Fem1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fem1b
Entrez Gene ID	14155
Full Name	feminization 1 homolog b (C. elegans)
Synonyms	mKIAA0396
General protein information	Preferred Names feminization 1 homolog b (C. elegans) Names protein fem-1 homolog B F1A-alpha FEM1-beta fem-1-like death receptor-binding protein alpha fem-1-like in apoptotic pathway protein alpha mt-Fem
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 B\|9 33.87 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010193.4	NP_034323.1	protein fem-1 homolog B

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	FEM1B	NP_001025724.1
Danio rerio (zebrafish)	fem1b	XP_695502.4
Xenopus tropicalis (tropical clawed frog)	fem1b	NP_001238770.1
Homo sapiens (human)	FEM1B	NP_056137.1
Pan troglodytes (chimpanzee)	FEM1B	XP_523110.2
Bos taurus (cattle)	FEM1B	NP_001179312.1
Mus musculus (house mouse)	Fem1b	NP_034323.1
Rattus norvegicus (Norway rat)	Fem1b	NP_001101627.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007382	XP_308449.4
	FEM1B	XP_001083413.1
Canis lupus familiaris (dog)	FEM1B	XP_535526.3
Drosophila melanogaster (fruit fly)	Fem-1	NP_611508.1

Gene Ontology
Bibliography

Related articles in PubMed

Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37.
Shi YQ, Liao SY, Zhuang XJ, Han CS
Gene485(2)153-9(2011 Oct)

Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia.
Subauste MC, Ventura-Holman T, Lu D, Du L, Sansom OJ, Maher JF
Cancer epidemiology35(1)97-100(2011 Feb)

A genomic atlas of mouse hypothalamic development.
Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S
Nature neuroscience13(6)767-75(2010 Jun)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell stem cell5(4)420-33(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fem1b is a binding partner of Ankrd37, and their interaction resulted in Ankrd37 degradation through the ubiquitin-mediated proteolysis pathway.
Title: Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37.

Increased Fem1b is associated with intestinal neoplasia.
Title: Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia.

Fem1b may have a conserved role in the generation of sexual dimorphism through its interaction with Nkx3.1 in the developing prostate gland
Title: Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.

Fem1b is implicated in pancreatic islet function and insulin secretion
Title: Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.

neither FEM1B nor PHTF1 are directly implicated in apoptosis in testis tissue
Title: Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells.

The following Fem1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fem1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05708	NM_010193.4 Latest version!	Mus musculus fem 1 homolog b (Fem1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fem1b ( NM_010193.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034323.1 Mus musculus fem 1 homolog b (Fem1b), mRNA.

Price & Availability↑

CloneID	OMu05708
Clone ID Related Accession (Same CDS sequence)	NM_010193.4
Accession Version	NM_010193.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1884bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	protein fem-1 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ047815.1, AK149329.1, AK160393.1, AK122272.1 and AI854655.1. On Nov 15, 2007 this sequence version replaced NM_010193.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068236.1, SRR1660813.2592.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGGCC TGGCTGGCTA TGTGTACAAG GCGGCCAGCG AGGGCAAGGT GCTCACTCTG 
GCTGCCTTGC TCCTTAACCG GTCAGAGAGC GATATCCGCT ACCTGCTGGG CTATGTCAGT 
CAGCAGGGAG GACAGCGCTC CACACCCCTC ATCATCGCAG CCCGCAATGG GCACGCCAAG 
GTGGTGCGCT TGCTGTTAGA ACACTACCGT GTGCAGACCC AGCAGACCGG CACCGTCCGC 
TTCGACGGGT ATGTCATTGA CGGTGCCACT GCTCTTTGGT GTGCTGCGGG AGCCGGACAT 
TTTGAAGTTG TTAAACTTCT AGTCAGCCAT GGAGCCAACG TGAACCACAC CACAGTCACT 
AACTCAACTC CATTGCGGGC AGCATGCTTT GATGGCAGAC TGGACATTGT GAAATATTTG 
GTTGAAAATA ATGCCAATAT CAGCATTGCC AACAAGTATG ACAACACCTG CCTAATGATC 
GCAGCATATA AAGGGCACAC TGATGTGGTC AGATACCTCT TAGAACAACG TGCTGATCCC 
AATGCTAAAG CACACTGTGG AGCCACAGCT TTGCACTTTG CAGCCGAAGC TGGTCACATT 
GACATTGTGA AAGAACTGAT AAAATGGAGA GCTGCAATAG TGGTGAATGG CCATGGGATG 
ACACCATTGA AGGTGGCCGC TGAAAGCTGT AAAGCTGATG TCGTTGAACT GTTGCTCTCT 
CATGCTGATT GTGACCGCAG AAGTCGGATT GAAGCCTTGG AGCTCTTGGG TGCCTCCTTT 
GCAAATGATC GTGAGAACTA TGACATCATG AAGACATACC ACTATTTATA TTTAGCTATG 
TTGGAGAGAT TTCAGGATGG TGACAACATT CTTGAAAAAG AGGTTCTCCC ACCCATCCAT 
GCTTATGGGA ACAGAACTGA GTGTAGGAAC CCACAGGAAT TGGAGGCTAT TCGGCAAGAC 
AGAGATGCTC TTCACATGGA GGGCCTTATA GTTCGGGAAC GGATTTTAGG TGCTGACAAC 
ATTGATGTTT CCCACCCCAT CATTTACAGA GGGGCTGTCT ATGCTGATAA CATGGAGTTC 
GAGCAGTGCA TCAAATTGTG GCTCCACGCA CTACACCTGA GGCAGAAAGG TAACAGGAAT 
ACCCACAAAG ATCTGCTTCG GTTTGCTCAA GTCTTCTCTC AGATGATACA CCTCAATGAA 
GCTGTGAAGG CCCCAGACAT AGAGTGCGTT TTGAGATGCA GTGTCTTGGA AATAGAGCAG 
AGCATGAACA GAGTTAAAAA TATCTCCGAT GCCGACGTCC ACAGTGCCAT GGATAACTAT 
GAGTGTAACC TCTATACCTT TCTGTACCTC GTGTGCATCT CCACCAAGAC ACAGTGTAGC 
GAAGAAGATC AGTGCAGAAT TAACAAGCAG ATCTACAACC TGATTCACCT GGACCCCAGA 
ACACGGGAAG GTTTTTCCTT GCTACACCTG GCTGTCAACT CGAACACACC AGTTGATGAT 
TTCCATACTA ACGATGTCTG CAGCTTTCCC AACGCTCTGG TCACAAAGCT CCTGCTGGAC 
TGTGGCGCTG AGGTAAATGC AGTGGACAAT GAGGGGAACA GTGCCCTCCA CATTATCGTC 
CAGTACAACA GGCCCATCAG TGATTTTCTG ACCTTGCACT CCATCATCAT CAGCCTTGTG 
GAGGCTGGAG CTCACACCGA CATGACAAAC AAGCAGAATA AAACTCCGCT AGACAAAAGT 
ACAACTGGGG TGTCTGAAAT ACTACTTAAA ACTCAGATGA AGATGAGCCT CAAGTGCCTG 
GCTGCCCGAG CAGTTCGGGC TAATGACATT AACTACCAAG ACCAGATCCC CCGGACTCTT 
GAAGAGTTTG TTGGATTTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034323.1
CDS	344..2227
Translation	MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNEAVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHSAMDNYECNLYTFLYLVCISTKTQCSEEDQCRINKQIYNLIHLDPRTREGFSLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH

Target ORF information:

RefSeq Version	NM_010193.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fem 1 homolog b (Fem1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010193.4

ORF Insert Sequence:

ATGGAGGGCC TGGCTGGCTA TGTGTACAAG GCGGCCAGCG AGGGCAAGGT GCTCACTCTG 
GCTGCCTTGC TCCTTAACCG GTCAGAGAGC GATATCCGCT ACCTGCTGGG CTATGTCAGT 
CAGCAGGGAG GACAGCGCTC CACACCCCTC ATCATCGCAG CCCGCAATGG GCACGCCAAG 
GTGGTGCGCT TGCTGTTAGA ACACTACCGT GTGCAGACCC AGCAGACCGG CACCGTCCGC 
TTCGACGGGT ATGTCATTGA CGGTGCCACT GCTCTTTGGT GTGCTGCGGG AGCCGGACAT 
TTTGAAGTTG TTAAACTTCT AGTCAGCCAT GGAGCCAACG TGAACCACAC CACAGTCACT 
AACTCAACTC CATTGCGGGC AGCATGCTTT GATGGCAGAC TGGACATTGT GAAATATTTG 
GTTGAAAATA ATGCCAATAT CAGCATTGCC AACAAGTATG ACAACACCTG CCTAATGATC 
GCAGCATATA AAGGGCACAC TGATGTGGTC AGATACCTCT TAGAACAACG TGCTGATCCC 
AATGCTAAAG CACACTGTGG AGCCACAGCT TTGCACTTTG CAGCCGAAGC TGGTCACATT 
GACATTGTGA AAGAACTGAT AAAATGGAGA GCTGCAATAG TGGTGAATGG CCATGGGATG 
ACACCATTGA AGGTGGCCGC TGAAAGCTGT AAAGCTGATG TCGTTGAACT GTTGCTCTCT 
CATGCTGATT GTGACCGCAG AAGTCGGATT GAAGCCTTGG AGCTCTTGGG TGCCTCCTTT 
GCAAATGATC GTGAGAACTA TGACATCATG AAGACATACC ACTATTTATA TTTAGCTATG 
TTGGAGAGAT TTCAGGATGG TGACAACATT CTTGAAAAAG AGGTTCTCCC ACCCATCCAT 
GCTTATGGGA ACAGAACTGA GTGTAGGAAC CCACAGGAAT TGGAGGCTAT TCGGCAAGAC 
AGAGATGCTC TTCACATGGA GGGCCTTATA GTTCGGGAAC GGATTTTAGG TGCTGACAAC 
ATTGATGTTT CCCACCCCAT CATTTACAGA GGGGCTGTCT ATGCTGATAA CATGGAGTTC 
GAGCAGTGCA TCAAATTGTG GCTCCACGCA CTACACCTGA GGCAGAAAGG TAACAGGAAT 
ACCCACAAAG ATCTGCTTCG GTTTGCTCAA GTCTTCTCTC AGATGATACA CCTCAATGAA 
GCTGTGAAGG CCCCAGACAT AGAGTGCGTT TTGAGATGCA GTGTCTTGGA AATAGAGCAG 
AGCATGAACA GAGTTAAAAA TATCTCCGAT GCCGACGTCC ACAGTGCCAT GGATAACTAT 
GAGTGTAACC TCTATACCTT TCTGTACCTC GTGTGCATCT CCACCAAGAC ACAGTGTAGC 
GAAGAAGATC AGTGCAGAAT TAACAAGCAG ATCTACAACC TGATTCACCT GGACCCCAGA 
ACACGGGAAG GTTTTTCCTT GCTACACCTG GCTGTCAACT CGAACACACC AGTTGATGAT 
TTCCATACTA ACGATGTCTG CAGCTTTCCC AACGCTCTGG TCACAAAGCT CCTGCTGGAC 
TGTGGCGCTG AGGTAAATGC AGTGGACAAT GAGGGGAACA GTGCCCTCCA CATTATCGTC 
CAGTACAACA GGCCCATCAG TGATTTTCTG ACCTTGCACT CCATCATCAT CAGCCTTGTG 
GAGGCTGGAG CTCACACCGA CATGACAAAC AAGCAGAATA AAACTCCGCT AGACAAAAGT 
ACAACTGGGG TGTCTGAAAT ACTACTTAAA ACTCAGATGA AGATGAGCCT CAAGTGCCTG 
GCTGCCCGAG CAGTTCGGGC TAATGACATT AACTACCAAG ACCAGATCCC CCGGACTCTT 
GAAGAGTTTG TTGGATTTCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37.
Gene485(2)153-9(2011 Oct)
Shi YQ,Liao SY,Zhuang XJ,Han CS

Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia.
Cancer epidemiology35(1)97-100(2011 Feb)
Subauste MC,Ventura-Holman T,Lu D,Du L,Sansom OJ,Maher JF

A genomic atlas of mouse hypothalamic development.
Nature neuroscience13(6)767-75(2010 Jun)
Shimogori T,Lee DA,Miranda-Angulo A,Yang Y,Wang H,Jiang L,Yoshida AC,Kataoka A,Mashiko H,Avetisyan M,Qi L,Qian J,Blackshaw S

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Cell stem cell5(4)420-33(2009 Oct)
Nishiyama A,Xin L,Sharov AA,Thomas M,Mowrer G,Meyers E,Piao Y,Mehta S,Yee S,Nakatake Y,Stagg C,Sharova L,Correa-Cerro LS,Bassey U,Hoang H,Kim E,Tapnio R,Qian Y,Dudekula D,Zalzman M,Li M,Falco G,Yang HT,Lee SL,Monti M,Stanghellini I,Islam MN,Nagaraja R,Goldberg I,Wang W,Longo DL,Schlessinger D,Ko MS

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Fem1b cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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