Galnt3 cDNA ORF clone, Mus musculus(house mouse)

A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.
Ichikawa S, Gerard-O'Riley RL, Acton D, McQueen AK, Strobel IE, Witcher PC, Feng JQ, Econs MJ
Endocrinology158(3)470-476(2017 03)

Galnt1 is required for normal heart valve development and cardiac function.
Tian E, Stevens SR, Guan Y, Springer DA, Anderson SA, Starost MF, Patel V, Ten Hagen KG, Tabak LA
PloS one10(1)e0115861(2015)

Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse.
Ichikawa S, Gray AK, Padgett LR, Allen MR, Clinkenbeard EL, Sarpa NM, White KE, Econs MJ
Endocrinology155(10)3891-8(2014 Oct)

Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression.
Ichikawa S, Sorenson AH, Austin AM, Mackenzie DS, Fritz TA, Moh A, Hui SL, Econs MJ
Endocrinology150(6)2543-50(2009 Jun)

The stabilized Fgf23-Autosomal dominant hypophosphatemic rickets allele reversed the Galnt3-null phenotype and normalized total Fgf23, serum phosphorus, and bone Fgf23 mRNA.
Title: Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse.

Overexpression of Galnt3 in chondrocytes causes dwarfism due to the increase of mucin-type O-glycans and a reduction in chondroitin sulfates.
Title: Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

The deficiency of Galnt3 results in a severe reduction of mucin-type O-glycans in spermatids and causes impaired acrosome formation, leading to oligoasthenoteratozoospermia, and Galnt3 may also be involved in the process of fertilization.
Title: Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia.

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
Title: A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.

dietary phosphate restriction normalizes biochemical and skeletal phenotypes of Galnt3 knockout mice and, thus, can be an effective therapy for tumoral calcinosis.
Title: Dietary phosphate restriction normalizes biochemical and skeletal abnormalities in a murine model of tumoral calcinosis.