Gene Symbol | GDF5 |
Entrez Gene ID | 14563 |
Full Name | growth differentiation factor 5 |
Synonyms | BMP-14,Cdmp-1,bp,brp |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome | |
Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]. |