Fhl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fhl2
Entrez Gene ID	14200
Full Name	four and a half LIM domains 2
Synonyms	FHL-2,SLIM-3,SLIM3
General protein information	Preferred Names four and a half LIM domains 2 Names four and a half LIM domains protein 2 skeletal muscle LIM-protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 B
Summary	This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_011238434.2	XP_011236736.1	four and a half LIM domains protein 2 isoform X1
NM_010212.4	NP_034342.1	four and a half LIM domains protein 2
NM_001289533.1	NP_001276462.1	four and a half LIM domains protein 2
XM_011238434.3	XP_011236736.1	four and a half LIM domains protein 2 isoform X1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Lmpt	NP_996110.1
Xenopus tropicalis (tropical clawed frog)	fhl2	NP_001120233.1
Danio rerio (zebrafish)	fhl2a	NP_001003732.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005400	XP_315409.2
Canis lupus familiaris (dog)	FHL2	XP_005626045.1
Rattus norvegicus (Norway rat)	Fhl2	NP_113865.1
Danio rerio (zebrafish)	fhl2b	NP_001006028.2
Caenorhabditis elegans (roundworm)	lim-9	NP_001021410.2
Homo sapiens (human)	FHL2	NP_001034581.1
Pan troglodytes (chimpanzee)	FHL2	XP_530486.3
	FHL2	XP_001109260.1
Bos taurus (cattle)	FHL2	NP_001039511.1
Mus musculus (house mouse)	Fhl2	NP_034342.1
Gallus gallus (chicken)	FHL2	XP_004938568.1

Gene Ontology
Bibliography

Related articles in PubMed

The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release.
Leite Dantas R, Brachvogel B, Schied T, Bergmeier V, Skryabin B, Vogl T, Ludwig S, Wixler V
The American journal of pathology187(11)2388-2398(2017 Nov)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor ?1 Expression.
Dahan J, Levillayer F, Xia T, Nou?t Y, Werts C, Fanton d'Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y
Molecular and cellular biology37(10)(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF
Title: The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release.

Loss of FHL2 is associated with liver fibrosis.
Title: LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor ?1 Expression.

FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription.
Title: The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription.

FHL2 might interact with Runx2 to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation.
Title: FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2.

loss of Fhl2 leads to an altered immune response to myocardial ischemia, which results in smaller infarcts and better hemodynamic performance up to 21 days after myocardial ischemia reperfusion.
Title: Loss of the LIM-only protein Fhl2 impairs inflammatory reaction and scar formation after cardiac ischemia leading to better hemodynamic performance.

The following Fhl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fhl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19782	NM_010212.4 Latest version!	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu19782	NM_001289533.1 Latest version!	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu19782	XM_011238434.3 Latest version!	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu19782	XM_011238434.2	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fhl2 ( NM_010212.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034342.1 Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19782
Clone ID Related Accession (Same CDS sequence)	XM_011238434.2 , NM_010212.4 , NM_001289533.1 , XM_011238434.3
Accession Version	NM_010212.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	four and a half LIM domains protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK147024.1 and AC161207.4. On Jan 24, 2014 this sequence version replaced NM_010212.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147024.1, AK133708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034342.1
CDS	284..1123
Translation	MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI

Target ORF information:

RefSeq Version	NM_010212.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010212.4

ORF Insert Sequence:

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fhl2 ( NM_001289533.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276462.1 Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19782
Clone ID Related Accession (Same CDS sequence)	XM_011238434.2 , NM_010212.4 , NM_001289533.1 , XM_011238434.3
Accession Version	NM_001289533.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	four and a half LIM domains protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK052936.1, AK147024.1 and AC161207.4. On Jan 24, 2014 this sequence version replaced XM_006495696.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK052936.1, CA787058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276462.1
CDS	135..974
Translation	MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI

Target ORF information:

RefSeq Version	NM_001289533.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289533.1

ORF Insert Sequence:

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fhl2 ( XM_011238434.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011236736.1 Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19782
Clone ID Related Accession (Same CDS sequence)	XM_011238434.2 , NM_010212.4 , NM_001289533.1 , XM_011238434.3
Accession Version	XM_011238434.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	four and a half LIM domains protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011238434.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011236736.1
CDS	49..888
Translation	MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI

Target ORF information:

RefSeq Version	XM_011238434.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011238434.2

ORF Insert Sequence:

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fhl2 ( XM_011238434.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011236736.1 Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19782
Clone ID Related Accession (Same CDS sequence)	XM_011238434.2 , NM_010212.4 , NM_001289533.1 , XM_011238434.3
Accession Version	XM_011238434.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	four and a half LIM domains protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011238434.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011236736.1
CDS	93..932
Translation	MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI

Target ORF information:

RefSeq Version	XM_011238434.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus four and a half LIM domains 2 (Fhl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011238434.3

ORF Insert Sequence:

ATGACTGAAC GCTTTGACTG CCACCACTGC AATGAATCTC TGTACGGCAA GAAGTACATT 
CTAAAGGAGG AGAACCCACA CTGTGTGGCC TGCTTTGAGG AACTCTATGC CAATACCTGT 
GAGGAGTGTG GAACACCCAT CGGCTGCGAC TGCAAGGACT TGTCCTACAA GGATCGGCAC 
TGGCATGAAG GCTGCTTCCA TTGCTCCCGG TGTGGAAGCT CGCTGGTGGA CAAGCCCTTT 
GCTGCCAAGG AGGAACAGCT GCTGTGCACC GACTGCTATT CCAATGAATA CTCGTCCAAG 
TGCCAGGAAT GCAAGAAAAC CATCATGCCA GGTACCCGCA AGATGGAATA CAAGGGCAGC 
AGCTGGCACG AGACCTGCTT CACCTGTCAG CGCTGCCAGC AGCCCATTGG AACCAAGAGC 
TTCATACCTA AGGAGAATCA GAACTTCTGC GTGCCCTGCT ATGAGAAGCA GTATGCCCTG 
CAGTGCGTGC AGTGCAAAAA GCCTATCACC ACAGGAGGTG TTACTTACCG GGAGCAGCCC 
TGGCACAAGG AATGCTTTGT GTGCACAGCC TGCAAGAAGC AGCTATCTGG GCAACGCTTC 
ACAGCACGGG ATGAGTTTCC ATACTGCCTG ACCTGCTTCT GTGACTTGTA CGCTAAGAAA 
TGTGCTGGGT GCACCAACCC CATTAGTGGT CTGGGTGGCA CAAAGTACAT CTCTTTCGAG 
GAACGCCAAT GGCACAACGA CTGCTTTAAC TGTAAGAAGT GCTCCCTGTC TCTGGTGGGA 
CGAGGCTTCC TCACAGAGAG AGATGACATC CTCTGTCCTG ACTGTGGAAA GGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release.
The American journal of pathology187(11)2388-2398(2017 Nov)
Leite Dantas R,Brachvogel B,Schied T,Bergmeier V,Skryabin B,Vogl T,Ludwig S,Wixler V

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor ?1 Expression.
Molecular and cellular biology37(10)(2017 May)
Dahan J,Levillayer F,Xia T,Nou?t Y,Werts C,Fanton d'Andon M,Adib-Conquy M,Cassard-Doulcier AM,Khanna V,Chen J,Tordjmann T,Buendia MA,Jouvion G,Wei Y

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Fhl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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