Frat1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Frat1
Entrez Gene ID	14296
Full Name	frequently rearranged in advanced T cell lymphomas
Synonyms	AW060382
General protein information	Preferred Names frequently rearranged in advanced T cell lymphomas Names proto-oncogene FRAT1 frequently rearranged in advanced T-cell lymphomas 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C3\|19 35.3 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008043.3	NP_032069.2	proto-oncogene FRAT1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Frat1	NP_032069.2
	FRAT1	XP_001101995.1
Bos taurus (cattle)	FRAT1	XP_002698461.1
Pan troglodytes (chimpanzee)	FRAT1	XP_521571.1
Canis lupus familiaris (dog)	FRAT1	XP_005637927.1
Rattus norvegicus (Norway rat)	Peg12	NP_001164033.1
Homo sapiens (human)	FRAT1	NP_005470.2

Gene Ontology
Bibliography

Related articles in PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3? subcellular localization in pluripotent cells.
Bechard M, Trost R, Singh AM, Dalton S
Molecular and cellular biology32(2)288-96(2012 Jan)

Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
van Amerongen R, Nawijn MC, Lambooij JP, Proost N, Jonkers J, Berns A
Oncogene29(1)93-104(2010 Jan)

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU
Investigative ophthalmology & visual science50(10)4794-806(2009 Oct)

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.
Hay E, Faucheu C, Suc-Royer I, Touitou R, Stiot V, Vayssi?re B, Baron R, Roman-Roman S, Rawadi G
The Journal of biological chemistry280(14)13616-23(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.
Title: Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3? subcellular localization in pluripotent cells.

Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
Title: Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.

Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3.
Title: Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

FRAT has a role in mediating GSK-3 nuclear export in mouse cells
Title: The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.

The following Frat1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Frat1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58592	NM_008043.3 Latest version!	Mus musculus frequently rearranged in advanced T cell lymphomas (Frat1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Frat1 ( NM_008043.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032069.2 Mus musculus frequently rearranged in advanced T cell lymphomas (Frat1), mRNA.

Price & Availability↑

CloneID	OMu58592
Clone ID Related Accession (Same CDS sequence)	NM_008043.3
Accession Version	NM_008043.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	proto-oncogene FRAT1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC145557.3. On Oct 21, 2009 this sequence version replaced NM_008043.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGCCTTGCC GGAGGGAGGA GGAGGAGGAA GCCGGCGACG AGGCGGAGGG GGAGGAGGAC 
GACGACAGCT TCCTCCTGCT GCAGCAGTCG GTGACTCTGG GTGGCTCGAC CGACGTGGAC 
CAGCTCATCG TCCAGATCGG CGAGACGCTG CAGCTGGACG CAGCGCACGA TCGCCCGGCC 
TCGCCGTGTG CCGCCCCGGG TCCCCCGCCC CCGCAGGTCC TGGCGGCGCT GCCGGCGGAC 
AAGACCGGGA CCCCAGCTAG GAGGCTGCTG CGGCCGACGG GGTCAGCGGA GACCGGGAAC 
CCTGCGCCCC CGGGGGCCGT GCGCTGCGTG CTAGGGGAGC GCGGGCGCGT GCGGGGACGG 
TCGGCGCCCT ACTGCGTGGC GGAGATCTCC CCCGGCGCCA GCGCGCTGCC CCAGCAGCCG 
GGCCTTGACG GACCCCCGGG GACCGGCAAA CTAAGCACCC CGCAGCCACT GTCGGGCCCG 
TGCCGCCGGG GTTGGCTCCG GAACGCAGCC GCGTCCCGCC GCTTGCAACA GCGACGCGGA 
TCTCAGCCGG AGACCCGCAC TGGCGACGAC GACGACCCGC ACCGGCTCCT GCAGCAGCTC 
GTGCTCTCGG GAAACCTCAT CAAGGAGGCG GTGCGCAGAC TTCATTCGCG ACAGCTACAG 
TTACACGCAA AGCTTCCCGC ACACCCGTTC CTCGGGCCTC TGTCAGCCCC AGTGCATGAG 
CCGCCTTCGC CCGGGAGCCC TCGCGCGGCC TGCAGCGACC CTGGCGCTTT CATGGGGAGG 
GCGCAGCTCA GAACTGGGGA CGACCTTCTT GTCCCTGGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032069.2
CDS	199..1023
Translation	MPCRREEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHDRPASPCAAPGPPPPQVLAALPADKTGTPARRLLRPTGSAETGNPAPPGAVRCVLGERGRVRGRSAPYCVAEISPGASALPQQPGLDGPPGTGKLSTPQPLSGPCRRGWLRNAAASRRLQQRRGSQPETRTGDDDDPHRLLQQLVLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGPLSAPVHEPPSPGSPRAACSDPGAFMGRAQLRTGDDLLVPGS

Target ORF information:

RefSeq Version	NM_008043.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus frequently rearranged in advanced T cell lymphomas (Frat1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008043.3

ORF Insert Sequence:

ATGCCTTGCC GGAGGGAGGA GGAGGAGGAA GCCGGCGACG AGGCGGAGGG GGAGGAGGAC 
GACGACAGCT TCCTCCTGCT GCAGCAGTCG GTGACTCTGG GTGGCTCGAC CGACGTGGAC 
CAGCTCATCG TCCAGATCGG CGAGACGCTG CAGCTGGACG CAGCGCACGA TCGCCCGGCC 
TCGCCGTGTG CCGCCCCGGG TCCCCCGCCC CCGCAGGTCC TGGCGGCGCT GCCGGCGGAC 
AAGACCGGGA CCCCAGCTAG GAGGCTGCTG CGGCCGACGG GGTCAGCGGA GACCGGGAAC 
CCTGCGCCCC CGGGGGCCGT GCGCTGCGTG CTAGGGGAGC GCGGGCGCGT GCGGGGACGG 
TCGGCGCCCT ACTGCGTGGC GGAGATCTCC CCCGGCGCCA GCGCGCTGCC CCAGCAGCCG 
GGCCTTGACG GACCCCCGGG GACCGGCAAA CTAAGCACCC CGCAGCCACT GTCGGGCCCG 
TGCCGCCGGG GTTGGCTCCG GAACGCAGCC GCGTCCCGCC GCTTGCAACA GCGACGCGGA 
TCTCAGCCGG AGACCCGCAC TGGCGACGAC GACGACCCGC ACCGGCTCCT GCAGCAGCTC 
GTGCTCTCGG GAAACCTCAT CAAGGAGGCG GTGCGCAGAC TTCATTCGCG ACAGCTACAG 
TTACACGCAA AGCTTCCCGC ACACCCGTTC CTCGGGCCTC TGTCAGCCCC AGTGCATGAG 
CCGCCTTCGC CCGGGAGCCC TCGCGCGGCC TGCAGCGACC CTGGCGCTTT CATGGGGAGG 
GCGCAGCTCA GAACTGGGGA CGACCTTCTT GTCCCTGGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3? subcellular localization in pluripotent cells.
Molecular and cellular biology32(2)288-96(2012 Jan)
Bechard M,Trost R,Singh AM,Dalton S

Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
Oncogene29(1)93-104(2010 Jan)
van Amerongen R,Nawijn MC,Lambooij JP,Proost N,Jonkers J,Berns A

Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Investigative ophthalmology & visual science50(10)4794-806(2009 Oct)
Martinez G,Wijesinghe M,Turner K,Abud HE,Taketo MM,Noda T,Robinson ML,de Iongh RU

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.
The Journal of biological chemistry280(14)13616-23(2005 Apr)
Hay E,Faucheu C,Suc-Royer I,Touitou R,Stiot V,Vayssi?re B,Baron R,Roman-Roman S,Rawadi G

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Frat1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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