F2rl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2rl2
Entrez Gene ID	14064
Full Name	coagulation factor II (thrombin) receptor-like 2
Synonyms	F730031A08,PAR3
General protein information	Preferred Names coagulation factor II (thrombin) receptor-like 2 Names proteinase-activated receptor 3 PAR-3 Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2) coagulation factor II receptor-like 2 protease-activated receptor 3 thrombin receptor-like 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D1\|13 50.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010170.4	NP_034300.3	proteinase-activated receptor 3 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	F2RL2	XP_849866.1
Danio rerio (zebrafish)	LOC100333265	XP_002665915.2
	F2RL2	XP_001106069.1
Mus musculus (house mouse)	F2rl2	NP_034300.3
Rattus norvegicus (Norway rat)	F2rl2	NP_445765.1
Homo sapiens (human)	F2RL2	NP_004092.1
Bos taurus (cattle)	F2RL2	NP_001033622.2
Pan troglodytes (chimpanzee)	F2RL2	XP_003310722.1
Gallus gallus (chicken)	F2RL2	XP_001231246.1
Xenopus tropicalis (tropical clawed frog)	f2rl2	NP_001039234.1
Danio rerio (zebrafish)	f2rl2	XP_005165306.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K
Blood130(24)2664-2677(2017 12)

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, K?hne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schn?der TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B
Nature communications8(1)311(2017 08)

Altered methylation of specific DNA loci in the liver of
Lupu DS, Orozco LD, Wang Y, Cullen JM, Pellegrini M, Zeisel SH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(5)2090-2103(2017 05)

Early embryonic expression of murine coagulation system components.
Ong K, Horsfall W, Conway EM, Schuh AC
Thrombosis and haemostasis84(6)1023-30(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that activated protein C signals via protease activated receptors PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.
Title: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2
Title: Altered methylation of specific DNA loci in the liver of

these data point to a novel kallikrein 6 -signaling axis in neurons that is mediated by PAR1 and PAR2 and is positioned to contribute to neurodegeneration
Title: Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.

Simultaneous depletion of PAR-1 and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
Title: Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis.

Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 by the active site of thrombin.
Title: Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.

The following F2rl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2rl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18693	NM_010170.4 Latest version!	Mus musculus coagulation factor II (thrombin) receptor-like 2 (F2rl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2rl2 ( NM_010170.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034300.3 Mus musculus coagulation factor II (thrombin) receptor-like 2 (F2rl2), mRNA.

Price & Availability↑

CloneID	OMu18693
Clone ID Related Accession (Same CDS sequence)	NM_010170.4
Accession Version	NM_010170.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	proteinase-activated receptor 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171003.2. On Jul 25, 2007 this sequence version replaced NM_010170.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089444.1, U92972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATCC TTATCTTGGT TGCAGCTGGG CTGCTGTTTC TGCCAGTCAC TGTTTGCCAA 
AGTGGCATAA ATGTTTCAGA CAACTCAGCA AAGCCAACCT TAACTATTAA GAGTTTTAAT 
GGGGGTCCCC AAAATACCTT TGAAGAATTC CCACTTTCTG ACATAGAGGG CTGGACAGGA 
GCCACCACAA CTATAAAAGC GGAGTGTCCC GAGGACAGTA TTTCAACTCT CCACGTGAAT 
AATGCTACCA TAGGATACCT GAGAAGTTCC TTAAGTACCC AAGTGATACC TGCCATCTAC 
ATCCTGCTGT TTGTGGTTGG TGTACCAGCC AACATCGTGA CCCTGTGGAA ACTCTCCTTA 
AGGACCAAAT CCATCAGTCT GGTCATCTTT CACACCAACC TGGCCATCGC AGATCTCCTT 
TTCTGTGTCA CACTGCCATT TAAGATCGCC TACCATCTCA ATGGCAACAA CTGGGTATTT 
GGCGAGGTCA CGTGCCGGAT CACCACGGTT GTTTTCTACG GCAACATGTA CTGCGCTATC 
CTGATCCTCA CCTGCATGGG CATCAACCGC TACCTGGCCA CGGCTCACCC TTTCACATAC 
CAGAAGCTGC CCAAACGCAG CTTCTCCATG CTCATGTGTG GCATGGTGTG GGTCATGGTT 
TTCTTATACA TGCTGCCCTT TGTCATCCTG AAGCAGGAGT ACCACCTCGT CCACTCCGAG 
ATCACCACCT GCCACGATGT CGTTGACGCG TGCGAGTCCC CATCATCCTT CCGATTCTAC 
TACTTCGTCT CCTTAGCATT CTTTGGGTTC CTCATCCCGT TTGTGATCAT CATCTTCTGT 
TACACGACTC TCATCCACAA ACTTAAATCA AAGGATCGGA TATGGCTGGG CTACATCAAG 
GCCGTCCTCC TCATCCTTGT GATTTTCACA ATTTGCTTTG CCCCCACCAA CATCATACTC 
GTAATCCACC ATGCCAACTA CTACTACCAC AATACCGACA GCTTGTACTT TATGTATCTT 
ATTGCTCTGT GCCTGGGGAG CCTGAATAGC TGCCTAGATC CATTCCTTTA CTTTGTCATG 
TCGAAAGTTG TAGATCAGCT TAATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034300.3
CDS	145..1254
Translation	MKILILVAAGLLFLPVTVCQSGINVSDNSAKPTLTIKSFNGGPQNTFEEFPLSDIEGWTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYILLFVVGVPANIVTLWKLSLRTKSISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVFGEVTCRITTVVFYGNMYCAILILTCMGINRYLATAHPFTYQKLPKRSFSMLMCGMVWVMVFLYMLPFVILKQEYHLVHSEITTCHDVVDACESPSSFRFYYFVSLAFFGFLIPFVIIIFCYTTLIHKLKSKDRIWLGYIKAVLLILVIFTICFAPTNIILVIHHANYYYHNTDSLYFMYLIALCLGSLNSCLDPFLYFVMSKVVDQLNP

Target ORF information:

RefSeq Version	NM_010170.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor II (thrombin) receptor-like 2 (F2rl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010170.4

ORF Insert Sequence:

ATGAAAATCC TTATCTTGGT TGCAGCTGGG CTGCTGTTTC TGCCAGTCAC TGTTTGCCAA 
AGTGGCATAA ATGTTTCAGA CAACTCAGCA AAGCCAACCT TAACTATTAA GAGTTTTAAT 
GGGGGTCCCC AAAATACCTT TGAAGAATTC CCACTTTCTG ACATAGAGGG CTGGACAGGA 
GCCACCACAA CTATAAAAGC GGAGTGTCCC GAGGACAGTA TTTCAACTCT CCACGTGAAT 
AATGCTACCA TAGGATACCT GAGAAGTTCC TTAAGTACCC AAGTGATACC TGCCATCTAC 
ATCCTGCTGT TTGTGGTTGG TGTACCAGCC AACATCGTGA CCCTGTGGAA ACTCTCCTTA 
AGGACCAAAT CCATCAGTCT GGTCATCTTT CACACCAACC TGGCCATCGC AGATCTCCTT 
TTCTGTGTCA CACTGCCATT TAAGATCGCC TACCATCTCA ATGGCAACAA CTGGGTATTT 
GGCGAGGTCA CGTGCCGGAT CACCACGGTT GTTTTCTACG GCAACATGTA CTGCGCTATC 
CTGATCCTCA CCTGCATGGG CATCAACCGC TACCTGGCCA CGGCTCACCC TTTCACATAC 
CAGAAGCTGC CCAAACGCAG CTTCTCCATG CTCATGTGTG GCATGGTGTG GGTCATGGTT 
TTCTTATACA TGCTGCCCTT TGTCATCCTG AAGCAGGAGT ACCACCTCGT CCACTCCGAG 
ATCACCACCT GCCACGATGT CGTTGACGCG TGCGAGTCCC CATCATCCTT CCGATTCTAC 
TACTTCGTCT CCTTAGCATT CTTTGGGTTC CTCATCCCGT TTGTGATCAT CATCTTCTGT 
TACACGACTC TCATCCACAA ACTTAAATCA AAGGATCGGA TATGGCTGGG CTACATCAAG 
GCCGTCCTCC TCATCCTTGT GATTTTCACA ATTTGCTTTG CCCCCACCAA CATCATACTC 
GTAATCCACC ATGCCAACTA CTACTACCAC AATACCGACA GCTTGTACTT TATGTATCTT 
ATTGCTCTGT GCCTGGGGAG CCTGAATAGC TGCCTAGATC CATTCCTTTA CTTTGTCATG 
TCGAAAGTTG TAGATCAGCT TAATCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Blood130(24)2664-2677(2017 12)
Nazir S,Gadi I,Al-Dabet MM,Elwakiel A,Kohli S,Ghosh S,Manoharan J,Ranjan S,Bock F,Braun-Dullaeus RC,Esmon CT,Huber TB,Camerer E,Dockendorff C,Griffin JH,Isermann B,Shahzad K

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nature communications8(1)311(2017 08)
Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,K?hne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schn?der TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B

Altered methylation of specific DNA loci in the liver of
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(5)2090-2103(2017 05)
Lupu DS,Orozco LD,Wang Y,Cullen JM,Pellegrini M,Zeisel SH

Early embryonic expression of murine coagulation system components.
Thrombosis and haemostasis84(6)1023-30(2000 Dec)
Ong K,Horsfall W,Conway EM,Schuh AC

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F2rl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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