Igf2bp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igf2bp1
Entrez Gene ID	140486
Full Name	insulin-like growth factor 2 mRNA binding protein 1
Synonyms	AL024068,AW549074,CRD-BP,Crdbp,D030026A21Rik,D11Moh40e,D11Moh45,IMP-1,IMP1,Neilsen,ZBP-1,Zbp1,mir-3063
General protein information	Preferred Names insulin-like growth factor 2 mRNA binding protein 1 Names insulin-like growth factor 2 mRNA-binding protein 1 IGF-II mRNA-binding protein 1 IGF2 mRNA-binding protein 1 VICKZ family member 1 coding region determinant binding protein insulin-like growth factor 2 mRNA binding protein 1 dN CRDBP-2 insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP insulin-like growth factor 2, binding protein 1 zipcode binding protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 D\|11 59.08 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009951.4	NP_034081.1	insulin-like growth factor 2 mRNA-binding protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IGF2BP1	XP_005624680.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012103	XP_320427.3
Rattus norvegicus (Norway rat)	Igf2bp1	NP_783184.1
Danio rerio (zebrafish)	igf2bp1	NP_001070027.1
Homo sapiens (human)	IGF2BP1	NP_006537.3
Gallus gallus (chicken)	IGF2BP1	NP_990402.1
Bos taurus (cattle)	IGF2BP1	NP_001179383.1
Drosophila melanogaster (fruit fly)	Imp	NP_001036268.2
Pan troglodytes (chimpanzee)	IGF2BP1	XP_511944.2
	IGF2BP1	XP_001091611.1
Mus musculus (house mouse)	Igf2bp1	NP_034081.1

Gene Ontology
Bibliography

Related articles in PubMed

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.
Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH
Proceedings of the National Academy of Sciences of the United States of America114(46)E9873-E9882(2017 Nov)

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.
Lepelletier L, Langlois SD, Kent CB, Welshhans K, Morin S, Bassell GJ, Yam PT, Charron F
The Journal of neuroscience : the official journal of the Society for Neuroscience37(7)1685-1695(2017 Feb)

IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories.
Preitner N, Quan J, Li X, Nielsen FC, Flanagan JG
Development (Cambridge, England)143(15)2753-9(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that Zipcode binding protein 1 (ZBP1) is an mRNA-binding protein that regulates the local translation of proteins, including actin, in the growth cone and is required for Shh-mediated axon guidance.
Title: Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.

The tumor-suppressive role of stromal IMP1 and its ability to modulate protumorigenic factors suggest that IMP1 status is important for the initiation and growth of epithelial tumors
Title: Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.

High CRD-BP expression is associated with Breast Tumor.
Title: Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.

Results identify IGF2BP1 as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
Title: IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

This study demonstrate that ZBP1 and the phosphorylation of ZBP1 are required for attractive guidance of cortical neurons, and appropriate filopodial dynamics.
Title: Netrin-1-induced local ?-actin synthesis and growth cone guidance requires zipcode binding protein 1.

The following Igf2bp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igf2bp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21366	NM_009951.4 Latest version!	Mus musculus insulin-like growth factor 2 mRNA binding protein 1 (Igf2bp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igf2bp1 ( NM_009951.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034081.1 Mus musculus insulin-like growth factor 2 mRNA binding protein 1 (Igf2bp1), mRNA.

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CloneID	OMu21366
Clone ID Related Accession (Same CDS sequence)	NM_009951.4
Accession Version	NM_009951.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	insulin-like growth factor 2 mRNA-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL603682.36 and AL606704.20. On Mar 1, 2008 this sequence version replaced NM_009951.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK013940.1, AK044850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGAACAAGC TTTACATCGG CAACCTCAAC GAGAGTGTGA CCCCCGCAGA CTTGGAGAAA 
GTATTCGCGG AGCACAAGAT CTCCTACAGC GGCCAGTTCT TGGTCAAATC CGGCTACGCC 
TTCGTGGATT GCCCCGACGA GCACTGGGCG ATGAAGGCCA TCGAAACTTT CTCGGGGAAA 
GTAGAACTGC AAGGAAAACG TCTAGAGATT GAACACTCAG TCCCCAAAAA ACAAAGGAGT 
CGGAAAATAC AGATCCGCAA TATTCCACCT CAGCTCCGAT GGGAAGTGCT AGATAGCCTG 
CTGGCTCAGT ACGGTACAGT GGAGAACTGT GAGCAAGTGA ACACTGAAAG TGAGACAGCT 
GTGGTCAACG TCACCTACTC TAACCGGGAG CAGACCAGGC AAGCTATCAT GAAGCTAAAT 
GGCCATCAAC TGGAGAACCA TGCCCTGAAG GTCTCCTACA TACCTGATGA GCAGATAACG 
CAAGGTCCTG AGAATGGGCG TCGTGGAGGC TTTGGGTCTC GGGGCCAGCC CCGGCAAGGG 
TCGCCCGTGG CAGCAGGGGC TCCAGCCAAG CAGCAGCCAG TGGACATCCC TCTCCGGCTC 
CTGGTGCCTA CGCAGTATGT AGGCGCTATC ATTGGCAAGG AGGGTGCCAC CATCCGAAAC 
ATCACAAAAC AGACGCAGTC CAAAATAGAC GTGCATAGGA AGGAGAATGC GGGCGCTGCG 
GAGAAGGCCA TCAGCGTGCA TTCAACCCCT GAAGGCTGCT CCTCCGCGTG CAAGATGATC 
TTGGAGATTA TGCACAAGGA GGCAAAGGAC ACCAAAACGG CAGATGAAGT TCCCCTGAAG 
ATCCTGGCTC ATAACAACTT CGTCGGGCGA CTCATTGGCA AGGAAGGGCG GAACCTGAAG 
AAGGTGGAGC AGGACACAGA GACGAAGATC ACCATCTCAT CGCTCCAGGA CCTCACGCTC 
TATAACCCTG AGAGGACCAT CACTGTGAAG GGCGCCATTG AGAACTGTTG CAGGGCCGAG 
CAGGAGATCA TGAAGAAAGT TCGAGAGGCT TACGAGAACG ACGTGGCCGC CATGAGCTTG 
CAGTCCCACC TCATCCCTGG GCTTAACCTG GCTGCTGTAG GTCTCTTCCC AGCTTCATCC 
AGCGCTGTCC CTCCTCCTCC CAGCAGTGTC ACCGGGGCTG CTCCCTATAG CTCCTTCATG 
CAGGCTCCGG AGCAGGAGAT GGTACAAGTG TTCATCCCCG CCCAGGCTGT GGGCGCCATC 
ATTGGCAAGA AGGGCCAGCA CATCAAACAA CTCTCCCGCT TCGCCAGCGC CTCCATCAAG 
ATTGCACCAC CAGAAACACC TGACTCCAAA GTTCGAATGG TCGTCATCAC TGGACCCCCA 
GAGGCTCAGT TCAAGGCCCA GGGAAGAATC TATGGCAAAC TAAAAGAAGA GAATTTCTTT 
GGTCCCAAGG AGGAAGTAAA GCTAGAGACC CACATACGGG TTCCGGCTTC AGCAGCCGGC 
CGTGTCATCG GCAAAGGCGG CAAAACGGTG AATGAGCTGC AGAACTTGAC CGCAGCTGAG 
GTGGTAGTGC CAAGAGACCA GACCCCGGAT GAGAACGACC AAGTCATTGT TAAGATCATC 
GGACATTTCT ATGCCAGCCA GATGGCTCAG CGGAAGATCC GAGACATCCT GGCTCAAGTT 
AAGCAACAGC ACCAGAAGGG ACAGAGCAAC CTGGCCCAGG CTCGGAGGAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034081.1
CDS	312..2045
Translation	MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDCPDEHWAMKAIETFSGKVELQGKRLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQITQGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQPVDIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPASSSAVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPETPDSKVRMVVITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPRDQTPDENDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQKGQSNLAQARRK

Target ORF information:

RefSeq Version	NM_009951.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like growth factor 2 mRNA binding protein 1 (Igf2bp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009951.4

ORF Insert Sequence:

ATGAACAAGC TTTACATCGG CAACCTCAAC GAGAGTGTGA CCCCCGCAGA CTTGGAGAAA 
GTATTCGCGG AGCACAAGAT CTCCTACAGC GGCCAGTTCT TGGTCAAATC CGGCTACGCC 
TTCGTGGATT GCCCCGACGA GCACTGGGCG ATGAAGGCCA TCGAAACTTT CTCGGGGAAA 
GTAGAACTGC AAGGAAAACG TCTAGAGATT GAACACTCAG TCCCCAAAAA ACAAAGGAGT 
CGGAAAATAC AGATCCGCAA TATTCCACCT CAGCTCCGAT GGGAAGTGCT AGATAGCCTG 
CTGGCTCAGT ACGGTACAGT GGAGAACTGT GAGCAAGTGA ACACTGAAAG TGAGACAGCT 
GTGGTCAACG TCACCTACTC TAACCGGGAG CAGACCAGGC AAGCTATCAT GAAGCTAAAT 
GGCCATCAAC TGGAGAACCA TGCCCTGAAG GTCTCCTACA TACCTGATGA GCAGATAACG 
CAAGGTCCTG AGAATGGGCG TCGTGGAGGC TTTGGGTCTC GGGGCCAGCC CCGGCAAGGG 
TCGCCCGTGG CAGCAGGGGC TCCAGCCAAG CAGCAGCCAG TGGACATCCC TCTCCGGCTC 
CTGGTGCCTA CGCAGTATGT AGGCGCTATC ATTGGCAAGG AGGGTGCCAC CATCCGAAAC 
ATCACAAAAC AGACGCAGTC CAAAATAGAC GTGCATAGGA AGGAGAATGC GGGCGCTGCG 
GAGAAGGCCA TCAGCGTGCA TTCAACCCCT GAAGGCTGCT CCTCCGCGTG CAAGATGATC 
TTGGAGATTA TGCACAAGGA GGCAAAGGAC ACCAAAACGG CAGATGAAGT TCCCCTGAAG 
ATCCTGGCTC ATAACAACTT CGTCGGGCGA CTCATTGGCA AGGAAGGGCG GAACCTGAAG 
AAGGTGGAGC AGGACACAGA GACGAAGATC ACCATCTCAT CGCTCCAGGA CCTCACGCTC 
TATAACCCTG AGAGGACCAT CACTGTGAAG GGCGCCATTG AGAACTGTTG CAGGGCCGAG 
CAGGAGATCA TGAAGAAAGT TCGAGAGGCT TACGAGAACG ACGTGGCCGC CATGAGCTTG 
CAGTCCCACC TCATCCCTGG GCTTAACCTG GCTGCTGTAG GTCTCTTCCC AGCTTCATCC 
AGCGCTGTCC CTCCTCCTCC CAGCAGTGTC ACCGGGGCTG CTCCCTATAG CTCCTTCATG 
CAGGCTCCGG AGCAGGAGAT GGTACAAGTG TTCATCCCCG CCCAGGCTGT GGGCGCCATC 
ATTGGCAAGA AGGGCCAGCA CATCAAACAA CTCTCCCGCT TCGCCAGCGC CTCCATCAAG 
ATTGCACCAC CAGAAACACC TGACTCCAAA GTTCGAATGG TCGTCATCAC TGGACCCCCA 
GAGGCTCAGT TCAAGGCCCA GGGAAGAATC TATGGCAAAC TAAAAGAAGA GAATTTCTTT 
GGTCCCAAGG AGGAAGTAAA GCTAGAGACC CACATACGGG TTCCGGCTTC AGCAGCCGGC 
CGTGTCATCG GCAAAGGCGG CAAAACGGTG AATGAGCTGC AGAACTTGAC CGCAGCTGAG 
GTGGTAGTGC CAAGAGACCA GACCCCGGAT GAGAACGACC AAGTCATTGT TAAGATCATC 
GGACATTTCT ATGCCAGCCA GATGGCTCAG CGGAAGATCC GAGACATCCT GGCTCAAGTT 
AAGCAACAGC ACCAGAAGGG ACAGAGCAAC CTGGCCCAGG CTCGGAGGAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America114(46)E9873-E9882(2017 Nov)
Haimovich G,Ecker CM,Dunagin MC,Eggan E,Raj A,Gerst JE,Singer RH

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(7)1685-1695(2017 Feb)
Lepelletier L,Langlois SD,Kent CB,Welshhans K,Morin S,Bassell GJ,Yam PT,Charron F

IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories.
Development (Cambridge, England)143(15)2753-9(2016 08)
Preitner N,Quan J,Li X,Nielsen FC,Flanagan JG

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Igf2bp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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