Fbp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbp1
Entrez Gene ID	14121
Full Name	fructose bisphosphatase 1
Synonyms	Fbp-2,Fbp2,Fbp3
General protein information	Preferred Names fructose bisphosphatase 1 Names fructose-1,6-bisphosphatase 1 D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 D-fructose-1,6-bisphosphate 1-phosphohydrolase 3 FBPase brain isoform FBPase liver fructose-1,6-bisphosphatase isozyme 3 liver FBPase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 B3

mRNA and Protein(s)

mRNA	Protein	Name
XM_011244488.2	XP_011242790.1	fructose-1,6-bisphosphatase 1 isoform X1
NM_019395.3	NP_062268.1	fructose-1,6-bisphosphatase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FBP1	XP_520717.2
Canis lupus familiaris (dog)	FBP1	XP_848306.1
Rattus norvegicus (Norway rat)	Fbp1	NP_036690.2
Danio rerio (zebrafish)	fbp1b	NP_998297.1
Magnaporthe oryzae (rice blast fungus)	MGG_08895	XP_003713924.1
	FBP1	XP_001105272.1
Bos taurus (cattle)	FBP1	NP_001029619.1
Mus musculus (house mouse)	Fbp1	NP_062268.1
Homo sapiens (human)	FBP1	NP_001121100.1
Saccharomyces cerevisiae (baker's yeast)	FBP1	NP_013481.3
Kluyveromyces lactis	KLLA0E01211g	XP_454003.1
Eremothecium gossypii	AGOS_AFR593C	NP_986140.2
Gallus gallus (chicken)	FBP1	NP_001264977.1
Danio rerio (zebrafish)	fbp1a	NP_956236.1
Schizosaccharomyces pombe (fission yeast)	fbp1	NP_595083.2
Xenopus tropicalis (tropical clawed frog)	fbp1	NP_989145.1
Neurospora crassa	NCU04797	XP_960423.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of fructose?1,6?bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration.
Liu T, Zhao H, Wang J, Shu X, Gao Y, Mu X, Gao F, Liu H
Molecular medicine reports16(5)6489-6498(2017 Nov)

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Duteil D, Tosic M, Lausecker F, Nenseth HZ, M?ller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Br?ning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Sch?le R
Cell reports17(4)1008-1021(2016 10)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
Title: Cell cycle-dependent expression and subcellular localization of fructose 1,6-bisphosphatase.

FBPase plays an important role in regulating glucose sensing and insulin secretion of beta-cells and serves a promising target for diabetes treatment.
Title: Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.

Data show that NF-kappaB functions downstream of Ras to promote epigenetic downregulation of FBP1.
Title: Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.

The following Fbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu67723	XM_011244488.2 Latest version!	Mus musculus fructose bisphosphatase 1 (Fbp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu23363	NM_019395.3 Latest version!	Mus musculus fructose bisphosphatase 1 (Fbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbp1 ( XM_011244488.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011242790.1 Mus musculus fructose bisphosphatase 1 (Fbp1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67723
Clone ID Related Accession (Same CDS sequence)	XM_011244488.2
Accession Version	XM_011244488.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	fructose-1,6-bisphosphatase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011244488.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAAGT CGTCCTACGC TACCTGTGTT CTTGTGTCTG AAGAAAACAC AAATGCCATC 
ATAATCGAAC CTGAGAAGAG GGGCAAATAT GTTGTCTGTT TCGATCCCCT TGATGGCTCA 
TCCAACATTG ACTGCCTTGT GTCCATCGGA ACCATTTTTG GCATTTACAG AAAGAAAAGT 
ACTGATGAGC CTTCTGAGAA GGATGCTCTG CAGCCCGGCC GGGACCTGGT GGCAGCCGGG 
TATGCGCTCT ATGGCAGTGC CACCATGTTG GTCCTTGCCA TGGATTGTGG TGTCAACTGC 
TTCATGCTGG ACCCGTCCAT TGGAGAATTC ATTATGGTGG ACAGGGACGT GAAGATGAAG 
AAGAAAGGTA ACATCTACAG CCTTAATGAG GGTTATGCCA AGGACTTTGA CCCTGCCATC 
AATGAGTATC TCCAGAGGAA AAAGTTCCCT CCGGATGGTT CAGCCCCCTA TGGTGCCCGG 
TATGTGGGGT CCATGGTGGC TGATATTCAC CGCACTCTGG TATATGGAGG GATCTTTTTA 
TACCCCGCCA ACAAGAAAAG CCCAAGTGGA AAGCTGCGGC TGCTGTATGA GTGCAACCCC 
ATAGCTTATG TCATGGAGAA GGCCGGTGGG CTCGCCACCA CGGGGGACAA AGATATATTA 
GACATCGTTC CCACCGAGAT CCACCAGAAG GCACCAGTCG TCATGGGGTC CTCTGAAGAT 
GTGCAGGAGT TCCTGGAGAT CTACAGGAAG CACAAAGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011242790.1
CDS	731..1495
Translation	MLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK

Target ORF information:

RefSeq Version	XM_011244488.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fructose bisphosphatase 1 (Fbp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011244488.2

ORF Insert Sequence:

ATGCTGAAGT CGTCCTACGC TACCTGTGTT CTTGTGTCTG AAGAAAACAC AAATGCCATC 
ATAATCGAAC CTGAGAAGAG GGGCAAATAT GTTGTCTGTT TCGATCCCCT TGATGGCTCA 
TCCAACATTG ACTGCCTTGT GTCCATCGGA ACCATTTTTG GCATTTACAG AAAGAAAAGT 
ACTGATGAGC CTTCTGAGAA GGATGCTCTG CAGCCCGGCC GGGACCTGGT GGCAGCCGGG 
TATGCGCTCT ATGGCAGTGC CACCATGTTG GTCCTTGCCA TGGATTGTGG TGTCAACTGC 
TTCATGCTGG ACCCGTCCAT TGGAGAATTC ATTATGGTGG ACAGGGACGT GAAGATGAAG 
AAGAAAGGTA ACATCTACAG CCTTAATGAG GGTTATGCCA AGGACTTTGA CCCTGCCATC 
AATGAGTATC TCCAGAGGAA AAAGTTCCCT CCGGATGGTT CAGCCCCCTA TGGTGCCCGG 
TATGTGGGGT CCATGGTGGC TGATATTCAC CGCACTCTGG TATATGGAGG GATCTTTTTA 
TACCCCGCCA ACAAGAAAAG CCCAAGTGGA AAGCTGCGGC TGCTGTATGA GTGCAACCCC 
ATAGCTTATG TCATGGAGAA GGCCGGTGGG CTCGCCACCA CGGGGGACAA AGATATATTA 
GACATCGTTC CCACCGAGAT CCACCAGAAG GCACCAGTCG TCATGGGGTC CTCTGAAGAT 
GTGCAGGAGT TCCTGGAGAT CTACAGGAAG CACAAAGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbp1 ( NM_019395.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062268.1 Mus musculus fructose bisphosphatase 1 (Fbp1), mRNA.

Price & Availability↑

CloneID	OMu23363
Clone ID Related Accession (Same CDS sequence)	NM_019395.3
Accession Version	NM_019395.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	fructose-1,6-bisphosphatase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171004.2, AK149527.1 and AC156572.3. On Feb 15, 2013 this sequence version replaced NM_019395.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ132693.1, AK149527.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849385 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAACC ATGCGCCCTT CGAAACGGAT ATCAGCACCC TGACCCGCTT CGTCATGGAG 
CAGGGCAGGA AGGCTCAGGG CACGGGGGAG TTGACCCAGC TGCTGAATTC GCTCTGCACC 
GCGATCAAAG CCATCTCGTC TGCGGTGCGC CAGGCGGGCA TCGCACAGCT CTATGGTATC 
GCTGGCTCAA CCAATGTGAC TGGGGATCAA GTAAAGAAGC TGGACATACT TTCCAATGAC 
CTGGTGATCA ATATGCTGAA GTCGTCCTAC GCTACCTGTG TTCTTGTGTC TGAAGAAAAC 
ACAAATGCCA TCATAATCGA ACCTGAGAAG AGGGGCAAAT ATGTTGTCTG TTTCGATCCC 
CTTGATGGCT CATCCAACAT TGACTGCCTT GTGTCCATCG GAACCATTTT TGGCATTTAC 
AGAAAGAAAA GTACTGATGA GCCTTCTGAG AAGGATGCTC TGCAGCCCGG CCGGGACCTG 
GTGGCAGCCG GGTATGCGCT CTATGGCAGT GCCACCATGT TGGTCCTTGC CATGGATTGT 
GGTGTCAACT GCTTCATGCT GGACCCGTCC ATTGGAGAAT TCATTATGGT GGACAGGGAC 
GTGAAGATGA AGAAGAAAGG TAACATCTAC AGCCTTAATG AGGGTTATGC CAAGGACTTT 
GACCCTGCCA TCAATGAGTA TCTCCAGAGG AAAAAGTTCC CTCCGGATGG TTCAGCCCCC 
TATGGTGCCC GGTATGTGGG GTCCATGGTG GCTGATATTC ACCGCACTCT GGTATATGGA 
GGGATCTTTT TATACCCCGC CAACAAGAAA AGCCCAAGTG GAAAGCTGCG GCTGCTGTAT 
GAGTGCAACC CCATAGCTTA TGTCATGGAG AAGGCCGGTG GGCTCGCCAC CACGGGGGAC 
AAAGATATAT TAGACATCGT TCCCACCGAG ATCCACCAGA AGGCACCAGT CGTCATGGGG 
TCCTCTGAAG ATGTGCAGGA GTTCCTGGAG ATCTACAGGA AGCACAAAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062268.1
CDS	240..1256
Translation	MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK

Target ORF information:

RefSeq Version	NM_019395.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fructose bisphosphatase 1 (Fbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019395.3

ORF Insert Sequence:

ATGGCGAACC ATGCGCCCTT CGAAACGGAT ATCAGCACCC TGACCCGCTT CGTCATGGAG 
CAGGGCAGGA AGGCTCAGGG CACGGGGGAG TTGACCCAGC TGCTGAATTC GCTCTGCACC 
GCGATCAAAG CCATCTCGTC TGCGGTGCGC CAGGCGGGCA TCGCACAGCT CTATGGTATC 
GCTGGCTCAA CCAATGTGAC TGGGGATCAA GTAAAGAAGC TGGACATACT TTCCAATGAC 
CTGGTGATCA ATATGCTGAA GTCGTCCTAC GCTACCTGTG TTCTTGTGTC TGAAGAAAAC 
ACAAATGCCA TCATAATCGA ACCTGAGAAG AGGGGCAAAT ATGTTGTCTG TTTCGATCCC 
CTTGATGGCT CATCCAACAT TGACTGCCTT GTGTCCATCG GAACCATTTT TGGCATTTAC 
AGAAAGAAAA GTACTGATGA GCCTTCTGAG AAGGATGCTC TGCAGCCCGG CCGGGACCTG 
GTGGCAGCCG GGTATGCGCT CTATGGCAGT GCCACCATGT TGGTCCTTGC CATGGATTGT 
GGTGTCAACT GCTTCATGCT GGACCCGTCC ATTGGAGAAT TCATTATGGT GGACAGGGAC 
GTGAAGATGA AGAAGAAAGG TAACATCTAC AGCCTTAATG AGGGTTATGC CAAGGACTTT 
GACCCTGCCA TCAATGAGTA TCTCCAGAGG AAAAAGTTCC CTCCGGATGG TTCAGCCCCC 
TATGGTGCCC GGTATGTGGG GTCCATGGTG GCTGATATTC ACCGCACTCT GGTATATGGA 
GGGATCTTTT TATACCCCGC CAACAAGAAA AGCCCAAGTG GAAAGCTGCG GCTGCTGTAT 
GAGTGCAACC CCATAGCTTA TGTCATGGAG AAGGCCGGTG GGCTCGCCAC CACGGGGGAC 
AAAGATATAT TAGACATCGT TCCCACCGAG ATCCACCAGA AGGCACCAGT CGTCATGGGG 
TCCTCTGAAG ATGTGCAGGA GTTCCTGGAG ATCTACAGGA AGCACAAAGC CAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of fructose?1,6?bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration.
Molecular medicine reports16(5)6489-6498(2017 Nov)
Liu T,Zhao H,Wang J,Shu X,Gao Y,Mu X,Gao F,Liu H

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Developmental cell40(4)331-341.e4(2017 02)
Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Cell reports17(4)1008-1021(2016 10)
Duteil D,Tosic M,Lausecker F,Nenseth HZ,M?ller JM,Urban S,Willmann D,Petroll K,Messaddeq N,Arrigoni L,Manke T,Kornfeld JW,Br?ning JC,Zagoriy V,Meret M,Dengjel J,Kanouni T,Sch?le R

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K