Il4i1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il4i1
Entrez Gene ID	14204
Full Name	interleukin 4 induced 1
Synonyms	Fig1,Fig1-ps,LAAO,LAO
General protein information	Preferred Names interleukin 4 induced 1 Names L-amino-acid oxidase IL4-induced protein 1 interleukin-4-induced protein 1 interleukin-four induced gene 1 interleukin-four induced gene-1 protein interleukin-four induced protein-1 protein Fig-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.93 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010215.3	NP_034345.2	L-amino-acid oxidase precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL4I1	NP_758962.1
Canis lupus familiaris (dog)	IL4I1	XP_005616339.1
Neurospora crassa	NCU01066	XP_961678.1
Pan troglodytes (chimpanzee)	IL4I1	XP_003316599.2
Danio rerio (zebrafish)	si:dkey-40g16.6	XP_003200080.1
Mus musculus (house mouse)	Il4i1	NP_034345.2
Rattus norvegicus (Norway rat)	LOC100360621	XP_006229255.1
	IL4I1	XP_001115764.1
Mus musculus (house mouse)	Nup62-il4i1	NP_001164495.1
Magnaporthe oryzae (rice blast fungus)	MGG_16373	XP_003710351.1
Xenopus tropicalis (tropical clawed frog)	LOC100493881	XP_002937668.2

Gene Ontology
Bibliography

Related articles in PubMed

IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation.
Bod L, Douguet L, Auffray C, Lengagne R, Bekkat F, Rondeau E, Molinier-Frenkel V, Castellano F, Richard Y, Pr?vost-Blondel A
Journal of immunology (Baltimore, Md. : 1950)200(3)1027-1038(2018 Feb)

IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.
Psachoulia K, Chamberlain KA, Heo D, Davis SE, Paskus JD, Nanescu SE, Dupree JL, Wynn TA, Huang JK
Brain : a journal of neurology139(Pt 12)3121-3136(2016 Dec)

The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
Cousin C, Aubatin A, Le Gouvello S, Apetoh L, Castellano F, Molinier-Frenkel V
European journal of immunology45(6)1772-82(2015 Jun)

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.
Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, Zheng M, Cai Z, Lu L, Wang J
PloS one10(11)e0142979(2015)

IL4I1: an inhibitor of the CD8? antitumor T-cell response in vivo.
Lasoudris F, Cousin C, Prevost-Blondel A, Martin-Garcia N, Abd-Alsamad I, Ortonne N, Farcet JP, Castellano F, Molinier-Frenkel V
European journal of immunology41(6)1629-38(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL4I1 promotes central nervous system remyelination and axonal integrity.
Title: IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.

our findings indicate that IL4I1 promotes an enhanced M2 functional phenotype.
Title: IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.

inhibits CD8+ antitumor T-cell response in vivo
Title: IL4I1: an inhibitor of the CD8? antitumor T-cell response in vivo.

The H46 locus on chromosome 7 was found to encode the interleukin 4-induced IL4i1 gene.
Title: Second class minors: molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by major histocompatibility complex class II molecules.

The following Il4i1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il4i1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05766	NM_010215.3 Latest version!	Mus musculus interleukin 4 induced 1 (Il4i1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il4i1 ( NM_010215.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034345.2 Mus musculus interleukin 4 induced 1 (Il4i1), mRNA.

Price & Availability↑

CloneID	OMu05766
Clone ID Related Accession (Same CDS sequence)	NM_010215.3
Accession Version	NM_010215.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	L-amino-acid oxidase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK151731.1, AK150582.1 and U70429.1. On Jul 22, 2009 this sequence version replaced NM_010215.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U70429.1, AK151731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGGGC TGGCCCTGCG TCTTGTCCTG GCGGCCACCC TCCTTGGTCT GGCAGGCTCT 
CTGGACTGGA AGGCAGCCTC CAGCTTGAAC CCTATTGAGA AGTGTATGGA GGACCACGAT 
TATGAGCAGC TACTCAAGGT GGTGACCTTG GGCCTCAATC GGACTTCGAA GCCCCAGAAG 
GTGGTAGTGG TTGGTGCAGG CGTGGCAGGG CTGGTAGCAG CCAAGATGCT CAGTGATGCA 
GGACACAAGG TCACCATCCT GGAGGCAGAT AACAGGATTG GGGGCCGTAT CTTCACTTTC 
CGGGATGAGA AGACAGGCTG GATAGGGGAG CTTGGGGCCA TGCGAATGCC CAGCTCTCAC 
AGGATCTTGC ACAAGCTCTG CAGGACCCTG GGCCTCAACC TGACTCAGTT CACACAGTAT 
GATGAGAACA CGTGGACGGA GGTGCATAAT GTGAAGCTGC GAAACTATGT GGTGGAGAAG 
ATGCCAGAAA AGCTGGGCTA CAACCTGAAC AACAGGGAAA GGGGCCATTC CCCAGAGGAC 
ATCTACCAGA TGGCACTCAA CAAGGCCTTC AAAGACCTCA AGGCCTTGGG CTGCAAGAAA 
GCCATGAATA AGTTCAACAA GCATACGCTT CTGGAATACC TCCTCGAGGA GGGCAACCTG 
TCCCGGCCGG CTGTGCAGCT CCTGGGAGAT GTGATGTCCG AGGAGGGCTT CTTCTACCTC 
AGCTTTGCAG AAGCCTTACG TGCGCACGCC TGCCTGAGCG ATAGACTCCG GTACAGCCGC 
ATCGTAGGTG GCTGGGACCT GCTTCCGCGA GCTCTGCTGA GCTCACTGTC CGGGGCGCTG 
CTACTGAACG CGCCTGTGGT GTCGATCACT CAGGGGAGGA ACGATGTGCG CGTGCACATT 
GCCACCTCGC TTCACAGCGA GAAGACGCTG ACAGCCGACG TGGTGCTGCT GACTGCCAGT 
GGACCCGCGC TGCAGCGCAT TACCTTCTCG CCGCCCTTGA CTCGCAAGAG GCAGGAGGCA 
CTGCGCGCGC TTCACTACGT AGCAGCCAGC AAGGTTTTTC TGAGTTTCCG TCGGCCCTTC 
TGGCACGAGG AGCACATCGA GGGCGGCCAC TCCAACACTG ACCGCCCATC GCGCCTCATA 
TTCTATCCCG CGCAGGGCGA GGGCTCACTG CTTCTGGCCT CCTACACGTG GTCGGACGCT 
GCAGCCCCCT TCGCTGGACT GAGCACCGAC CAGACCCTGC GTTTGGTGCT CCAGGACGTG 
GCGGCCCTGC ACGGGCCTGT GGTGTTCCGG CTGTGGGACG GCAGGGGTGT GGTCAAGCGC 
TGGGCAGAGG ACCCGCATAG CCAGGGAGGC TTCGTGGTGC AGCCGCCATT GTACGGGCGC 
GAGGCTGAGG ACTATGACTG GTCAGCCCCC TTCGGCCGCA TTTACTTCGC GGGCGAGCAC 
ACAGCTCTCC CGCATGGCTG GGTAGAGACC GCTGTCAAGT CCGGGTTGCG GGCCGCGGTG 
AGAATCAATA ATAACTATGG GTACGGGGAG GTCGACCCCC AGATGATGGA GCATGCATAT 
GCAGAGGCCA ACTATCTGGA CCAGTATCCT GAAGGGGAGA GGCCCGAGGA GCAGCAGGCG 
CGGGAAGAAG TCAGCCCAGA TGAACAGGAG CCCTCTCACA AACACTTGTT GGTGGAAACG 
AGCCCCGAGG GGCAGCAACA CGCGTTTGTG GAGGCCATTC CCGAGCTGCA GGGACACGTG 
TTCGTGGAGA CTGTCCCCCA GGAGAAGGGG CACGCCCACC AGAATATATA TCCTTCGGAG 
CATGTACAGG TGCATGGGGA AGTCATCCCT GAGTGGCATG GTCATGGGGG ATCTGGCACC 
CCGCAAATGC ACCGAGTGGG GGACCACTCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034345.2
CDS	51..1943
Translation	MAGLALRLVLAATLLGLAGSLDWKAASSLNPIEKCMEDHDYEQLLKVVTLGLNRTSKPQKVVVVGAGVAGLVAAKMLSDAGHKVTILEADNRIGGRIFTFRDEKTGWIGELGAMRMPSSHRILHKLCRTLGLNLTQFTQYDENTWTEVHNVKLRNYVVEKMPEKLGYNLNNRERGHSPEDIYQMALNKAFKDLKALGCKKAMNKFNKHTLLEYLLEEGNLSRPAVQLLGDVMSEEGFFYLSFAEALRAHACLSDRLRYSRIVGGWDLLPRALLSSLSGALLLNAPVVSITQGRNDVRVHIATSLHSEKTLTADVVLLTASGPALQRITFSPPLTRKRQEALRALHYVAASKVFLSFRRPFWHEEHIEGGHSNTDRPSRLIFYPAQGEGSLLLASYTWSDAAAPFAGLSTDQTLRLVLQDVAALHGPVVFRLWDGRGVVKRWAEDPHSQGGFVVQPPLYGREAEDYDWSAPFGRIYFAGEHTALPHGWVETAVKSGLRAAVRINNNYGYGEVDPQMMEHAYAEANYLDQYPEGERPEEQQAREEVSPDEQEPSHKHLLVETSPEGQQHAFVEAIPELQGHVFVETVPQEKGHAHQNIYPSEHVQVHGEVIPEWHGHGGSGTPQMHRVGDHS

Target ORF information:

RefSeq Version	NM_010215.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 4 induced 1 (Il4i1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010215.3

ORF Insert Sequence:

ATGGCTGGGC TGGCCCTGCG TCTTGTCCTG GCGGCCACCC TCCTTGGTCT GGCAGGCTCT 
CTGGACTGGA AGGCAGCCTC CAGCTTGAAC CCTATTGAGA AGTGTATGGA GGACCACGAT 
TATGAGCAGC TACTCAAGGT GGTGACCTTG GGCCTCAATC GGACTTCGAA GCCCCAGAAG 
GTGGTAGTGG TTGGTGCAGG CGTGGCAGGG CTGGTAGCAG CCAAGATGCT CAGTGATGCA 
GGACACAAGG TCACCATCCT GGAGGCAGAT AACAGGATTG GGGGCCGTAT CTTCACTTTC 
CGGGATGAGA AGACAGGCTG GATAGGGGAG CTTGGGGCCA TGCGAATGCC CAGCTCTCAC 
AGGATCTTGC ACAAGCTCTG CAGGACCCTG GGCCTCAACC TGACTCAGTT CACACAGTAT 
GATGAGAACA CGTGGACGGA GGTGCATAAT GTGAAGCTGC GAAACTATGT GGTGGAGAAG 
ATGCCAGAAA AGCTGGGCTA CAACCTGAAC AACAGGGAAA GGGGCCATTC CCCAGAGGAC 
ATCTACCAGA TGGCACTCAA CAAGGCCTTC AAAGACCTCA AGGCCTTGGG CTGCAAGAAA 
GCCATGAATA AGTTCAACAA GCATACGCTT CTGGAATACC TCCTCGAGGA GGGCAACCTG 
TCCCGGCCGG CTGTGCAGCT CCTGGGAGAT GTGATGTCCG AGGAGGGCTT CTTCTACCTC 
AGCTTTGCAG AAGCCTTACG TGCGCACGCC TGCCTGAGCG ATAGACTCCG GTACAGCCGC 
ATCGTAGGTG GCTGGGACCT GCTTCCGCGA GCTCTGCTGA GCTCACTGTC CGGGGCGCTG 
CTACTGAACG CGCCTGTGGT GTCGATCACT CAGGGGAGGA ACGATGTGCG CGTGCACATT 
GCCACCTCGC TTCACAGCGA GAAGACGCTG ACAGCCGACG TGGTGCTGCT GACTGCCAGT 
GGACCCGCGC TGCAGCGCAT TACCTTCTCG CCGCCCTTGA CTCGCAAGAG GCAGGAGGCA 
CTGCGCGCGC TTCACTACGT AGCAGCCAGC AAGGTTTTTC TGAGTTTCCG TCGGCCCTTC 
TGGCACGAGG AGCACATCGA GGGCGGCCAC TCCAACACTG ACCGCCCATC GCGCCTCATA 
TTCTATCCCG CGCAGGGCGA GGGCTCACTG CTTCTGGCCT CCTACACGTG GTCGGACGCT 
GCAGCCCCCT TCGCTGGACT GAGCACCGAC CAGACCCTGC GTTTGGTGCT CCAGGACGTG 
GCGGCCCTGC ACGGGCCTGT GGTGTTCCGG CTGTGGGACG GCAGGGGTGT GGTCAAGCGC 
TGGGCAGAGG ACCCGCATAG CCAGGGAGGC TTCGTGGTGC AGCCGCCATT GTACGGGCGC 
GAGGCTGAGG ACTATGACTG GTCAGCCCCC TTCGGCCGCA TTTACTTCGC GGGCGAGCAC 
ACAGCTCTCC CGCATGGCTG GGTAGAGACC GCTGTCAAGT CCGGGTTGCG GGCCGCGGTG 
AGAATCAATA ATAACTATGG GTACGGGGAG GTCGACCCCC AGATGATGGA GCATGCATAT 
GCAGAGGCCA ACTATCTGGA CCAGTATCCT GAAGGGGAGA GGCCCGAGGA GCAGCAGGCG 
CGGGAAGAAG TCAGCCCAGA TGAACAGGAG CCCTCTCACA AACACTTGTT GGTGGAAACG 
AGCCCCGAGG GGCAGCAACA CGCGTTTGTG GAGGCCATTC CCGAGCTGCA GGGACACGTG 
TTCGTGGAGA CTGTCCCCCA GGAGAAGGGG CACGCCCACC AGAATATATA TCCTTCGGAG 
CATGTACAGG TGCATGGGGA AGTCATCCCT GAGTGGCATG GTCATGGGGG ATCTGGCACC 
CCGCAAATGC ACCGAGTGGG GGACCACTCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation.
Journal of immunology (Baltimore, Md. : 1950)200(3)1027-1038(2018 Feb)
Bod L,Douguet L,Auffray C,Lengagne R,Bekkat F,Rondeau E,Molinier-Frenkel V,Castellano F,Richard Y,Pr?vost-Blondel A

IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.
Brain : a journal of neurology139(Pt 12)3121-3136(2016 Dec)
Psachoulia K,Chamberlain KA,Heo D,Davis SE,Paskus JD,Nanescu SE,Dupree JL,Wynn TA,Huang JK

The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology45(6)1772-82(2015 Jun)
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.
PloS one10(11)e0142979(2015)
Yue Y,Huang W,Liang J,Guo J,Ji J,Yao Y,Zheng M,Cai Z,Lu L,Wang J

IL4I1: an inhibitor of the CD8? antitumor T-cell response in vivo.
European journal of immunology41(6)1629-38(2011 Jun)
Lasoudris F,Cousin C,Prevost-Blondel A,Martin-Garcia N,Abd-Alsamad I,Ortonne N,Farcet JP,Castellano F,Molinier-Frenkel V

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Il4i1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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