Gdap1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdap1
Entrez Gene ID	14545
Full Name	ganglioside-induced differentiation-associated-protein 1
General protein information	Preferred Names ganglioside-induced differentiation-associated-protein 1 Names ganglioside-induced differentiation-associated protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_010267.3	NP_034397.1	ganglioside-induced differentiation-associated protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GDAP1	XP_519814.2
Bos taurus (cattle)	GDAP1	NP_001094692.1
Gallus gallus (chicken)	GDAP1	XP_004939972.1
Mus musculus (house mouse)	Gdap1	NP_034397.1
Rattus norvegicus (Norway rat)	Gdap1	NP_001101367.1
Danio rerio (zebrafish)	gdap1	NP_001018511.1
Homo sapiens (human)	GDAP1	NP_061845.2
Canis lupus familiaris (dog)	GDAP1	XP_544131.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006132	XP_316195.3
Xenopus tropicalis (tropical clawed frog)	gdap1	XP_002937122.1
	GDAP1	XP_001086782.1
Drosophila melanogaster (fruit fly)	CG4623	NP_001261437.1
Arabidopsis thaliana (thale cress)	AT1G77290	NP_001031292.1
Oryza sativa (rice)	Os04g0435500	NP_001052848.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.
Barneo-Mu?oz M, Ju?rez P, Civera-Treg?n A, Yndriago L, Pla-Martin D, Zenker J, Cuevas-Mart?n C, Estela A, S?nchez-Arag? M, Forteza-Vila J, Cuezva JM, Chrast R, Palau F
PLoS genetics11(4)e1005115(2015 Apr)

The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.
Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U
Brain : a journal of neurology137(Pt 3)668-82(2014 Mar)

Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P
Glia57(13)1450-7(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

absence of GDAP1 induces a peripheral neuropathy with loss of motor neurons, mitochondrial defects and abnormal calcium homeostasis.
Title: Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.

Members of the GDAP1 family are responsive and protective against stress associated with increased levels of oxidized glutathione.
Title: The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.

Cell expression of Gdap1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease are reported.
Title: Cell expression of GDAP1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease.

The following Gdap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05859	NM_010267.3 Latest version!	Mus musculus ganglioside-induced differentiation-associated-protein 1 (Gdap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdap1 ( NM_010267.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034397.1 Mus musculus ganglioside-induced differentiation-associated-protein 1 (Gdap1), mRNA.

Price & Availability↑

CloneID	OMu05859
Clone ID Related Accession (Same CDS sequence)	NM_010267.3
Accession Version	NM_010267.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	ganglioside-induced differentiation-associated protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK083814.1 and BC048177.1. On Apr 29, 2009 this sequence version replaced NM_010267.2. ##Evidence-Data-START## Transcript exon combination :: BC048177.1, SRR1660821.120841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGGA GGCAGGACGA GGCGCGGGCC GGTGTGCCCC TGAGGGTTGA AGGCCCGCCG 
GACAAGGAGG TCCACCTCAT TCTGTACCAC TGGACGCACT CCTTCAGCTC TCAAAAGGTG 
CGCTTGGTAA TTGCTGAAAA GGCACTGAAG TGCGAGGAAC ACGATGTAAG TCTGCCCCTG 
AGTGAGCACA ATGAGCCTTG GTTTATGCGC TTGAACTCAG CTGGAGAAGT ACCGGTCCTT 
GTCCACGGGG AGAACATAAT CTGTGAGGCC ACTCAGATCA TTGATTATCT TGAGCAGACT 
TTCCTGGATG AAAGAACACC CAGGTTAATG CCCGATGAAG GAAGCATGTA TTACCCACGG 
GTGCAGCATT ACCGAGAGCT TCTTGACTCC TTGCCAATGG ATGCTTACAC ACATGGCTGC 
ATTTTGCATC CTGAGCTCAC TGTGGATTCC ATGATCCCCG CTTATGCAAC CACAAGGATT 
CGCAGCCAGA TTGGTAACAC AGAGTCTGAA CTAAAGAAAC TTGCTGAAGA AAACCCTGAC 
TTACAAGAGG CATACATTGC CAAACAGAAG CGACTTAAGT CAAAGCTGCT TGATCATGAC 
AATGTCAAAT ACTTGAAGAA AATTCTTGAT GAGTTGGAGA AGGTCTTGGA TCAGGTGGAA 
ACTGAATTAC AAAGAAGAAA TGAGGAAACT CCAGAGGAGG GCAACCAGCC TTGGCTCTGT 
GGAGAATCCT TTACACTGGC AGATGTCTCA CTGGCTGTCA CATTGCATCG GCTGAAGTTC 
CTGGGGTTTG CAAGACGAAA CTGGGGACAT GGAAAGAGAC CGAACTTGGA AACCTATTAT 
GAGCGTGTCT TGAAGAGAAA AACATTTAAC AAGGTTTTAG GACATGTCAA CAATATATTA 
ATCTCTGCGG TGCTGCCAAC AGCATTCCGG GTGGCCAAAA AAAGGGCCCC AAAAGTTCTT 
GGCAGCACCC TTGTGGTTGG TTTGCTTGTA GGAATGGGAT ATTTTGCATT TATGCTTTTC 
AGAAGGAGAC TTGGCAGCAT GATATTAGCA CTTAGACCCA GACCAAATTA TTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034397.1
CDS	100..1176
Translation	MARRQDEARAGVPLRVEGPPDKEVHLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSAGEVPVLVHGENIICEATQIIDYLEQTFLDERTPRLMPDEGSMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEETPEEGNQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGHGKRPNLETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGSTLVVGLLVGMGYFAFMLFRRRLGSMILALRPRPNYF

Target ORF information:

RefSeq Version	NM_010267.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ganglioside-induced differentiation-associated-protein 1 (Gdap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010267.3

ORF Insert Sequence:

ATGGCTCGGA GGCAGGACGA GGCGCGGGCC GGTGTGCCCC TGAGGGTTGA AGGCCCGCCG 
GACAAGGAGG TCCACCTCAT TCTGTACCAC TGGACGCACT CCTTCAGCTC TCAAAAGGTG 
CGCTTGGTAA TTGCTGAAAA GGCACTGAAG TGCGAGGAAC ACGATGTAAG TCTGCCCCTG 
AGTGAGCACA ATGAGCCTTG GTTTATGCGC TTGAACTCAG CTGGAGAAGT ACCGGTCCTT 
GTCCACGGGG AGAACATAAT CTGTGAGGCC ACTCAGATCA TTGATTATCT TGAGCAGACT 
TTCCTGGATG AAAGAACACC CAGGTTAATG CCCGATGAAG GAAGCATGTA TTACCCACGG 
GTGCAGCATT ACCGAGAGCT TCTTGACTCC TTGCCAATGG ATGCTTACAC ACATGGCTGC 
ATTTTGCATC CTGAGCTCAC TGTGGATTCC ATGATCCCCG CTTATGCAAC CACAAGGATT 
CGCAGCCAGA TTGGTAACAC AGAGTCTGAA CTAAAGAAAC TTGCTGAAGA AAACCCTGAC 
TTACAAGAGG CATACATTGC CAAACAGAAG CGACTTAAGT CAAAGCTGCT TGATCATGAC 
AATGTCAAAT ACTTGAAGAA AATTCTTGAT GAGTTGGAGA AGGTCTTGGA TCAGGTGGAA 
ACTGAATTAC AAAGAAGAAA TGAGGAAACT CCAGAGGAGG GCAACCAGCC TTGGCTCTGT 
GGAGAATCCT TTACACTGGC AGATGTCTCA CTGGCTGTCA CATTGCATCG GCTGAAGTTC 
CTGGGGTTTG CAAGACGAAA CTGGGGACAT GGAAAGAGAC CGAACTTGGA AACCTATTAT 
GAGCGTGTCT TGAAGAGAAA AACATTTAAC AAGGTTTTAG GACATGTCAA CAATATATTA 
ATCTCTGCGG TGCTGCCAAC AGCATTCCGG GTGGCCAAAA AAAGGGCCCC AAAAGTTCTT 
GGCAGCACCC TTGTGGTTGG TTTGCTTGTA GGAATGGGAT ATTTTGCATT TATGCTTTTC 
AGAAGGAGAC TTGGCAGCAT GATATTAGCA CTTAGACCCA GACCAAATTA TTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.
PLoS genetics11(4)e1005115(2015 Apr)
Barneo-Mu?oz M,Ju?rez P,Civera-Treg?n A,Yndriago L,Pla-Martin D,Zenker J,Cuevas-Mart?n C,Estela A,S?nchez-Arag? M,Forteza-Vila J,Cuezva JM,Chrast R,Palau F

The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.
Brain : a journal of neurology137(Pt 3)668-82(2014 Mar)
Niemann A,Huber N,Wagner KM,Somandin C,Horn M,Lebrun-Julien F,Angst B,Pereira JA,Halfter H,Welzl H,Feltri ML,Wrabetz L,Young P,Wessig C,Toyka KV,Suter U

Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
Glia57(13)1450-7(2009 Oct)
Coulpier F,Le Crom S,Maro GS,Manent J,Giovannini M,Maciorowski Z,Fischer A,Gessler M,Charnay P,Topilko P

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Gdap1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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