Fabp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp2
Entrez Gene ID	14079
Full Name	fatty acid binding protein 2, intestinal
Synonyms	Fabpi,I-FABP
General protein information	Preferred Names fatty acid binding protein 2, intestinal Names fatty acid-binding protein, intestinal intestinal fatty acid binding protein 2 intestinal-type fatty acid-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 G1\|3 53.74 cM
Summary	The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007980.3	NP_032006.1	fatty acid-binding protein, intestinal

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FABP2	XP_001149448.1
	FABP2	XP_001099243.1
Canis lupus familiaris (dog)	FABP2	XP_545047.1
Mus musculus (house mouse)	Fabp2	NP_032006.1
Rattus norvegicus (Norway rat)	Fabp2	NP_037200.1
Gallus gallus (chicken)	FABP2	NP_001007924.1
Danio rerio (zebrafish)	fabp2	NP_571506.1
Homo sapiens (human)	FABP2	NP_000125.2
Bos taurus (cattle)	FABP2	NP_001020503.1
Xenopus tropicalis (tropical clawed frog)	fabp2	NP_001106373.1

Gene Ontology
Bibliography

Related articles in PubMed

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Walker EM, Thompson CA, Battle MA
Developmental biology392(2)283-94(2014 Aug)

Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver.
Agellon LB, Drozdowski L, Li L, Iordache C, Luong L, Clandinin MT, Uwiera RR, Toth MJ, Thomson AB
Biochimica et biophysica acta1771(10)1283-8(2007 Oct)

The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice.
Vassileva G, Huwyler L, Poirier K, Agellon LB, Toth MJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology14(13)2040-6(2000 Oct)

Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).
Oesterreicher TJ, Leeper LL, Finegold MJ, Darlington GJ, Henning SJ
The Biochemical journal330 ( Pt 3)1165-71(1998 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This direct comparison provides evidence that LFABP and IFABP have distinct roles in intestinal lipid metabolism; differential intracellular functions in intestine and in liver
Title: Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding.

detected the common as well as sex-differential pathways that are modified due to the loss of Fabp2. These findings suggest that the pathways involved in nutrient and xenobiotic metabolism in the intestine are regulated by sex-specific mechanisms
Title: Visualization of sex-dimorphic changes in the intestinal transcriptome of Fabp2 gene-ablated mice.

loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP
Title: Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver.

The following Fabp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01164	NM_007980.3 Latest version!	Mus musculus fatty acid binding protein 2, intestinal (Fabp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp2 ( NM_007980.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032006.1 Mus musculus fatty acid binding protein 2, intestinal (Fabp2), mRNA.

Price & Availability↑

CloneID	OMu01164
Clone ID Related Accession (Same CDS sequence)	NM_007980.3
Accession Version	NM_007980.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	fatty acid-binding protein, intestinal
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA245078.1, AK007995.1 and BY707992.1. On Jan 11, 2013 this sequence version replaced NM_007980.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY707992.1, BB610447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCATTCG ACGGCACGTG GAAAGTAGAC CGGAACGAGA ACTATGAAAA GTTCATGGAG 
AAAATGGGCA TTAATGTGAT GAAGAGGAAG CTTGGAGCTC ATGACAATCT GAAACTGACA 
ATCACACAGG ATGGAAATAA ATTCACAGTC AAAGAATCAA GCAACTTCAG AAACATTGAT 
GTTGTGTTTG AGCTCGGTGT AAACTTTCCC TACAGTCTAG CAGACGGAAC GGAGCTCACT 
GGGGCCTGGA CCATTGAGGG AAATAAACTT ATTGGGAAAT TCACACGTGT AGACAATGGA 
AAGGAGCTGA TTGCTGTCCG AGAGGTTTCT GGTAATGAAC TAATCCAGAC CTACACATAT 
GAAGGAGTTG AGGCCAAGCG ATTCTTTAAG AAGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032006.1
CDS	342..740
Translation	MAFDGTWKVDRNENYEKFMEKMGINVMKRKLGAHDNLKLTITQDGNKFTVKESSNFRNIDVVFELGVNFPYSLADGTELTGAWTIEGNKLIGKFTRVDNGKELIAVREVSGNELIQTYTYEGVEAKRFFKKE

Target ORF information:

RefSeq Version	NM_007980.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fatty acid binding protein 2, intestinal (Fabp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007980.3

ORF Insert Sequence:

ATGGCATTCG ACGGCACGTG GAAAGTAGAC CGGAACGAGA ACTATGAAAA GTTCATGGAG 
AAAATGGGCA TTAATGTGAT GAAGAGGAAG CTTGGAGCTC ATGACAATCT GAAACTGACA 
ATCACACAGG ATGGAAATAA ATTCACAGTC AAAGAATCAA GCAACTTCAG AAACATTGAT 
GTTGTGTTTG AGCTCGGTGT AAACTTTCCC TACAGTCTAG CAGACGGAAC GGAGCTCACT 
GGGGCCTGGA CCATTGAGGG AAATAAACTT ATTGGGAAAT TCACACGTGT AGACAATGGA 
AAGGAGCTGA TTGCTGTCCG AGAGGTTTCT GGTAATGAAC TAATCCAGAC CTACACATAT 
GAAGGAGTTG AGGCCAAGCG ATTCTTTAAG AAGGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Developmental biology392(2)283-94(2014 Aug)
Walker EM,Thompson CA,Battle MA

Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver.
Biochimica et biophysica acta1771(10)1283-8(2007 Oct)
Agellon LB,Drozdowski L,Li L,Iordache C,Luong L,Clandinin MT,Uwiera RR,Toth MJ,Thomson AB

The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology14(13)2040-6(2000 Oct)
Vassileva G,Huwyler L,Poirier K,Agellon LB,Toth MJ

Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).
The Biochemical journal330 ( Pt 3)1165-71(1998 Mar)
Oesterreicher TJ,Leeper LL,Finegold MJ,Darlington GJ,Henning SJ

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Fabp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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