain regions at the pre-synaptic sites involved in memory formation.
Title: Forebrain deletion of ?GDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.

Lack of alphaGDI impairs synaptic vesicle biogenesis and recycling in the hippocampus.
Title: Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.