Dclre1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dclre1b
Entrez Gene ID	140917
Full Name	DNA cross-link repair 1B
Synonyms	AI452214,Apollo,SNMIB,mSNM1B
General protein information	Preferred Names DNA cross-link repair 1B Names 5' exonuclease Apollo DNA cross-link repair 1B protein DNA cross-link repair 1B, PSO2 homolog SNM1 homolog B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025312.1	NP_001020483.1	5' exonuclease Apollo isoform b
NM_133865.2	NP_598626.2	5' exonuclease Apollo isoform a

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	dclre1b	NP_001070751.1
Canis lupus familiaris (dog)	DCLRE1B	XP_848274.1
Rattus norvegicus (Norway rat)	Dclre1b	NP_001020858.1
Gallus gallus (chicken)	DCLRE1B	NP_001026671.2
Arabidopsis thaliana (thale cress)	AT1G27410	NP_174061.1
Pan troglodytes (chimpanzee)	DCLRE1B	XP_524804.1
Xenopus tropicalis (tropical clawed frog)	dclre1b	XP_002932166.1
	DCLRE1B	XP_001110949.1
Bos taurus (cattle)	DCLRE1B	XP_002686220.1
Oryza sativa (rice)	Os01g0783400	NP_001044453.2
Homo sapiens (human)	DCLRE1B	NP_073747.1
Mus musculus (house mouse)	Dclre1b	NP_598626.2

Gene Ontology
Bibliography

Related articles in PubMed

Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Wu P, Takai H, de Lange T
Cell150(1)39-52(2012 Jul)

The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
Akhter S, Lam YC, Chang S, Legerski RJ
Aging cell9(6)1047-56(2010 Dec)

Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Wu P, van Overbeek M, Rooney S, de Lange T
Molecular cell39(4)606-17(2010 Aug)

SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
Lam YC, Akhter S, Gu P, Ye J, Poulet A, Giraud-Panis MJ, Bailey SM, Gilson E, Legerski RJ, Chang S
The EMBO journal29(13)2230-41(2010 Jul)

SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.
Akhter S, Legerski RJ
Biochemical and biophysical research communications377(1)236-41(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.

The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development
Title: The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.

TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.
Title: Apollo contributes to G overhang maintenance and protects leading-end telomeres.

Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
Title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.

The following Dclre1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dclre1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10288	NM_133865.2 Latest version!	Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$321.30 $459.00
OMu12093	NM_001025312.1 Latest version!	Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dclre1b ( NM_133865.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598626.2 Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10288
Clone ID Related Accession (Same CDS sequence)	NM_133865.2
Accession Version	NM_133865.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	5' exonuclease Apollo isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA548899.1, AK049115.1, AK084347.1 and BC067017.1. On Jul 13, 2005 this sequence version replaced NM_133865.1. ##Evidence-Data-START## Transcript exon combination :: AK137495.1, AK134324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAACGGGG TCGTAATCCC CCAAACGCCC ATTGCTGTGG ACTTTTGGAG CCTGCGCCGT 
GCCGGTTCGG CGCGGCTCTT CTTCTTAACC CACATGCACT GTGACCACAC GGTGGGTTTG 
TCTAGCACTT GGGCCCGGCC CCTCTACTGC TCTCCCATCA CTGCTTGCCT CTTGCATCGT 
CGCCTGCAGG TGTCTAAGCA CTGGATCCGG GCCCTGGAGG TTGGCGAGAG TCATGTATTA 
CCTCTAGATG AAATTGGGCA AGAAACCATG ACTGTAACGC TCATAGATGC CAATCACTGC 
CCTGGTTCTG TCATGTTTCT CTTTGAAGGA TACTTTGGAA CAATTCTATA CACAGGTGAT 
TTTCGATATA CACCATCCAT GCTGAAGGAA CCTGCTCTGA TACTGGGGAA ACAGATTCAT 
ACTTTGTATC TAGACAACAC TAATTGCAAT CCAGCCCTGG TTCTTCCTTC CCGACAAGAG 
GCTACTCAGC AGATTGTCCA GCTAATCCGA CAGTTCCCAC AACACAACAT AAAAATTGGA 
CTCTATAGTC TAGGAAAAGA ATCACTGCTG GAGCAACTAG CCCTTGAGTT TCGGACCTGG 
GTGGTATTAA GTCCTCAACG CCTGGAGTTG GTACAGTTGC TGGGCCTGGC AGACGTGTTC 
ACAGTTGAGG AAGAAGCCGG GCGCATCCAT GCTGTGGACC ATACGGAGAT CTGCCACTCT 
GCCATGCTTC AGTGGAACCA GAGTCACCCT ACCATTGCTA TTTTCCCCAC AAGCCGGAAA 
GTGCGCAGCC CTCACCCCAG CATCTACACC GTCCCGTACT CTGACCATTC ATCTTACTCC 
GAGCTCCGTG CTTTTGTGGC AGCGCTGAGG CCTTGTCAGG TGGTGCCCAT CGTCCATCAA 
AAGCCTTGTG GAGAGTTCTT TCAGGACAGC TTGAGTCCTA GGCTCGCTAT GCCTCTGATT 
CCACACTCTG TGCAGCAGTA CATGAGTTCC TCCTCTAGGA AAACAAATGT GCTTTGGCAG 
TTAGAAAGGA GGCTCAAGAG GCCAAGAACT CAGGGTGTTG TGTTTGAATC CCCTGAGGAG 
AAAGCTAATC AGGTTAAAGT TGACAGAGAC TCAAAGAAGC ACAAAAAGGA AAACCTCTCT 
CCCTGGGCTG GGCACCTTGA GAGGCTTTGC CCCCATCCTC TGCAGGCCAG GAAGCAGTTG 
TTCCCAGACT TCTGCAGGAA AGAACGTGAT GAGCCAGTCC TCTTTTGTGA CTCCAACAAG 
ATGGCGACTG TGTTGACTGC CCCACTGGAA TTCTCAGTGC AATTACAACC TATAGATGAG 
TTTCTCTTTC CAGAAACCAG GGAGAAAATT GGCTTAGAGT CCCCATTGCT GTCAAGGGGA 
GACAGTGGCT CACCAGCGAG AGGGAACCAA AGTGACTGCG TAGGCTGTGG TTCTCCCCCG 
GCTCACATTA GCAGAGCTGT TCCTCTAACT CCTGAGTCCA GGGGCCTGGC GCTAAAATAC 
CTTCTCACTC CAGTGCATTT CCTCCAAGCA GGCTTCTCTT CCAGGAACTT CGACAAGCAA 
GTGGAAAAAC ACCAGAGAGT ACAGCGTAGC AGTCCTGCAG TTCTGAGCCC GGTGGATGTT 
GGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598626.2
CDS	300..1925
Translation	MNGVVIPQTPIAVDFWSLRRAGSARLFFLTHMHCDHTVGLSSTWARPLYCSPITACLLHRRLQVSKHWIRALEVGESHVLPLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALILGKQIHTLYLDNTNCNPALVLPSRQEATQQIVQLIRQFPQHNIKIGLYSLGKESLLEQLALEFRTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHTEICHSAMLQWNQSHPTIAIFPTSRKVRSPHPSIYTVPYSDHSSYSELRAFVAALRPCQVVPIVHQKPCGEFFQDSLSPRLAMPLIPHSVQQYMSSSSRKTNVLWQLERRLKRPRTQGVVFESPEEKANQVKVDRDSKKHKKENLSPWAGHLERLCPHPLQARKQLFPDFCRKERDEPVLFCDSNKMATVLTAPLEFSVQLQPIDEFLFPETREKIGLESPLLSRGDSGSPARGNQSDCVGCGSPPAHISRAVPLTPESRGLALKYLLTPVHFLQAGFSSRNFDKQVEKHQRVQRSSPAVLSPVDVG

Target ORF information:

RefSeq Version	NM_133865.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133865.2

ORF Insert Sequence:

ATGAACGGGG TCGTAATCCC CCAAACGCCC ATTGCTGTGG ACTTTTGGAG CCTGCGCCGT 
GCCGGTTCGG CGCGGCTCTT CTTCTTAACC CACATGCACT GTGACCACAC GGTGGGTTTG 
TCTAGCACTT GGGCCCGGCC CCTCTACTGC TCTCCCATCA CTGCTTGCCT CTTGCATCGT 
CGCCTGCAGG TGTCTAAGCA CTGGATCCGG GCCCTGGAGG TTGGCGAGAG TCATGTATTA 
CCTCTAGATG AAATTGGGCA AGAAACCATG ACTGTAACGC TCATAGATGC CAATCACTGC 
CCTGGTTCTG TCATGTTTCT CTTTGAAGGA TACTTTGGAA CAATTCTATA CACAGGTGAT 
TTTCGATATA CACCATCCAT GCTGAAGGAA CCTGCTCTGA TACTGGGGAA ACAGATTCAT 
ACTTTGTATC TAGACAACAC TAATTGCAAT CCAGCCCTGG TTCTTCCTTC CCGACAAGAG 
GCTACTCAGC AGATTGTCCA GCTAATCCGA CAGTTCCCAC AACACAACAT AAAAATTGGA 
CTCTATAGTC TAGGAAAAGA ATCACTGCTG GAGCAACTAG CCCTTGAGTT TCGGACCTGG 
GTGGTATTAA GTCCTCAACG CCTGGAGTTG GTACAGTTGC TGGGCCTGGC AGACGTGTTC 
ACAGTTGAGG AAGAAGCCGG GCGCATCCAT GCTGTGGACC ATACGGAGAT CTGCCACTCT 
GCCATGCTTC AGTGGAACCA GAGTCACCCT ACCATTGCTA TTTTCCCCAC AAGCCGGAAA 
GTGCGCAGCC CTCACCCCAG CATCTACACC GTCCCGTACT CTGACCATTC ATCTTACTCC 
GAGCTCCGTG CTTTTGTGGC AGCGCTGAGG CCTTGTCAGG TGGTGCCCAT CGTCCATCAA 
AAGCCTTGTG GAGAGTTCTT TCAGGACAGC TTGAGTCCTA GGCTCGCTAT GCCTCTGATT 
CCACACTCTG TGCAGCAGTA CATGAGTTCC TCCTCTAGGA AAACAAATGT GCTTTGGCAG 
TTAGAAAGGA GGCTCAAGAG GCCAAGAACT CAGGGTGTTG TGTTTGAATC CCCTGAGGAG 
AAAGCTAATC AGGTTAAAGT TGACAGAGAC TCAAAGAAGC ACAAAAAGGA AAACCTCTCT 
CCCTGGGCTG GGCACCTTGA GAGGCTTTGC CCCCATCCTC TGCAGGCCAG GAAGCAGTTG 
TTCCCAGACT TCTGCAGGAA AGAACGTGAT GAGCCAGTCC TCTTTTGTGA CTCCAACAAG 
ATGGCGACTG TGTTGACTGC CCCACTGGAA TTCTCAGTGC AATTACAACC TATAGATGAG 
TTTCTCTTTC CAGAAACCAG GGAGAAAATT GGCTTAGAGT CCCCATTGCT GTCAAGGGGA 
GACAGTGGCT CACCAGCGAG AGGGAACCAA AGTGACTGCG TAGGCTGTGG TTCTCCCCCG 
GCTCACATTA GCAGAGCTGT TCCTCTAACT CCTGAGTCCA GGGGCCTGGC GCTAAAATAC 
CTTCTCACTC CAGTGCATTT CCTCCAAGCA GGCTTCTCTT CCAGGAACTT CGACAAGCAA 
GTGGAAAAAC ACCAGAGAGT ACAGCGTAGC AGTCCTGCAG TTCTGAGCCC GGTGGATGTT 
GGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dclre1b ( NM_001025312.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001020483.1 Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu12093
Clone ID Related Accession (Same CDS sequence)	NM_001025312.1
Accession Version	NM_001025312.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	5' exonuclease Apollo isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ559794.1, BC067017.1 and CA317555.1. ##Evidence-Data-START## Transcript exon combination :: BC067017.1, AK084347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAAGG AACCTGCTCT GATACTGGGG AAACAGATTC ATACTTTGTA TCTAGACAAC 
ACTAATTGCA ATCCAGCCCT GGTTCTTCCT TCCCGACAAG AGGCTACTCA GCAGATTGTC 
CAGCTAATCC GACAGTTCCC ACAACACAAC ATAAAAATTG GACTCTATAG TCTAGGAAAA 
GAATCACTGC TGGAGCAACT AGCCCTTGAG TTTCGGACCT GGGTGGTATT AAGTCCTCAA 
CGCCTGGAGT TGGTACAGTT GCTGGGCCTG GCAGACGTGT TCACAGTTGA GGAAGAAGCC 
GGGCGCATCC ATGCTGTGGA CCATACGGAG ATCTGCCACT CTGCCATGCT TCAGTGGAAC 
CAGAGTCACC CTACCATTGC TATTTTCCCC ACAAGCCGGA AAGTGCGCAG CCCTCACCCC 
AGCATCTACA CCGTCCCGTA CTCTGACCAT TCATCTTACT CCGAGCTCCG TGCTTTTGTG 
GCAGCGCTGA GGCCTTGTCA GGTGGTGCCC ATCGTCCATC AAAAGCCTTG TGGAGAGTTC 
TTTCAGGACA GCTTGAGTCC TAGGCTCGCT ATGCCTCTGA TTCCACACTC TGTGCAGCAG 
TACATGAGTT CCTCCTCTAG GAAAACAAAT GTGCTTTGGC AGTTAGAAAG GAGGCTCAAG 
AGGCCAAGAA CTCAGGGTGT TGTGTTTGAA TCCCCTGAGG AGAAAGCTAA TCAGGTTAAA 
GTTGACAGAG ACTCAAAGAA GCACAAAAAG GAAAACCTCT CTCCCTGGGC TGGGCACCTT 
GAGAGGCTTT GCCCCCATCC TCTGCAGGCC AGGAAGCAGT TGTTCCCAGA CTTCTGCAGG 
AAAGAACGTG ATGAGCCAGT CCTCTTTTGT GACTCCAACA AGATGGCGAC TGTGTTGACT 
GCCCCACTGG AATTCTCAGT GCAATTACAA CCTATAGATG AGTTTCTCTT TCCAGAAACC 
AGGGAGAAAA TTGGCTTAGA GTCCCCATTG CTGTCAAGGG GAGACAGTGG CTCACCAGCG 
AGAGGGAACC AAAGTGACTG CGTAGGCTGT GGTTCTCCCC CGGCTCACAT TAGCAGAGCT 
GTTCCTCTAA CTCCTGAGTC CAGGGGCCTG GCGCTAAAAT ACCTTCTCAC TCCAGTGCAT 
TTCCTCCAAG CAGGCTTCTC TTCCAGGAAC TTCGACAAGC AAGTGGAAAA ACACCAGAGA 
GTACAGCGTA GCAGTCCTGC AGTTCTGAGC CCGGTGGATG TTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020483.1
CDS	512..1759
Translation	MLKEPALILGKQIHTLYLDNTNCNPALVLPSRQEATQQIVQLIRQFPQHNIKIGLYSLGKESLLEQLALEFRTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHTEICHSAMLQWNQSHPTIAIFPTSRKVRSPHPSIYTVPYSDHSSYSELRAFVAALRPCQVVPIVHQKPCGEFFQDSLSPRLAMPLIPHSVQQYMSSSSRKTNVLWQLERRLKRPRTQGVVFESPEEKANQVKVDRDSKKHKKENLSPWAGHLERLCPHPLQARKQLFPDFCRKERDEPVLFCDSNKMATVLTAPLEFSVQLQPIDEFLFPETREKIGLESPLLSRGDSGSPARGNQSDCVGCGSPPAHISRAVPLTPESRGLALKYLLTPVHFLQAGFSSRNFDKQVEKHQRVQRSSPAVLSPVDVG

Target ORF information:

RefSeq Version	NM_001025312.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA cross-link repair 1B (Dclre1b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025312.1

ORF Insert Sequence:

ATGCTGAAGG AACCTGCTCT GATACTGGGG AAACAGATTC ATACTTTGTA TCTAGACAAC 
ACTAATTGCA ATCCAGCCCT GGTTCTTCCT TCCCGACAAG AGGCTACTCA GCAGATTGTC 
CAGCTAATCC GACAGTTCCC ACAACACAAC ATAAAAATTG GACTCTATAG TCTAGGAAAA 
GAATCACTGC TGGAGCAACT AGCCCTTGAG TTTCGGACCT GGGTGGTATT AAGTCCTCAA 
CGCCTGGAGT TGGTACAGTT GCTGGGCCTG GCAGACGTGT TCACAGTTGA GGAAGAAGCC 
GGGCGCATCC ATGCTGTGGA CCATACGGAG ATCTGCCACT CTGCCATGCT TCAGTGGAAC 
CAGAGTCACC CTACCATTGC TATTTTCCCC ACAAGCCGGA AAGTGCGCAG CCCTCACCCC 
AGCATCTACA CCGTCCCGTA CTCTGACCAT TCATCTTACT CCGAGCTCCG TGCTTTTGTG 
GCAGCGCTGA GGCCTTGTCA GGTGGTGCCC ATCGTCCATC AAAAGCCTTG TGGAGAGTTC 
TTTCAGGACA GCTTGAGTCC TAGGCTCGCT ATGCCTCTGA TTCCACACTC TGTGCAGCAG 
TACATGAGTT CCTCCTCTAG GAAAACAAAT GTGCTTTGGC AGTTAGAAAG GAGGCTCAAG 
AGGCCAAGAA CTCAGGGTGT TGTGTTTGAA TCCCCTGAGG AGAAAGCTAA TCAGGTTAAA 
GTTGACAGAG ACTCAAAGAA GCACAAAAAG GAAAACCTCT CTCCCTGGGC TGGGCACCTT 
GAGAGGCTTT GCCCCCATCC TCTGCAGGCC AGGAAGCAGT TGTTCCCAGA CTTCTGCAGG 
AAAGAACGTG ATGAGCCAGT CCTCTTTTGT GACTCCAACA AGATGGCGAC TGTGTTGACT 
GCCCCACTGG AATTCTCAGT GCAATTACAA CCTATAGATG AGTTTCTCTT TCCAGAAACC 
AGGGAGAAAA TTGGCTTAGA GTCCCCATTG CTGTCAAGGG GAGACAGTGG CTCACCAGCG 
AGAGGGAACC AAAGTGACTG CGTAGGCTGT GGTTCTCCCC CGGCTCACAT TAGCAGAGCT 
GTTCCTCTAA CTCCTGAGTC CAGGGGCCTG GCGCTAAAAT ACCTTCTCAC TCCAGTGCAT 
TTCCTCCAAG CAGGCTTCTC TTCCAGGAAC TTCGACAAGC AAGTGGAAAA ACACCAGAGA 
GTACAGCGTA GCAGTCCTGC AGTTCTGAGC CCGGTGGATG TTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Cell150(1)39-52(2012 Jul)
Wu P,Takai H,de Lange T

The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
Aging cell9(6)1047-56(2010 Dec)
Akhter S,Lam YC,Chang S,Legerski RJ

Apollo contributes to G overhang maintenance and protects leading-end telomeres.
Molecular cell39(4)606-17(2010 Aug)
Wu P,van Overbeek M,Rooney S,de Lange T

SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
The EMBO journal29(13)2230-41(2010 Jul)
Lam YC,Akhter S,Gu P,Ye J,Poulet A,Giraud-Panis MJ,Bailey SM,Gilson E,Legerski RJ,Chang S

SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.
Biochemical and biophysical research communications377(1)236-41(2008 Dec)
Akhter S,Legerski RJ

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Dclre1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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